Proteome analysis of bacterial pathogens. Medical search. Frequent questions

These data suggest that the intercellular space of X fastidiosa colonies is a multifunctional microenvironment containing proteins related to in vivo bacterial survival and pathogenesis. (ca.gov)
A codon usage analysis of the most expressed proteins from the whole cell extract revealed a low biased distribution, which we propose is related to the slow growing nature of X fastidiosa. (ca.gov)
We identified a total of 587 glycoproteins, including 1239 glycopeptides, 526 monosaccharide components, and 8326 intact glycopeptides in glycoproteomics, as well as a total of 4496 proteins identified in proteomic analysis. (frontiersin.org)
In a previous host-pathogen interaction study performed with epithelial cells, we showed proteome variation in with upregulation of many important bacterial proteins (36) that could potentially trigger direct or indirect epigenetic modifications in the host. (pkc-inhibitor.com)
In this study, we used shotgun proteomics-based differential protein expression analysis and relative quantification of both and host proteins to study pathogen-dependent host modulations. (pkc-inhibitor.com)
The team found host cells use autophagy to target specific bacterial proteins for recycling. (germz.ca)
Scientists found that different host autophagy proteins were probably targeting different sets of bacterial proteins from each pathogen. (germz.ca)
Looking at which bacterial proteins could potentially modulate autophagy showed different types of bacteria were acting against different phases in the process. (germz.ca)
Expanded T cells are screened in stimulations with pathogen proteins in the presence of autologous PBMC as antigen-presenting cells (APC). (antigendiscovery.com)
Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4-10% of the total protein amount in meconium, making it one of the most abundant proteins. (researchgate.net)
Moreover, although the abundance of most protein groups reflected that of related bacterial populations, we found a specific independent regulation of bacteria-derived cell envelope proteins. (bmj.com)
A recent publication reports the identification of nearly 3000 yeast proteins and almost 5400 mammalian cell line proteins, both in triplicate single-run MS analyses [10], which demonstrates the significant improvement in proteome coverage. (cell-metabolism.com)
Thus, with adequate sample material, modern MS instruments, and sufficient MS measurement time a complete recording of a bacterial proteome like that of with about 2800 to 2900 theoretically expected proteins is feasible today. (cell-metabolism.com)
Bacterial exported proteins represent key components of the host-pathogen interplay. (biomedcentral.com)
Analysis with the SurfG+ tool showed that more than 75% (70/93) of the identified proteins could be predicted as containing signals for active exportation. (biomedcentral.com)
Comparative analyses of the exoproteomes of two C. pseudotuberculosis strains, in addition to comparison with other experimentally determined corynebacterial exoproteomes, were helpful to gain novel insights into the contribution of the exported proteins in the virulence of this bacterium. (biomedcentral.com)
In fact, one might expect that the majority of the virulence determinants of C. pseudotuberculosis would be present in the exoproteome, i.e . the entire set of bacterial proteins found in the extracellular milieu [ 7 ]. (biomedcentral.com)
Identification of these proteins represents an important goal for bacterial proteomics, because it aids in vaccine development. (univ-antilles.fr)
The study indicates that suitable subcellular fractionation experiments combined with straightforward computational analysis approaches are powerful for determining the predominant subcellular localization of the experimentally observed proteins.We identified proteins potentially involved in E. ruminantium athogenesis, which are good novel targets for candidate vaccines. (univ-antilles.fr)

Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. (mdpi.com)
A comparison of the TF repertoire of S. aureus against 1209 sequenced bacterial genomes was carried out allowing us to identify a core set of orthologous TFs for the Staphylococacceae , and also allowing us to assign potential functions to previously uncharacterized TFs. (biomedcentral.com)
We have evaluated the orthologous distribution of these elements in other sequenced bacterial genomes using the repertoire of TFs identified in USA300, and identified a core set of regulators for both the Firmicutes phylum, and the Staphylococacceae group. (biomedcentral.com)
Bacterial genomes tend to be fairly streamlined things, probably because the rapid generation times and hence rapid evolutionary rates mean that non-functional genetic elements would soon be pruned from the genome. (fieldofscience.com)
A genome-wide analysis resulted in the detection of more than eight hundred putative chitin synthases in proteomes associated with about 130 genomes. (biomedcentral.com)
According to Shomron 7 (2010), this field of the clinical pharmacology studies the contribution of genomes, transcriptomes and proteomes in determining drug-response phenotypes (safety and efficacy). (bvsalud.org)

