Proteins to dna dna replication. Medical search. Frequent questions

These processes are responsible for genetic continuity and protein synthesis, enabling life as we know it. (aboutdarwin.com)
On the other hand, RNA is a single chain of nucleotides primarily involved in protein synthesis following the master plan outlined by DNA. (aboutdarwin.com)
In contrast, quantitative Western blot analysis demonstrates that CENP-A protein synthesis occurs later, in G2. (rupress.org)
Thus, unlike most genomic chromatin, histone synthesis and assembly are uncoupled from DNA replication at the kinetochore. (rupress.org)
Uncoupling DNA replication from CENP-A synthesis suggests that regulated chromatin assembly or remodeling could play a role in epigenetic centromere propagation. (rupress.org)
It undergoes DNA replication and synthesis of viral capsid proteins inside the cell. (medscape.com)
On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. (kegg.jp)
Replication may be categorized into immediate early, delayed early, and late gene expression based on time of synthesis after infection. (medscape.com)

The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. (wikipedia.org)
Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
Two such fundamental processes that keep the wheels of life turning are Replication and Transcription. (aboutdarwin.com)
DNA Replication and RNA Transcription, although seemingly complex terms, hold within them concepts that are beautifully precise, methodical - true marvels of nature. (aboutdarwin.com)
However, as similar as they may appear to those newly introduced to these concepts, replication and transcription have unique roles to play in cellular activity. (aboutdarwin.com)
This interplay forms the foundation of processes like Replication and Transcription. (aboutdarwin.com)
The communication between molecular motors and double-stranded DNA binding proteins is a common feature in DNA replication, repair, recombination and transcription and also in instances where conflict occurs between these processes. (sciencedaily.com)
Retroviruses use reverse transcription to create a double-stranded DNA copy (a provirus) of their RNA genome, which is inserted into the genome of their host cell. (msdmanuals.com)
Because RNA transcription does not involve the same error-checking mechanisms as DNA transcription, RNA viruses, particularly retroviruses, are particularly prone to mutation. (msdmanuals.com)
They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability. (bvsalud.org)
Published September 5, 2007 transcription factors and replicating extra DNA, rather than going directly into growth of the cell. (lu.se)

Gp32 interacts with both enzymes acting on DNA and enzymes acting on membrane proteins. (neb.com)
The cellular response to DNA damage involves an intricate network of enzymes responsible for sensing, signaling, and repairing damaged DNA, as well as the regulation of cell cycle checkpoints that collectively maintain genomic integrity 2 . (nature.com)
The course plot for the saga of replication involves an array of characters, including enzymes like DNA polymerase, working tirelessly as diligent scribes, replicating each chapter accurately from the DNA template. (aboutdarwin.com)
Prior to cell division, double-stranded DNA is encircled by two separate MCM complex enzymes. (sciencedaily.com)
Furthermore, double-strand DNA has relatively small grooves where damaging enzymes can't attach, making it more difficult for them to 'attack' the DNA. (wikibooks.org)
A complex network of interacting proteins and enzymes is required for DNA replication. (kegg.jp)
Several of these genes, the TREX1 , RNASEH2A , RNASEH2B , and RNASEH2C genes, provide instructions for making nucleases, which are enzymes that help break down molecules of DNA and its chemical cousin RNA when they are no longer needed. (medlineplus.gov)
Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)

Reference: In vivo interactions of genes and proteins in DNA replication and recombination of phage T4. (neb.com)
Many mutations that interfere with recombination also interfere with initiation of secondary replication. (neb.com)
Most viruses, inject their host with linear DNA, and this gets incorporated into the host genome through the process of recombination. (wikipedia.org)
This recombination is crucial to viral replication. (wikipedia.org)
DNA exonucleases have roles to play in DNA metabolism, such as: replication, repair, and recombination. (wikipedia.org)
Furthermore, PARP-1 abrogation leads to increased DNA resection tracks and an increase of homologous recombination in cellulo. (nature.com)
Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction. (yeastgenome.org)

