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Transcription FactorsPromoter Regions, GeneticDNA-Binding ProteinsTranscription, GeneticBase SequenceMolecular Sequence DataGene Expression RegulationTranscriptional ActivationRNA, MessengerTrans-ActivatorsRepressor ProteinsSignal TransductionNuclear ProteinsProtein BindingHMGA ProteinsNF-kappa BElectrophoretic Mobility Shift AssayCell LineBinding SitesCells, CulturedReverse Transcriptase Polymerase Chain ReactionSp1 Transcription FactorTransfectionChromatin ImmunoprecipitationCell NucleusMutationResponse ElementsAmino Acid SequenceTranscription Factor AP-1Genes, ReporterHomeodomain ProteinsBlepharophimosisUp-RegulationCell DifferentiationGene ExpressionBasic Helix-Loop-Helix Transcription FactorsCell Line, TumorBlotting, WesternLuciferasesEnhancer Elements, GeneticDNAConsensus Sequence5' Flanking RegionNFATC Transcription FactorsForkhead Transcription FactorsHypoxia-Inducible Factor 1, alpha SubunitCloning, MolecularZinc FingersProto-Oncogene Proteins c-junPlasmidsDown-RegulationNF-E2-Related Factor 2Tumor Cells, CulturedGene Expression ProfilingGene Expression Regulation, BacterialProto-Oncogene Protein c-ets-1DNA PrimersGene Expression Regulation, NeoplasticRNA, Small InterferingCCAAT-Enhancer-Binding ProteinsProto-Oncogene Proteins c-etsHypoxia-Inducible Factor 1ImmunohistochemistryBasic-Leucine Zipper Transcription FactorsRecombinant Fusion ProteinsKruppel-Like Transcription FactorsOligonucleotide Array Sequence AnalysisPhosphorylationProto-Oncogene ProteinsSequence Homology, Amino AcidBacterial ProteinsGene Expression Regulation, DevelopmentalImmediate-Early ProteinsApoptosisMyogenic Regulatory FactorsTranscription Factor CHOPGene Expression Regulation, PlantRegulatory Sequences, Nucleic AcidReceptors, Cytoplasmic and NuclearMEF2 Transcription FactorsChloramphenicol O-AcetyltransferaseArtificial Gene FusionSequence Homology, Nucleic AcidPlant ProteinsCell ProliferationMice, KnockoutPPAR gammaCCAAT-Enhancer-Binding Protein-alphaHeLa CellsGATA1 Transcription FactorEarly Growth Response Protein 1Gene DeletionBlotting, NorthernCREB-Binding ProteinSequence DeletionProto-Oncogene Proteins c-fosDNA, ComplementaryFungal ProteinsGene Expression Regulation, FungalTwo-Hybrid System Techniques
RepressorRegulatorsTranscription factorGenesRegulationActivationComplexesPost-transcriptional regulatoryKinaseActivatorsActivatorNuclearGenomicRegulatory proteinsMediates transcriptionalRegulatorModulateInteractionPhosphorylationCorepressorReceptorsStructural ClassifiVirulence FactorsMRNAEndogenousMutationReceptorGeneticPathwaysAbiotic stressForkheadSubcellularSequencePosttranslational modificationRNAsFamily of proteinsPreviously uncharacterizedPromoterRegulatesElucidateExtracellularMembrane proteinsMotifDomain proteinsComplexHistone deacetylaseLocalizationControlZincActivitySpecificity
Repressor8
  • We show that GltR is a transcriptional repressor that is released from DNA upon phosphorylation. (nih.gov)
  • GmNAC11 is a transcriptional activator, whereas GmNAC20 is a mild transcriptional repressor. (frontiersin.org)
  • Since the mid-20th century, from discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. (cshlpress.com)
  • Hence the tetrameric nature of the TBL1 suggests that the protein may serve as a scaffold for a multivalent chromatin-targeted repression machine that contains multiple co-repressor proteins and histone deacetylase enzymes. (esrf.fr)
  • The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. (hmdb.ca)
  • Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. (medlineplus.gov)
  • TCF1 is inactivated by association with the transcriptional repressor TLE proteins. (biolegend.com)
  • During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. (biolegend.com)
Regulators4
  • However, I-Smads are predominantly found in the nucleus, where they can act as direct transcriptional regulators. (wikipedia.org)
  • Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
  • In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)
  • Among these developmental actors are the co-transcriptional regulators Yap and Taz (YT). (lu.se)
Transcription factor16
  • LMX1B encodes a LIM-homeodomain transcription factor. (nih.gov)
  • The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. (sinica.edu.tw)
  • As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
  • Runx2 is a transcription factor essential for bone formation in mammals, affecting osteoblast and chondrocyte differentiation by regulating key genes crucial for bone and cartilage development. (bath.ac.uk)
  • In vivo microinjection of XIMGP promoter constructs and runx2 mRNA confirmed that those promoters are targets for this transcription factor. (bath.ac.uk)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
