• In order to get the most comprehensive information from an experiment, there will be many decisions required to be made as understanding and handling mass spectrometry data is a multifaceted task. (rasayanika.com)
  • focuses on the development and implementation of innovative mass spectrometric methods for the more efficient and detailed characterization of proteins in relation to their biological function. (uu.nl)
  • Finally, we apply GPS to the identification of blood-based biomarkers and identify a panel of proteins that are highly accurate in discriminating between subphenotypes of septic acute kidney injury from undepleted plasma to showcase the utility of GPS in discovery DIA-MS proteomics. (lu.se)
  • and there is significant demand for mass spectrometry (MS) based proteomics tools that can be used to rapidly quantify large numbers of proteins using simple sample preparation. (genomebc.ca)
  • While quantitative multiple reaction monitoring mass spectrometry (MRM-MS) assays have already been established to measure proteins in human fluids, similar assays have yet to be developed in mice, despite their key role in drug development and biomedical research. (genomebc.ca)
  • Here, we employ stable isotope labeling with amino acids in cell culture (SILAC)-based proteomics to quantify the response of over 6200 proteins to increasing concentrations of tunicamycin in HeLa cells. (torvergata.it)
  • For identification, characterization & quantification of proteins, Mass spectrometry-based proteomics is emerging as a broadly effective means. (rasayanika.com)
  • Having the ability to handle the complexities associated with the proteome, mass spectrometry (MS) has gained popularity amongst the toolkit of techniques with which proteins can be investigated on a large scale. (rasayanika.com)
  • Mass Spectrometry-based proteomics advances our understanding of biology and its concepts on a systems-wide level for a wide range of applications including the investigations of human health, bioremediation, and microbial communities, as it increasingly contributes to our understanding of the dynamics, interactions, and roles that proteins & peptides play. (rasayanika.com)
  • Additionally, the course also includes topics such as how mass spectrometers can be used to accurately distinguish different isoforms or modified forms of proteins (Post-translational modification), even in mixtures, that can provide added dimensions in the design of quantitative strategies and simplifies multiplex assay development. (rasayanika.com)
  • Conventional surfactants such as sodium dodecyl sulfate (SDS), the preferred surfactant for protein solubilization, are not compatible with MS. Herein, we have screened a library of surfactant-like compounds and discovered an MS-compatible degradable surfactant (MaSDeS) for tissue proteomics that solubilizes all categories of proteins with performance comparable to SDS. (umn.edu)
  • Notably, MaSDeS significantly enriches membrane proteins, which are often under-represented in proteomics studies. (umn.edu)
  • Furthermore, we have shown that MaSDeS outperforms the other MS-compatible surfactants in terms of overall protein solubility and the total number of identified proteins in tissue proteomics. (umn.edu)
  • Dr. Krokhin's research interests lie in the field of proteomics, with a focus on peptide chromatography and its applications for the analysis of proteins in complex biological samples. (umanitoba.ca)
  • Proteomics deals with the study of proteins at large scale. (proprofs.com)
  • Proteomics is the study of proteins and their functions within an organism. (proprofs.com)
  • Identification is the process of determining the identity of the proteins, often done through mass spectrometry or protein sequencing. (proprofs.com)
  • Proteomics is a field of study that involves the identification and characterization of proteins. (proprofs.com)
  • Mass spectrometry is a powerful technique used in proteomics to analyze and measure the mass of proteins. (proprofs.com)
  • It helps in identifying proteins by measuring the mass-to-charge ratio of ions produced from the protein sample. (proprofs.com)
  • Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
  • The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)
  • Analysing the composition of proteins using mass spectrometry could be the future of medical diagnosis. (lu.se)
  • Within the research field of proteomics, researchers study the link between proteins and disease. (lu.se)
  • However, mapping all our proteins, which is the initial goal of the new research field known as proteomics, will take a long time. (lu.se)
  • Cancer stem cell-associated proteins revealed by proteomics. (medscape.com)
