• Tissue repair was assessed by proliferating cell nuclear antigen (PCNA) immunoreactivity and by expression of keratinocyte growth factor (KGF) mRNA by real-time PCR. (cdc.gov)
  • Integrins are the cellular receptors for the proteins which constitute the extracellular matrix of all tissues. (upstate.edu)
  • The binding of integrin receptors to extraceullular proteins permits cell adhesion and migration during development, wound healing, and inflammation. (upstate.edu)
  • First, how does the leukocyte utilize these receptors to mediate selective adhesion and migration through complex extracellular tissues? (upstate.edu)
  • Second, how does the ligation of integrin receptors affect leukocyte behavior? (upstate.edu)
  • Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
  • In particular, the CXC family of chemokines are active as monomers, homodimers, and heterodimers, with binding affinities for multiple CXC G-protein-coupled receptors. (hawaii.edu)
  • The prototypical fMet-containing oligopeptide is N -formylmethionine-leucyl-phenylalanine (FMLP) which activates leukocytes and other cell types by binding with these cells' formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2) G protein coupled receptors (see also formyl peptide receptor 3 ). (wikipedia.org)
  • CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
  • The laboratory utilizes techniques ranging from molecular biology to whole animal inflammation models, with an emphasis on cell biology and protein biochemistry. (upstate.edu)
  • During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)
  • The resulting infiltration of tissues by the leukocytes, plasma proteins, and fluid causes the redness, swelling, and pain that are characteristic of inflammation. (medscape.com)
  • In turn, bacterial peptidoglycan components are found in the synovial tissue of RA patients, which may contribute to inflammation within the microenvironment of the joint ( 12 , 13 ). (frontiersin.org)
  • 2 3 Moreover, highly sensitive assays for C reactive protein and serum amyloid A protein are now available that can detect low grade inflammation that would previously have been unnoticed. (bmj.com)
  • Several reports have suggested that plasma C reactive protein and other possible markers of low grade inflammation can predict increased risks of coronary heart disease, but it is not known whether the associations are causal. (bmj.com)
  • controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level. (medscape.com)
  • Proteolytic cascades trigger blood clotting, fibrinolysis, and complement activation, while proteases released upon leukocyte degranulation are integral to the processes of inflammation and immunity. (nih.gov)
  • The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. (antikoerper-online.de)
  • The large proteoglycan molecules made up of protein cores, and GAG branches are secreted by cells and constitute a significant fraction of the extracellular matrix of connective tissue. (medscape.com)
  • Polarized epithelial cells compartmentalize tissue cavities and are often exposed to inflammatory challenges such as toxics or infections in non-lymphoid tissues. (hindawi.com)
  • We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)
  • Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
  • Bronchoalveolar lavage was performed to determine epithelial and leukocyte counts, and protein content. (cdc.gov)
  • Next, they evaluated the potential for these cells to release oxygen free radicals (reactive molecules that can damage lung cells), their capacity to break down fibronectin (a lung structural protein), and their ability to damage epithelial cells in tissue culture. (healtheffects.org)
  • Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)
  • As chemoattractants are critical for both systemic leukocyte positioning by triggering integrin activation and subsequent recruitment from circulation, and local intratissue leukocyte positioning via chemotaxis, modulation of attractant activities by proteases may have profound effects on the immune response. (nih.gov)
  • The chemokines are small, signaling proteins responsible for leukocyte recruitment through concentration gradient driven responses for inflammatory diseases such as tissue damage or sun burn, tumor suppression and regulation, and obesity from insulin resistance. (hawaii.edu)
  • Reconstitution of whole body irradiated mice with IL-1Ra-producing bone marrow cells is associated with neuroprotection and recruitment of IL-1Ra-producing leukocytes after stroke. (lu.se)
  • 16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
  • Local blood flow increases to transport the polymorphonuclear leukocytes, macrophages, and plasma proteins to the injured area. (medscape.com)
  • These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. (medscape.com)
  • Polymorphonuclear cells can bind proteins starting with fMet, and use them to initiate the attraction of circulating blood leukocytes and then stimulate microbicidal activities such as phagocytosis . (wikipedia.org)
  • The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. (antikoerper-online.de)
  • We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)
  • These transcripts match previously known patterns of lncRNA, such as generally lower expression levels than protein-coding genes and higher tissue specificity. (usda.gov)
