Proteins to mice. Medical search. Frequent questions

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)

The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
both methods indicated suppression of genes and proteins participating in mitochondrial metabolism. (jci.org)
Increasingly, mutations in genes that encode postsynaptic proteins belonging to the PSD-95 protein complex, continue to be identified in neurodevelopmental disorders (NDDs) such as autism spectrum disorder, intellectual disability and epilepsy. (nih.gov)
Here, by using genetically engineered mice and innovative touchscreen-based cognitive testing, we sought to investigate whether loss-of-function mutations in genes encoding key interactors of the PSD-95 protein complex display shared phenotypes in associative learning, updating of learned associations and reaction times. (nih.gov)
p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
Our data indicate, for the first time, a requirement for MAPK signaling in the developing XY gonad in order to facilitate normal expression of SRY and the downstream testis-determining genes and also suggest that reduced dosage of MAP3K4 may be the cause of a previously described autosomal sex-reversing mutation in the mouse. (plos.org)
DALLAS, Sept. 22, 2021 - A naturally occurring protein that blocks an inflammatory immune response was associated with better stroke recovery in a study conducted in mice, according to preliminary research to be presented at the American Heart Association's Vascular Discovery: From Genes to Medicine Scientific Sessions 2021. (heart.org)
RafK carries a C-terminal regulatory domain present in a subset of ATP-binding proteins that has been involved in both direct regulation of transporter activity (inducer exclusion) and transcription of transporter genes. (lu.se)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Pantomics Array Description: Normal tissues of 22 major organs duplicated or triplicated from 3 C57BL/6J strain mice. (delos.info)
Previously, we reported that orthotopic xenografts of Lewis lung carcinoma 1 in C57BL/6 mice caused them to develop lung cancer with albuminuria . (bvsalud.org)

The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. (wikipedia.org)
profiling of the substrate repertoire of RHBDL2 has identified a number of additional type I membrane proteins substrates, including BCAM, SPINT1, and CLCP1. (wikipedia.org)

Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (nih.gov)

Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. (nih.gov)
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis and subtle defects in cell cycle-dependent nuclear movement in neural progenitors. (jax.org)
C ) Western blot analysis of the expression of Hap1 and Ahi1 in embryonic mouse brains. (jci.org)
We identified a mouse mutant that causes embryonic gonadal sex reversal: the development of ovaries in an XY embryo. (plos.org)

Rodgers and his colleagues found that a protein called hepatocyte growth factor, which exists in a latent form in the spaces between muscle cells and tissue, can activate a critical signaling pathway in the cells by binding to their surfaces. (stanford.edu)
This pathway stimulates the production of proteins important in alerting the stem cells. (stanford.edu)
These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS. (jneurosci.org)
In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. (rndsystems.com)
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)

The purity of Mouse IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant mIL-11 and staining with Coomassie Blue. (cellsignal.com)

It was recently discovered that the mitochondrial genome codes for a protein called MOTS-c, which enters the cell nucleus during times of stress in order to regulate the cell's genome and help it resolve the situation. (iflscience.com)
The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. (lu.se)
Specifically, proteins involved in metabolic pathways and in mitochondrial functions are mainly downregulated in mice fed with obesogenic diets compared to SD. (lu.se)

One source of confusion may be that proxy measures of protein synthesis, such as mGluR-LTD or phosphorylation of signaling molecules, have been used in intact hippocampal slice preparations, whereas metabolic labeling experiments have been performed in synaptoneurosome preparations of cortex that are not easily related to altered hippocampal synaptic plasticity. (jneurosci.org)

Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. (cellsignal.com)
Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid with BSA as a carrier protein. (novusbio.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)

The results showed in this study suggest that, together with cytoskeletal proteins, mitochondria and metabolic proteins are changing their post-translational status in brains of obese mice. (lu.se)

