Proteins that regulate gata6 transcription factor. Medical search. Frequent questions

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. (wikipedia.org)
GATA-6, a zinc finger transcription factor, is important in the endodermal differentiation of organ tissues. (wikipedia.org)
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. (jax.org)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
In addition, we demonstrate that this family is critical in maintaining stemness of EpCAM + AFP + HepCSCs, in part by directly targeting an inhibitor of Wnt/β-catenin signaling (nemo-like kinase [NLK]) and two hepatic transcriptional regulators of differentiation, i.e., caudal type homeobox transcription factor 2 (CDX2) and GATA binding protein 6 (GATA6). (biomedcentral.com)

Annotation enrichment analysis showed that "cilium" and "immunity" were enriched in functions of the top-1500 up-regulated genes. (biomedcentral.com)
Compared to the large airway cell line BCi-NS1.1, differentiated of hSABCi-NS1.1 cells on ALI were enriched with small airway epithelial genes, including surfactant protein genes, LTF and small airway development relevant transcription factors NKX2-1, GATA6, SOX9, HOPX, ID2 and ETV5. (biomedcentral.com)
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. (jax.org)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
By recruiting more than thousand kindreds with early onset CAD and multiple metabolic risk factors for genetics and metabolic studies we have been able to map, identify and characterize a dozen of human disease genes for CAD and MetS, which have been reported in leading journals such as Nat Genet, Science, NEJM, Cell Metab, JCI, PNAS, AJHG, etc. (yale.edu)
Although HMG proteins do not possess intrinsic transcriptional activity, they are called architectural transcription factors because they modulate the transcription of their target genes by altering the chromatin structure at the promoter and/or enhancers 15 . (nature.com)
Separately, E2a is necessary to drive transcription of Smad2 /3 target genes, including critical regulators of dorsal cell fate and morphogenesis. (xenbase.org)
Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) for 2 h. (gsea-msigdb.org)
Interestingly we discovered that the main element genes that regulate endodermal differentiation (Gata4 Gata6 and Fgf8) are induced in the Paf1/PD2 heterozygous knockout ESCs. (ecologicalsgardens.com)

ACE2 protein levels are also increased by the E3 ligase PIAS4-mediated SUMOylation or the methyltransferase PRMT5-mediated ACE2 methylation, whereas ACE2 protein levels are decreased by AP2-mediated lysosomal degradation. (bvsalud.org)
Chromatin-mediated regulation of transcription involves DNA methylation and histone modifications. (nature.com)
Aberrant changes in epigenetic mechanisms regulating DNA methylation, histone methylation and acetylation, expression of noncoding RNAs, and mRNA methylation are associated with the initiation, growth, and progression of digestive system tumors [ 2 , 4 ]. (ijbs.com)
If it is a cause, then DNA methylation may affect the affinity of transcription factors (TFs) for their binding sites (TFBSs). (biomedcentral.com)
Our results indicate that direct and selective methylation of certain TFBS that prevents TF binding is restricted to special cases and cannot be considered as a general regulatory mechanism of transcription. (biomedcentral.com)
In short, whether or not the distinct methylation status of a single CpG affects specific transcription-related functions remains an open question. (biomedcentral.com)

ACE2 levels are also regulated by histone modification or miRNA-induced destabilization. (bvsalud.org)
In addition to nucleosomes, chromatin contains non-histone chromatin-associated proteins, of which the high-mobility group proteins are the most abundant. (nature.com)
Here we show that high-mobility group AT-hook 2 protein (HMGA2) induces DNA nicks at the transcription start site, which are required by the histone chaperone FACT complex to incorporate nucleosomes containing the histone variant H2A.X. Further, phosphorylation of H2A.X at S139 (γ-H2AX) is required for repair-mediated DNA demethylation and transcription activation. (nature.com)
The histone chaperone FACT (facilitates chromatin transcription) is a heterodimeric complex, consisting of SUPT16 and SSRP1 (Spt16 and Pob3 in yeast) that is responsible for the deposition of H2A/H2B-dimers onto DNA 11 , 12 . (nature.com)

The lack of suppression of PDX1, PTF1A, GATA4, and GATA6 indicates that MODY5-mediated pancreatic hypoplasia is mechanistically independent. (harvard.edu)
Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)

The resulting cell line (hSABCi-NS1.1) was characterized by RNAseq, TaqMan PCR, protein immunofluorescence, differentiation capacity on an air-liquid interface (ALI) culture, transepithelial electrical resistance (TEER), airway region-associated features and response to genetic modification with SPDEF. (biomedcentral.com)
This shows that Paf1/PD2 takes on a specific part in regulating early dedication of ESCs to endodermal differentiation. (ecologicalsgardens.com)