Researchers led by Dr. Ioannis Nezis from the University of Warwick and Dr. Tamas Korscmaros from Earlham Institute and Quadram Institute screened the proteome from 56 pathogenic bacterial species - including Salmonella, Shigella, Listeria, and Staphylococcus to see how autophagy reacts with them. (germz.ca)
The bacterial pangenome concept was introduced in 2005 for analyzing pathogenic bacterial species and can be defined as the entire set of genes in a group of representative strains of the same genus/species. (biomedcentral.com)

She is engaged in 'in-silico' analysis of genome/proteome architectures of host/vector/pathogen systems in quest of novel intervention strategies. (wikipedia.org)
Comparative genome analysis of various bacterial, viral and parasitic pathogens conducted by her group have not only given an insight into the natural forces driving the molecular evolution of the microbial world, but also provided a better understanding of the intricacies of pathogen-host interactions and co-evolution. (wikipedia.org)
We microarrays and proteomics are allowing the response of thus endeavor to understand how the pathogen adapts to bacterial pathogens to different environments to be probed the host microenvironment, what selective pressures are at the whole genome level. (cdc.gov)
Further detailed analyses of across the whole genome. (cdc.gov)
The additional information gen- these responses will increase understanding of the molec- erated by whole genome studies goes far beyond that ular mechanisms of pathogenesis, identify new bacterial derived by characterizing in isolation more genes and gene virulence factors, and aid in the design of new vaccines. (cdc.gov)
We sequenced and constructed the complete genome of an environmental strain CR1 of P. aeruginosa and performed the comparative genomic analysis. (frontiersin.org)
Hence, there is a need for developing efficient computational models to predict the interaction between host and pathogen in a genome scale, and find novel candidate effectors and/or their targets. (biomedcentral.com)
As prominent human pathogens, M. tuberculosis and M. leprae have both been subject to genome-sequencing projects. (fieldofscience.com)
Reverse vaccinology is considered as a cost-effective and proficient approach to screen the entire pathogen genome. (biomedcentral.com)
Advancements in genome sequencing technologies and high-throughput bioinformatics analyses have assisted the basic in-vivo vaccine design via in-silico practices [ 2 ]. (biomedcentral.com)
We have seen the journal evolve along with the changing landscape of health and disease, including the increasing use of genome-scale approaches in medical research and clinical practice, the generation and analysis of patient- and population-level data, and the clinical implementation of these approaches in precision medicine and public health. (cdc.gov)

The host-pathogen interactions that define a disease are homeostasis. (cdc.gov)
Thus, pathogens must have specific mecha- clearly complex, and, in many cases, the study of these nisms for mediating colonization, avoiding the host's interactions is limited by the lack of a suitable animal immune system, and acquiring necessary nutrients. (cdc.gov)
has focused on the study of the composition of the human microbiome, the inherent mechanisms underlying the complex interpathogen and host-pathogen interactions leading to polymicrobial infectious diseases of an inflammatory nature are still poorly defined. (pkc-inhibitor.com)
Tenovin-6 IC50 Host-pathogen interactions are known to induce significant changes in the transcriptional program of the host cells resulting in the mobilization of genes involved in key processes that mediate the appropriate response. (pkc-inhibitor.com)
While much has been reported on T6SS-mediated prokaryotic competition, very little is understood about the mechanisms of bacterial interactions with eukaryotic hosts. (preprints.org)
We, therefore, summarize the impacts of the T6SS effectors with a special focus on bacterial interactions with animals, plants, and fungi. (preprints.org)
The analysis of the complex molecular interactions between bacteria and human cells provides clues as to what makes bacteria successful invaders. (germz.ca)
In agriculture, study of plant-microbe interactions is demanding a special attention to develop management strategies for the destructive pathogen induced diseases that cause huge crop losses every year worldwide. (biomedcentral.com)
Among its various strains, pathovar tomato strain DC3000 ( PstDC3000 ) is asserted to infect the plant host Arabidopsis thaliana and thus, has been accepted as a model system for experimental characterization of the molecular dynamics of plant-pathogen interactions. (biomedcentral.com)
A particular focus is development of new proteomics techniques to investigate protein interactions between host and pathogen and to investigate systemic proteome changes during sepsis. (lu.se)
His research aims to elucidate molecular mechanisms underlying bacterial interactions with human cells and to use that information to identify targets for treatment and diagnostics of bacterial infections. (lu.se)
Thermal proteome profiling for interrogating protein interactions. (nih.gov)