In vitro , recombinant agrin promotes the division of cardiomyocytes that are derived from mouse and human induced pluripotent stem cells through a mechanism that involves the disassembly of the dystrophin-glycoprotein complex, and Yap- and ERK-mediated signalling. (nature.com)

Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. (jneurosci.org)
Our data suggest that elevated protein synthesis in the Fmr1 KO is due to saturation of mRNA translation downstream of the MAP kinase ERK1/2 which is basally activated by mGluR5. (jneurosci.org)
This manuscript reports data consistent with a new and unanticipated phenomenon: that Cre or its mRNA may be transmitted between tissues in the mouse and that the male reproductive tract (epididymis) appears to be the most common target of such transported molecules. (elifesciences.org)

In this study, we found that mouse Ahi1 formed a stable complex with huntingtin-associated protein 1 (Hap1), which is critical for neonatal development and involved in intracellular trafficking. (jci.org)

Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. (jneurosci.org)
A strong rationale for taking this approach is that slice has been shown to accurately reproduce the in vivo phenotype of elevated basal protein synthesis in the Fmr1 KO hippocampus (cf. (jneurosci.org)
Eye phenotype and lens histology and ultrastructure were analyzed in adult mice. (molvis.org)

Mutations in the Abelson helper integration site 1 gene, which encodes the protein AHI1, have been shown to cause Joubert syndrome. (jci.org)
Our genetic dissection of mice with loss-of-function mutations in Syngap1, Nlgn3, Dlgap1, Dlgap2 and Shank2 showed that distinct components of the PSD-95 protein complex differentially regulate learning, cognitive flexibility and reaction times in cognitive processing. (nih.gov)
NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)

Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. (nih.gov)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice. (bvsalud.org)
As an example, in post-mortem brain of patients with Alzheimer's disease (AD), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the AD patient's brain. (lu.se)
pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
The NEMO protein is required for the activation of the kinase complex. (medscape.com)

C and D ) Respiration control ratio was obtained from permeabilized cardiac fibers incubated with indicated substrates in 11 WT and 7 Txnip-KO mice. (jci.org)

It interacts also with anticoagulant protein S and with serum amyloid P component. (lu.se)

This problem has been circumvented with the use of several knockout, knock-in, and overexpressing transgenic mouse models. (molvis.org)
Transgenic mouse models pro- fection. (who.int)

Zyagen provides high quality ready to use cytoplasmic protein of wide variety of normal healthy human tissues that might difficult to obtain because of size, anatomical complexity, or high protease activity. (delos.info)
Tissues are freshly dissected and homogenized in modified protein lysis buffer supplemented with a cocktail of 7 protease inhibitors to minimize proteolysis. (delos.info)
Pantomics Array Description: Normal tissues of 22 major organs duplicated or triplicated from 3 KM strain mice. (delos.info)
Therefore, we analyzed a series of glycoproteomes in several mouse tissues to identify glycosylated proteins and their glycosylation sites. (nih.gov)

A team at NIDDK's intramural Genetics of Development and Disease Branch led by Elisabetta Mueller, Ph.D., has found that deleting a protein named Foxa3 protects mice from developing obesity and type 2 diabetes as they age. (nih.gov)

Things are looking up for aging mice and, if this research pays off, for aging humans, too. (foxnews.com)
It could be that SIRT6 is to mice (and humans) as Sir2 is to yeast, a regulator of life span. (foxnews.com)
The researchers said that because they still saw the GM-CSF benefiting the mice several days after the mice had been infected with the flu, there is potential for using GM-CSF to treat flu and pneumonia in humans. (news-medical.net)
These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
In this study, Denorme and his team looked at a particular immune cell, called a neutrophil, in humans and in mice. (heart.org)
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene. (wikipedia.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

A ) Immuno-histo-chemical staining of mouse brains with antibodies against Hap1 (top) and Ahi1 (bottom). (jci.org)
E ) Immuno-staining of the adult mouse cerebellum with antibodies against calbindin and Hap1 together or antibodies against Ahi1 and Hap1 together. (jci.org)