  • This method adds another dimension to the standard proteomics approaches, which are largely based on quantification of protein abundances and/or the occupancies of their PTMs. (nature.com)
  • In this White Paper, we walk through the two main strategies for collecting and analyzing mass spectrometry data for discovery proteomics using a label-free quantification (LFQ) approach: data-dependent and data-independent acquisition-based strategies. (biognosys.com)
  • The variability introduced by different methods prior to quantitative mass spectrometry should be considered, and accuracy and precision of MS measurements can also vary depending on the strategy used for MS quantification. (openaccesspub.org)
  • Cristian Ruse, Emily I. Chen (2014) Discovery and Quantification in Mass Spectrometry-Based Proteomics. (openaccesspub.org)
  • This experiment is commonly performed to identify transitions used for quantification by tandem MS. In a neutral loss scan, the first mass analyzer scans all the masses. (wikipedia.org)
  • However, current proteomics workflows entail several manual sample preparation steps and are challenged by the microscopic mass-limited samples generated by LCM, impacting measurement robustness, quantification and throughput. (nih.gov)
  • Its pages include single-cell proteomics methods , computational analysis tools , and data and metadata from single mammalian cells, both primary cells and cell lines. (slavovlab.net)
  • At the Proteomics and Mass Spectrometry Facility, our mission is to provide state-of-the-art instrumentation and software products, along with expert training, assistance, and partnering opportunities, to ensure that our colleagues and customers receive the highest-quality data to support their research endeavors. (psu.edu)
  • The Institut Curie Mass Spectrometry and Proteomics facility (LSMP) was established in 2001 to answer a request in proteomics. (institut-curie.org)
  • The Mass Spectrometry and Proteomics Facility is unaffected by the fire in the main BMS building. (st-andrews.ac.uk)
  • The UMass Chan Medical School Proteomics and Mass Spectrometry Facility is a core resource offering state-of-the-art proteomic and small molecule mass spectrometric analyses to UMass Chan investigators and to the external scientific community at large. (umassmed.edu)
  • The Lund Stem Cell Center Proteomics facility is designed to meet the need of high-quality mass spectrometry-based proteomic studies at the Center, enable access to expertise in the application of proteomics in stem cell biology research, as well as access to the latest methods. (lu.se)
  • If you are working with thermally labile compounds, analyses of these samples may be accomplished using the Bruker Esquire 3000 plus ion trap mass spectrometer equipped with an ESI (electrospray) ion source. (uga.edu)
  • Through this course, one can understand in-depth basics of mass spectrometry, quantitative proteomics techniques such as iTRAQ, SILAC, and TMT using mass spectrometry, sample preparation for analysis in the mass spectrometer, analysis strategy best suited to an individual sample as this technique is mostly used in proteomics-based research nowadays, fragmentation method, type of instrumentation, and more. (rasayanika.com)
  • Here we report the first application of a matrix-assisted laser desorption/ionization (MALDI) triplequadrupole mass spectrometer for targeted proteomics. (canada.ca)
  • The molecules of a given sample are ionized and the first spectrometer (designated MS1) separates these ions by their mass-to-charge ratio (often given as m/z or m/Q). Ions of a particular m/z-ratio coming from MS1 are selected and then made to split into smaller fragment ions, e.g. by collision-induced dissociation, ion-molecule reaction, or photodissociation. (wikipedia.org)
  • These fragments are then introduced into the second mass spectrometer (MS2), which in turn separates the fragments by their m/z-ratio and detects them. (wikipedia.org)
  • Typical tandem mass spectrometry instrumentation setups include triple quadrupole mass spectrometers (QqQ), multi-sector mass spectrometer, quadrupole-time of flight (Q-TOF), Fourier transform ion cyclotron resonance mass spectrometers, and hybrid mass spectrometers. (wikipedia.org)
  • Q-TOF mass spectrometer combines TOF and quadrupole instruments, which cause high mass accuracy for product ions, accurate quantitation capability, and fragmentation experiment applicability. (wikipedia.org)
  • Hybrid mass spectrometer consists of more than two mass analyzers. (wikipedia.org)
  • Multiple stages of mass analysis separation can be accomplished with individual mass spectrometer elements separated in space or using a single mass spectrometer with the MS steps separated in time. (wikipedia.org)
