Proteomic analysis of microtubule associated proteins during macrophage activation. Medical search. Frequent questions

Mechanisms by which E. chaffeensis establishes intracellular infection, and avoids host defenses are not well understood, but involve functionally relevant host-pathogen interactions associated with tandem and ankyrin repeat effector proteins. (frontiersin.org)
Despite its small genome and limited number of effector proteins, Ehrlichia efficiently establishes an intracellular infection and avoids immune defenses in vertebrate and invertebrate hosts through complex molecular and cellular reprogramming strategies. (frontiersin.org)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Importantly, these structurally distinct ubiquitin modifications are recognized by effector proteins with linkage-specific ubiquitin-binding domains to result in diverse functional outcomes, such as degradation, signal transduction, and alteration in subcellular localization. (biomedcentral.com)

As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. (wikipedia.org)
In particular, PPIA is predominantly expressed in the nucleus and cytoplasm of the cell, where it partakes in intracellular signaling, protein transport, and transcription regulation. (wikipedia.org)
It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. (thermofisher.com)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
hippocampal neurons to e tracellular soluble AB oligomers induce in vivo and in vitro intracellular Tau hyperphosphorylation and trigger decreased microtubule Brefeldin A supplier stability and Inhibitors,Modulators,Libraries NFT Inhibitors,Modulators,Libraries formation. (kspinhibitors.com)

Jansen 2019) Since microglia and astrocytes are the primary producers of APOE, the protein with the strongest genetic link to AD, they are predicted to have a critical and complementary role in pathophysiology. (howwechangedourminds.com)
in the brain this occurs in the microglia, which have the same embryonic origin as macrophages. (howwechangedourminds.com)
Lipid overload leads to formation of lipid droplet-accumulating microglia which resemble the foamy macrophages of atherosclerotic lesions. (howwechangedourminds.com)

A transcriptome analysis proved 2680 differently expressed genes (DEGs) between the model and didymin groups and suggested that the PI3K/Akt and metabolic pathways might be the most relevant targets. (bvsalud.org)

PPIA-mediated activation of the ERK, JNK, and p38 kinase pathways also contributes to angiogenesis. (wikipedia.org)
Ingenuity® Pathway Analysis was used to identify significantly affected pathways in the transcriptomic and proteomic data sets. (biomedcentral.com)

Endosomal/lysosomal proteins were particularly highly enriched in amyloid plaques. (researchsquare.com)
Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)

In siliteo analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT & revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. (baoninhsunrise.com)
Hits common to both data sets indicate disrupted cellular metabolism, calcium signaling, protein stability, DNA binding, and cytoskeletal cell structure. (biomedcentral.com)
Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)

As specialized, inducible cytoplasmic organelles, lipid droplets have functions beyond the regulation of lipid metabolism, in cell signalling and activation, membrane trafficking and control of inflammatory mediator synthesis and secretion. (microbiologyresearch.org)
Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. (microbiologyresearch.org)
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein. (microbiologyresearch.org)
The first step in the cascade is microglial lipid accumulation and immune activation. (howwechangedourminds.com)
Specifically, 3 areas of genetic correlation with AD-lipid regulation, immune regulation, and protein clearance-are promising areas of focus for targeted intervention. (howwechangedourminds.com)
Lipid catabolism, we carried out colocalization analyses by confocal microscopy. (angiotensinreceptor.com)
Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)

PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate protein folding. (wikipedia.org)
Each type of amyloidosis is classified according to clinical signs and the main peptide or protein that constitutes the amyloid fibrils. (hyperthermicwellness.com)

Recent developments in mass spectrometry-based phosphoproteomics have led to the identification of thousands of differentially phosphorylated proteins and their phosphorylation sites. (molcells.org)
Our integrated approach can be used to identify functionally important phosphorylation sites among differentially phosphorylated sites, and unlike conventional approaches, it is easily applicable for large-scale and/or high-throughput analyses. (molcells.org)
High-accuracy identification and bioinformatic analysis of in vivo protein phosphorylation sites in yeast. (mpg.de)

Under severe hypoxia, N,N-DMT robustly increased the survival of in vitro cultured human cortical neurons, monocyte-derived macrophages, và dendritic cells acting through σ-1Rs15. (baoninhsunrise.com)

In hemopoietic cells, subcellular localization of PPIA from the nucleus to the cytoplasm has been observed during c-Jun N-terminal kinase- and serine protease-dependent microtubule disruption. (wikipedia.org)
Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)