The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. (biomedcentral.com)
These changes are regulated primarily at the epigenetic and transcriptional levels. (musculoskeletalkey.com)
The aberrant transcription of key oncogenes is driven by super-enhancers (SEs), which are characterized by large clusters of enhancers with significantly high density of transcription factors, cofactors, and epigenetic modulatory proteins. (ijbs.com)
SEs are defined as large clusters of active enhancers in large clusters that are enriched with high levels of transcription factors (TFs), master co-factors, mediator complexes, RNA polymerase II (RNA pol II), and epigenetic modifications [ 5 , 7 ]. (ijbs.com)

d - i Type IV collagen protein and mRNA expression in the lung. (biomedcentral.com)
Recent advancements in the analysis from the hPAF complicated have revealed different functions of the complicated in human beings act like those of the yPAF complicated including effective transcription elongation mRNA quality control and cell routine regulation. (ecologicalsgardens.com)

The protein kinase AMPK, CK1α, or MAP4K3 phosphorylates ACE2 protein and induces ACE2 protein levels by decreasing its ubiquitination. (bvsalud.org)
We have previously shown that HMGA2-induced transcription requires phosphorylation of H2A.X at S139, which in turn is mediated by the protein kinase ataxia telangiectasia mutated (ATM) 10 . (nature.com)
CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
In the early reprogramming process, fatty acid oxidation upregulated oxidative phosphorylation and downregulated protein kinase C activity. (biomedcentral.com)
Inhibition of protein kinase C also promoted reprogramming. (biomedcentral.com)
We demonstrated that fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C activity in the early stage of the reprogramming process. (biomedcentral.com)
Target gene prediction and dual luciferase assays showed that miR-188-5p could target the 3'untranslated region of the calcium/calmodulin dependent protein kinase II beta (CAMK2B) gene and inhibit luciferase activity. (koreascience.kr)

Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. (jax.org)
The characterization of this protein in vivo has shown that it widely expressed in different tissues and circulates in the blood, its levels rise after food intake in humans and stimulates insulin secretion and sensitivity and inhibits platelet aggregation. (yale.edu)

Here, we differentiated MODY5 human-induced pluripotent stem cells (hiPSCs) into pancreatic progenitors, and show that the HNF1BS148L/+ mutation causes a compensatory increase in several pancreatic transcription factors, and surprisingly, a decrease in PAX6 pancreatic gene expression. (harvard.edu)
Our results demonstrate compensatory mechanisms in the pancreatic transcription factor network due to mutant HNF1BS148L/+ protein. (harvard.edu)

Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Eight of these SNPs were analyzed for transcriptional regulation using reporter assays where all tested regions exerted regulatory effects on transcription in epithelial and/or immune cell lines, and seven SNPs showed allelic differences. (biomedcentral.com)
Whereas the disruption of cell-cell contacts alone does not enable metastasis, the loss of E-cadherin protein does, through induction of an epithelial-to-mesenchymal transition, invasiveness, and anoikis resistance. (gsea-msigdb.org)
Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. (jax.org)

It was also shown that a single differentially methylated CpG might affect transcription of the ESR1 gene [ 11 ]. (biomedcentral.com)
Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma. (uams.edu)

Collectively, DUSP8 induces TGF-ß-stimulated IL-9 transcription and Th9-induced allergic responses by inhibiting the nuclear translocation of the transcriptional repressor Pur-α. (bvsalud.org)
Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. (jax.org)
Overall, we find that E2a functions as both a transcriptional repressor and activator to precisely regulate Nodal signaling. (xenbase.org)

Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. (zju.edu.cn)
When cultured on ALI, hSABCi-NS1.1 cells consistently formed tight junctions and differentiated into ciliated, club (SCGB1A1 + ), mucous (MUC5AC + , MUC5B + ), neuroendocrine (CHGA + ), ionocyte (FOXI1 + ) and surfactant protein positive cells (SFTPA + , SFTPB + , SFTPD + ), observations confirmed by RNAseq and TaqMan PCR. (biomedcentral.com)

2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
Mouse embryonic fibroblasts isolated from transgenic mice carrying doxycycline (Dox)-inducible Yamanaka factor constructs were used for reprogramming. (biomedcentral.com)

In order to understand the development of adiposity, it is crucial to identify the factors and mechanisms that regulate the recruitment of mesenchymal stem cells (MSCs) of the vascular stromal fraction of the adipose tissue and its transformation into lipid-filled adipocytes. (biomedcentral.com)
Active DNA demethylation also requires GADD45A (growth arrest and DNA damage protein 45 alpha) and TET1 (ten-eleven translocation methylcytosine dioxygenase 1), which sequentially oxidize 5-methylcytosine (5mC) to 5-carboxylcytosine (5caC) 18 , 19 and are cleared through DNA repair mechanisms. (nature.com)

HERP, a new primary target of Notch regulated by ligand binding. (jax.org)