  • It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
  • NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
  • Photoactivation of AKT inhibited the transcriptional activity of Forkhead box transcription factor O1 (FoxO1), reducing expression of lipolytic enzymes and FFA generation and release. (google.com)
  • This protein is a transcription factor, which means it helps regulate the activity of other genes. (medlineplus.gov)
  • TCF1 is the first identified member of the T-cell-specific transcription factor family. (biolegend.com)
  • TCF1 is a transcription factor, involved in the canonical Wingless/Integration 1 (Wnt) signaling pathway. (biolegend.com)
  • Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
  • We establish that IGF-II-induced HIF2A/EPAS1 expression during hypoxia is due to de novo transcription and further present the estrogen-related receptor alpha (ERRα) transcription factor as a positive regulator of HIF2A. (lu.se)
Genes13
  • We propose that 2-KG is a key metabolite in the stringent transcriptional control of genes involved in virulence and glucose metabolism. (nih.gov)
  • Trimers of two receptor-regulated SMADs and one co-SMAD act as transcription factors that regulate the expression of certain genes. (wikipedia.org)
  • A similar screen done in the Caenorhabditis elegans protein SMA (from gene sma for small body size) revealed three genes, Sma-2, Sma-3, and Sma-4, that had similar mutant phenotypes to those of the TGF-B like receptor Daf-4. (wikipedia.org)
  • Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
  • We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
  • Transcriptional repression complexes play important roles in both repressing gene transcription and in "resetting" genes after rounds of active transcription. (esrf.fr)
  • In this context, DNA-binding transcription factors (TFs) play an important regulatory role by either repressing or activating genes in response to environmental and physiological conditions. (biomedcentral.com)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • This is the first demonstration that defective transcriptional regulation of nuclear-encoded mitochondrial genes can result in experimental glomerular disease. (jci.org)
  • Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
  • The latter include upregulation of genes encoding intracellular stress proteins (groES/EL, CtsR regulated genes). (rug.nl)
  • Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
Regulation8
  • Trimers of one Smad4 molecule and two receptor-phosphorylated R-Smad molecules are thought to be the predominant effectors of TGF-β transcriptional regulation. (wikipedia.org)
  • The linker region between MH1 and MH2 is not just a connector, but also plays a role in protein function and regulation. (wikipedia.org)
  • The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
  • These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes. (bath.ac.uk)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • Here we describe a different method of transgene regulation by the use of the human glial ®brillary acidic protein (GFAP) promoter. (lu.se)
Activation11
  • Qin, C, Singh, P & Safe, S 1999, ' Transcriptional activation of insulin-like growth factor-binding protein-4 by 17β-estradiol in MCF-7 cells: Role of estrogen receptor-sp1 complexes ', Endocrinology , vol. 140, no. 6, pp. 2501-2508. (utmb.edu)
  • The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. (fishersci.com)
  • Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
  • Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. (igbmc.fr)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • PBMT promoted mitochondrial reactive oxygen species (ROS) generation, which inhibited phosphatase and tensin homologue (PTEN) and promoted protein kinase B (AKT) activation. (google.com)
  • In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3. (biolegend.com)
  • The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors. (europa.eu)
  • We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
Complexes3
  • YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
  • The conserved "core" of the SMRT/NCoR repression complexes (called repression domain 1 or RD1) recruits HDAC3, TBL1 (and/or its homologue TBLR1) as well as a protein called GPS2 (also known as AMF1). (esrf.fr)
  • NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. (hmdb.ca)
Post-transcriptional regulatory1
  • This project seeks to elucidate transcriptional and post-transcriptional regulatory networks that determine cell fate and guide the development of photoreceptors from retinal progenitor cells. (nih.gov)
Kinase9
  • Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
  • Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
  • PKA: a portrait of protein kinase dynamics. (nature.com)
  • Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
  • Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • Our previous report showed that FO inhibits HCC cell invasion via AKT-, mitogen-activated protein kinase- (MAPK-), and EMT-related signals [ 7 ]. (hindawi.com)
  • Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
  • VEGF-induced pMF was attenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis( o -aminophenylmercapto)butadiene] and was abolished by the phosphotidinositol 3 kinase/Akt inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one hydrochloride], demonstrating that ERK mitogen-activated protein kinases and Akt are both required for full expression of VEGF-induced pMF. (jneurosci.org)
Activators5
  • The MH1 domain is primarily involved in DNA binding, while the MH2 is responsible for the interaction with other Smads and also for the recognition of transcriptional co-activators and co-repressors. (wikipedia.org)
  • Specifically, R-Smads are phosphorylated in the nucleus at the linker domain by CDK8 and 9, and these phosphorylations modulate the interaction of Smad proteins with transcriptional activators and repressors. (wikipedia.org)
  • Group 1 and 3 KLFs are transcriptional repressors, while group 2 KLFs are generally transcriptional activators. (jci.org)
  • Different dimer combinations act as transcriptional activators or repressors, respectively. (hmdb.ca)
  • CBP and EP300 are ubiquitously expressed homologous proteins that act as transcriptional co-activators. (medscape.com)
Activator2
  • Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Nuclear5
  • This process requires the involvement of nuclear transport receptors, collectively termed karyopherin-ß (Kap-ß) in yeast, and various regulatory factors. (sinica.edu.tw)
  • The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
  • The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. (fishersci.com)
  • We previously reported that importin 13 (IPO13), a member of the importin-β family of nuclear import proteins, regulates nuclear import of the glucocorticoid receptor in airway epithelial cells, IPO13 serves as a potential marker for corneal epithelial progenitor cells, and IPO13 is associated with corneal cell proliferation. (molvis.org)
  • also p21SNFT) is a 20 kDa nuclear member of the bZIP family of proteins. (rndsystems.com)
Genomic2
  • Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
  • This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
Regulatory proteins3
  • How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
  • Using the novel CRISPR/Cas9-based enChIP technology in combination with SILAC-MS, we have isolated and identified potential regulatory proteins bound to the HIF2A promoter at normoxia and hypoxia. (lu.se)
  • These vectors have a number of appealing features including the expression by using the machinery of the host cell instead of depending abilities to ef®ciently transduce cells in the central nervous system, on recombinant regulatory proteins. (lu.se)
Mediates transcriptional1
  • Interestingly, we have also identified a runx2-binding site that mediates transcriptional repression of XIMGP. (bath.ac.uk)
Regulator2
  • With this research we display that PTPN14 binds to YAP and become a poor regulator of YAP-mediated transcriptional activity. (colinsbraincancer.com)
  • Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
Modulate2
  • How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)
  • This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)
Interaction3
  • We mapped the regions in the three proteins required for interaction and demonstrated that the amino-terminal domain of TBL1 (TBL1-NTD) is able to bind both GPS2 and SMRT forming a ternary complex. (esrf.fr)
  • Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
  • YT do not have a DNA binding domain but act through interaction with other transcription factors (TFs). (lu.se)
Phosphorylation2
  • Phosphorylation of YAP at S381 by Lats1/2 primes the proteins for following phosphorylation at multiple sites, which in turn prospects to polyubiquitination and degradation 27. (colinsbraincancer.com)
  • We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
Corepressor1
Receptors2
  • Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. (wikipedia.org)
  • We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
Structural Classifi2
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Virulence Factors3
  • We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
