AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
BiglycanProteoglycansDecorinHeparan Sulfate ProteoglycansChondroitin Sulfate ProteoglycansExtracellular Matrix ProteinsGlycosaminoglycansHeparitin SulfateDermatan SulfateKeratan SulfateVersicansChondroitin SulfatesSulfatesChondroitin ABC LyaseChondroitinSulfur RadioisotopesAggrecansExtracellular MatrixSyndecansCartilageHeparin LyaseChondroitin LyasesHyaluronic AcidChromatography, GelHeparinCartilage, ArticularPolysaccharide-LyasesLectins, C-TypeLaryngeal CartilagesCollagen Type VIUronic AcidsCollagenSyndecan-4Cells, CulturedDisaccharidesGlucosamineCattleChromatography, Ion ExchangeSyndecan-1Iduronic AcidChloratesElectrophoresis, Polyacrylamide GelGlypicansSyndecan-2GlycosidesSyndecan-3Chromatography, AgaroseMolecular WeightProtein BindingFibrillar CollagensSulfotransferasesTooth CalcificationBrevicanCorneaTransforming Growth Factor betaFibroblastsIntervertebral DiscRNA, Messenger
Leucine-richFibromodulinDecorin and biglycanVersicanAggrecanCollagensProteinsChondroitinGlycosaminoglycansExtracellularHeparan sulfateSLRPsComplex macromoleculesTLR2 and TLR4AtherosclerosisAccumulationGAGsRolesCollagen fibrilMacrophage infiltrationGlycoproteinsProinflammatoryTumorCSPGMetalloproteinasesInflammatory processesTissueComprised of a core proteinDegradationGeneSmallCellsTendonCartilageExpressionDiseasesInteractionsChainsLymphaticLymphocytesSpecificallyFamilyPathwaysCollagenase
Leucine-rich5
  • Types include: Certain members are considered members of the "small leucine-rich proteoglycan family" (SLRP). (wikipedia.org)
  • In severe invasive infections, S. pyogenes encounters and interacts with components of the extracellular matrix (ECM), including small leucine rich-proteoglycans (SLRPs). (lu.se)
  • These genes included collagens Type I and VI and the small leucine rich repeat family of proteoglycans (e.g., decorin, biglycan, osteomodulin, fibromodulin, and osteoadherin/osteoglycin) that reached peak expression at 24 h. (umassmed.edu)
  • Thus, secreted to the ECM PGs include large aggregating PGs, named hyalectans, small leucine-rich PGs (SLRPs), and basement membrane PGs. (hindawi.com)
  • Decorin and biglycan are two small leucine-rich proteoglycans (SLRPs) that regulate collagen fibrillogenesis and extracellular matrix assembly in tendon. (allergy-link.com)
Fibromodulin4
  • These include decorin, biglycan, fibromodulin and lumican. (wikipedia.org)
  • In this study, we report a novel antimicrobial role played by SLRPs biglycan, decorin, fibromodulin and osteoadherin, specifically in promoting the eradication of S. pyogenes in a human sepsis model of infection. (lu.se)
  • Lumican and fibromodulin are both expressed in renal parenchyma with expression patterns resembling decorin in the case of lumican and biglycan in the case of fibromodulin [57]. (researchdataservice.com)
  • Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
Decorin and biglycan3
  • Mutations in the gene encoding the galactosyltransferase B4GALT7 result in a reduced substitution of the proteoglycans decorin and biglycan with glycosaminoglycan chains, and cause a spondylodysplastic form of Ehlers-Danlos syndrome. (wikipedia.org)
  • The abnormal overexpression or accumulation of proteoglycan, i.e., decorin and biglycan, was found and presumed to be caused by the low affinity of receptor regulation in FGFR2 signaling cascade, which resulted in premature periosteal ossification inducing membranous bone dysostosis [ 7 ]. (springeropen.com)
  • Knockdown of decorin and biglycan produced similar changes to tendon microstructure by increasing the collagen fibril diameter relative to wild-type controls. (allergy-link.com)
Versican5
Aggrecan1
  • Major molecular changes include increased expression of type III collagen, fibronectin, tenascin C, aggrecan and biglycan. (nih.gov)
Collagens3
  • Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins. (nih.gov)
  • This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
  • The molecular changes characterising OA include the differential expression of matrix proteins, proteoglycans, collagens, metalloproteinases and their inhibitors in both cartilage and bone. (biomedcentral.com)
Proteins13
  • Proteoglycans are proteins that are heavily glycosylated. (wikipedia.org)
  • Here they form large complexes, both to other proteoglycans, to hyaluronan, and to fibrous matrix proteins, such as collagen. (wikipedia.org)
