Proteins to intracellular membranes. Medical search. Frequent questions

Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons. (nih.gov)
Sorting nexins (SNXs) are phox homology (PX) domain-containing proteins thought to regulate endosomal sorting of internalized receptors. (nih.gov)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)
For example, photo-activatable G-protein-coupled receptors (e.g. (frontiersin.org)
Multiple factors contribute to angiogenesis, including soluble growth and differentiative factors, extracellular matrix components, membrane-bound receptors, and intracellular signaling molecules. (rndsystems.com)

Identification by anti-idiotype antibodies of an intracellular membrane protein that recognizes a mammalian endoplasmic reticulum retention signal. (ox.ac.uk)
Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. (ox.ac.uk)
These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of resident proteins to the endoplasmic reticulum. (ox.ac.uk)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
SERCA is responsible for pumping cytosolic Ca 2+ into the endoplasmic reticulum (ER) store and thus maintaining the intracellular concentrations of Ca 2+ both in the cytosol and in the ER store. (jneurosci.org)

ABC proteins transport various molecules across extra- and intra-cellular membranes. (nih.gov)
A metabolic disorder is any disease or disorder that negatively affects the biochemical reactions through which individual animal cells process nutrient molecules (such as the components of carbohydrates , proteins , and fats ) to yield energy or perform the functions necessary to sustain life (such as building complex molecules and creating cellular structure). (newworldencyclopedia.org)
Cell death by necroptosis involves membrane breakage, which leaks intracellular molecules such as heat shock proteins. (news-medical.net)
A major barrier for the efficacy of many clinically relevant anti-cancer drugs (e.g. gemcitabine, 5-flurouracil, cisplatin) is the passage of these molecules across biological membranes, whether in the context of transit across an endothelial monolayer or across the plasma membrane of the cancer cell itself [ 5 ]. (plos.org)
Eukaryotic cells, including human cells, surround themselves with bilayer membranes, i.e. thin, flexible layers that are only two molecules thick. (umn.edu)
As an escort protein, REP-1 attaches to molecules called Rab proteins within the cell and directs them to the membranes of various cell compartments ( organelles ). (medlineplus.gov)

Intracellular transport of lysosomes is carried out in membrane-bound vesicles through the use of motor proteins. (awm-math.org)
A) Clathrin-coated vesicles (CCVs), circular vesicles with a fringe of clathrin protein (arrow), in the cell cytoplasm range in size from 60 nm−100 nm. (cdc.gov)
B) Multivesicular body (MVB), a collection of membrane-bound roughly spherical vesicles formed by the inward budding of an endosomal membrane. (cdc.gov)
We recently developed a generic method for producing polymer-supported lipid bilayers directly from cell-derived native membrane vesicles (NMVs). (lu.se)
Ultrastructural analysis of infected Vero cells showed the virions within cell vesicles and around the cell membrane. (cdc.gov)

Cell membranes are continually remodelled to achieve communication between intracellular compartments and to selectively exchange materials between them. (unifr.ch)
She was particularly interested in the Golgi apparatus, a cluster of membrane-bound compartments that help coordinate this trafficking, and spent much of her time manipulating the organelle's activity to try to better understand how it works. (the-scientist.com)
Bilayer membranes also serve as internal partitions to enable formation of functionally-specialized compartments within cells. (umn.edu)

When a neurotransmitter binds to a receptor, an extracellular signal is transduced into an intracellular one, causing a functional change inside target neurons. (psychiatrictimes.com)
The membrane integral receptor kinases function to receive extracellular signals and transmit them across the plasma membrane into the cells, while many intracellular kinases function to relay and amplify the signals in the cells. (ncsu.edu)