  • This organism produces a diverse array of virulence factors, including toxins, adhesins, colonization and biofilm factors. (biomedcentral.com)
  • Given the high number of virulence factors present in these bacteria, and the niche-specific role many of them play during different stages of the infectious process, gene expression must be finely tuned in order to efficiently coordinate their expression, and also continue to preserve energy pools. (biomedcentral.com)
MRNA3
  • However, mRNA and protein levels for CD2AP and podocin were greatly reduced, suggesting a cooperative role for these molecules in foot process and slit diaphragm formation. (nih.gov)
  • However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during "immediate-to-early" DDR. (europa.eu)
  • Quantitative proteomics will be applied to identify the differentially mRNA-bound proteins after the exposure of human cultured cells to ionizing radiation. (europa.eu)
Endogenous2
  • Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Mutation2
  • Tetramerisation in solution was confirmed by comparing the mobility of wild-type protein and protein with a mutation at the tetramer interface on a size exclusion column. (esrf.fr)
  • A mutation that inhibited binding of the protein to the A-T-rich region also aborted the transcriptional stimulatory effect of the region. (lu.se)
Receptor2
  • The non-receptor proteins tyrosine phosphatase type 14 (PTPN14) is situated in the adheren junctions (AJ) in both endothelial and epithelial cells and is important in rules of cell adhesion and cell development 32C35. (colinsbraincancer.com)
  • Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
Genetic5
  • A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
  • Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
  • Background: Bacillus subtilis is a favorable host for the production of industrially relevant proteins because of its capacity of secreting proteins into the medium to high levels, its GRAS (Generally Recognized As Safe) status, its genetic accessibility and its capacity to grow in large fermentations. (rug.nl)
  • Conclusions: The results give better insights into B. subtilis responses to protein overproduction stress and provide potential targets for genetic engineering in order to further improve B. subtilis as a protein production host. (rug.nl)
  • This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
Pathways7
  • Our results indicated that CmNAC1 is a critical factor in ABA signaling pathways and it can be utilized in transgenic breeding to improve the abiotic stress tolerance of crops. (frontiersin.org)
  • Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
  • By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
  • We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Please note that proteins can be included in multiple pathways, ie. (embl.de)
  • In summary, we have identified, and at the molecular level characterized, signaling pathways and specific factors through which oncogenic HIF2A activity is regulated and may be targeted. (lu.se)
Abiotic stress2
  • GmNAC11 and GmNAC20 from soybean are induced by phytohormones and abiotic stress with different transcriptional activities. (frontiersin.org)
  • These are human health and plant resistance to pathogens and to biotic and abiotic stress factors. (mdpi.com)
Forkhead1
  • The FOXG1 gene provides instructions for making a protein known as forkhead box G1. (medlineplus.gov)
Subcellular1
  • The CmNAC1-GFP fusion protein was transiently expressed in tobacco leaves for subcellular localization analysis, and we found that CmNAC1 is localized in the nucleus. (frontiersin.org)
Sequence4
  • The remaining atypical protein kinases (aPK) belong to several families, some of which have structural, but not sequence similarity to ePKs. (wormbook.org)
  • In this work, using diverse sequence analysis, we evaluated the repertoire of TFs and sigma factors in the community-associated methicillin resistant S. aureus (CA-MRSA) strain USA300-FPR3757. (biomedcentral.com)
  • Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
  • Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
Posttranslational modification2
  • It catalyses the O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of the transcriptional coregulator Host cell factor 1 (HCF1). (rcsb.org)
  • Two Ets proteins, PU.1 and elf-1, that have previously been shown to bind to an adjacent DNA element were shown to physically interact with CArG- box binding factor.A. An antiserum raised against the protein recognized two different forms indicating either that different splice-forms of CArG-box binding factor-A are expressed, or that the protein is subject to posttranslational modification. (lu.se)
RNAs1