Results of a recent study in mice have revealed that a transporter protein called KF17 can help to boost intelligence in the animals. (worldhealth.net)

This CLIA kit applies to the in vitro quantitative determination of Mouse TP53 concentrations in Serum, plasma and other biological fluids. (caslab.com)

Researchers believe that this protein may also help regulate the relative acidity (pH) of melanosomes. (medlineplus.gov)

In a 2014 paper published in Nature , Rodgers and Rando showed in laboratory mice that an injury to the muscle of one leg caused a change in the muscle stem cells of the other leg. (stanford.edu)
In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)

The team's previous work revealed that mice genetically bred to have lots of SIRT6 could get fat on rich diets yet show no signs of heart disease, fatty liver disease and other diseases associated with obesity. (foxnews.com)
Previous research by other groups showed that mice genetically bred to have little SIRT6 don't live very long. (foxnews.com)
They note that measuring life spans in longer-lived and more complex animals can be tricky, because, for example, life spans can vary by many months for genetically similar mice in similar environments with similar feed. (foxnews.com)

d) Survival after rechallenge with 100 MID 50 of HK/483 of mice primed with A/NP+A/M DNA and which had all survived the previous HK/156 infection. (cdc.gov)
They found that the mice that had been given large amounts of a special cytokine -- molecules that warn other cells that there's an infection or other trauma in the body -- called GM-CSF, had better survival and lung function than the other mice. (news-medical.net)
At 13 days post-infection, 90 percent of the mice with GM-CSF were still alive versus 50 percent of the mice without. (news-medical.net)

Description: RNA profiling data sets generated by the Mouse ENCODE project. (nih.gov)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (joplink.net)

Pretreatment with a stem-cell-activating protein significantly enhances healing in mice, Stanford researchers say. (stanford.edu)

Here, we modeled GWI in 30 BXD recombinant inbred mouse strains with a combined treatment of corticosterone (CORT) and diisopropyl fluorophosphate (DFP). (cdc.gov)

In a wild-type genetic background ( mdm2 +/+ ), lens damage and microphthalmia were observed only in mice homozygous for Tg p53 ( t/t ). (molvis.org)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)

In their write-up, the authors suggest that the protein promotes "adaptive responses to exercise-related stress conditions," such as metabolic imbalance and heat shock. (iflscience.com)

Researchers have found that a long-suspected anti-aging protein called sirtuin can make male mice live about 16 percent longer than average, the first such advance for mammals in a field that has thus far only offered the blessings of extended life span to yeast , nematodes and fruit flies. (foxnews.com)
The researchers speculate that, considering how male mice have a higher rate of cancers compared with the females, the SIRT6 could be acting as a tumor suppressor and thus have a larger effect on male life span than female life span. (foxnews.com)
Given the title of the Nature study, "The sirtuin SIRT6 regulates lifespan in male mice," that's what the researchers are hoping. (foxnews.com)
GM-CSF, a protein that modifies the immune response to the flu, may also help reduce lung inflammation and improve survival during influenza, according to Penn State researchers. (news-medical.net)
The researchers studied the survival and lung function of mice with influenza in the lab. (news-medical.net)
Previous studies demonstrated that mice born with higher levels of GM-CSF were naturally protected from influenza, but the researchers wanted to know if introducing GM-CSF after the mice already had the flu was just as effective. (news-medical.net)
In the study, the researchers used mice born with a special gene that allows them to create GM-CSF in their lungs when given the antibiotic doxycycline. (news-medical.net)
Three days after giving them influenza, the researchers gave the mice a dose of doxycycline, triggering the production of GM-CSF in the mice's lungs. (news-medical.net)
The researchers found that the mice with GM-CSF had a better chance of survival than the other mice. (news-medical.net)
After 2.5 days, the researchers found that muscle stem cells from the recipient animals were in an alert state and completed their first cell division much more quickly than occurred in animals that had received blood serum from uninjured mice. (stanford.edu)
The data serve as a timely warning to mouse researchers about an unexpected complication of Cre-mediated gene manipulation. (elifesciences.org)