Currently, the main focus of the lab is to understand how specific lipids and membrane properties influence intracellular trafficking processes and fat storage in eukaryotic cells. (unifr.ch)
and (iii) the intracellular storage lipids, which are mostly triacylglycerols. (nih.gov)
The molecular building blocks of bilayer membranes are specialized lipids that are polar and nonpolar at their opposite ends. (umn.edu)
Interestingly, there are many more varieties of lipids found in membranes than are needed to form bilayers. (umn.edu)
What is now clear is that certain membrane lipids can function as messenger signals that regulate cell growth, proliferation, inflammation, and programmed cell death processes, while other membrane lipids appear to cluster together in bilayers to form microdomains that regulate the spatial distribution and lateral interactions of membrane proteins. (umn.edu)
Our research focuses on membrane lipids known as sphingolipids and on proteins that interact in non-enzymatic fashion with sphingolipids. (umn.edu)
Our research elucidated sphingolipid structural features that regulate their interactions with other membrane lipids and provided insights into the unique physical features at the heart of the lateral organizing functionality of sphingolipid-enriched microdomains. (umn.edu)
The findings have proven to be important for current understanding how the spatial organization of lipids in membranes can regulate proteins that translocate onto membranes to function. (umn.edu)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Cell damage was assessed using MTT assays, and the lactate dehydrogenase (LDH) release rate and flow cytometry were used to detect the accumulation of reactive oxygen species (ROS) and mitochondrial membrane potential respectively. (sdbonline.org)
Lymphedema occurs when disruption of normal lymphatic drainage leads to accumulation of protein-rich lymph fluid in the interstitial space. (oncolink.org)
This paper reports on the kinetics of accumulation of these lipid classes during pollen maturation and the expression patterns of several lipid biosynthetic genes and their protein products that are differentially regulated in developing microspores/ pollen grains (gametophyte) and tapetal cells (sporophyte) of B. napus. (nih.gov)
This pattern of expression coincided with accumulation of the intracellular storage and membrane lipid components of pollen. (nih.gov)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al. (novusbio.com)

There are 518 protein kinases in the Human genome, comprising about 2% of all genes. (ncsu.edu)

They consist of two types, peripheral and integral proteins. (curehunter.com)

Our data support an evolutionarily conserved function for SNX1 from yeast to mammals and provide functional insight into the molecular mechanisms underlying lipid-mediated protein targeting and tubular-based protein sorting. (nih.gov)
Our main goal is to understand how the molecular properties of proteins and membranes modulate cellular processes. (unifr.ch)
The energetics of these remodelling processes are governed by the interplay between specialized proteins and membrane properties, but in most cases, we still lack a detailed molecular explanation of how these processes can be modulated in a cellular environment. (unifr.ch)
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. (novusbio.com)
The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)
Molecular Membrane Biology 2013, 30 (3):246-260. (lu.se)

Fatty acid binding protein 9 (FABP9) belongs to the fatty acid-binding proteins (FABPs) which are a family of small, extremely conserved, cytoplasmic proteins to bind long-chain fatty acids and other hydrophobic ligands. (prospecbio.com)

In vitro exposure of BEAS-2B bronchial epithelial cells and A549 alveolar adenocarcinoma cells results in cytotoxicity, increased oxidative stress, increased intracellular [Ca2 + ], decreased mitochondrial membrane potential, and interleukin (IL)-8 production. (dovepress.com)
exposure results in cytotoxicity, oxidative stress, intracellular Ca2 + flux, decreased mitochondrial membrane potential, and production of IL-1β and chemokine CXCL9. (dovepress.com)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)

Additionally, continual oxidative stress from CCl 3 causes DNA damage, protein malfunction, and disrupted calcium homeostasis. (cdc.gov)

PACE4 (paired basic amino acid cleaving system 4, SPC4) is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. (eu.org)
This calcium-dependent serine endoprotease is concentrated in the trans-Golgi network, associated with membranes, and is not secreted. (eu.org)
The Ca 2+ signal is characterized by a rapid increase in the concentration of free cytosolic calcium ([Ca 2+ ] i ) attributable to the opening of calcium channels located in the plasma membrane and in the membranes of intracellular calcium stores. (jneurosci.org)
Free Ca 2+ is then rapidly sequestered by the action of calcium pumps and exchangers and also with buffering by cytosolic calcium binding proteins. (jneurosci.org)