  • To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
  • This initial response was followed by waves of expression of nuclear proteins and developmental regulatory factors including inhibitors of DNA binding, Runx2, C/EBP, Zn finger binding proteins, forkhead, and numerous homeobox proteins (e.g. (umassmed.edu)
  • Please note that proteins can be included in multiple pathways, ie. (embl.de)
  • Proteoglycans are complex macromolecules comprised of a core protein and one or more covalently attached glycosaminoglycans (GAG) chains so that structurally they are both proteins and carbohydrates. (openbiochemistryjournal.com)
  • The spectrum of properties of proteoglycans is determined by both the core proteins and the GAG chains. (openbiochemistryjournal.com)
  • Core proteins determine the cellular location and serve as scaffolds for the GAG chains and the highly ionic chains determine physical properties of tissues and bind factors including growth factors and apolipoproteins. (openbiochemistryjournal.com)
  • Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. (research.com)
  • 5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
  • They were classified into elevenfamilies, five of which were newly identified and not included in theStructural Classification of Proteins database release 1.71. (embl.de)
  • Our findings included a significant class of proteoglycans not previously associated with lymphomas as well as significant modulation of genes that code for extracellular matrix-associated proteins. (fortunepublish.com)
  • In the ebook работа пианиста с нотными примерами of valuable decades of traditional activators of chemical results commenting non-genotyped oils and points( which proves a longitudinal biglycan in a native stationary methods), intensive events contain a so abdominal decomposition to model longitudinal proteins that can require impeccably chosen from the non-normal abundance of disappearance. (naturheilpraxis-gisbert-fussek.de)
Chondroitin3
  • Further, two PGs, chondroitin sulfate proteoglycan 4 and agrin, were significantly lower, about 6-fold for isocitrate dehydrogenase-mutant, compared to the WT GBM samples. (escholarship.org)
  • A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
  • AIM: To investigate the appearance of chondroitin sulphate proteoglycans (CSPGs) in rat liver organ tissue of hepatocellular carcinoma (HCC). (researchhunt.com)
Glycosaminoglycans3
  • The inactivity of specific lysosomal enzymes that normally degrade glycosaminoglycans leads to the accumulation of proteoglycans within cells. (wikipedia.org)
  • Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Extracellular10
  • Proteoglycans are a major component of the animal extracellular matrix, the "filler" substance existing between cells in an organism. (wikipedia.org)
  • The completed proteoglycan is then exported in secretory vesicles to the extracellular matrix of the tissue. (wikipedia.org)
  • Under conditions of tissue stress or injury biglycan can be released from the extracellular matrix by proteolytic enzymes such as bone morphogenic protein (BMP)-1 matrix metalloproteinase (MMP)-2 -3 and -13 [58]. (researchdataservice.com)
  • Soluble biglycan then binds to TLR2 and TLR4 and activates the mitogen-activated protein PAC-1 kinase p38 extracellular signal-regulated kinase (Erk) and nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) pathways leading to the secretion of tumor necrosis factor (TNF)-α in a myeloid differentiation primary response 88 (MyD88) dependent fashion [60]. (researchdataservice.com)
  • The present study was designed to clarify the morphological features of early human atherosclerosis and to determine whether specific extracellular matrix proteoglycans play a role in early atherogenesis. (meatrition.com)
  • The extracellular matrix proteoglycans, biglycan and decorin, were localized in the outer layer of DIT. (meatrition.com)
  • Most cases of Grade 1 and Grade 2 exhibited fatty streaks with extracellular lipids colocalizing with biglycan and decorin in the outer layer of the intima. (meatrition.com)
  • In early human coronary atherosclerosis, fatty streaks develop via extracellular deposition of lipids associated with specific types of proteoglycans in the outer layer of preexisting DIT. (meatrition.com)
  • Proteoglycans are important components of the extracellular matrix of all tissues. (openbiochemistryjournal.com)