  • The first stage of this immune steeplechase, the leukocyte transendothelial migration, is a multi-step cascade of interactions that have been extensively studied in recent years in different vascular beds and experimental models, and some comprehensive reviews on this topic can be found in this special issue [ 1 - 5 ]. (hindawi.com)
  • The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)
  • So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
  • The parenchymal three-dimensional organization contributes to establish an haptotactic and chemotactic gradient (1) Leukocyte adhesion and transendothelial migration or diapedesis. (hindawi.com)
  • In the present study, we examine the specific impacts of MSCs on mitochondrial morphology and function in host tissues. (frontiersin.org)
  • In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues following MSC treatment. (frontiersin.org)
  • Dexamethasone sodium phosphate solution for injection 4 mg/mL may be administered into joints, soft tissues, or lesions, but administration of dexamethasone via these routes requires specialized techniques. (pdr.net)
  • FALDH activity is also deficient in cultured keratinocytes, peripheral blood leukocytes, and other tissues of patients who are affected. (medscape.com)
  • Sp110 expression is induced in human peripheral blood leukocytes and spleen but not in other tissues [ 8 ]. (biomedcentral.com)
  • HLA stands for human leukocyte antigen. (readthespirit.com)
  • Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
  • CX3CR1 is expressed in a variety of human tissues and cell lines. (prosci-inc.com)
  • A tissue culture based reporter assay for activation of human CD30 receptor was developed. (nottingham.ac.uk)
  • Here, we demonstrate that ZIKV regulates the expression of pathways associated with lipid metabolism, including the upregulation and activation of lipogenesis-associated transcription factors and decreased expression of lipolysis-associated proteins, leading to significant LD accumulation in human neuroblastoma SH-SY5Y cells and in neural stem cells (NSCs). (bvsalud.org)
  • The first study, which examined whether early exposure to gluten was protective against celiac sprue, involved 944 children who were positive for the human leukocyte antigen (HLA) haplotype DQ2 or DQ8 and had at least one first-degree relative with celiac sprue. (medscape.com)
  • 1995). "V7, a novel leukocyte surface protein that participates in T cell activation. (wikipedia.org)
  • This monolayer of cells acts as a barrier to separate the vascular lumen from surrounding tissues and regulates the passage of fluid and nutrients between the two. (beckman.com)
  • The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade, that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. (qmul.ac.uk)
  • Modulation of effector protein activity by proteases provides a critical layer of posttranslational control that enables rapid enzymatic regulation of target proteins. (nih.gov)
  • The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)
  • HLAs help your infection-fighting system (immune system) tell the difference between body tissue and substances that are not from your own body. (medlineplus.gov)
  • Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. (abcam.com)
  • CD47 activation likely disrupts nitric oxide (.NO) signaling and promotes leukocyte-endothelial interactions. (cdc.gov)
  • A key approach is the application of confocal intravital microscopy that enables rigorous and direct means of investigating the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) in real-time in vivo. (qmul.ac.uk)
  • Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)
  • 2 6 A variety of mechanisms by which C reactive protein might directly promote vascular disease have been proposed, 7 but none is proved. (bmj.com)
  • Potential mechanisms underlying the diabetes-related changes in the blood-brain barrier (BBB) include altered expression of key structural and enzymatic proteins, alterations in the lipid composition and fluidity of the membranes, alterations in the neurotransmitter activity, and increased oxidative damage of the endothelial cells ( 2 , 6 ). (diabetesjournals.org)
  • MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
  • This intricate network has been linked to many cell signaling pathways, but the overall protein folding mechanisms as a concentration driven monomer-dimer equilibrium have yet to be established. (hawaii.edu)
  • The course therefore aims to provide knowledge of the causes and mechanisms of the diseases and the alterations that derive from them at a tissue, cellular and molecular level. (uninsubria.eu)
  • Thus, these initial studies of the CXC chemokines establishes the foundation for further characterization of chemokines to define fundamental principles governing protein-protein interaction. (hawaii.edu)
  • On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
  • Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
  • Drs. Kenneth Donaldson and coworkers at the Institute of Occupational Medicine examined whether exposure to ozone activates white blood cells to release substances that can damage lung tissue. (healtheffects.org)
  • In autoimmune disorders that involve the lungs, the immune system attacks and damages lung tissue. (msdmanuals.com)
  • No damage was detected in the histological and chemiluminescence analysis of lung and heart tissues of PEPs-exposed animals. (cdc.gov)
  • Primordial endothelial cells specialize into tissue-specific phenotypes of arterial, venous, hemogenic, and lymphatic subtypes with distinct functions for vascular development. (beckman.com)