We show here that SNX1 contains a BAR (Bin/Amphiphysin/Rvs) domain, a membrane binding domain that endows SNX1 with the ability to form dimers and to sense membrane curvature. (nih.gov)
We conclude that through coincidence detection SNX1 associates with a microdomain of the early endosome-characterized by high membrane curvature and the presence of 3-phosphoinositides-from where it regulates tubular-based endosome-to-TGN retrieval of the CI-MPR. (nih.gov)

Our studies revealed novel functions of intracellular complement components in β cells, presenting a new link between complement and diabetes development. (lu.se)
Surprisingly, this is related to intracellular functions of complement and therefore changes the way we perceive this "blood" system and will likely inspire discovery of many other intracellular effects of complement. (lu.se)
We study the role of intracellular complement factor C3 and membrane bound complement inhibitor CD59 in insulin secretion as well as physiology and metabolism of beta cells. (lu.se)
The complement system contains more than 40 proteins that circulate in the blood and these proteins play an important role in the innate defense against pathogens, and in the removal of unwanted materials. (lu.se)
one example is the intracellular functions of complement proteins in beta cells. (lu.se)
Our research aim is to further our understanding of the role of these complement proteins in physiology and metabolism of beta cells, focusing on intracellular complement factor C3 in beta cell survival and function, and membrane-bound complement inhibitor CD59 in insulin secretion. (lu.se)

1998 Philip Cohen, Discovery of a protein kinase cascade of major importance in insulin signal transduction 1997 Anthony Hunter, The phosphorylation of proteins on tyrosine: its role in cell growth and disease 1996 Thomas Lindahl, Endogenous damage to DNA. (wikipedia.org)
However, apoptosis can be blocked by caspase inhibitors resulting in a "ballooning cell membrane", typical of necrosis. (news-medical.net)
Combining spatial and abundance information yielded an unprecedented quantitative view of HeLa cell anatomy and organellar composition, at the protein level. (elifesciences.org)
Dynamic Organellar Maps enable the proteome-wide analysis of physiological protein movements, without requiring any reagents specific to the investigated process, and will thus be widely applicable in cell biology. (elifesciences.org)
Proteins are the tools and machines of the cell, and each organelle has its own set of proteins that it requires to work correctly. (elifesciences.org)
Each cell contains ten or more organelles, and several thousand different types of proteins. (elifesciences.org)
The location of many proteins in a cell is unclear or simply not known. (elifesciences.org)
set out to develop a method that reveals the locations of all the proteins in a cell at any given time. (elifesciences.org)
The resulting technique maps the location of most of the proteins in a human cancer cell line and, in addition, determines how many copies of each protein there are. (elifesciences.org)
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. (plos.org)
By combining coarse grain MD simulations and biochemical and cellular experiments, we investigate how membrane properties modulate remodelling processes and how this might influence cell functioning. (unifr.ch)
Interactions between proteins and membranes are a vital part of cell functioning. (unifr.ch)
For Mukherjee, the paper was a revelation: not only did it identify the fastest way yet to target Golgi biology, it suggested that scientists could use intracellular bacteria "as a lens to understand basic processes inside the cell. (the-scientist.com)
So-called facultative intracellular bacteria such as Listeria monocytogenes and Legionella pneumophila do not need to be inside a host cell to reproduce. (the-scientist.com)
The discovery of these membrane lipid functions underscores why cell membranes so often come under direct attack during cancer and infectious disease. (umn.edu)
This results in intracellular storage of excess sialyloligosaccharides and is histologically observed as abnormal vacuolization of various cell types. (medscape.com)
Hereditary spherocytosis and hereditary elliptocytosis are congenital red blood cell (RBC) membrane disorders that can cause a mild hemolytic anemia. (msdmanuals.com)
In hereditary spherocytosis, the cell membrane surface area is decreased disproportionately to the intracellular content due to loss of proteins associated with the cell membrane. (msdmanuals.com)
As cell membranes are both dynamic and compositionally complex, replicating these aspects in a model membrane are essential. (lu.se)