Mouse IL-11 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/ml which can be further diluted in aqueous solutions as needed. (cellsignal.com)
Protein concentration was determined with Bio-Rad protein assay. (abcam.com)
The extracted protein is provided in vials at a concentration of 2-3mg/ml and shipped on dry ice. (delos.info)
Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20? (joplink.net)
The RLU value is positively associated with the concentration of Mouse TP53. (caslab.com)
You can calculate the concentration of Mouse TP53 in the samples by comparing the RLU value of the samples to the standard curve. (caslab.com)

Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)

The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling and plasticity underlying behaviour. (nih.gov)
Although the exact function of the P protein is unknown, it is essential for normal pigmentation and is likely involved in the production of melanin. (medlineplus.gov)
In the mouse model, mature osteoclasts, which are essential for tooth eruption, are lacking. (medscape.com)

abstract = "RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. (lu.se)

Cytoplasmic protein is ready to immediate use for studying cytoplasmic soluble proteins. (delos.info)
Cytoplasmic protein is ideal for many downstream applications such as Western blotting, protein assays, enzyme-activity assays, gel electrophoresis, immunoprecipitation, protein-protein interaction analysis, and tissue specific expression identification. (delos.info)
The quality of cytoplasmic protein as indicated by the absence of smear (no degradation) and sharpness and resolution of the protein bands are verified by denatured SDS-PAGE with Coomassie blue staining. (delos.info)
Protein is also validated by Western Blot using specific cytoplasmic protein biomarker, GAPDH or beta-actin. (delos.info)

NEMO is an ubiquitous protein that becomes active during embryogenesis. (medscape.com)

In order to test whether ligands with an imidazoline structure elicit pharmacological effects via alpha2-adrenergic receptors or via "imidazoline receptors", mice were generated with a targeted deletion of all three alpha2-adrenergic receptor subtypes (alpha2ABC-KO). (uni-wuerzburg.de)
These alpha2ABC-KO mice were an ideal model in which to examine the pharmacological effects of the centrally acting antihypertensives clonidine, moxonidine and rilmenidine in the absence of alpha2-adrenergic receptors. (uni-wuerzburg.de)
As expected, sedative and analgesic actions of clonidine were completely absent in alpha2ABC-KO mice, confirming the sole role of alpha2-receptors in these properties of clonidine. (uni-wuerzburg.de)

Hap1-knockout mice showed significantly reduced Ahi1 levels, defective cerebellar development, and abnormal axonal decussation. (jci.org)
Results showed that mice engineered to have higher-than-normal levels of KF17 learned how to navigate mazes and perform tasks significantly more quickly than normal mice. (worldhealth.net)
Clonidine significantly lowered heart rate in anesthetized alpha2ABC-KO and wild-type mice by up to 150 beats/min. (uni-wuerzburg.de)
Mice of all ages performed significantly better after receiving MOTS-c, and were able to run faster and for longer than untreated mice, while also displaying superior grip and balance. (iflscience.com)
The degree of protection provided by the nNIF protein exceeded our expectations and makes us really excited about a future where NET inhibition may significantly improve stroke outcomes," Denorme said. (heart.org)

Figure 3: Agrin induces cardiac regeneration in adult mice. (nature.com)
Vascular endothelial growth factor is an important signaling protein involved in both angiogenesis and vasculogenesis.VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. (prospecbio.com)
Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
Z200379Macrophage Inflammatory Protein-1 is a factor produced by macrophages that causes local inflammatory responses and induces superoxide production by neutrophils. (topsan.org)

Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)

Ultrastructural examination shows the accumulation of proteins and the presence of foot process (FP) effacement in the glomeruli of PNS patients . (bvsalud.org)