The DNA fragment with the top-associated SNP 27:19,086,778 displayed the highest activity in keratinocytes with 11-fold induction of transcription by the risk allele versus 8-fold by the control allele (p difference = 0.003), and also mapped close (~3 kb) to an ENCODE skin-specific enhancer region. (biomedcentral.com)

In the eukaryotic cell nucleus, chromatin is the physiological template of all DNA-dependent processes including transcription. (nature.com)

The core transcription regulatory loop of the digestive system tumors is complex and a high density of transcription regulatory complexes in the SEs and the crosstalk between SEs and the noncoding RNAs. (ijbs.com)
From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)
Transcription factor complexes have varied effects on cell fate and behavior, but how this diversification of function occurs is largely unknown. (xenbase.org)

thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. (zju.edu.cn)
as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. (zju.edu.cn)
In this review, we summarize the role of this transcription factor in the development, diagnosis , and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer . (zju.edu.cn)

Therefore the Paf1/PD2 proteins is a recently discovered part of the interconnected regulatory network that maintains the self-renewal of mouse ESCs. (ecologicalsgardens.com)

Furthermore, HNF1B does not appear to directly regulate PAX6 gene expression necessary for glucose tolerance. (harvard.edu)

elongation factor for RN. (gsea-msigdb.org)

First, the expression of miR-188-5p in goat muscle tissues at different developmental stages was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (koreascience.kr)
Furthermore for the very first time we demonstrated that Paf1/PD2 proteins interacts with Oct3/4 and RNA polymerase II and through this discussion Paf1/PD2 may regulate Oct3/4-mediated gene manifestation. (ecologicalsgardens.com)
RNA Isolation and Quantitative Reverse-Transcription Polymerase String Reaction Total mobile RNA was extracted from ESCs using the RNAeasy package (Qiagen Hilden rac-Rotigotine Hydrochloride Germany http://www1.qiagen.com) and processed for change transcription. (ecologicalsgardens.com)

Despite of the relevance of this issue, very little is known about the factors regulating the development of adipose tissue in fish, and the possible health alterations associated to an increased fat deposition. (biomedcentral.com)
We find that E2a regulates early development in two ways. (xenbase.org)

ACE2 levels are regulated by transcriptional, post-transcriptional, and post-translational regulation or modification. (bvsalud.org)

In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at least one of which, Twist, is necessary for E-cadherin loss-induced metastasis. (gsea-msigdb.org)

Remarkably, DUSP8 protein levels and the DUSP8-Pur-α interaction were indeed increased in the cytoplasm of T cells from people with asthma and patients with atopic dermatitis. (bvsalud.org)

Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonarry neuroendocrine tumors. (zju.edu.cn)

Dynamic transcription factor activity profiling in 2D and 3D cell cultures. (chicagobiomedicalconsortium.org)
Proteins found in the nucleus of a cell. (uams.edu)

Nuclear Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Nuclear Proteins" by people in UAMS Profiles by year, and whether "Nuclear Proteins" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Nuclear Proteins" by people in Profiles over the past ten years. (uams.edu)

Moreover, soluble ACE2 protein and exosomal ACE2 protein facilitate SARS-CoV-2 infection into host cells. (bvsalud.org)
These mice express tamoxifen-induced Cre recombinase (Mer-cre-Mer) that enzymatically removes a stop codon flanked by lox sequences (floxed) on a reporter gene such as green fluorescent protein or yellow fluorescent protein, thus resulting in traceable fluorescence on the cells of interest. (musculoskeletalkey.com)

HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. (jax.org)
however, the specific role of type IV collagen in regulating alveologenesis remains unknown. (biomedcentral.com)

We are now fully characterizing this protein and evaluating its utility as a drug target for diabetes, dyslipidemia, and fatty liver disease. (yale.edu)

The encoded protein is upregulated in human steatosis (NASH). (yale.edu)

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. (jax.org)

Here we will focus on HMG AT-hook 2 protein (HMGA2), a member of the HMGA family that mediates transforming growth factor beta 1 (TGFB1, commonly known as TGFβ1) signaling 16 . (nature.com)
insulin like growth factor binding pr. (gsea-msigdb.org)
latent transforming growth factor bet. (gsea-msigdb.org)

Anatomy16

Organisms10

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes70

Disciplines and Occupations1

Information Science4

GATA6

Genes10

Methylation6

Histone4

GATA42

Differentiation2

Epigenetic4

MRNA2

Kinase8

Vivo2

Pancreatic2

Mutations2

Epithelial3

Downstream1

Differentially2

Transcriptional repressor3

Surfactant2

Fibroblasts2

Mechanisms2

Ligand1

Enhancer1

Chromatin1

Complexes3

Lung3

Regulatory1

Glucose1

Elongation1

Polymerase3

Development2

Modification1

Expression2

Patients1

Tumors1

Cell2

Nuclear3

Cells2

Specific2

Fatty1

Human1

Mice1

Growth3