• amyloid increases neurocan expression through regulating Sox9 in astrocytes: A potential relationship between Sox9 and chondroitin sulfate proteoglycans in Alzheimer's disease. (genscript.com)
  • This has prompted us to develop a vaccination strategy employing the tumor antigen chondroitin sulfate proteoglycan (CSPG)4 as a target. (bmj.com)
  • Imaging of ARC PNNs, which are comprised of the chondroitin sulfate (CS) proteoglycan aggrecan and attached CS glycosaminoglycans (GAGs), show that T2D-ZDF rats exhibit a 66.4% and 77.3% decrease in aggrecan in the medial and lateral ARC areas, respectively, compared to normoglycemic controls. (diabetesjournals.org)
  • Reduced mRNA expression of chondroitin sulfate proteoglycan 4 (CSPG4), carbohydrate sulfotransferase 15 (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase), and matrix metalloproteinases 2 and 9 resulted. (bvsalud.org)
  • His longstanding research interest has been the role of the extracellular matrix in nervous system development, especially the function of the heparan sulfate proteoglycan agrin. (nccu.edu)
  • Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. (nccu.edu)
  • Heparan sulfate proteoglycan 2 (Perlecan). (cdc.gov)
  • I n this highly cited paper , we identify heparan sulfate proteoglycan as a novel receptor and potential target for inhibition of exosome mediated glioma tumor development. (lu.se)
  • Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans. (peprotech.com)
  • The biological effects of FGF1 are mediated through the activation of the four transmembrane phosphotyrosine kinase fibroblast growth factor receptors in the presence of heparin sulfate proteoglycans and, therefore, require the release of the protein into the extracellular space. (rcsb.org)
  • The novel Cymerus™ manufacturing facilitates production of a virtually limitless supply of consistent human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells, which could play a key role in selective immunosuppression and graft repair during rejection. (biomedcentral.com)
  • Structural characteristics of articular cartilage proteoglycan in IgG induced experimental immune synovitis. (bmj.com)
  • superficial structural changes (e.g., pannus) and reduced proteoglycan staining were observed in wrist articular cartilages. (cdc.gov)
  • Thus, ibuprofen treatment was effective in attenuating HRHF-induced inflammation and early articular cartilage degeneration. (cdc.gov)
  • This study aimed to investigate the anti-osteoarthritic activities of intra-articular administration of SHINBARO and determine its underlying molecular mechanism in a monosodium iodoacetate (MIA)-induced osteoarthritis rat model. (biomedcentral.com)
  • Monosodium iodoacetate (MIA) is an inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) that results in a reduction of glycolysis and causes articular cartilage changes related to the histological and morphological features of OA by impeding integration of the chondral structure and inducing cell death of chondrocytes [ 15 ]. (biomedcentral.com)
  • Furthermore, MIA causes a repeated progression of synovial hyperplasia and inflammatory cell infiltration, destroys articular cartilage, and induces bone loss and chondral deformation [ 16 ]. (biomedcentral.com)
  • Administration of CCN1 protein or soluble JAG1 induced cholangiocyte proliferation in mice, which was blocked by inhibitors of NF-κB or NOTCH signaling. (jci.org)
  • These findings demonstrate that CCN1 induces cholangiocyte proliferation and ductular reaction and identify CCN1/α v β 5 /NF-κB/JAG1 as a critical axis for biliary injury repair. (jci.org)
  • the products of the GH-IGF-1 system induce proliferation without maturation of the growth plate and thus induce linear skeletal growth. (orthobullets.com)
  • CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial and epithelial cells, and binds to IGF, TGF-β1 and BMP-4. (peprotech.com)
  • Fibroblast growth factors (FGFs) are key regulators of cell proliferation, tumor-induced angiogenesis, and migration. (rcsb.org)
  • The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES. (bvsalud.org)
  • Tamoxifen, an estrogen antagonist, reduced erosive changes in meniscectomy-induced osteoarthritis in rabbits. (lww.com)
  • Histological changes in the femur of the MIA-induced osteoarthritis rat model were observed by micro-computed tomography scanning and staining with hematoxylin and eosin, and safranin-O fast green. (biomedcentral.com)
  • IAS treatment also downregulated the NF-κB level and increased the IκB-α level in the MIA- induced osteoarthritis rat model. (biomedcentral.com)
  • Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1β (IL-1β)-induced chondrocytes. (oncotarget.com)
  • In conclusion, our stduy demonstrates that wogonoside attenuates IL-1β-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-κB/HIF-2α by the PI3K/AKT pathway. (oncotarget.com)
  • Adding exogenous HA to unstimulated cells that had undetectable pericellular coats of HA selectively reduced perlecan and versican turnover, whereas other proteoglycans were unaffected. (cardiff.ac.uk)
  • SJS types IA and IB derive from mutations of the same gene, the HSPG2 gene, which codes for perlecan, a heparin sulfate proteoglycan. (medscape.com)
  • Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)
  • This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
  • Reorganization reflects the adaptation of the network to a changing environment, either encoding new information or compensating for injury-induced degeneration. (frontiersin.org)
  • Fig. 4: Impact of ChABC digestion of Arc PNNs on sustained blood glucose lowering induced by icv FGF1. (nature.com)
  • The present study was conducted to determine whether corneal cells differentially express genes for T4 regulation, keratan sulfate proteoglycan (KSPG) synthesis, crystallins, and endothelial cell ion transporters during transparency development and whether these expressions are altered when E9 embryos are treated with T4. (unboundmedicine.com)
  • Moreover they induce the upregulation of activating FcR on effector cells. (hindawi.com)