RNA sequencing (RNA-seq), quantitative proteomics, and phosphoproteomic analyses were also performed. (biomedcentral.com)
The aim of this study was to comprehensively identify proteins that are enriched in amyloid plaques using unbiased proteomics in two subtypes of early onset AD: sporadic early onset AD (EOAD) and Down Syndrome (DS) with AD. (researchsquare.com)
Mass spectrometry-based proteomics is an alternative approach that allows efficient quantification of thousands of amyloid plaque proteins simultaneously. (researchsquare.com)
Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression to better understand the biology between transcriptional and translational regulation. (biomedcentral.com)

Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
Tunable light and drug induced depletion of target proteins. (opencampus.net)

A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. (molcells.org)
Tau is a protein that is important in neuronal function, but can misfold and aggregate into pathological structures that accumulate in neurodegenerative disorders such as Alzheimer's disease. (utsa.edu)
Pathological hallmarks of AD include the presence of hyperphosphorylated tau and amyloid protein deposition. (frontiersin.org)
Currently, these pathological biomarkers are detected either through cerebrospinal fluid analysis, brain imaging or post-mortem. (frontiersin.org)
Here, we reviewed the physiological/pathological roles and therapeutic significance of nearly all the proteins associated with AD that addresses putative as well as probable targets for developing effective anti-AD therapies. (benthamscience.com)
The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)

Our goal was to identify novel mutations, proteins, and mRNA transcripts that are dysregulated in LGSOC, particularly in short-term survivors. (biomedcentral.com)
Additionally, we identified novel indels, regions with CNVs, dysregulated mRNA, dysregulated proteins, and phosphosites that are more prevalent in short-term survivors. (biomedcentral.com)
Secondary, mRNA-seq analysis identified Gadd45 as a potential transcriptional target of dGLYAT, as depletion of dGLYAT decreased Gadd45 mRNA level. (sdbonline.org)
In addition to confirming previous works regarding mRNA expression in Mecp2 -deficient animals, the current study identified hundreds of novel protein targets. (biomedcentral.com)

PPIA may also activate Akt and NF-κB signaling, resulting in the upregulation of Bcl-2, an antiapoptotic protein, and thus preventing apoptosis in ECs in response to oxidative stress. (wikipedia.org)
HSPs, which ameliorate oxidative stress, calpains, which help in regulating synaptic plasticity, and calmodulin-like skin protein (CLSP) with its neuroprotective role are few promising future targets for developing anti-AD therapies. (benthamscience.com)
These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation. (sdbonline.org)
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)

Meanwhile, the metabolome analysis revealed 67 differently expressed metabolites (DEMs) between the didymin and model groups that were mainly clustered into the glycerophospholipid metabolism, which was consistent with the transcriptome study. (bvsalud.org)
Much of our understanding of MeCP2 function is derived from transcriptomic studies with the general assumption that alterations in the transcriptome correlate with proteomic changes. (biomedcentral.com)

SEAP (secreted embryonic alkaline phosphatase) has been suggested as versatile reporter protein inter alia for cell ligand interaction. (envite.org)

In general, short-lived and soluble misfolded/unfolded proteins are targeted by UPS, whereas long-lived and insoluble protein aggregates are eliminated by autophagy [ 1 , 2 ]. (biomedcentral.com)

Generally, amyloid refers to misfolded peptides or proteins that demonstrate a stable, cross-beta super-secondary structure that renders it insoluble, fibrous-like, and resistant to proteolysis. (hyperthermicwellness.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)

However, functional studies of these differentially phosphorylated proteins have not been conducted in a large-scale or high-throughput manner due to a lack of methods capable of revealing the functional relevance of each phosphorylation site. (molcells.org)
Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. (baoninhsunrise.com)

Importantly, a comprehensive analysis of both the omics indicated a strong correlation between the DEGs and DEMs, and an in-depth study demonstrated that didymin alleviated metabolic disorder and hepatocyte injury likely by inhibiting the glycerophospholipid metabolism pathway through the regulation of PLA2G4B, LPCAT3, and CEPT1 expression. (bvsalud.org)

Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
Another prime degradation pathway in the cells is ubiquitin-proteasome system (UPS), in which proteins tagged by certain types of polyubiquitin chains are selectively recognized and removed by proteasome. (biomedcentral.com)

The study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis, methylation quantitative trait loci, colocalization, and promoter-anchored chromatin interaction. (inra.fr)