  • and BEBE - four-sector (reverse geometry) mass spectrometer. (wikipedia.org)
  • Mass spectrometry (MS) has been a key player in biological investigation for some time and is the instrument of choice for high throughput proteomics. (utexas.edu)
  • Background: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. (arxiv.org)
  • Proteomic analysis and discovery using affinity proteomics and mass spectrometry. (lu.se)
  • How- recurrence after primary operation could be assessed for each pa- ever, recent developments in affinity proteomics have advanced tient, using her molecular portraits. (lu.se)
  • Tandem mass spectra of 2 peptides from sheep hemoglobin β-subunit identified in a nymph of an Amblyomma americanum tick. (cdc.gov)
  • Next, I detail research efforts in the integration of mass spectrometry data sets to increase the number of quantifiable peptides. (utexas.edu)
  • An indirect benefit of the isotopic labelling technique is a significant enhancement of the a1 ion in tandem mass (MS/MS) spectra of all peptides studied. (canada.ca)
  • The technique was then applied to validate an important virulence biomarker of the fungal pathogen Candida albicans, which was not accurately quantified using global proteomics experiment employing two-dimensional liquid chromatography/electrospray ionization tandem mass spectrometry (2D-LC/ESI)-MS/MS. Using LC/MALDI-MRM analysis of five tryptic peptides, the protein PHR1 was found to be upregulated in the hyphal (pathogenic) form of C. albicans by a factor of 7.7W0.8. (canada.ca)
  • These peptides are then identified and quantified with high-precision mass spectrometry, revealing detailed information about on- and off-target binding events and generating a ranked list of predicted drug targets across the proteome. (biognosys.com)
  • First, the digested proteome is exposed to these antibodies, whereby motif-containing peptides are enriched, which then are detected and identified by mass spectrometry. (lu.se)
  • Generating and analyzing overlapping peptides through multienzymatic digestion is an efficient procedure for de novo protein using from bottom-up mass spectrometry (MS). Despite improved instrumentation and software, de novo MS data analysis remains challenging. (lu.se)
  • The Heck laboratory is also a pioneer in macromolecular or native mass spectrometry, which enable the analysis of intact protein assemblies by mass spectrometry. (uu.nl)
  • Then, she pursued her postdoctoral training of mass spectrometry-based proteomics technology at the Scripps Research Institute in Dr. John Yate's laboratory. (openaccesspub.org)
  • Euro Mass Spectrometry 2019 is a unique opportunity to discuss best practices within the laboratory research and those in other industries if the people are doing related things getting a variety of viewpoints can help us see where we can change or improve our own ideas and processes. (massspectra.com)
  • To predict Anopheles drivers of malaria transmission, such as mosquito age, blood feeding and Plasmodium infection, we evaluated artificial neural networks (ANNs) coupled to matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) and analysed the impact on the proteome of laboratory-reared Anopheles stephensi mosquitoes. (nature.com)
  • In previous work, our laboratory focused on developing Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT/A-G serotypes in buffer and BoNT/A, /B, /E, and /F in clinical samples. (cdc.gov)
  • ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
  • He has an extensive track-record in quantitative proteomics, introducing metabolic stable isotope labeling in multicellular organisms such as Drosophila and C. elegans, using SILAC for studying stem cell and B cell differentiation, and stable isotope labeling by using chemical approaches, for example to follow differential pTyr phosphorylation in differentiating stem cells. (uu.nl)
  • Mass spectrometry (MS) has been successfully used to analyze biological samples and advances of MS-based approaches have turn MS data from largely qualitative to quantitative. (openaccesspub.org)
  • This conference brings together individuals who are interested in fields of mass spectrometry the Therapeutic approaches for mass spectrometry paving way to explore issues of mutual concern as well as exchange knowledge, share evidence and ideas, and generate solutions. (massspectra.com)
  • In tandem mass spectrometry (MS2)-based multiplexed quantitative proteomics, the complement reporter ion approaches (TMTc and TMTproC) were developed to eliminate the ratio-compression problem of conventional MS2-level approaches. (princeton.edu)