The neonatal mouse heart can regenerate, but only during the first week of life. (nature.com)
We identify agrin, a component of neonatal extracellular matrix, as required for the full regenerative capacity of neonatal mouse hearts. (nature.com)
Transient regenerative potential of the neonatal mouse heart. (nature.com)
A naturally occurring protein that blocks this inflammatory immune response, known as neonatal NET-inhibitory factor, or nNIF, was associated with better stroke recovery in a study conducted in mice. (heart.org)
To block NET formation, they administered a naturally occurring protein called nNIF, for neonatal NET-inhibitory factor, found in human umbilical cord blood. (heart.org)

The infrared images compare tissue from mice with the protein (top) to mice without the protein (bottom) before and after being exposed to cooler temperatures to determine ability to generate heat. (nih.gov)
In each image, the tissue from mice without the protein shows more red and white areas, pointing to enhanced energy expenditure. (nih.gov)
D ) Western blots of the cerebellar tissue from mice at different postnatal days (days 1-30). (jci.org)

Orthologous to human MTMR9 (myotubularin related protein 9). (nih.gov)
But better to be a human than a mouse. (foxnews.com)
Orthologous to human CSRNP3 (cysteine and serine rich nuclear protein 3). (nih.gov)
Recombinant Protein;Cynomolgus LAG-3 / CD223 Protein, Mouse IgG2a Fc Tag;100UG;Cynomolgus LAG-3, Mouse IgG2a Fc tag (LA3-C52A0) is expressed from human 293 cells (HEK293). (fishersci.com)
Mature human BMP-2 shares 100% aa sequence identity with mouse and rat BMP-2. (novusbio.com)
This co-immunoprecipitation protocol allows to study the interaction between the influenza A virus nucleoprotein and the antiviral Mx1 protein in human cells. (jove.com)
We analyzed mice expressing human p53 transgene (Tg p53 ) selectively in the lens in the presence or absence of Mdm2 . (molvis.org)
We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells. (amsbio.com)
A protein that is produced in human muscle cells during exercise may be the key to preventing age-related physical decline, after tests revealed that elderly mice were able to sprint like young pups after being injected with the compound. (iflscience.com)
The older mice were the human equivalent of 65 and above and once treated, they doubled their running capacity on the treadmill," explained study author Changhan Lee in a statement . (iflscience.com)
This implies that these mice can be used as a model of human disease and suggests that Lewis lung carcinoma 1 cell -secreted proteins (LCSePs) contain nephrotoxic molecules and cause inflammation in renal cells . (bvsalud.org)

These male mice lived longer , about 16 percent longer on average, than regular mice kept in the same conditions. (foxnews.com)

Mice given the priming protein recover muscle function more quickly after damage, their skin heals more rapidly and even the shaved area around the injury regrows hair more quickly, the study found. (stanford.edu)
Protein glycosylation is a common post-translational modification that plays important roles in terms of protein function. (nih.gov)
However, analyzing the relationship between glycosylation and protein function remains technically challenging. (nih.gov)
We believe that the first step to elucidate glycan function is to systematically determine the status of protein glycosylation under physiological conditions. (nih.gov)
Each group refers to a group of proteins with common function or process. (jci.org)
Although it is now clear that mGluR5 participates in the pathogenesis of FXS, at least in animal models, it is still poorly understood how Gp1 mGluRs trigger protein synthesis and how this process is altered in the absence of FMRP to disrupt synaptic function. (jneurosci.org)
Although the role of abnormal prion protein (PrP) conformation in generating infectious brain diseases (transmissible spongiform encephalopathy) has been recognized, the function of PrP in the normal brain remains mostly unknown. (amrita.edu)
The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. (elifesciences.org)
The mice that were pretreated with nNIF had reduced brain injury, improved neurological and motor function and enhanced survival after stroke. (heart.org)