It has DNA helicase and ATPase activity. (nih.gov)
Their results showed that efficiency of fork arrest is weakened by kinetic competition between the rate of strand separation by the helicase motor at the fork and the rate of rearrangement of Tus−Ter interactions that maintain Tus's strong grip on the DNA. (sciencedaily.com)
At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. (kegg.jp)
Om de replicatie te beginnen, wikkelt een enzym, helicase, de DNA-helix af en verbreekt de waterstofbruggen tussen de twee strengen. (jove.com)
Exhibits a Magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. (lu.se)

Moreover, replication ensures that genetic information stays consistent and the life story written in our genes continues for another generation. (aboutdarwin.com)
Genes are small blocks of DNA that tell the cell which proteins it should create. (wikibooks.org)
In conclusion, our study demonstrated that hypomethylation of IFN-related genes is a common feature of GD/RA/SLE/SSc patients in CD4+ T cells, and the DNA methylation profile of IFN-related genes could be promising biomarkers for the diagnosis of GD, RA, SLE, and SSc. (frontiersin.org)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)
Expression changes in all these genes, detected by DNA microarrays, have been verified by real-time PCR. (cdc.gov)
FAP may be associated with mutations in the APC gene, but mutations in several other genes, particularly mismatch DNA repair genes, which are primarily responsible for ensuring integrity of polymerases responsible for DNA replication, may also result in familial colonic polyposis. (medscape.com)

An artist in its own right, Ligase dutifully connects Okazaki fragments (short sequences produced at the lagging strand) during replication. (aboutdarwin.com)
Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. (kegg.jp)

In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
Genomic features of gemycircularviruses HV-GcV1 and HV-GcV2 and of a novel circular single-stranded DNA (ssDNA) virus, HV-CV1, including hairpin structure and predicted open reading frames. (cdc.gov)
Cytological analysis of DNA replication further demonstrated that centromeres replicate asynchronously in parallel with numerous other genomic regions. (rupress.org)
Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)

The ORC-Cdc6 complex (product 1) assembles in step 1 around origin DNA and with the help of another replication initiator protein, Cdt1, it recruits the Mcm2-7 hexamer to the origin in step 2. (nature.com)
The pre-replication complex (pre-RC) assembly or the DNA replication licensing is the first step in DNA replication initiation, characterized by the sequential recruitment of ORCs, Cdc6, Cdt1 and MCMs to the DNA replication origins to form the pre-RC at the end of mitosis ( Bell and Dutta 2002 ). (intechopen.com)

Repairs are made by removing the section of DNA that contains errors and replacing it with a corrected DNA sequence. (medlineplus.gov)
In DNA a sequence of three bases, which is called a codon, is responsible for the encoding of a single amino acid. (wikibooks.org)
Epigenetics refers to the study of heritable changes in gene function without alterations in DNA sequence ( Bird, 2007 ). (frontiersin.org)
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. (yeastgenome.org)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
A termination site comprises a 23-base pair termination sequence (Ter) bound to the protein terminus utilization substance (Tus). (sciencedaily.com)
Towards in silico CLIP-seq : predicting protein-RNA interaction via sequence-to-signal learning. (ki.si)
Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
1. Is electrophilic or can be metabolical y activated to electrophiles does not alter the linear sequence of nucleotides (or bases) in the DNA, 2. (who.int)

Viral replication is nuclear. (wikipedia.org)
As many as 90% of healthy individuals have serum antibodies to this virus, but less than 10% show any evidence of ongoing viral replication. (medscape.com)
Periods of viral replication without any clinical symptoms occur and can be detected when it is shed in the urine. (medscape.com)
When reactivation happens in the setting of immune suppression, viral replication ensues, causing dissemination to the brain. (medscape.com)