In the presence of reactive oxygen species (ROS), vascular smooth muscle cells (VSMCs), monocytes/macrophages, and endothelial cells (ECs) secrete PPIA to induce an inflammatory response and mitigate tissue injury. (wikipedia.org)
Also, it markedly reduced proinflammatory cytokines release by inhibiting the TLR4/NF-κB pathway activation, alleviating inflammatory injury. (bvsalud.org)
The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is involved in inflammatory signaling and is elevated within the plaques of AD brains. (bvsalud.org)
The activation of autophagy helps to relieve the excessive inflammatory response, and its dysfunction can lead to the occurrence of a variety of inflammation, immune, and metabolic disorders [ 7 ]. (hindawi.com)

Amyloid plaques and neighbouring non-plaque tissue were microdissected from human brain sections using laser capture microdissection and label-free LC-MS was used to quantify the proteins present. (researchsquare.com)
Therefore, a clearer understanding of how these toxic proteins accumulate in the brain of AD patients is significant for the development of more effective therapeutic and preventive strategies. (hyperthermicwellness.com)

Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
Amyloidosis is a large group of pathologic conditions in which a particular type of protein, called amyloid, is abnormally deposited in various tissues or organs. (hyperthermicwellness.com)
Failure to clear amyloid beta, and prionlike proliferation of pathologic proteins, including amyloid plaque and tau tangle formation, represent the end stage of the disease. (howwechangedourminds.com)

Association of RUNX3 with the events: clear biogenesis has activation of the astrocytes: mitochondrial to the CTGF surface, very co-translationally inhibiting activation of the CTGF damage which is the bovine machinery source pH( Yagi et al. (evakoch.com)

Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease and primarily consist of the protein beta amyloid (Aβ). (researchsquare.com)
Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
Alzheimer's disease (AD) and the toxicity and mechanisms of amyloid protein aggregation will be emphasized in this review. (hyperthermicwellness.com)
Emodin derivatives can also inhibit proteases and microtubule-associated proteins, which play an important role in Alzheimer's disease. (longdom.org)

Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)

Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships. (lookformedical.com)

This localization has been correlated with G2/M arrest, indicating that the protein's PPIase function may be regulated by microtubule dynamics during the cell cycle. (wikipedia.org)

Structure of the Bcs1 AAA-ATPase suggests an airlock-like translocation mechanism for folded proteins. (opencampus.net)

Cardiac hypertrophic signaling cascades resulting in heart failure diseases are mediated by protein phosphorylation. (molcells.org)
In cardiac hypertrophy, phosphorylation-dependent functional modulation of proteins, especially sarcoplasmic reticulum (SR) and sarcomere proteins, has been demonstrated. (molcells.org)

Ubiquitination is a posttranslational modification involving the conjugation of the 76 amino acid ubiquitin to the lysine residue of other proteins. (biomedcentral.com)

A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)

Many of these proteins were more significantly enriched in amyloid plaques than Aβ. (researchsquare.com)
However, we observed that the number of invaded and non attached LCLs in the lower well was significantly Inhibitors,Modulators,Libraries Fascin protein, Western blot analysis was performed upon treatment of LCLs with low doses of ACHP. (kspinhibitors.com)

The actual study examines the actual handful of offered info extracted from size spectrometry (Microsoft)-based proteomic research evaluating the impact associated with distinct varieties of exercising education around the necessary protein account associated with center (remaining ventricle as well as remote mitochondria) and the potential cross-tolerance between exercising education and illnesses as myocardial infarction as well as being overweight. (kspinhibitors.com)

A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. (rndsystems.com)
Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). (thermofisher.com)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. (lookformedical.com)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)

Based on the multiomics analysis, this study is aimed at investigating the underlying mechanism of didymin against acute liver injury (ALI). (bvsalud.org)

As a sub-objective, since PDE10A transcript variants were reported strictly through analyses of bovine genomic sequence, we also wanted to determine the nucleotide and amino acid sequences by experimental evidence. (plos.org)

Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)

Here we used shotgun mass spectrometry lớn explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. (baoninhsunrise.com)

Although a high level of PDE10A gene expression is observed in the testis, information on the identity of the isoforms or on the cell type that express the PDE10 protein is lacking. (plos.org)
Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING. (lookformedical.com)

As a consequence, proteins can be modified by ubiquitin monomer or polymer with different length and linkage types, making ubiquitination as one of the most elaborate and versatile posttranslational modifications [ 8 , 9 , 10 ]. (biomedcentral.com)

However, erroneous activation of the immune system can lead to autoimmune diseases. (utsa.edu)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)