Virulence genotype analysis revealed that strain CR1 lacked hemolytic phospholipase C and D, three genes for LPS biosynthesis and had reduced antibiotic resistance genes when compared with clinical strains. (frontiersin.org)
A comparative analysis of several isolates showed heterogeneity in their levels of virulence potential (23). (pkc-inhibitor.com)
As a result, our understanding of the population biology of these clades remains biased, limiting our knowledge of the evolution of virulence and our ability to design reliable assays that distinguish pathogen signatures from the background in the clinic and environment [ 6 ]. (biomedcentral.com)
All three human pathogens carry a 70-kb pYV virulence plasmid (also known as pCD), which carries the Ysc type III secretion system and Yops effectors [ 18 - 20 ], that is not detected in non-pathogenic species. (biomedcentral.com)

The possibility to record proteomes in high throughput and at high quality has opened new avenues for biomedical research, drug discovery, systems biology, and clinical translation. (elifesciences.org)
Mass spectrum-based high-throughput characterization of glycosylation as well as proteomic analysis has been used for years ( 7 - 11 ). (frontiersin.org)

The most famous members of this genus, of course, are the human pathogens Mycobacterium tuberculosis (the cause of, well, tuberculosis - image above from here ) and M. leprae (causing leprosy). (fieldofscience.com)
Corynebacterium pseudotuberculosis is a facultative intracellular pathogen that belongs to the so-called CMN ( Corynebacterium-Mycobacterium-Nocardia ) group, a distinct subgroup of the Actinobacteria that also includes other highly important bacterial pathogens, such as Corynebacterium diphtheriae and Mycobacterium tuberculosis . (biomedcentral.com)

Pierce's Disease is a bacterial infection, which is spread by bugs that feed on grapevines, particularly the "glassy winged sharpshooter. (ca.gov)
Pathogens including Salmonella, Shigella, and Helicobacter have developed ways of subverting or hijacking the process to aid their survival and infection strategies. (germz.ca)
Biophysical and proteomic analyses suggest functions of Pseudomonas syringae pv tomato DC3000 extracellular vesicles in bacterial growth during plant infection. (jcu.cz)
Identification of phospholipase D genes in Brassica napus and the transcriptional analysis after phytohormone treatment and pathogen infection. (jcu.cz)
His research focus is to develop and apply proteomics based techniques to characterize the molecular mechanisms behind invasive bacterial infection. (lu.se)

Bacteria such as (have previously been demonstrated to be major pathogens associated with periodontal diseases (6,C8). (pkc-inhibitor.com)

A. radioresistens is generally considered to be a commensal bacterium on human skin or an opportunistic pathogen. (nature.com)