She learned that researchers had identified more than 300 Legionella peptides that mimic host proteins or otherwise hijack existing cellular pathways to the bacterium's advantage. (the-scientist.com)

They have shown that UVRAG function and autophagy are inactivated by oncogenes such as cellular Bcl-2 and oncogenic γ-herpesvirus-encoded Bcl-2 proteins, by the oncogenic BRAF kinase, and by genetic mutations that increase inflammation and cancer susceptibility and can also be hitchhiked by viruses for their efficient infection. (upenn.edu)
We chose the Leucine-Rich Repeats Receptor Kinases as an example to understand the general mechanism of ligand-induced receptor kinase activation, and investigate the activation mechanism of IkB kinase to understand the role of intracellular signalling kinases in signal transduction. (ncsu.edu)
IKK is a large protein complex containing the kinase subunits IKKα and IKKβ, and the regulatory subunit NF-κB essential modifier (NEMO, also known as IKKγ). (ncsu.edu)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
Auxin gradients are established and maintained by polarized distribution of auxin transporters that undergo constitutive endocytic recycling from the PM (plasma membrane) and are essential for the gravitropic response in plants. (portlandpress.com)
Such proteins include sphingolipid transfer proteins that function as transporters to shuttle sphingolipids between intracellular membranes as well as lipid-binding domains (e.g. (umn.edu)

Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. (nih.gov)

[ 2 ] The MNK protein also became localized toward the basolateral membrane and increased copper transport. (medscape.com)

Solute transport on the sub 100 ms scale across the lipid bilayer membrane of individual proteoliposomes. (lu.se)

The prohormone-processing yeast KEX2 protease can act as an intracellular membrane protein or a soluble, secreted endopeptidase. (eu.org)

Liang lab has identified and studied the mammalian essential autophagy protein, UV irradiation resistance associated gene (UVRAG), which functions in and beyond autophagy and has emerging significance in cancer research. (upenn.edu)

The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
4. Membrane-protein interactions. (unifr.ch)

Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Protein function is critically determined by subcellular localization, as organelles offer different chemical environments and interaction partners. (elifesciences.org)
In order to regulate protein activity, many biological processes involve changes in protein subcellular localization. (elifesciences.org)

In this study, the effects of intracellular delivery of various concentrations of gallic acid (GA) as a semistable antioxidant, gallic acid-loaded mesoporous silica nanoparticles (MSNs-GA), and cellular uptake of nanoparticles into Caco-2 cells were investigated. (springer.com)
USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. (plos.org)
Decreased Ca 2+ release in aminergic neurons during development of the flight circuit can be compensated by reducing Ca 2+ uptake from the cytosol to intracellular stores. (jneurosci.org)
Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice. (lu.se)

3. Membrane remodelling processes. (unifr.ch)
Using a combination of MD simulations and biochemical approaches, we study how membrane properties regulate protein functions, and hence how lipid metabolism may play a role in unexpected, and apparently unrelated, trafficking processes. (unifr.ch)
Research in our lab focuses on structural and mechanistic studies of protein kinases in various biological processes. (ncsu.edu)
Heterotrimeric G proteins are intracellular membrane-attached signal transducers involved in various cellular processes in both plants and animals. (lu.se)
Ionic Ca 2+ functions as a second messenger to control several intracellular processes. (jneurosci.org)

Captured proteins are visualized using chemiluminescent detection reagents (Step 3) . (rndsystems.com)
R&D Systems has an extensive and diverse offering of reagents for studying proteins that are known to be involved in both angiogenesis and its natural counterpart, anti-angiogenesis. (rndsystems.com)