  • CCN1 also induced Jag1 expression in hepatic stellate cells, whereupon they interacted with hepatic progenitor cells to promote their differentiation into cholangiocytes. (jci.org)
  • Reprogramming of human fibroblasts into multipotent cells with a single ECM proteoglycan, fibromodulin. (ca.gov)
  • Like virally-induced pluripotent stem (iPS) cells, FMOD reprogrammed (FReP) cells express pluripotency markers, form embryoid bodies (EBs), and differentiate into ectoderm, mesoderm, and endoderm derivatives in vitro. (ca.gov)
  • Contact-mediated FGF-FGFR binding induces bidirectional signaling, which, in turn, promotes ASP and source cells to polarize cytonemes toward each other and reinforce signaling contacts. (biorxiv.org)
  • These conserved families of secreted morphogens/signals, such as Fibroblast Growth Factor (FGF), Hedgehog (Hh), Wingless (Wg)/Wnt, Epidermal Growth Factor (EGF), and Decapentaplegic (Dpp - a BMP homolog), act away from their sources and, upon binding to receptors, activate gene regulatory pathways to induce functions in recipient cells 1 , 2 . (biorxiv.org)
  • In addition, Shen et al ( 14 ) reported that the autophagy of rat AF cells was induced by serum deprivation in vitro and that IL-1β upregulated serum deprivation-induced autophagy in a dose-dependent manner. (spandidos-publications.com)
  • Ma et al ( 15 ) revealed that compression activated autophagy in NP cells and that compression-induced autophagy was closely associated with intracellular reactive oxygen species production. (spandidos-publications.com)
  • Ganoderma Lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function. (shen-nong.com)
  • Conventional therapies have limited efficacy, and overall response is still unsatisfactory considering that immune checkpoint inhibitors induce lasting clinical responses only in a low percentage of patients. (bmj.com)
  • Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. (cdc.gov)
  • Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β). (spandidos-publications.com)
  • Both estradiol and tamoxifen affected proteoglycan, prostaglandin, and proteoglycanase production by cartilage components. (lww.com)
  • To investigate the expression of alkaline phosphatase (ALP) activity in gingival fibroblasts from individuals with chronic periodontitis (CP) and drug-induced gingival hyperplasia (DGH) induced by diphenylhydantoin. (bvsalud.org)
  • In vitro and in vivo protective effects of proteoglycan isolated from mycelia of Ganoderma lucidum on carbon tetrachloride-induced liver injury. (shen-nong.com)
  • This study examines proteoglycan and hyaluronan (HA) synthesis by MCs triggered by proinflammatory agents and investigates the effect of an exogenous HA matrix on matrix synthesis by MCs. (cardiff.ac.uk)
  • The authors previously reported that transforming growth factor-beta (TGF-beta) induces similar aberrant morphologic changes in lens epithelial explants. (arvojournals.org)
  • Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • Rabbit keratocytes were induced into myofibroblasts by transforming growth factor β1 (TGFβ1) either with or without Y-27632. (molvis.org)
  • El ligando es específico para el RECEPTOR 4-1BB y puede desempeñar un papel en la indución de la proliferación de los LINFOCITOS T activados de la sangre periférica. (bvsalud.org)
  • However, the autophagy induced by TNF‑α and IL‑1β and the corresponding molecular mechanism appear to be cell‑type dependent. (spandidos-publications.com)
  • In the present study, autophagy activator and inhibitor were used to demonstrate the impact of autophagy on the catabolic effect induced by TNF‑α. (spandidos-publications.com)
  • This unique method is referred to as 'Proteoglycan Replacement Therapy (PRT)' in clinical literature. (researchgate.net)
  • Orth, P., *Eldracher, M., Cucchiarini, M., Madry, H. Small diameter subchondral drilling improves DNA and proteoglycan contents of the cartilaginous repair tissue in a large animal model of a full-thickness chondral defect Journal of Clinical Medicine , 2020, 18;9(6):E1903. (uniklinikum-saarland.de)
  • The above findings indicate that Reelin signaling is capable of inducing the formation of the dendrite-rich, cell-body-sparse MZ and a birthdate-dependent "inside-out" alignment of neurons independently of other factors/structures near the MZ. (jneurosci.org)
  • Hepatoprotective effects of Ganoderma lucidum peptides against D-galactosamine-induced liver injury in mice. (shen-nong.com)
  • We also studied the effectiveness of ibuprofen, administered in the last 8 weeks, in attenuating HRHF-induced changes in these joints. (cdc.gov)
  • Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. (nature.com)
  • Long-term administration of Nourkrin ® Woman in our study did not induce any side effects. (researchgate.net)
  • The hypothalamic arcuate nucleus-median eminence is a target for sustained diabetes remission induced by fibroblast growth factor 1. (nature.com)
  • To address these issues, we expressed Reelin ectopically in the developing mouse cortex, and the results showed that Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form cellular aggregates around Reelin. (jneurosci.org)
  • The results showed that ectopic Reelin caused the leading processes of migrating neurons to assemble in the Reelin-rich region, which in turn induced their cell bodies to form aggregates, and the late-born neurons migrated past their predecessors, resulting in a birthdate-dependent "inside-out" alignment within the aggregates. (jneurosci.org)
  • CONCLUSIONS: These results show that TGF-beta induces whole lenses to form opacities that contain morphologic and biochemical markers for subcapsular cataract. (arvojournals.org)
  • Subsequent to this finding, good effort had been made in research centres in Denmark, Norway, and Sweden to formulate a specific enzymatic-extracted mixture of proteoglycans aimed to treat hair loss problems. (researchgate.net)
  • The current research emphasis of Dr. Cole's laboratory is to understand the mechanisms of ethanol- and cannabinoid-induced central nervous system abnormalities in zebrafish. (nccu.edu)
  • Cell surface proteoglycan that bears heparan sulfate. (joplink.net)