The star enzyme that plays a critical role in synthesizing new DNA strands by following the older DNA as a template. (aboutdarwin.com)
These are essentially the core building blocks of new DNA strands. (aboutdarwin.com)
Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. (sciencedaily.com)
The process may also help to solve what the study's senior researcher called one of the greatest mysteries of biology: How double-stranded DNA separates into single strands to start the replication process. (sciencedaily.com)
During DNA replication, the MCM complex is positioned at the fork where double-stranded DNA separates into single strands. (sciencedaily.com)
Those strands are copied to produce a new DNA molecule. (sciencedaily.com)
Based on the newly determined structure of the replication machinery, the researchers proposed that the MCM complexes begin to move in different directions, leading to separation of double-stranded DNA into single strands. (sciencedaily.com)
When DNA is not self-replicating it exists in the cell as a double stranded helical molecule with the strands lined up anti-parallel to each other. (wikibooks.org)
The connection between the strands of double-stranded DNA is tighter than double-stranded RNA . (wikibooks.org)
In this process, the two strands of DNA making up the circular DNA molecule unwind and separate to become templates for generating new strands. (sciencedaily.com)
To ensure the process is well regulated, the bacterium has set a number of "roadblocks," or termination sites on the DNA, to ensure the permanent stoppage of replication forks, Y-shaped structures formed between the strands as the DNA molecule splits. (sciencedaily.com)
DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied. (jove.com)
How many individual DNA strands exist after one molecule of DNA has been replicated? (answers.com)
DNA is made of 2 strands so when it replicates the strands separate and 2 new strands complete the old strands. (answers.com)
This results in a total of four strands of DNA. (answers.com)
either DNA or RNA viruses may have single or double strands of genetic material. (msdmanuals.com)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

DNA, a double-stranded molecule, is the primary genetic material directly responsible for development and inheritable traits. (aboutdarwin.com)
Proteins are one of the major classes of bio molecule polymers that are made up of amino acid monomers, and so amino acids are the monomers that make up proteins. (pearson.com)
They used single-molecule imaging to record molecular movies that zoomed in with high temporal and spatial resolution on the fate of Escherichia coli replication forks as they approached a termination site from either direction. (sciencedaily.com)
After a molecule of DNA replicates, two double-stranded molecules are formed. (answers.com)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT inhibitor. (cdc.gov)

In the budding yeast Saccharomyces cerevisiae , there are over 400 origins of DNA replication located on 16 chromosomes and they can function as autonomously replicating sequences (ARSs) when inserted into a plasmid 19 . (nature.com)
Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae. (yeastgenome.org)
Familia de proteínas que en un principio fueron identificadas en el SACCHAROMYCES CEREVISIAE como elementos esenciales para el mantenimiento de la estructura de microcromosomas00. (bvsalud.org)
A family of proteins that were originally identified in SACCHAROMYCES CEREVISIAE as being essential for maintaining the structure of minichromosomes00. (bvsalud.org)

DNA replication involves producing new copies of DNA molecules. (answers.com)

July 31, 2019 A new study examines the evolutionary dynamics of circular Rep-encoding single-stranded (CRESS) DNA viruses. (sciencedaily.com)
DNA viruses typically replicate in the host cell nucleus, and RNA viruses typically replicate in the cytoplasm. (msdmanuals.com)
Certain single-strand, (+) sense RNA viruses termed retroviruses use a very different method of replication. (msdmanuals.com)
the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)

To identify novel KSHV antiviral targets, we propose to identify virus-specific protein functions and protein conformations by employing highly specialized electron microscopy methods to directly visualize purified KSHV DNA replication proteins and viral DNA sequences during the formation of the DNA replication fork at the viral origins of replication. (nccu.edu)
The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replication initiator Cdc6. (nature.com)
The specification of metazoan centromeres does not depend strictly on centromeric DNA sequences, but also requires epigenetic factors. (rupress.org)

J.H.Taylor confirmed semi conservative replication of DNA in Vicia faba chromosomes in 1963. (biologyexams4u.com)
It's quite an intricate dance aimed at making sure every new chromosome is equipped with one old and one new strand of DNA - this is referred to as semi-conservative replication. (aboutdarwin.com)

