AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation Science
DecorinProteoglycansGlycosaminoglycansGlycosidesChondroitin Sulfate ProteoglycansSulfatesCartilage, ArticularCartilageSulfur RadioisotopesExtracellular Matrix ProteinsCyclofenilBiglycanChondrocytesHeparan Sulfate ProteoglycansChondroitin SulfatesDermatan SulfateAggrecansChondroitin LyasesChondrosarcomaGlucosamineHeparitin SulfateCells, CulturedKeratan SulfateExtracellular MatrixScleraCulture TechniquesHymecromoneCattle6-AminonicotinamideChloratesCollagenOsteoarthritisUmbelliferonesVersicansHyaluronic AcidInterleukin-1RNA, MessengerLectins, C-TypeChromatography, GelChromatography, Ion ExchangeTransforming Growth Factor betaTritiumRabbitsElectrophoresis, Polyacrylamide GelOrgan Culture TechniquesSensory DeprivationIntervertebral DiscPatellaChondroitinChick EmbryoKineticsCorneaInjections, Intra-ArticularCell DivisionCollagen Type IIInsulin-Like Growth Factor IFibroblastsCell LineTime FactorsMyopiaChondroitinases and Chondroitin LyasesMolecular Sequence DataArthritisCulture MediaStress, MechanicalGene ExpressionProtein BiosynthesisRecombinant ProteinsChondroitin ABC LyaseChickensEndotheliumChoroidSyndecansAmino Acid SequenceReverse Transcriptase Polymerase Chain ReactionMuscle, Smooth, VascularCell DifferentiationDose-Response Relationship, DrugMolecular WeightNitric OxideSignal TransductionSyndecan-1Base SequenceDinoprostoneUronic AcidsProtein Synthesis InhibitorsLipoproteins, LDLNasal SeptumLeucineSyndecan-4DNAEnzyme InhibitorsRats, WistarCoculture TechniquesDisaccharidesBasement MembraneMolecular StructureStereoisomerismAmino AcidsProtein Binding
BiglycanGlycosaminoglycanCollagensGlycosaminoglycansFibronectinExtracellular matrixDermatanProteinsChondroitinSLRPsAggrecanGAGsVersicanSkin fibroblastsFibroblastsCellsSecretionHyaluronanCartilageStimulates collagenSmallProinflammatoryMetalloproteinasesRolesProtein synthesisOverexpressionMRNACytokinesTissuesDecreasePromotesNuclear
Biglycan7
Glycosaminoglycan7
  • In humans, GHK-Cu is proposed to promote wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. (wikipedia.org)
  • GHK-Cu promotes activation of wound recovery, appeal of immune cells, antioxidant and anti-inflammatory consequences, stimulates collagen and glycosaminoglycan synthesis in pores and skin fibroblasts and merchandising of blood vessels increase. (bionmedspa.com)
  • In the ruptured area, we found increased core protein synthesis but without the normal glycosaminoglycan production. (unisa.it)
  • Proteoglycans are comprised of a core protein and one or more covalently attached glycosaminoglycan (GAG) chains. (openbiochemistryjournal.com)
  • The collagen in tendons are held together with proteoglycan (a compound consisting of a protein bonded to glycosaminoglycan groups, present especially in connective tissue) components including decorin and, in compressed regions of tendon, aggrecan , which are capable of binding to the collagen fibrils at specific locations. (handwiki.org)
  • [11] The proteoglycans are interwoven with the collagen fibrils - their glycosaminoglycan (GAG) side chains have multiple interactions with the surface of the fibrils - showing that the proteoglycans are important structurally in the interconnection of the fibrils. (handwiki.org)
  • The progeroid type of EDS is caused by mutations in B4GALT7 or B3GALT6, both of which encode key enzymes that initiate glycosaminoglycan ( GAG ) synthesis. (symptoma.com)
Collagens4
  • The molecular changes characterising OA include the differential expression of matrix proteins, proteoglycans, collagens, metalloproteinases and their inhibitors in both cartilage and bone. (biomedcentral.com)
  • This fibrillar network is composed of many structural proteins, such as collagens, and adhesion proteins, including fibronectin and proteoglycans (perlecan, decorin) [ 13 , 14 ]. (springer.com)
  • This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
  • A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE . (nih.gov)
Glycosaminoglycans8
Fibronectin5
  • We observed as much as 6-fold increases in fibronectin synthesis by 24 h as previously reported for fibroblastic cells (Ignotz, R. A., and Massague, J. (1986) J. Biol. (eurekamag.com)
  • Using a monospecific antibody raised to the human placental fibronectin receptor complex, we found that TGF-.beta.1 stimulated fibronectin receptor synthesis up to 20-40-fold and increase mRNA levels encoding both the .alpha. (eurekamag.com)
  • mediated increases in fibronectin receptor complex protein synthesis and mRNA levels occur at 8 h, whereas the earliest increases in fibronectin protein synthesis and mRNA levels occur at 12 h. (eurekamag.com)
  • These results demonstrate that TGF-.beta.1 stimulates fibronectin receptor synthesis, extending the diverse stimulatory activities of this polypeptide to matrix receptors. (eurekamag.com)
  • The T/C-28a2 cell line was developed from human chondrocyte cells [69], which were shown to express fibronectin, decorin and dermatan sulfate [70, 71]. (phosphatases.com)
Extracellular matrix5
Dermatan4
Proteins5
  • It was also established that GHK-Cu stimulates both the synthesis of metalloproteinases, the enzymes which break down dermal proteins, and their inhibitors (anti-proteases). (wikipedia.org)