  • [ 5 ] Obviously, the study of CSCs in any given tumor type, by proteomics or other approaches, requires prior validation of their actual existence. (medscape.com)
  • Triple quadrupole mass spectrometers use the first and third quadrupoles as mass filters. (wikipedia.org)
  • Johan Malmström is Professor and principal investigator of the Infection Medicine Proteomics group at the Department of Clinical Sciences. (lu.se)
  • Studying the phenomenon of life and promoting human health is the main significance of proteomics research. (rasayanika.com)
  • Thus, the use of MaSDeS will greatly advance tissue proteomics and realize its potential in basic biomedical and clinical research. (umn.edu)
  • Journal Of Proteomics And Genomics Research - 1(3):4-15. (openaccesspub.org)
  • She has been developing and conducting multidisciplinary research projects to bridge the knowledge between biology and mass spectrometry. (openaccesspub.org)
  • Mass spectrometry (MS), with its qualitative and quantitative capabilities, has proven to be a power tool for biological and biomedical research. (openaccesspub.org)
  • News in Proteomics Research: A (modern) beginner's guide to mass spectrometry-based proteomics! (blogspot.com)
  • https://www.dzne.de/en/research/research-areas/fun. (proteomics-academy.org)
  • We have our own equipment for highly competitive biomarker research including state-of-the-art mass spectrometry (Exploris 480 with FAIMS, QTRAP6500), immunoassay instruments (Simoa, Ella) and devices for sample handling (e.g. (proteomics-academy.org)
  • Targeted protein degradation is one of our key therapeutic focus areas , and our three next-generation mass spectrometry (MS) proteomics research service platforms - TrueDiscovery™ , TrueTarget™ and TrueSignature™ - all have something to offer biopharma companies working in this fast-growing field. (biognosys.com)
  • His research has contributed significantly to the establishment of a world-leading research program in proteomics and has provided analytical support to many research and industrial labs conducting leading studies in human health, biochemistry, biofuels, and the food industry. (umanitoba.ca)
  • The Center for Scientific Computing and Visualization Research at the University of Massachusetts Dartmouth focuses on computationally-driven research that addresses the pressing needs of modern engineering, mechanics, fluid dynamics, and electromagnetics. (umassmed.edu)
  • My early research was on mass-spectrometry proteomics. (lu.se)
  • Later, I moved to NNF Center for Protein Research in Copenhagen, where I was working with application of machine learning on LC-MS/MS proteomics data and PPI networks. (lu.se)
  • His research focus is to develop and apply proteomics based techniques to characterize the molecular mechanisms behind invasive bacterial infection. (lu.se)
  • His research utilises miniaturised bioanalytical techniques, lab-on-a-chip, where microchip based biomarker analysis and sample preparation in proteomics is in focus. (lu.se)
  • We are at the forefront when it comes to exposure/emission characterization with advanced state-of-the-art online and offline instrumentation, such as time-of-flight aerosol mass spectrometry and electron microscopy. (lu.se)
  • Some of you ridiculous people are great at mass spectrometry and biology things. (blogspot.com)
  • Here, the authors review the novel insights that these studies have provided and present a comprehensive strategy for the use of proteomics in studying cancer SC biology. (medscape.com)
  • Comparative proteomics of the larval and adult stages of the model cestode parasite Mesocestoides corti. (cdc.gov)
  • Mass spectrometric data can provide intact protein molecular weight as well as protein identification by peptide mass fingerprint or MS/MS data, combined with protein database searching. (umn.edu)
  • Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol. (cdc.gov)
  • Z3 offers qualitative and quantitative proteomics to understanding the dynamics involved in leukemic processes. (uni-ulm.de)
  • Continuous improvement and development of bioanalytical techniques, particularly mass spectrometry, enable accurate qualitative and quantitative determination and even spatial localization of biomolecules in various biological systems. (uni-giessen.de)
  • However, the generation of large, inherently rich, proteomics data sets has far outpaced our ability to utilize them to produce biological knowledge. (utexas.edu)
  • The ultimate utility of MS proteomics is closely tied to our ability to interpret, integrate and validate this voluminous data. (utexas.edu)
  • By way of introduction, I discuss the creation of the Open Proteomics Database, which aims to increase publicly available data and to encourage broader contribution from the statistical and bioinformatic communities. (utexas.edu)