In previous studies, we suggested that this inhibition is likely a defense mechanism developed by phage phi29 to prevent the action of UDG if uracilation occurs in DNA either from deamination of cytosine or the incorporation of dUMP during viral DNA replication. (nih.gov)
It is now well established that DNA Replication occurs semi conservatively, copying each strand of DNA separately, to produce two new DNA double helices. (biologyexams4u.com)
DNA replication occurs once and only once per cell cycle mainly regulated by DNA replication initiation factors in eukaryotic cells. (intechopen.com)

RNA, lipids, and proteins. (who.int)

A type of RNA polymerase, it sets the starting point for replication by adding small RNA primers. (aboutdarwin.com)
The DNA primase (DnaG) is needed to form RNA primers. (kegg.jp)
Deze primers zijn essentieel voor de synthese van DNA, aangezien DNA-polymerase alleen nucleotiden kan toevoegen aan een bestaande streng. (jove.com)
Verwijder na de synthese van de nieuwe strengen, RNase H of aanvullende varianten van DNA-polymerase, de primers en synthetiseer DNA in hun plaats. (jove.com)

Rep, replication initiation protein. (cdc.gov)

The Origin Recognition Complex (ORC) binds to sites in chromosomes to specify the location of origins of DNA replication. (nature.com)
The results illuminate the molecular mechanism of a critical biochemical step in the licensing of eukaryotic replication origins. (nature.com)
Dukaj L and Rhind N (2021) The capacity of origins to load MCM establishes replication timing patterns. (yeastgenome.org)
DNA replication origins retain mobile licensing proteins. (yeastgenome.org)
Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. (yeastgenome.org)

Replication, in the world of genetics, is a mesmerizing process through which a cell makes an exact copy or, to draw a more precise picture - duplicates its DNA. (aboutdarwin.com)

PARP-1 is the best-characterized member of the diphtheria toxin-like ADP-ribosyl transferases (ARTDs) family of proteins. (nature.com)

Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors. (nature.com)
Enemark and his colleagues have produced the first atomic resolution image of the MCM complex bound to single-strand DNA and the molecules that fuel replication. (sciencedaily.com)
The image captured key structural details, including the orientation of both the MCM complex and single-strand DNA. (sciencedaily.com)
The elements illustrated how the process works like a pulley system to "pull" a single strand of DNA through the MCM complex and unwind the DNA. (sciencedaily.com)
The PMS2 protein joins with another protein called MLH1 (produced from the MLH1 gene) to form a two-protein complex called a dimer. (medlineplus.gov)
This complex coordinates the activities of other proteins that repair errors made during DNA replication. (medlineplus.gov)
Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. (yeastgenome.org)
Interactions of the human MCM-BP protein with MCM complex components and Dbf4. (yeastgenome.org)
In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). (kegg.jp)
DNA primase forms a permanent complex with DNA polymerase alpha. (kegg.jp)
It is the largest (220 nm in diameter) and most complex herpesvirus, with a 235,000 double-stranded DNA genome. (medscape.com)
A hexameric protein complex of minichromosome maintenance proteins. (bvsalud.org)

DNA methylation is one of the major epigenetic mechanisms, and it plays an important role in determining gene function ( Hedrich and Tsokos, 2011 ). (frontiersin.org)
An alternative view is that centromere identity is specified by an epigenetic mark on the chromosome that is independent of its underlying DNA ( Karpen and Allshire 1997 ). (rupress.org)
4. Induces epigenetic alterations usual y arises as the cell attempts to repair the DNA damage. (who.int)

The non-structural protein NSP2 of rotavirus, which exhibits nucleoside triphosphatase, single-stranded RNA binding, and nucleic-acid helix-destabilizing activities, is a major component of viral replicase complexes. (nih.gov)
It is thought that the tapered channel is large enough to accommodate double-stranded DNA at the wide end but only single-stranded DNA at the other end. (wikipedia.org)
Stabilizers at heart, these proteins prevent re-annealing (reunion) of single-stranded DNAs before it's their time to replicate. (aboutdarwin.com)