Two of these environment, pathogens must be able to regulate the neces- methods, signature-tagged mutagenesis and in vivo sary genes in coordination as they move from the environ- expression technology, do not directly measure gene ment to the host and from one host niche to another. (cdc.gov)
expression and do not allow true genomic-scale analysis, The primary aim of investigating bacterial pathogenesis but they have been devised to identify genes necessary for is to understand the way that pathogens interact with the pathogens during real infections. (cdc.gov)
Genes belonging to proteases, bacterial exporters and DNA stabilization were found to be under strong positive selection, thus facilitating pathogenicity and survival of the outliers. (frontiersin.org)
Metabolic activity of the bacterial biofilm communities have altered as compared to the planktonic one such as increased rates of EPS production, activation or inhibition of particular genes associated with biofilm formation and decreased growth rate [ 39 ]. (biomedcentral.com)
This harmless commensal organism can acquire a mixture of comprehensive mobile genetic elements that contain genes encoding viru-lence factors, becoming an emerging human pathogen capable of causing a broad spectrum of intestinal and extraintestinal diseases. (preprints.org)
Even those genes that retain the appearance of functionality may not actually be so - comparative proteome analysis recovered only 391 soluble protein species in M. leprae , as opposed to ~1800 in M. tuberculosis . (fieldofscience.com)
Due to genomic diversity in bacterial species, a large number of variable genes accumulate in species gene pool ultimately resulting in the species pangenome expansion [ 4 ]. (biomedcentral.com)
It also highlights the importance of HGT in the evolutionary history of CHS and describes bacterial chs genes for the first time. (biomedcentral.com)
an in-depth analysis of the first 2000 cases revealed that approximately 30% of patients with suspected genetic disease harbored presumptive causative mutations in disease genes that were discovered in the previous 3 years. (cdc.gov)
Categoría amplia de factores celulares endógenos de las células huésped regulados al alza en respuesta a patógenos (es decir, genes estimulados por INTERFERONES) y reclutados para interferir en la REPLICACIÓN VIRAL y/o desencadenar una respuesta de INMUNIDAD CELULAR antiviral del huésped. (bvsalud.org)

A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. (lu.se)
PERSPECTIVE their application to analysis of bacterial pathogens during terial gene expression during growth in vitro under condi- real infections is still in its infancy. (cdc.gov)
In response to pathogen infections, rice produces many phytoalexins, including diterpenoid compounds and the flavonoid sakuranetin [ 5 ]. (researchsquare.com)
There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs. (biomedcentral.com)
Staphylococcus aureus is a facultative human pathogen and the casual agent of a diverse array of diseases, including superficial skin and wound-related tissue infections, food poisoning, bacteremia, endocarditis and pneumonia. (biomedcentral.com)
Dr. Nezis said bacterial infections pose one of the greatest global threats to human health. (germz.ca)
Our systems-level analysis has highlighted the complex interplay between host autophagy and bacteria to inspire future experimental studies to elucidate the detailed molecular mechanisms of autophagy in the pathogenesis of bacterial infections. (germz.ca)
Using activators of autophagy with antibiotics, as antibiotic resistance breakers, would be a very promising way to fight bacterial infections. (germz.ca)
Raman spectroscopy has slipped into biomedical science proving its utility in medical diagnostics for diseases as diverse as cancer, cardiovascular disease and bacterial infections. (news-medical.net)

Proteomics analyses have significantly contributed toward a deeper understanding of the molecular mechanisms utilized by several oral pathogens such as (30), (31), (32), and (33,C35) during their interaction with the host. (pkc-inhibitor.com)
Quantitative proteomics strategies such as SILAC and iTRAQ have been widely applied to study the dynamics of proteome. (genengnews.com)
His research utilises miniaturised bioanalytical techniques, lab-on-a-chip, where microchip based biomarker analysis and sample preparation in proteomics is in focus. (lu.se)

Recent works from her group on 'pan-genomic analysis of human microbiome in health and diseases' have also been highly acknowledged in scientific literature. (wikipedia.org)
A comparative oral microbiome analysis of the healthy and diseased states has indicated diversity in the microbial communities (9, 10). (pkc-inhibitor.com)

Understanding the PPI network between a host and pathogen is a critical step for studying the molecular basis of pathogenesis. (biomedcentral.com)

