Cell SurvivalSurvival RateApoptosisProto-Oncogene Proteins c-aktSignal TransductionDisease-Free SurvivalPhosphatidylinositol 3-KinasesSurvivalSurvival AnalysisCell Line, TumorGraft Survivalbcl-Associated Death ProteinProtein-Serine-Threonine KinasesPhosphorylationProto-Oncogene ProteinsAntineoplastic AgentsChromonesEnzyme ActivationTime FactorsCaspase 3Cell DeathMorpholinesCaspasesOncogene Protein v-aktbcl-X ProteinTreatment OutcomeNF-kappa BDrug Resistance, NeoplasmProto-Oncogene Proteins c-bcl-2Cells, CulturedBlotting, WesternPTEN PhosphohydrolaseEnzyme InhibitorsCell ProliferationApoptosis Regulatory ProteinsKaplan-Meier EstimateRNA, Small InterferingRetrospective StudiesAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCell LineTumor Cells, CulturedPhosphatidylinositol 3-KinaseLung NeoplasmsGlycochenodeoxycholic AcidNeoplasm StagingX-Linked Inhibitor of Apoptosis ProteinGlycogen Synthase Kinase 3NeoplasmsProportional Hazards ModelsProstatic NeoplasmsImmunohistochemistryDown-RegulationCaspase 9STAT3 Transcription FactorGene Expression Regulation, NeoplasticFollow-Up StudiesMice, Inbred C57BLMyeloid Cell Leukemia Sequence 1 ProteinAutophagyDose-Response Relationship, DrugIn Situ Nick-End LabelingMice, KnockoutProto-Oncogene Proteins c-pim-1Up-RegulationModels, BiologicalReverse Transcriptase Polymerase Chain ReactionRNA InterferenceMAP Kinase Signaling SystemMutationTransfectionCombined Modality TherapyReceptor, Epidermal Growth FactorProtein Kinase InhibitorsDisease Models, AnimalCytoprotectionDoxorubicinPrognosisReceptor, IGF Type 1Mitogen-Activated Protein KinasesTOR Serine-Threonine KinasesTaurochenodeoxycholic AcidInhibitor of Apoptosis ProteinsGlioblastomaDisease ProgressionXenograft Model Antitumor AssaysMice, NudeTumor Suppressor Protein p53QuinazolinesMice, TransgenicExtracellular Signal-Regulated MAP KinasesNeoplasm Recurrence, LocalProtein-Tyrosine KinasesAnoikisDNA FragmentationCell CycleMultivariate AnalysisImmunoblottingGene Expression ProfilingMitochondria