Decreased expression of six RNA species was seen at various time points in all cell strains analyzed, these were: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1) and a gene of unknown function (GenBank accession number AI859865). (cdc.gov)
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

Before a bacterium can divide, it must make a copy of its genetic material, the circular DNA molecules that resemble bunched rubber bands, through a process called DNA replication. (sciencedaily.com)
copying (replication) of cells' genetic material in preparation for cell division, DNA repair, cell death (apoptosis), and other processes. (medlineplus.gov)
Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)

The papers cover recent results on the topology and geometry of DNA and protein knotting using techniques from knot theory, spatial graph theory, differential geometry, molecular simulations, and laboratory experimentation. (ams.org)
Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. (lu.se)

Miller CLW and Winston F (2023) The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability. (yeastgenome.org)

It was also recently shown that PARP-1 is a sensor of unligated Okazaki fragments during DNA replication 16 and cells deficient in ribonucleotide excision repair are sensitized to PARP inhibition 17 . (nature.com)
FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. (kegg.jp)

Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. (cdc.gov)
Treatment with NMT inhibitor IMP-1088 potently abrogated VACV infection, while VACV gene expression, DNA replication, morphogenesis and EV formation remained unaffected. (cdc.gov)

Protein p56 encoded by the Bacillus subtilis phage phi29 inhibits host uracil-DNA glycosylase (UDG) activity. (nih.gov)

Identifying conserved protein complexes between species by constructing interolog networks. (yeastgenome.org)

YqaJ is one of three protein subunits that form a toroid with a tapered channel passing through the middle. (wikipedia.org)

Several RNA binding sites, resulting from the quaternary organization of NSP2 monomers, may be required for the helix destabilizing activity of NSP2 and its function during genome replication and packaging. (nih.gov)
The function of this protein domain is to digest DNA. (wikipedia.org)
Here, we identify a function for PARP-1 in DNA DSB resection. (nature.com)

To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. (lu.se)
Generally, DNA replication follows a multistep enzymatic pathway. (kegg.jp)

On the other hand, the action of UDG on uracil-containing phi29 DNA impaired in vitro viral DNA replication, which was prevented by the presence of protein p56. (nih.gov)

Quantitative fluorescence microscopy and transient transfection in the presence of aphidicolin, an inhibitor of DNA replication, show that CENP-A can assemble into centromeres in the absence of DNA replication. (rupress.org)

The mRNA and protein expression levels of the cartilage formation marker SOX9, type II collagen (COL2A1), and Aggrecan were measured by real-time fluorescent quantitative PCR (RT-qPCR) and western blot, respectively. (bvsalud.org)

polymerase involved, and this in- macromolecules including DNA, 2012) . (who.int)

A shortage of this protein eliminates mismatch repair activity and prevents the proper repair of DNA replication errors. (medlineplus.gov)
Because there is some functional PMS2 protein produced from the normal copy of the gene, mismatch repair activity in Lynch syndrome is reduced but not absent, as it is in CMMRD syndrome (described above). (medlineplus.gov)

[ 1 ] It is a small non-enveloped double-stranded DNA virus that was identified as the etiological agent in 1967 and was named JC virus in 1971 after John Cunningham, from whom it was first isolated. (medscape.com)
Cytomegalovirus (CMV) is a double-stranded DNA virus and is a member of the Herpesviridae family. (medscape.com)

Bryant JA and Aves SJ (2011) Initiation of DNA replication: functional and evolutionary aspects. (yeastgenome.org)

The modern double helix structure of DNA was first proposed by Watson and Crick, and the functions of DNA were demonstrated in a series of experiments which will be discussed in the next few sections. (wikibooks.org)