Last, functional, genomic, and phylogenetic analyses indicate that the optional top gate provides a gain of watertightness. (bvsalud.org)
Phylogenetic analyses were performed with special care to avoid any pitfalls associated with the peculiarities of these sequences (e.g. highly variable regions, truncated or recombined sequences, long-branch attraction). (biomedcentral.com)

Comparative genomic analysis of Haemophilus haemolyticus and non-typeable Haemophilus influenzae and a new testing scheme for their discrimination. (cdc.gov)
New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. (biomedcentral.com)

Further analyses revealed that the SA content increased much more rapidly in H471 than in HHZ after the inoculation, suggesting that the SA signaling pathway was activated faster in the incompatible interaction than in the compatible interaction. (researchsquare.com)
Overall, our results indicate that during an incompatible interaction between H471 and PXO99 A , rice plants prevent pathogen invasion and also initiate multi-component defense responses that inhibit disease development. (researchsquare.com)
Comparative analysis and unification of domain-domain interaction networks. (leibniz-fli.de)
This can be a useful resource to the plant community to characterize the host-pathogen interaction in Arabidopsis and Pseudomonas system. (biomedcentral.com)
In case there is hostCpathogen interaction research, data through the HPP may be used to elucidate the response from the sponsor when encountering the pathogen. (cell-metabolism.com)

Turning to the proteome to elucidate the complex potential relationship between sugar intake and T2D incidence did not provide a clear enlightenment, but despite the fact that no significant associations were observed between added sugar and SSB intake with levels of CRP, the data suggests that SSB intake is related to a T2D-pathological proteomic signature, while this was not observed for added sugar intake. (lu.se)

Pseudomonas syringae is a major bacterial leaf pathogen that causes diseases in a wide range of plant species. (biomedcentral.com)
To date, only a few predictors are available for identifying general bacterial promoters with limited predictive performance.In this study, we developed TIMER, a Siamese neural network-based approach for identifying both general and species-specific bacterial promoters. (giwebb.com)
Specifically, TIMER uses DNA sequences as the input and employs three Siamese neural networks with the attention layers to train and optimize the models for a total of 13 species-specific and general bacterial promoters. (giwebb.com)
To look for broad-spectrum immunogenic targets and analysis of closely-related bacterial species, the assimilation of pangenome concept into reverse vaccinology approach is essential. (biomedcentral.com)
On the other hand, closely related bacterial species share a large number of genomic contents and hence remain less diverge. (biomedcentral.com)
Thus, pangenome analysis is a suitable approach for estimating the diversity in strains of the same species and in rarely in Genera [ 4 ]. (biomedcentral.com)
This comprehensive multi-species analysis contributes to the classification of fungal CHS, in particular by optimizing its robustness, consensuality and accessibility. (biomedcentral.com)

Although using these technolo- acting on the pathogen in each microenvironment, what gies to analyze pathogens within a host is still in its infancy, bacterial factors are responsible for the host damage, and initial studies indicate that these technologies will be valu- able tools for understanding how the pathogen reacts to the how the immune system is evaded. (cdc.gov)
Working with your team, our dedicated team of bioinformatics analysts run the data through a proprietary statistical analysis pipeline to construct heatmaps, develop univariate and multivariate statistical models for group comparisons to help analyze and interpret results and generate publication-quality figures to visualize the data. (antigendiscovery.com)
In general, previous attempts to analyze the proteome of have been limited by the necessity of preparing several samples from different bacterial cell compartments and the resulting long MS acquisition time in order to provide a more comprehensive coverage of the proteome. (cell-metabolism.com)

Secretins are outer membrane (OM) channels found in various bacterial nanomachines that secrete or assemble large extracellular structures. (bvsalud.org)
Various bacterial pathogens release NADase enzymes into the host cell that deplete the host's NAD + pool, thereby causing rapid cell death. (nature.com)

Biophysical and proteomic analyses of Pseudomonas syringae pv. (jcu.cz)