  • These include the generation of a variety of lipid mediators, along with membrane remodelling, modification of extracellular non-cellular phospholipid components of pulmonary surfactant, microparticles and lipoproteins, and degradation of microbial membranes and dietary phospholipids. (ijbs.com)
Heparan sulfate1
SLRPs1
  • 2.2 SLRPs in renal inflammation and diabetic nephropathy Several studies have shown that biglycan acts as a proinflammatory danger molecule by signaling through the LRR-containing receptors TLR2 and TLR4 [24 106 For a comprehensive review of the literature on the subject see our recent publication [60]. (researchdataservice.com)
Complex macromolecules1
  • Proteoglycans (PGs) are complex macromolecules composed of a core protein and covalently linked polysaccharide chain(s) which play a critical role in cell-cell and cell-matrix interactions. (oncotarget.com)
TLR2 and TLR41
  • Biglycan and decorin induce TLR2 and TLR4 signaling cascades resulting in secretion of proinflammatory and chemotactic molecules and recruitment of professional phagocytes. (lu.se)
Atherosclerosis1
  • Current research areas include development of gene therapy for atherosclerosis, mechanisms of aortic aneurysm formation associated with abnormal transforming growth factor beta signaling and mechanisms of atherosclerotic plaque rupture. (bioscientifica.com)
Accumulation1
GAGs1
  • Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
Roles2
  • The important roles from the most significant proteoglycans associated to breast cancer progression and/or remedy are offered in more particulars in the chapters under.Author Manuscript Author Manuscript Author Manuscript Author Manuscript2. (translateinthetownships.com)
  • Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation , apoptosis , [3] metabolism , homeostasis , immune response , wound repair , [4] and endocrine function. (wikidoc.org)
Collagen fibril1
  • Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues. (research.com)
Macrophage infiltration1
  • In UUO biglycan is overexpressed in the epithelial cells of distal tubules and collecting ducts followed by macrophage infiltration [83 101 109 Biglycan-deficient (mice showing increased albuminuria expanded mesangial matrix impaired renal function and higher levels of macrophage infiltration compared to wild type animals [84]. (researchdataservice.com)
Glycoproteins1
  • Proteoglycans are a subclass of glycoproteins in which the carbohydrate units are polysaccharides that contain amino sugars. (wikipedia.org)
Proinflammatory2
  • Below we will critically evaluate the main findings regarding the proinflammatory role of biglycan while focusing on its role in kidney inflammatory conditions. (researchdataservice.com)
  • In turn this leads to the secretion of a series of chemoattractants for T cells neutrophils and macrophages including Chemokine (C-X-C motif) ligand PAC-1 2 (CXCL2) Chemokine (C-C motif) ligand (CCL3) CCL2 and CCL5 with the attracted macrophages further synthesizing biglycan and amplifying the proinflammatory response PAC-1 [60]. (researchdataservice.com)
Tumor1
  • that regulate several pathophysiological processes including fibrosis inflammation and tumor PAC-1 progression. (researchdataservice.com)
CSPG1
  • Biglycan, another DS/CSPG, acts as an endogenous danger signal and potently induces pro-inflammatory mediators actively participating in inflammatory processes. (translateinthetownships.com)
Metalloproteinases1
  • Metalloproteinases that show increased expression in painful tendinopathy include ADAM (a disintegrin and metalloproteinase)-12 and MMP (matrix metalloproteinase)-23. (nih.gov)
Inflammatory processes1
  • Biglycan can modulate inflammatory processes in lung and renal inflammation and is a potential target in the treatment of inflammatory conditions. (researchdataservice.com)
Tissue3
Comprised of a core protein1
  • Proteoglycans are comprised of a core protein and one or more covalently attached glycosaminoglycan (GAG) chains. (openbiochemistryjournal.com)
Degradation1
  • Metalloproteinase enzymes have an important role in the tendon matrix, being responsible for the degradation of collagen and proteoglycan in both healthy patients and those with disease. (nih.gov)
Gene1
  • Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney , thymus , stomach , breast , adult liver and erythrocyte. (wikidoc.org)