At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Whole cell extracts (30 µg lysate) of HeLa (Lane 1), SH-SY5Y (Lane 2), A549 (Lane 3), A-431 (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). (thermofisher.com)
dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. (cuni.cz)
A protocol for generation and live-cell imaging analysis of primary cilia reporter cell lines. (cuni.cz)
Ubiquitin-proteasome system (UPS) and autophagy are two major cellular degradation machineries in eukaryotes, both of which are crucial in eliminating misfolded/unfolded proteins to maintain cell and tissue homeostasis and to prevent aging-related changes and a plethora of human diseases. (biomedcentral.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
Your P1 proteins seemed to be EPZ015938 cell line essentially the most dominant within P2, despite the fact that added proteins of 6-7 KDa had been in addition well known. (kspinhibitors.com)

The last few decades were concentrated over identifying and studying protein targets of AD. (benthamscience.com)

Previous studies have shown that many of these plaque proteins have mechanistic role in AD. (researchsquare.com)
http://www.nserc-crsng.gc.ca ) to FJR and PL. This funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. (mpg.de)
Recent studies have shown that the activation of a neuroimmune response plays a key role in the development of PD. (biomedcentral.com)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
In this review, we summarize the roles of protein ubiquitination and deubiquitination in controlling the initiation, execution, and termination of bulk autophagy as well as the role of ubiquitination in signaling certain types of selective autophagy. (biomedcentral.com)
In this review, we chose to focus on the role of protein ubiquitination in regulating autophagy. (biomedcentral.com)

Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)

PPIA is an 18 kDa, 165-amino acid long cytosolic protein. (wikipedia.org)

Effective Representation and Storage of Mass Spectrometry-Based Proteomic Data Sets for the Scientific Community. (mpg.de)

The Gamblin laboratory studies the mechanisms that lead to the polymerization of the microtubule-associated protein tau. (utsa.edu)
Another area of interest is the study of pathogenic mechanisms of Francisella tularensis , a potential bioweapon, with particular interest in determining how this bacterium evades killing within host macrophages. (utsa.edu)

Disturbed expression of these proteins results in synaptic dysfunction, cognitive impairment, memory loss, and neuronal degradation. (benthamscience.com)

The α-Syn protein is a small acidic synaptic protein made up of 140 amino acids with a tendency to misfold and aggregate [ 7 ]. (biomedcentral.com)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

The phosphoproteome of toll-like receptor-activated macrophages. (mpg.de)
To increase the sensitivity of our analysis, cells were co transfected with an e pression plasmid for LNGFR, which encodes a cytoplasmic trun cated, low affinity nerve growth factor receptor that is not e pressed on Jurkat cells, and therefore allows positive selection of transfected cells by mag netic separation. (kspinhibitors.com)

Simultaneously detect the relative levels of these angiogenesis-related proteins in a single sample. (rndsystems.com)

Subsequently, whole-genome sequencing analysis was performed on 14 LGSOC samples (7 long-term survivors and 7 short-term survivors) with matched normal tissue samples. (biomedcentral.com)

Our study highlights the significant enrichment of many proteins in amyloid plaques, many of which may be potential therapeutic targets and/or biomarkers for AD. (researchsquare.com)
Therefore, comprehensively profiling the proteins that are enriched in amyloid plaques would increase our understanding about AD pathogenesis, and possibly identify new biomarkers and/or new therapeutic targets for AD. (researchsquare.com)
Several selected protein targets were validated by Western blot analysis. (biomedcentral.com)

On diagnostic grounds of AD C-reactive protein, pentraxins, collapsin response mediator protein-2, and growth-associated protein-43 represent the future of new possible biomarkers for diagnosing AD. (benthamscience.com)

Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)

Anatomy35

Organisms18

Diseases9

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes53

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science5

Health Care2

Effector proteins4

Intracellular6

Microglia3

Expressed Genes1

Pathways2

Lysosomal proteins2

Cytoskeletal3

Lipid7

Peptide2

Phosphorylation sites3

Neurons1

Kinase6

Proteomics4

Target proteins2

Pathological6

MRNA4

Oxidative4

Transcriptome2

Embryonic1

Aggregates1

Peptides2

Differentially2

Metabolism1

Selectively2

Colocalization1

Inflammatory4

Brain2

Pathologic3

Astrocytes1

Extracellular2

Alzheimer's4

Antibodies1

Pathogens1

Dynamics1

Translocation1

Cardiac2

Lysine1

Heterogeneous1

Significantly2

Distinct1

Membrane5

Multiomics analysis1

Bovine1

Depletion1

Differences1

Isoforms2

Consequence1

Immune2

Cell8

Studying protein targets1

Role7

Molecules1

Cytosolic1

Mass1

Mechanisms2

Neuronal1

Synaptic1

Dependent1

Receptor2

Simultaneously1

Tissue1

Targets3

Mediator1

Bind1