  • Endothelial cells form a semi-permeable barrier between the blood and surrounding tissues within all blood vessels in the body. (beckman.com)
  • Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (bvsalud.org)
  • One of the sentinel features of atherosclerosis is endothelial cell dysfunction that manifests itself in a variety of ways including poor nitric oxide production, poor vasodilatory response, and increased adhesiveness to leukocytes ( 1 ). (diabetesjournals.org)
  • TNF-α expression after stroke stimulates expression of tissue factor and adhesion molecules for leukocytes, release of interleukin-1 (IL-1), nitric oxide, factor VIII/von Willebrand factor, platelet-activating factor and endothelin, suppression of the thrombomodulin-protein C-protein S system, reduction of tissue-plasminogen activator and release of plasminogen activator inhibitor-1. (eurekaselect.com)
  • For example, lncRNAs specific to spleen were nearby genes enriched in immune system related GO terms such as leukocyte activation. (usda.gov)
  • [ 5 ] They also inhibit the release of destructive enzymes that attack the injury debris and destroy normal tissue indiscriminately. (medscape.com)
  • The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
  • Azathioprine antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. (medscape.com)
  • Florfenicol acts by inhibiting protein synthesis at the ribosomal level and its action is bacteriostatic and time-dependent. (drugs.com)
  • It is specifically used for initiation of protein synthesis from bacterial and organellar genes, and may be removed post-translationally . (wikipedia.org)
  • fMet plays a crucial part in the protein synthesis of bacteria, mitochondria and chloroplasts . (wikipedia.org)
  • It is not used in cytosolic protein synthesis of eukaryotes , where eukaryotic nuclear genes are translated . (wikipedia.org)
  • fMet is a starting residue in the synthesis of proteins in bacteria, and, consequently, is located at the N -terminus of the growing polypeptide . (wikipedia.org)
  • The mitochondria of eukaryotic cells, including those of humans, and the chloroplasts of plant cells also initiate protein synthesis with fMet. (wikipedia.org)
  • Given that mitochondria and chloroplasts have this initial protein synthesis with fMet in common with bacteria, this has been cited as evidence for the endosymbiotic theory . (wikipedia.org)
  • Cell and Tissue Display: An Alternative Multipurpose Tool for Microscopy. (harvard.edu)
  • This report reviews the emerging literature describing a novel class of proteolytic targets, leukocyte chemoattractants, and, in particular, chemerin, a dendritic cell and macrophage chemoattractant activated by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. (nih.gov)
  • Pra1 is a cell surface protein with a single N-terminal TMS involved in the host-parasite interaction during candidal infection. (tcdb.org)
  • A Biological Research on the Single Cell Protein Yeast (Paprin) Grown " by Sahibe ÇALIŞKANER, Yusuf KONCA et al. (tubitak.gov.tr)
  • The aim of this research is to find out the effects of yeast-ie one of the single cell protein, grown on liquid paraffin media (paprin) to be replaced instead of fish meal for protein quality and quantity. (tubitak.gov.tr)
  • Hereby, the effect of single cell protein on the weight gain, feed intake, fertility and growth were also calculated. (tubitak.gov.tr)
  • CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. (thermofisher.com)
  • T. Twellmann, T.W. Nattkemper, W. Schubert, H. Ritter, Cell detection in micrographs of tissue sections using support vector machines, in: Proceedings of the ICANN: workshop on Kernel & Subspace Methods for Computer Vision, Vienna, Austria, 2001, pp. 79–88. (crossref.org)
  • and the identification and characterization of biomarkers of early cell or tissue perturbation that can be used for diagnosis of the disease. (nih.gov)
  • They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. (bvsalud.org)
  • Here, we asked if cell-based delivery of the interleukin-1 receptor antagonist (IL-1Ra), a known neuroprotectant in stroke, can promote neuroprotection, by modulating the detrimental inflammatory response in the tissue at risk. (lu.se)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • Depending on their nature and function, ECs form either a continuous or porous endothelium, allowing various levels of passage of fluids and nutrients between the lumen and surrounding tissues. (beckman.com)
  • White blood cells, or leukocytes, are extremely dependent upon integrin receptor recognition of matrix proteins in order to exit the vasculature and resolve inflammatory events within the tissues. (upstate.edu)
  • Our laboratory studies two aspects of leukocyte integrin biology. (upstate.edu)
  • Chandhoke, S.K. and Blystone, S.D. Beta-3 integrin phosphorylation is essential for Arp3 organization into leukocyte avb3 -vitronectin adhesions. (upstate.edu)
  • The N -terminal fMet is removed from majority of proteins, both host and recombinant, by a sequence of two enzymatic reactions. (wikipedia.org)
  • White blood cells (also called leukocytes) fight infections. (kidshealth.org)
  • While leukocyte behavior remains a major laboratory focus, we also study a variety of vascular and tissue cells, both primary and immortal lines. (upstate.edu)
  • Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)
  • On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
  • Release of damaged cells and tissue debris occurs upon injury. (medscape.com)