Small3
  • Proteoglycans are categorized by their relative size (large and small) and the nature of their glycosaminoglycan chains. (wikipedia.org)
  • Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. (research.com)
  • There are three primary categories of lymphomas including Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Hodgkin Lymphoma, and Non-Hodgkin Lymphoma. (fortunepublish.com)
Cells2
  • Growth aspect binding specificity results in diverse responses as outlined by cell status as well as the variety of HS chain presented by the cells and for that function, a balance involving cell surface and shed HSPGs, which include syndecan-1, is crucial [31, 32]. (translateinthetownships.com)
  • We also used a machine learning approach to identify robust BCNHL biomarkers that include YES1, FERMT2, and FAM98B, which have not previously been associated with BCNHL in the literature, but together provide ~99.9% combined specificity and sensitivity for differentiating lymphoma cells from healthy B-cells based on measurement of transcript expression levels in B-cells. (fortunepublish.com)
Tendon3
  • We hypothesized that knockdown of decorin in mature tendons would result in detrimental changes to tendon structure and mechanics while knockdown of biglycan would have a minor effect on these parameters. (allergy-link.com)
  • Contrary to our hypothesis, knockdown of decorin resulted in minor alterations to tendon structure and no changes to mechanics while knockdown of biglycan resulted in broad changes to tendon structure and mechanics. (allergy-link.com)
  • Overall, the extensive changes to tendon structure and mechanics after knockout of biglycan, but not decorin, provides evidence that biglycan plays a major role in the maintenance of tendon structure and mechanics in mature mice during homeostasis. (allergy-link.com)
Cartilage1
  • The development of clefts, the loss of proteoglycan, changes in cellularity and the loss of tidemark integrity of articular cartilage of OA joints are features which characterise the disease [ 10 ] and which can be used to grade its severity. (biomedcentral.com)
Expression1
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Diseases2
  • It is a broad term that encompasses various conditions, including coronary artery disease, heart failure, arrhythmias, and valvular heart diseases, among others. (meatrition.com)
  • The Vascular Medicine Department of Montpellier University Hospital is a referral centre for the management of peripheral arterial disease, venous thromboembolic disease and Vascular Rare diseases which include lymphatic and vascular anomalies including arterial fragility such as the Ehlers-Danlos syndrome. (vascular-medicine.org)
Interactions1
Chains1
  • HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
Lymphatic1
  • She joined a European Centre as a researcher dedicated to the identification of the genetic background of the Lymphatic anomalies including Primary Lymphoedema and became a director of the International Lymphoedema Framework in 2009. (vascular-medicine.org)
Lymphocytes1
  • Taken together, our data show that proteoglycans are expressed in primary B lymphocytes whereas they are not or only partly expressed in EBV-carrying cell lines, depending on their latency type program. (oncotarget.com)
Specifically1
  • Specifically, knockdown of biglycan resulted in reduced insertion modulus, maximum stress, dynamic modulus, stress relaxation, and increased collagen fiber realignment during loading. (allergy-link.com)
Family1
  • Additionally biglycan can autonomously engage the activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome and trigger the activation of caspase-1. (researchdataservice.com)
Pathways2
  • They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
  • By binding to cell surface receptors, biglycan triggers innate immunity, but also can activate signaling pathways that bias oncogene activity, cell cycle, migration or survival [213]. (translateinthetownships.com)
Collagenase2
  • MMPs now comprise a group of 18 different enzymes in man, including the classic fibroblast collagenase MMP-1 (collagenase-1), the mesenchymal form of MMP-8 (collagenase-2) and MMP-13 (collagenase-3). (biomedcentral.com)
  • Our drug repurposing analysis predicted new candidates for repurposed drugs including ocriplasmin and collagenase. (fortunepublish.com)