The hallmark of eukaryotic cells is their compartmentalization into distinct membrane-bound organelles. (elifesciences.org)
Protein kinases are major signal transmitters in eukaryotic cells. (ncsu.edu)

Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)
Phylogeny of major intrinsic proteins. (lu.se)

Methylenediphenyl diisocyanate binds membrane and intracellular proteins of intact THP-1 cells. (cdc.gov)

FABP9 probably links intracellular membranes and signals abnormal sperm formation during spermatogenesis. (prospecbio.com)
Here, we have addressed these questions by altering intracellular Ca 2+ signals in flight-deficient itpr mutants through genetic means. (jneurosci.org)

Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)

Most metabolic disorders are inherited from one or both parents who carry a defective gene that regulates a particular protein in a class of the body's cells. (newworldencyclopedia.org)
Furthermore, development of various non-opsin based optogenetic systems has allowed for spatiotemporal regulation of protein functions, cellular signaling and gene expression (e.g. (frontiersin.org)
The CHM gene provides instructions for producing the Rab escort protein-1 (REP-1). (medlineplus.gov)
Mutations in the CHM gene lead to an absence of REP-1 protein or the production of a REP-1 protein that cannot carry out its protein escort function. (medlineplus.gov)

An increase in intracellular copper causes ATP7A to move to the plasma membrane. (medscape.com)
Intracellular fluid includes all fluid enclosed by the plasma membranes of cells. (oncolink.org)
Purification and Proteomic Analysis of Plant Plasma Membranes. (lu.se)
HvPIP1;6, a Barley (Hordeum vulgare L.) Plasma Membrane Water Channel Particularly Expressed in Growing Compared with Non-Growing Leaf Tissues. (lu.se)

The formation of necrosome, a multiprotein complex that stimulates necroptosis, is tightly regulated by proteins downstream of the receptor and can be the deciding factor in inducing necroptosis. (news-medical.net)

Moreover, removing the membrane-bound CD59 did not affect insulin secretion, suggesting that intracellular CD59 is involved in this function. (lu.se)
Non-GPI anchored CD59 interacts with SNARE protein: VAMP2 and rescues insulin secretion. (lu.se)
We also found that CD59, a protein present on the surface of almost all cells which protects cells from being attacked by the immune system, can also be found inside cells, where it regulates insulin secretion. (lu.se)

They are classified into mainly two types of protein kinases, membrane integral receptor kinases and intracellular kinases. (ncsu.edu)
Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

At the sub-cellular scale, maps document the spatial organization of proteins, RNA, DNA, and metabolites with nanometer precision and temporal acuity on the order of seconds. (stanford.edu)

The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. (portlandpress.com)

Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)

And she gained a new appreciation for the myriad other types of intracellular bacteria, a diverse group that includes many medically significant pathogens such as Salmonella , Listeria, and Chlamydia , as well as the causative agents of tuberculosis and leprosy. (the-scientist.com)
By contrast, obligate intracellular bacteria such as Chlamydia trachomatis and Mycobacterium leprae do, and this trait makes them a challenge to culture and study in the lab. (the-scientist.com)

This lack of functional REP-1 prevents Rab proteins from reaching and attaching (binding) to the organelle membranes. (medlineplus.gov)

These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)
For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)

In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
It was the early 2000s, and Mukherjee was working in Dennis Shields's lab at Albert Einstein College of Medicine, studying how cells organize the internal transport of proteins and other cargo. (the-scientist.com)
Single particle tracking methods utilize stochastic models to simulate intracellular transport and give rise to rigorous analysis of the resulting properties, specifically related to transitioning between inactive to active states. (awm-math.org)

ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells. (nih.gov)
Whether the increased intracellular [Zn2 + ] is due to the NPs being taken up by cells or to NP dissolution in medium is still unclear. (dovepress.com)
The Menkes protein is also in retinal pigment epithelial cells and the neurosensory retina. (medscape.com)
The Menkes protein is synthesized as a single-chain polypeptide localized to the trans-Golgi network in cells. (medscape.com)
We initially used maps statically to generate a database with localization and absolute copy number information for over 8700 proteins from HeLa cells, approaching comprehensive coverage. (elifesciences.org)
In all other cells, DMT1 is found in intracellular membranes where it promotes the exit of endocytosed Fe 2+ from endosomes into the cytoplasm 9 . (nature.com)
Roy's team had found that "this protein called AnkX, when microinjected into cells-even at picomole levels-could cause the entire Golgi to fragment in, like, five minutes," Mukherjee says. (the-scientist.com)
The release of Ca 2+ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP 3 R) occurs in both excitable and nonexcitable cells. (jneurosci.org)
We have since focused our efforts on specific proteins that can bind and transfer sphingolipids between membrane surfaces and that may help formation and maintain 'raft' microdomains in cells. (umn.edu)
Rab proteins are involved in the movement of proteins and organelles within cells (intracellular trafficking). (medlineplus.gov)
Without the aid of Rab proteins in intracellular trafficking, cells die prematurely. (medlineplus.gov)
Loss of REP-1 function and subsequent misplacement of Rab proteins within the cells of the retina causes the progressive vision loss characteristic of choroideremia. (medlineplus.gov)

In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)

Research on how intracellular bacteria take control of their hosts is not only informing scientists about how these microbes cause disease, but revealing secrets of mammalian biology, says Mukherjee, who now heads up a lab at the University of California (UC), San Francisco. (the-scientist.com)

In addition, we show that the BAR domain endows SNX1 with an ability to tubulate membranes in-vitro and drive the tubulation of the endosomal compartment in-vivo. (nih.gov)

A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. (rndsystems.com)
Why Use an Antibody Array to Detect Angiogenesis-Related Proteins? (rndsystems.com)
The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample. (rndsystems.com)

Proteins which are found in membranes including cellular and intracellular membranes. (curehunter.com)
Hardman et al found that insulin and estrogen increased the level of MNK mRNA and protein levels in the placenta. (medscape.com)
Intracellular coronaviruses are found within membrane-bound vacuoles, and spikes, if visible, are in contact with the vacuolar contents. (cdc.gov)
Additionally, the protein level of NICD was found to be lesser in aortic tissue sections from CLP mice. (bvsalud.org)

Buffy often acts opposite to Debcl , the other Drosophila Bcl-2-family protein. (sdbonline.org)
By altering intracellular Ca 2+ and InsP 3 levels through genetic means, we now show that signaling through the InsP 3 R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. (jneurosci.org)

While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)
With this Dynamics workshop, our goal is to bring together leading experts in the field of membrane dynamics, with a particular focus on neutrons and X-rays, but also complementary techniques including NMR, single molecule spectroscopy and computer modeling. (lu.se)

Anatomy57

Organisms13

Diseases1

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes50

Disciplines and Occupations2

Technology, Industry, Agriculture6

Information Science3

Health Care1

Receptors6

Endoplasmic5

Molecules6

Vesicles5

Compartments3

Extracellular2

Lipids10

Accumulation4

Effector proteins2

Genes1

Integral proteins1

Molecular6

Cytoplasmic1

Mitochondrial6

Oxidative stress1

Calcium4

Curvature2

Complement6

Cell19

Peptides1

Kinase3

Transporters4

Viral1

Basolateral1

Lipid bilayer1

Soluble1

Autophagy1

Interactions2

Subcellular3

Uptake4

Processes5

Reagents2

Eukaryotic cells2

Intrinsic2

Binds1

Signals2

Antibodies1

Gene4

Plasma4

Downstream1

Secretion3

Kinases2

Spatial organization1

Inhibitor1

Biological2

Chlamydia2

Functional1

Mechanism2

Transport3

Cells12

Functions1

Mammalian1

Endosomal1

Antibody3

Found4

Drosophila2

Dynamics2