  • This will provide a global insight into the dynamics of RNAs and proteins during DDR. (europa.eu)
Family of proteins1
  • Nucleocytoplasmic transport is an essential phenomenon in eukaryotic cells controlled by the family of proteins called importins and exportins. (molvis.org)
Previously uncharacterized1
  • The proposed project explores a previously uncharacterized link between post-transcriptional RNA operons and DDR. (europa.eu)
Promoter3
  • Gel mobility shift assays using 32 P-labeled -569 to -540 and -83 to -54 oligonucleotides from the IGFBP-4 gene promoter showed that Sp1 protein bound these oligonucleotides to form a retarded band, and the intensity of the band was competitively decreased after coincubation with unlabeled IGFBP-4-derived and consensus Sp1 oligonucleotides. (utmb.edu)
  • A protein interacting with an A-T-rich region that is a positive control element within the SP6 κ promoter was purified and identified as CArG-box binding factor-A. The purified protein was shown to interact specifically with the coding strand of single-stranded DNA and, with lower affinity, with double-stranded DNA. (lu.se)
  • This activity was significantly elevated following 5'-deletion analyses of ALOX5 promoter and further enhanced by MWCNT treatment, implicating a transcriptional mechanism in the induction of ALOX5. (cdc.gov)
Regulates1
  • In addition, the GtrS/GltR pair regulates the expression of toxA that encodes exotoxin A, the primary virulence factor. (nih.gov)
Elucidate1
  • Results Id of PTPN14 being a YAP-interacting proteins In order to elucidate the system mixed up in legislation of YAP, we performed immunoprecipitation (IP) and mass spectrometry evaluation to recognize the protein that type a complicated with YAP. (colinsbraincancer.com)
Extracellular1
  • Matrix Gla protein (MGP) is an extracellular mineral-binding protein expressed in several tissues but it only accumulates in bone and calcified cartilage under physiological conditions. (bath.ac.uk)
Membrane proteins2
Motif2
  • The protein is a member of the tripartite motif (TRIM) family. (fishersci.com)
  • Mutations in this motif in both proteins abolished recruitment to TBL1. (esrf.fr)
Domain proteins1
  • In addition, NAC domain proteins have become a popular research topic for different plant species. (frontiersin.org)
Complex3
  • When YAP is usually phosphorylated at S127 - an activity that is usually suffering from cell denseness C it forms a far more stable complex using the 14-3-3 protein and becomes maintained in the cytoplasm 6, 25C26. (colinsbraincancer.com)
  • They are large "platform" or "hub" proteins (c.2500 amino acids) that assemble a complex containing a number of histone deacetylase enzymes. (esrf.fr)
  • NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
Histone deacetylase1
  • The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. (cancerindex.org)
Localization2
  • YAP activity could be also inhibited through the relationships with angiomotin (AMOT) family members proteins, which result in localization and sequestration from the YAP proteins to limited junction 29C31. (colinsbraincancer.com)
  • Responses specific for proteins with a common localization as well as more general stress responses were observed. (rug.nl)
Control6
  • Is the Subject Area "Transcriptional control" applicable to this article? (plos.org)
  • One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. (cshlpress.com)
  • Do disease-associated non-coding variants primarily reside in transcriptional control elements? (nih.gov)
  • Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)
  • Efforts have therefore, designed a study to compare the expression of green ¯uor- been made to develop systems based on different drugs or hormones escent protein (GFP) and GDNF under the control of the hGFAP including tetracycline, rapamycine and progestrone (Clackson, 2000). (lu.se)
  • However, the proteins needed for transcriptional control have been reported to be immunogenic and there is often a substantial leakage in the systems (Clackson, 2000). (lu.se)
Zinc1
Activity3
  • The transcriptional activity of YAP is usually subject to unfavorable rules by cytoplasmic sequestration or ubiquitin-mediated degradation. (colinsbraincancer.com)
  • The factor VIII activity levels reflect measurements up to 61 weeks, the extent of follow-up for the longest-treated patient in the cohort. (businesswire.com)
  • We are excited that these data affirm previous findings from this Phase 1/2 study, and that all five patients have sustained levels of factor VIII activity with no bleeding events or use of factor replacement therapy. (businesswire.com)
Specificity1
  • Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)