It clustered with the outlier group, hence we scaled up the analyses to understand the differences in environmental and clinical outlier strains. (frontiersin.org)
The analysis presented herein highlights the complexity of regulatory networks in S. aureus strains, identifies key conserved TFs among the Staphylococacceae , and offers unique insights into several as yet uncharacterized TFs. (biomedcentral.com)
Comparison by multi-locus variable-number tandem repeat analysis and antimicrobial resistance among atypical enteropathogenic Escherichia coli strains isolated from foods and human and animal faecal specimens. (cdc.gov)

Although analyses that in vivo microenvironment. (cdc.gov)

Recently, a report combining the outcomes from six different evaluation strategies continues to 81732-46-9 be published to make different cell compartments of strain COL accessible for quantitative GATA2 analysis [7]. (cell-metabolism.com)
Technical advances in new MS instruments and applications have significantly improved the ability to provide comprehensive proteome coverage with higher degrees of quantitative accuracy [9]. (cell-metabolism.com)

Plants have developed rapid and sophisticated mechanisms that confer resistance to invading pathogens. (researchsquare.com)
In this mini-review, we will present what recently determined 3D structures have told us about the mechanisms of translocation through secretins of large substrates to the bacterial surface or in the extracellular milieu. (bvsalud.org)

This work represents the most complete proteome characterization of the OM fraction in Ehrlichia spp. (univ-antilles.fr)

This technology has been demonstrated for viral and bacterial proteomes, with work underway on the first proteome of a parasitic disease. (antigendiscovery.com)

A multicenter study benchmarks software tools for label-free proteome quantification. (cdc.gov)

Historically, periodontal disease is associated with several pathogens contributing to a complex Rabbit Polyclonal to Caspase 2 (p18, Cleaved-Thr325) microbial milieu which can initiate or directly contribute to host tissue destruction (5). (pkc-inhibitor.com)
Staphylococcus aureus is a widely distributed human pathogen capable of infecting almost every ecological niche of the host. (biomedcentral.com)
Efficient Enrichment of Bacterial mRNA from Host-Bacteria Total RNA Samples. (cdc.gov)
Dr. Korcsmáros said: "Our systems-level analysis has highlighted the complex interplay between host autophagy and bacteria and we hope that this will inspire future experiments to unpick exactly how autophagy protects against pathogen invasion and importantly could give us new targets to block pathogens that can overcome it. (germz.ca)
Among them, pathovar tomato strain DC3000 ( Pst DC3000 ) has been asserted to infect the plant host Arabidopsis thaliana and tomato causing bacterial spec and brown spot. (biomedcentral.com)
They correspond to functions allowing opportunistic pathogens to colonise the mucus layers, breach the host barriers and invade the mucosae, which could still be aggravated by decreased host-derived pancreatic zymogen granule membrane protein GP2 in CD patients. (bmj.com)
A broad category of endogenous host cellular factors upregulated in response to pathogens (i.e. (bvsalud.org)

If proteomic analysis is to overcome these challenges, it will need more traction at every stage, starting with sample preparation. (genengnews.com)

A new class of phenolic phytoalexins with antimicrobial activities against bacterial and fungal pathogens in rice comprises stress-induced phenylamides, which rely on the shikimate pathway for aromatic L-amino acids and the phenylpropanoid pathway for the phenolic acid moieties in phenylamides and sakuranetin [ 6 ]. (researchsquare.com)

The studies use both in vitro cellular models of bacterial communities (biofilms) to characterise the phenotype of disease-causing bacteria. (lu.se)

However, based on Tenovin-6 IC50 phylogenetic analysis using 16S rRNA sequences, it was reclassified in 1999 into the genus (22). (pkc-inhibitor.com)

2021) Comparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition. (oeaw.ac.at)

The Human being Proteome Task (HPP) is an extremely very clear and relevant example for the necessity and the usage of databases. (cell-metabolism.com)
Mass-spectrometry-based draft of the human proteome. (nih.gov)

Actin depolymerization is able to increase plant resistance against pathogens via activation of salicylic acid signalling pathway. (jcu.cz)

Conclusions This study provides the first evidence that quantifiable bacterial protein signals are associated with CD, which can have a profound impact on future molecular diagnosis. (bmj.com)