Even mice that had been fed on a high-fat diet displayed major improvements while also gaining less weight than those that didn't receive MOTS-c injections, backing up a previous study which suggested that the protein may protect against obesity and diabetes . (iflscience.com)

According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. (jneurosci.org)

The current study used 245 mice, but ultimately may need thousands of mice to produce more reliable statistics. (foxnews.com)
But in this study, we gave the mice GM-CSF after they got the flu, which is more similar to when a patient gets sick and then you do something to help them. (news-medical.net)
Like drag car racers revving their engines at the starting line, stem cells respond more quickly to injury when they've been previously primed with one dose of a single protein, according to a study from the Stanford University School of Medicine . (stanford.edu)
To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
By studying people who had an ischemic stroke and mice subjected to ischemic stroke, we discovered that during stroke, the immune system goes rogue in the brain," said lead study author Frederik R. Denorme, Ph.D., a postdoctoral researcher at the University of Utah in Salt Lake City. (heart.org)
To study the effects on stroke, the investigators blocked the formation of NETs in mice. (heart.org)
Given these lines of evidence, in the present study we investigated brains of mice treated with 2 obesogenic diets, high-fat diet (HFD) and high-glycaemic diet (HGD), compared to mice fed with a standard diet (SD) employing a quantitative mass spectrometry-based approach. (lu.se)
The aim of the study was to identify proteins present in the brain that are changing their expression based on the diet given to the mice. (lu.se)
In this study, we identified the raffinose ATP-binding protein RafK and showed that it was directly involved in raffinose and stachyose import. (lu.se)

Thioredoxin-interacting protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxins, but little is known about its roles in the myocardium. (jci.org)
p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
Analysing brain tissue from males of the Huntington's disease (HD) R6/2 mouse model uncovered differential RNA-binding of the alternative splicing regulator RBM5. (lu.se)
Analysing brain tissue from males of the Huntington{\textquoteright}s disease (HD) R6/2 mouse model uncovered differential RNA-binding of the alternative splicing regulator RBM5. (lu.se)

Two mouse brains (1 and 2) at E8, E12, and E18 were examined. (jci.org)

Mouse Recombinant produced in yeast is a disulfide-linked homodimer consisting of 2x121 amino acid polypeptide chains, having a molecular mass of approximately 20.7kDa each. (prospecbio.com)
No yeast two-hybrid interactions found for this protein. (yeastrc.org)

We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). (jneurosci.org)
This inhibition was demonstrated again in isolated sinoatrial node (SAN) cells from alpha2ABC-KO mice and was identical in potency and efficacy to clonidine inhibition observed in isolated wild-type SAN cells, confirming that inhibition of atrial HCN channels constitutes the alpha2-independent bradycardic action of clonidine. (uni-wuerzburg.de)

The 9A1.5 monoclonal antibody specifically binds to an extracellular domain of Delta-Like Protein 4 that is encoded by the Dll4 gene. (bdbiosciences.com)

Recombinant Proteins1

Genes12

C57BL2

Membrane Proteins2

Nuclear proteins1

Embryonic4

Pathway6

Transmembrane2

Purity1

Mitochondrial3

Signaling molecules1

Carrier protein3

Cytoskeletal1

Induced pluri1

MRNA3

Intracellular1

Phenotype3

Mutations4

Kinase7

Substrates1

Interacts1

Transgenic mouse models2

Tissues4

Genetics1

Humans10

Antibodies2

Transporter protein1

Vitro1

Regulate1

Laboratory2

Genetically3

Infection3

ENCODE1

Stability1

Enhances1

Strains1

Homozygous1

ELISA1

Metabolic1

Researchers11

Concentration6

Transcript2

Essential3

Abstract1

Cytoplasmic4

Embryogenesis1

Receptors3

Significantly5

Induces4

Localization1

Accumulation1

Neonatal5

Tissue from mice3

Human11

Male mice1

Function9

Obesity1

Downstream1

Study9

Regulator4

Brains1

Yeast2

Type2

Binds1