Several PAR-binding modules orchestrate the relocation of DDR-associated factors in addition to the accumulation of intrinsically disordered proteins through an intracellular liquid demixing mechanism 11 , 12 . (nature.com)

DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7. (yeastgenome.org)

Each new cell needs its very own complete set of DNA. (aboutdarwin.com)
As we gaze into the microscopic world of the cell, here's a brief introduction to the components that are critical to the replication of DNA. (aboutdarwin.com)
This protein helps fix errors that are made when DNA is copied (DNA replication) in preparation for cell division. (medlineplus.gov)
The absence of this Hydroxyl group is fundamental in determining the way in which DNA is able to condense itself within the nucleus of a cell. (wikibooks.org)

Based on the crystal structure in this research, we propose that a rotary mechanism drives the transformation to initiate DNA replication," said Eric Enemark, Ph.D., an associate member of the St. Jude Department of Structural Biology. (sciencedaily.com)

Our results, therefore, place PARP-1 activation as a critical early event for DNA DSB repair activation and regulation of resection. (nature.com)

De Murcia and colleagues provided the first evidence implicating PARP-1 in DNA repair by demonstrating that PARP-1-deficient mice are highly sensitive to γ-irradiation 21 . (nature.com)
The altered protein cannot efficiently repair errors made during DNA replication. (medlineplus.gov)
This difference in DNA repair activity levels likely explains why cancers in Lynch syndrome generally develop in adulthood while those in CMMRD syndrome often affect children. (medlineplus.gov)
Participates in DNA replication and may participate in repair. (lu.se)

Using the phi29 DNA amplification system, we found that phi29 DNA polymerase is also able to carry out the extension of the dA:dUMP pair and replicate past uracil. (nih.gov)
Serra-Garcia and Gneezy analyzed data from three influential replication projects which tried to systematically replicate the findings in top psychology, economic and general science journals (Nature and Science). (scitechdaily.com)
With the findings from these three replication projects, the authors used Google Scholar to test whether papers that failed to replicate are cited significantly more often than those that were successfully replicated, both before and after the replication projects were published. (scitechdaily.com)

DNA is a long chain of linear polymers containing deoxyribose sugars and their covalently bonded bases known as nucleic acids. (wikibooks.org)

This protein domain, often found in bacterial species, is actually of viral origin. (wikipedia.org)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)

Changing protein-DNA interactions promote ORC binding-site exchange during replication origin licensing. (yeastgenome.org)
Methods: Protein physical interactions were screened using the yeast two-hybrid system. (lu.se)
Disruption of plant plasma membrane by Nep1-like proteins in pathogen/plant interactions. (ki.si)

Here we report the cryo-EM structure at 3.3 Å resolution of the yeast ORC-Cdc6 bound to an 85-bp ARS1 origin DNA. (nature.com)
The structure reveals that Cdc6 contributes to origin DNA recognition via its winged helix domain (WHD) and its initiator-specific motif. (nature.com)

Anatomy21

Organisms40

Diseases1

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes80

Information Science3

Health Care2

Synthesis8

Transcription12

Enzymes8

Recombination7

Helicase5

Genes6

Lagging strand2

Genomic5

Cdt12

Sequence10

Viral replication4

Strands16

Structural Classifi1

Molecule5

Saccharomyces4

Involves1

Viruses4

Sequences3

Semi conservative replication2

Occurs3

Lipids1

Primers4

Initiation protein1

Origins5

Genetics1

Family of proteins1

Complex12

Epigenetic3

Single-stranded3

Mitotic2

Genetic material3

Molecular2

20231

Okazaki2

Gene Expression2

Bacillus1

Complexes1

Subunits1

Function3

Pathway2

Vitro1

Inhibitor1

MRNA1

Macromolecules1

Mismatch repair2

Double-stranded DNA virus2

Functional1

Watson and C1

Intracellular1

MCM21

Cell4

Biology1

Regulation1

Repair4

Replicate3

Nucleic acids1

Species2

Interactions3

Cdc62