  • Then, we introduce a method to independently validate large scale proteomics data sets. (utexas.edu)
  • The package eases the burden of working with MS proteomics data, reducing the barrier of entry to developers and offering useful tools to analysts of MS proteomics data. (utexas.edu)
  • Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers. (lu.se)
  • Results: We present a new algorithm, Sparse Proteomics Analysis (SPA), based on the theory of compressed sensing that allows us to identify a minimal discriminating set of features from mass spectrometry data-sets. (arxiv.org)
  • We show (1) how our method performs on artificial and real-world data-sets, (2) that its performance is competitive with standard (and widely used) algorithms for analyzing proteomics data, and (3) that it is robust against random and systematic noise. (arxiv.org)
  • Mass spectrometry proteomics is the perfect tool for this task, providing detailed data about target binding, degradation selectivity and mechanism of action in the early stages of drug development, as well as information about efficacy and safety in preclinical and clinical phases (Zhang et al. (biognosys.com)
  • What are the most common reasons for obtaining poor mass spectrometric data? (epfl.ch)
  • This data is used for the purposes of traffic analysis and can be used for mass surveillance . (wikipedia.org)
  • Tandem mass spectrometry analysis of MDI-albumin revealed MDI conjugation occurs at a dilysine motif at Lys525, as well as at a glutamine-lysine motif at Lys414, in good agreement with previously published in vitro data on diisocyanate-conjugated serum albumin. (cdc.gov)
  • Proteomic comparison of osteoarthritic and reference human menisci using data-independent acquisition mass spectrometry. (lu.se)
  • Recently, we presented the DirectMS1 method of ultrafast proteome-wide analysis based on minute-long LC gradients and MS1-only mass spectra acquisition. (sdu.dk)
  • To get a new insight into pluripotency, we employed a plurifaceted experimental design combining expression proteomics with the proteome-wide integral solubility alteration (PISA) assay 7 to compare pluripotent cells with their isogenic progenies and parental cells as well as with allogeneic cells. (nature.com)
  • Thermal profiling performs proteome-wide assessment of protein solubility interpreted as their thermal stability, via the melting curves acquired across a temperature range using multiplexed proteomics 10 . (nature.com)
  • She has also implemented new proteomics techniques to perform quantitative analysis on complex biological samples such as tissues from transgenic disease models and human tissues for biomarker discovery. (openaccesspub.org)
  • Tissue proteomics is increasingly recognized for its role in biomarker discovery and disease mechanism investigation. (umn.edu)
  • To characterize specific biomarker candidates and the related pathomechanisms in detail (e.g. synaptic marker beta-synuclein in blood), we develop highly sensitive and accurate methods using targeted mass spectrometry (MRM, PRM, IP-MS) to study samples from large patient cohorts and evaluate their value for use in the clinic or drug development (e.g. (proteomics-academy.org)
  • Capillary electrophoresis (CE) nanoelectrospray ionization (nanoESI) provides high-resolution mass spectrometry (HRMS) with trace-level sensitivity, but compressed separation during CE challenges protein identification by tandem HRMS with limited MS/MS duty cycle. (researchwithrutgers.com)
  • Tandem Mass Tag quantitative proteomics was utilized to disclose the temporal protein expression sample throughout osteogenic differentiation of hPDLSCs on days. (procognia.com)
  • Database search programs for peptide identification by tandem mass spectrometry ask their users to set various parameters, including precursor and fragment mass tolerances, digestion specificity, and allowed types of modifications. (parc.com)
  • In collaborations with other investigators, Dr. Chen applied discovery-based proteomics analysis to interrogate normal cellular processes such as regulatory mechanisms of iPSCs and post-translational modifications on pluripotent stem cells as well as disease processes such as heterogeneity of tumor microenvironment and neurodegeneration. (openaccesspub.org)
  • Here we describe a program called Preview that analyzes a set of mass spectra for mass errors, digestion specificity, and known and unknown modifications, thereby facilitating parameter selection. (parc.com)
  • In a clinical setting one is often interested in how mass spectra differ between patients of different classes, for example spectra from healthy patients vs. spectra from patients having a particular disease. (arxiv.org)