  • The influx of leukocytes facilitates the process of phagocytosis and the removal of damaged cells and other particulate matter. (medscape.com)
  • The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. (harvard.edu)
  • mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
  • DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization. (doximity.com)
  • I. Expression on dendritic cells and other subsets of mouse leukocytes. (doximity.com)
  • Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
  • A realistic hope of modern medicine is to replace damaged tissue with healthy cells grown in the lab. (neurosciencenews.com)
  • In order to avoid tissue rejection, they used autologous iPSCs-iPSCs that were created from the recipient's own skin cells. (neurosciencenews.com)
  • There are many genetic variations of MHCs, and after transplantation, if the MHCs of the transplanted cells are not recognized by the T cells of the host immune system, there is an immune response and the tissue is rejected. (neurosciencenews.com)
  • Antibodies One of the body's lines of defense ( immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and. (msdmanuals.com)
  • Leukocyte-platelet-rich plasma (L-PRP) is a bloodderived portion composed of high concentrations of platelets and white cells, and it has been applied as autogenous biomaterial in bone repair 13 . (bvsalud.org)
  • Characterization of the cellular and spatiotemporal production of IL-1Ra and IL-1α/β identifies microglia, not infiltrating leukocytes, as the major sources of IL-1Ra after experimental stroke, and shows IL-1Ra and IL-1β to be produced by segregated subsets of microglia with a small proportion of these cells co-expressing IL-1α. (lu.se)
  • The IL-1Ra-producing bone marrow cells increase the number of IL-1Ra-producing microglia, reduce the availability of IL-1β, and modulate mitogen-activated protein kinase (MAPK) signaling in the ischemic cortex. (lu.se)
  • Plasma concentrations of C reactive protein, serum amyloid A protein, and serum albumin and leucocyte count. (bmj.com)
  • 0.0001), although the association between low serum albumin concentration and leucocyte count was weaker (P=0.08). (bmj.com)
  • Circulating concentrations of C reactive protein, serum amyloid A protein, and serum albumin and the leucocyte count can fluctuate widely during acute responses to tissue damage or infection. (bmj.com)
  • Source of all serum proteins is from USDA inspected abattoirs located in the United States. (bdbiosciences.com)
  • Serum amylase, creatinine, and ALT were examined and pathological evaluation of pancreatic tissues was performed. (wanfangdata.com.cn)
  • Twenty-four hours post-exposure, intravital microscopy was performed to assess arteriolar dilation and venular leukocyte adhesion and rolling. (cdc.gov)
  • Two-parameter flow cytometric contour plots showing the correlated expression of CD45 (or Ig Isotype control staining) versus side-light scatter (SSC-A) signals were derived from gated events with the forward and side-light scatter characteristics of intact leucocyte populations. (bdbiosciences.com)
  • The expression of TREM-1 mRNA in peripheral blood leucocyte was determined by RT-PCR. (wanfangdata.com.cn)
  • The expression of TREM-1 protein in pancreatic tissue was detected by immunohistochemistry. (wanfangdata.com.cn)
  • Low or no expression in the other tissues tested. (lu.se)
  • The chromosome encodes a complete type VI secretion system and plasmid genes encode type IV secretion proteins. (nottingham.ac.uk)
  • Tissue-specific lncRNA were identified, and genes nearby tissue-specific lncRNAs were enriched for GO terms associated with those tissues. (usda.gov)
  • Tissue Embedding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Another likely contributor to these changes is the activation of protein kinase C that is shown to play an important role in increased permeability of the peripheral and cerebral circulation ( 7 , 8 ). (diabetesjournals.org)
  • Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype. (upstate.edu)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • Because fMet is present in proteins made by bacteria but not in those made by eukaryotes (other than in bacterially derived organelles), the immune system might use it to help distinguish self from non-self. (wikipedia.org)
  • Since fMet is present in proteins made by mitochondria and chloroplasts, more recent theories do not see it as a molecule that the immune system can use to distinguish self from non-self. (wikipedia.org)
  • Autoimmune Disorders An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues. (msdmanuals.com)
  • At the end of the feeding period blood samples of the mice were taken and the erythrocyte, leucocyte, hemoglobin and haematocrit values were determined. (tubitak.gov.tr)
  • In addition, some of the main histopathological observations were carried out in dedecting carcinogenic effects of paprin on muscle tissues and blood corpuscules. (tubitak.gov.tr)
  • Expressed in blood leukocytes. (lu.se)
  • There is also strong support for a mechanism of action for nasopharyngeal carcinogenesis in which inhaled formaldehyde causes DNA-protein crosslinks in nasopharyngeal tissue. (who.int)
  • The host response to tissue injury and/or infection is dependent on the action of numerous extracellular proteases. (nih.gov)
  • However, immune responses and tissue rejection are big issues to overcome when transplanting tissue derived from other individuals. (neurosciencenews.com)