This suggests autophagy has evolved to combat specific threats from different bacterial pathogens by targeting processes important to the bacteria's invasion strategy. (germz.ca)

After a lot of data processing, we ended up with 64 different bacterial genera to study. (lu.se)
We statistically evaluated if intake of added sugar (as well as with the support of the urinary sucrose and fructose biomarker as mentioned in a previous blog post ), sugar-sweetened beverages and artificially sweetened beverages associated with any of the 64 bacterial genera or with various measures of microbiota composition and diversity, such as alpa diversity, beta diversity and the Firmicutes:Bacteroidetes ratio. (lu.se)

The type 2 secretion system (T2SS) is a bacterial nanomachine composed of an inner membrane assembly platform, an outer membrane pore and a dynamic endopilus. (bvsalud.org)
Members of the bacterial secretin family share a common cylinder-shaped structure with a gated pore-forming part inserted in the outer membrane, and a periplasmic channel connected to the inner membrane components of the corresponding nanomachine. (bvsalud.org)
As the permeation barrier, the bacterial membrane stands at the forefront to sense and relay signals of environmental change for metabolic adaptation. (nature.com)

A Method for Bioinformatic Analysis of Transposon Insertion Sequencing (INSeq) Results for Identification of Microbial Fitness Determinants. (cdc.gov)
Identification of bacterial pathogens from formalin-fixed paraffin-embedded tissues by using 16S sequencing: Retrospective correlation of results to clinicians' responses. (cdc.gov)
Popp also demonstrated the potential of Raman spectroscopy as a point-of-care method for a fast identification of pathogens. (news-medical.net)
Oral Mycobiome Analysis of HIV-Infected Patients: Identification of as an Antagonist of Opportunistic Fungi. (prelekara.sk)
Here, we report the identification of NADases on the surface of fungi such as the pathogen Aspergillus fumigatus and the saprophyte Neurospora crassa . (nature.com)

For a variety of reasons, most research effort has been focused on characterizing these pathogens, while their closely related non-pathogenic relatives have only been lightly studied. (biomedcentral.com)

Here we explore the feasibility of extracting bacterial protein signals relevant to CD, by interrogating myriads of intestinal bacterial proteomes from a small number of patients and healthy controls. (bmj.com)
Results Our 2D-DIGE-based discovery approach revealed an imbalance of intestinal bacterial functions in CD. (bmj.com)

Nevertheless, efficient proteome approaches will include considerations on your time and effort also, like function and measurement period, with regards to the gain of info. (cell-metabolism.com)

New technology for glycomic and glycoproteomic analysis has been used in macrophage research. (frontiersin.org)

Finally, we develop new computational methods that enable faster and better analysis of complex biological data, as well as more interactive and intuitive data visualization. (ccmb.res.in)
Improvements at this stage may be especially important, since lapses here may be beyond correction at subsequent stages, which include the generation and detection of target fragments by MS, as well as the analysis of MS data by computational systems. (genengnews.com)
The RV is a stepwise computational screening process that analyzes each protein from the whole set of bacterial proteome for its antigenic and immunogenic potentials. (biomedcentral.com)

Anatomy12

Organisms48

Diseases17

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science7

Health Care2

Proteins19

Genomes6

Pathogenic bacterial species2

Genome11

Interactions12

Virulence4

High throughput2

Mycobacterium2

Infection5

Major pathogens1

Opportunistic pathogen1

Genes10

Infections9

Proteomics3

Microbiome2

Pathogenesis1

Phylogenetic analyses2

Comparative genomic2

Interaction5

Elucidate1

Species7

Analyze3

Various bacterial2

Pseudomonas1

Strains3

Microenvironment1

Quantitative2

Mechanisms2

Characterization1

Viral1

Quantification1

Host7

Proteomic1

Fungal1

Biofilms1

Genus1

20211

Human2

Resistance1

Conclusions1

Invasion1

Genera2

Membrane3

Identification5

Closely related1

Intestinal2

Approaches1

Macrophage1

Computational3