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  • 2000
  • Simons M., Kramer E.M., Thiele C., Stoffel W., Trotter J., (October 2000) [Assembly of Myelin by Association of Proteolipid Protien with Cholesterol- and Galactosylceramide- rich Membrane Domains], Journal of Cellular Biology, 151(1):143-54. (hotzehwc.com)
  • residue
  • TRPR and proteolipids were obtained in parallel from a single tissue sample by extraction with chloroform-methanolthe extract contained the proteolipids, and TRPR was obtained by tryptic digestion of the chloroform-methanol insoluble tissue residue. (springer.com)
  • In V-ATPases, there are three proteolipid subunits (c, c′ and c′′) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane. (wikipedia.org)
  • extracellular
  • 1991). "Pelizaeus-Merzbacher disease: a valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid" . (wikipedia.org)
  • and Yoshida and Colman (1996) have identified a family of closely related brain proteolipids, the primary structure of each containing within it functional N-glycosylation sequences, at least one of which is located in a hydrophilic segment that is presumably exposed on the extracellular surface. (jneurosci.org)
  • membranes
  • This proteolipid has now been incorporated into ultrathin lipidic membranes, and the membrane resistance was studied. (rupress.org)
  • In membranes containing another proteolipid having no cholinergic binding properties, the increase in conductance was smaller, and had a linear function with the concentration. (rupress.org)
  • The membranes containing the cholinergic proteolipid reacted to the addition of acetylcholine by a rapid and transient increase in conductance that was considerably reduced or abolished by a previous application of d -tubocurarine. (rupress.org)
  • These results suggest that this special proteolipid, when added to the artificial membranes, induces a "chemical excitability" toward cholinergic ligands. (rupress.org)
  • extract
  • Previous studies have shown that a special proteolipid extract from the electric organ of Electrophorus showed high affinity binding for acetylcholine and other cholinergic agents. (rupress.org)
  • main
  • This left, as main difference between the two, the insolubility of TRPR in chloroform-methanol as compared to the ready solubility of proteolipids in the same solvent mixtures. (springer.com)
  • addition
  • The resistance decreased from 7.27 ± 0.82 x 10 5 ohm cm 2 in the control membrane to 1.83 x 10 5 ohm cm 2 with addition of 72 µg/ml proteolipid. (rupress.org)
  • In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. (wikipedia.org)
  • known
  • Next, a retrospective of what is known of T-cell reactivity directed against proteolipids and glycolipids in patients with MS is presented, and the implications of the findings are discussed. (hindawi.com)