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  • ETS1
  • The participation of ETS in the regulation of PARP gene expression was further demonstrated in EWS cells stably transfected with Ets1 antisense cDNA constructs. (nih.gov)
  • mutations
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • First, we show that mutations in the LEF-1-binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells, and that LEF-1/GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. (ac.be)
  • Mutant competitor DNA consisted of sequence identical to the labeled probe but bearing scrambled mutations (underlined lower case lettering) at the Ets (mut-1), YY1 (mut-2), combined Ets/YY1 (mut-3) site, or irrelevant site (mut-4) used as a negative control. (nih.gov)
  • consensus
  • An overlapping Ets and yin yang 1 (YY1) consensus sequence, in addition to a SOX consensus sequence, was required for full enhancer activity. (nih.gov)
  • EMSAs were conducted using crude nuclear extracts prepared from A375 cells incubated with a labeled probe encompassing the consensus Ets/YY1 site as illustrated in the schematic of the minimal 3' element. (nih.gov)
  • Cancer
  • 1 To whom requests for reprints should be addressed, at Temple University, Fels Institute for Cancer Research, Medical Research Building, 3420 North Broad Street, Philadelphia, PA 19140. (aacrjournals.org)
  • apoptosis
  • ETS family members play important roles in development, differentiation and proliferation of cells in general and they are involved in apoptosis and tissue remodelling as well. (ox.ac.uk)
  • HUMAN
  • The human T-lymphotropic virus, type I (HTLV-I) is the causative agent of a progressive neurological disorder, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP [ 1 , 2 ]) and adult T-cell leukaemia/lymphoma (ATLL [ 3 , 4 ]) in addition to a number of other autoimmune disorders. (biomedcentral.com)
  • In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 (HIV-1) enhancer, which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1. (ac.be)
  • enhancer
  • en] Lymphoid enhancer-binding factor 1 (LEF-1) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha (TCR alpha) enhancer in a context-restricted manner in T cells. (ac.be)
  • B) Reporter constructs containing the full length 1-859 enhancer in either orientation or the minimal enhancer (294-527) were cloned upstream of the snrpn promoter and used to transfect A375 or Raji cells. (nih.gov)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • expression
  • during MC3T3-E1 osteoblast differentiation, both proteins are transiently co-expressed when Runx2 expression is enhanced. (umassmed.edu)
  • The isoflavones also inhibited Ets 1 expression, providing some insight into the molecular mechanisms of their action. (ox.ac.uk)
  • progression
  • In this review we focus on the roles of Ets-1 for tumour development and progression with special emphasis on tumour vascularization and invasion. (ox.ac.uk)
  • kinase
  • p38 Mitogen-Activated Protein Kinases;Tumor Necrosis Factor-alpha;Extracellular Signal-Regulated MAP Kinases;Interferon-gamma;Nitric Oxide;Microglia;Astrocytes;RNA, Messenger;Reverse Transcriptase Polymerase Chain Reaction;MAP Kinase Signaling. (musc.edu)
  • These proteins seem to function at a checkpoint for nutritional status in G 1 as well as in response to the phosphatidylinositol 3-kinase (PI3K)-dependent pathway. (biomedcentral.com)
  • activation
  • TSC2 acts as a GTPase-activating protein for the Rheb GTPase which has been proposed to induce conformational change in, and activation of, mTORC1 thereby enabling phosphorylation of downstream factors. (biomedcentral.com)
  • function
  • p>This subsection of the 'Function' section specifies the position and type of each DNA-binding domain present within the protein. (uniprot.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • sites
  • This element contains critical ETS-binding sites conserved between zebrafish and pufferfish. (zfin.org)
  • Source
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)