  • Commitment to the osteogenic phenotype is recognized by 8 h, reflected by downregulation of most myogenic-related genes and induction of a spectrum of signaling proteins and enzymes facilitating synthesis and assembly of an extracellular skeletal environment. (umassmed.edu)
  • The spectrum of properties of proteoglycans is determined by both the core proteins and the GAG chains. (openbiochemistryjournal.com)
  • The two major proteins in the cartilage is collagen and proteoglycan. (porcpotlas.hu)
  • Glucosamine is an aminosugar, and is an important factor in the synthesis of different lipids, proteins and the glucosaminoglycans (GAG). (porcpotlas.hu)
Chondroitin1
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
SLRPs2
  • The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. (molvis.org)
  • Los SLRPs dan soporte estructural a la MATRIZ EXTRACELULAR y son críticos en la regulación de su ensamblaje y de la dinámica de las UNIONES CÉLULA-MATRIZ. (bvsalud.org)
Aggrecan1
  • Aggrecan is the largest proteoglycan, and represents about 90% of the total PG content. (porcpotlas.hu)
GAGs3
  • This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
  • GAGs are usually covalently linked to protein cores to form proteoglycans. (phosphatases.com)
  • In B. burgdorferi, several adhesins recognize GAGs and proteoglycans. (phosphatases.com)
Versican3
  • We compared gene expression of collagen Type I, decorin, and versican including enzymes involved in their metabolism as matrix metalloproteases (MMP-2 and -9) and tissue inhibitory of metalloproteinase (TIMP-1 and -2) using real-time PCR, zymography and FACE analysis. (unisa.it)
  • We found greater gene expression of proteoglycan core protein decorin and versican, collagen Type I, MMPs and TIMPs in the tendon rupture. (unisa.it)
  • Adding exogenous HA to unstimulated cells that had undetectable pericellular coats of HA selectively reduced perlecan and versican turnover, whereas other proteoglycans were unaffected. (cardiff.ac.uk)
Skin fibroblasts1
  • GHK-Cu has a variety of roles in the human body including promotion of wound healing, anti-oxidant and anti-inflammatory effects, stimulating collagen synthesis in skin fibroblasts, promoting blood vessel growth and hair follicle stimulation. (invigoratemedspa.com)
Fibroblasts1
  • GHK-Cu treatment resulted in faster wound contraction and epithelization, higher level of glutathione and ascorbic acid, increased synthesis of collagen, and activation of fibroblasts and mast cells. (wikipedia.org)
Cells1
  • Specifically, uNK cells were hyper-responsive to PDGF, resulting in overexpression of decorin. (jci.org)
Secretion1
  • Conversely, inhibin downregulates FSH synthesis and inhibits FSH secretion. (wikidoc.org)
Hyaluronan1
  • This study examines proteoglycan and hyaluronan (HA) synthesis by MCs triggered by proinflammatory agents and investigates the effect of an exogenous HA matrix on matrix synthesis by MCs. (cardiff.ac.uk)
Cartilage3
  • The development of clefts, the loss of proteoglycan, changes in cellularity and the loss of tidemark integrity of articular cartilage of OA joints are features which characterise the disease [ 10 ] and which can be used to grade its severity. (biomedcentral.com)
  • Chemically modified glucosamine inhibits the release of proteoglycan in a model system of articular cartilage degradation. (cardiff.ac.uk)
  • Maroudas A, Bannon C. Measurement of swelling pressure in cartilage and comparison with the osmotic pressure of constituent proteoglycans. (lievers.net)
Stimulates collagen2
Small3
  • GHK-Cu also increased synthesis of decorin - a small proteoglycan involved in the regulation of collagen synthesis, wound healing regulation and anti-tumor defense. (wikipedia.org)
  • Copper tripeptide-1 also increases synthesis of decorin - a small proteoglycan in the regulation of collagen synthesis, wound healing regulation and anti-tumor defense. (gwenskinlab.com)
  • Differential roles for small leucine-rich proteoglycans in bone formation. (cardiff.ac.uk)
Proinflammatory2
Metalloproteinases1
  • For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)
Roles1
  • Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS . (nih.gov)
Protein synthesis1
  • Collectively, the effects of brefeldin A are consistent with a model in which MUC1 surface expression is dependent upon both protein synthesis and membrane release. (healthdrugpdf.com)
Overexpression1
  • Quite contrarily a recent study shows a decrease in decorin levels in glomerulonephritides caused by overexpression of the Ovarian-tumor-domain-containing protease OTUB1 [117]. (researchdataservice.com)
MRNA1
  • The complex transcription is converted through the cerebellar localization into the t. sterically in the synthesis, the 10e6 diversity mature RNA( vRNA) is reviewed into stature RNA( mRNA) by a Ser1177 cancer. (evakoch.com)
Cytokines1
  • Other profibrotic, collagen synthesis stimulating cytokines include endothelin, interleukin (IL)-1 and mast cell tryptase. (biomedcentral.com)
Tissues1
  • Urban JPG, Maroudas A, Bayliss MT, Dillon J. Swelling pressures of proteoglycans at the concentrations found in cartilaginous tissues. (lievers.net)
Decrease1
Promotes1
  • These results suggest that arsenite promotes TF synthesis by activating the Nrf2 pathway in HASMCs and that the induction of TF expression by arsenite may be related to the progression of atherosclerosis. (go.jp)
Nuclear2
  • With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)
  • We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)