  • This project has addressed the growing need for MS-based proteomics tools for protein quantitation in the mouse. (genomebc.ca)
  • Therefore, the development of methods for accurate protein quantitation is one of the most challenging areas of proteomics. (openaccesspub.org)
  • During MS/MS analysis, each isobaric tag is fragmented to produce a unique reporter ion mass that is used for quantitation 1 . (openaccesspub.org)
  • Moreover, Preview optionally recalibrates mass over charge measurements, leading to further improvement in identification results. (parc.com)
  • We use SBV to compare the false identification rate accuracy (FIRA) and recall capabilities of widely used techniques for error estimation in MS based proteomics. (utexas.edu)
  • Each instrumental configuration utilizes a unique mode of mass identification. (wikipedia.org)
  • Identification of Changing Ribosome Protein Compositions using Mass Spectrometry. (bvsalud.org)
  • The Heck group evelops mass spectrometers dedicated for this work and applies these technologies to study the structure and dynamics of for instance transcription complexes and virus assembly. (uu.nl)
  • The fragmentation step makes it possible to identify and separate ions that have very similar m/z-ratios in regular mass spectrometers. (wikipedia.org)
  • Moreover, we employed autofocusing atmospheric-pressure scanning microprobe matrix-assisted laser desorption/ionization (AP-SMALDI) mass spectrometry imaging (MSI) to investigate endogenous biomolecular localizations and distribution patterns in the venom glands of ECS. (uni-giessen.de)
  • Consistent with this finding, venom characterization via top-down and bottom-up proteomics, applied to both crude venoms and size-exclusion chromatographic fractions, revealed highly similar venom compositions among the different populations. (uni-giessen.de)
  • The Oeckl lab ( www.oeckllab.com ) uses state-of-the-art mass spectrometry for the discovery, characterization and implementation of fluid biomarkers (blood, cerebrospinal fluid) for neurodegenerative diseases such as Alzheimer´s disease, amyotrophic lateral sclerosis (ALS) or frontotemporal dementia. (proteomics-academy.org)
  • At Biognosys, we are always pushing the boundaries of mass spectrometry to develop new and exciting applications that support the latest advances in drug discovery and development. (biognosys.com)
  • The method involves simple sample preparation, is compatible with low sample volumes, and involves assay validation according to high-standard guidelines created by the proteomics community. (genomebc.ca)
  • Using our integrative proteomics approach and the web-based tool, we uncover a molecular basis for the uncoupling of robust transcription from parsimonious translation in stem cells and propose a method for maintaining pluripotency in vitro. (nature.com)
  • Use of a staining method that is not compatible for mass spectrometry based-proteomics. (epfl.ch)
  • The researchers are now using mass spectrometry instead, a method that has long been used routinely around the world to measure levels of drugs or steroid hormones. (lu.se)
  • This service consists of personnel with specialized know-how and expertise in the proteomics field as well as state-of-the-art proteomics equipment (MS, LC, softwares, etc. (institut-curie.org)
  • This central project will continue to provide means to various groups within CRC 1074 to use state-of-the-art mass spectrometry-based proteomics. (uni-ulm.de)
  • MaSDeS could be utilized in a variety of proteomics studies as well as general biochemical and biological experiments that employ surfactants for protein solubilization. (umn.edu)
  • For a precursor ion scan, the product ion is selected in the second mass analyzer, and the precursor masses are scanned in the first mass analyzer. (wikipedia.org)
  • In a product ion scan, a precursor ion is selected in the first stage, allowed to fragment and then all resultant masses are scanned in the second mass analyzer and detected in the detector that is positioned after the second mass analyzer. (wikipedia.org)
  • A particular focus is development of new proteomics techniques to investigate protein interactions between host and pathogen and to investigate systemic proteome changes during sepsis. (lu.se)
  • Tandem MS in space uses the coupling of two instrument components which measure the same mass spectrum range but with a controlled fractionation between them in space, while tandem MS in time involves the use of an ion trap. (wikipedia.org)
  • The Heck group has a track record in proteomics and especially in the analysis of protein post-translational modifications. (uu.nl)