Proteins tenascin. Medical search. Frequent questions

The adhesion molecules tenascin, chondroitin sulfate proteoglycans, highly polysialylated neural cell adhesion molecule (PSA-NCAM), and laminin did not change significantly in the gray matter of the dorsolateral striatum after either type of lesion. (jneurosci.org)
To acquire a comprehensive understanding of the biological functions of the matrisome and its components, including proteoglycans and glycosaminoglycans (GAGs), in GBM tumorigenesis, and to identify potential biomarker candidates, we studied the alterations of GAGs, including heparan sulfate (HS) and chondroitin sulfate (CS), the core proteins of proteoglycans, and other glycosylated matrisomal proteins in GBM subtypes vs. control human brain tissue samples. (bu.edu)
Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
EDS is caused by various abnormalities in the synthesis and metabolism of collagen and other connective-tissue proteins in the ECM, such as elastin, proteoglycans, and macromolecular proteins. (medscape.com)

Tenascin C (TN-C) is a glycoprotein that in humans is encoded by the TNC gene. (wikipedia.org)
The human tenascin C gene, TN-C, is located on chromosome 9 with location of the cytogenic band at the 9q33. (wikipedia.org)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
In hypermobility type of Ehlers-Danlos syndrome , haploinsufficiency (where one copy is unable to produce the protein in sufficient quantity) due to a 30-kb deletion of tenascin-X (TNXB) gene is responsible for the disease. (dorak.info)
Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
The single nucleotide polymorphisms in Smad-interacting protein 1 gene contribute to its ectopic expression and susceptibility in Hirschsprung's disease. (cdc.gov)

In addition, MPTR fibroblasts produced youthful levels of collagen proteins, and showed partial functional rejuvenation of their migration speed. (elifesciences.org)
[1] Typically, these variations result in defects in the structure or processing of the protein collagen . (wikipedia.org)
We assessed hemodynamic, morphological light microscopy, morphometry, immunohistochemistry for extracellular matrix components: collagen (types I, III, IV and VI), fibronectin, tenascin-C, elastin, metalloproteinases (types 2 and 9) and quantification of some proteins related to intracellular signaling pathways of the mitogen-activated protein kinase (MAPK) using Western Blotting. (usp.br)
The major structural protein of basement membrane, collagen type IV, in the lens capsule was substantially altered in the absence of SPARC. (silverchair.com)
Collagen is the most abundant protein in the body and is the most common protein found in the ECM. (medscape.com)
[ 8 ] Collagen proteins are multimeric, occurring in trimers with a central triple helical region. (medscape.com)
A minimum of 29 genes contribute to collagen protein structure, and these genes are located on 15 different human chromosomes, genetically coding for no less than 19 identifiable forms of collagen molecules. (medscape.com)

AIM: Tenascin C (TNC) is a large extracellular matrix glycoprotein. (lu.se)
The expression of tenascin (Tn), an extracellular matrix glycoprotein, was analyzed in the human small intestine. (shengsci.com)

The molecular events which direct melanocytic proliferation to the pathogenesis of dysplastic (atypical, Clark) melanocytic nevi formation from melanoma is unknown, but it appears to include a constellation of genetic, epigenetic, and environmental factors (eg, B-RAF mutation status, cell cycle protein expression, histone modifications, and ultraviolet radiation exposure), which may regulate cellular mechanisms that bypass cellular senescence. (medscape.com)
Expression of TGF-β1 mRNA by airway eosinophils was assessed by in situ hybridization, and TGF-β1 protein was measured in bronchoalveolar lavage (BAL) fluid by ELISA. (jci.org)
Treating asthmatics with anti-IL-5 antibody, which specifically decreased airway eosinophil numbers, significantly reduced the expression of tenascin, lumican, and procollagen III in the bronchial mucosal RBM when compared with placebo. (jci.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
While, for PTEN protein expression, we used immunohistochemistry. (cancerindex.org)
Results: We found that LOH and methylation of the PTEN promoter were significantly associated with loss of PTEN protein expression, while, PTEN mutation was a rare event. (cancerindex.org)
To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
Expression of the tenascin-C-binding integrin α9 promotes axon regeneration. (manchester.ac.uk)
SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
Of note was the significant increase in expression of tenascin-C (TN-C), a known regulator of FN matrix assembly. (princeton.edu)
Results: Changes in both global expression levels of proteins and proteins differentially glycosylated in the retinas of wild-type and diabetic mice have been identified. (bvsalud.org)
We provide evidence that diabetes shifts both global expression levels and O-glycosylation of metabolic and synaptic proteins in the retina. (bvsalud.org)
Expression of tenascin in the developing human small intestine. (shengsci.com)
Expression of Tenascin C, EGFR, E-Cadherin, and TTF-1 in Medullary Thyroid Carcinoma and the Correlation with RET Mutation Status. (cdc.gov)

Methods Monoclonal antibodies recognising the fibrinogen-like globe (FBG) of tenascin-C were generated by phage display. (bmj.com)
Each of the cell lines also reacted with antibodies against neural cell adhesion molecules, but none of them were positive for antibodies against glial fibrillary acidic protein, keratin, microtubule-associated protein tau and microtubule-associated protein 2, human lymphocyte antigen-DR, epidermal growth factor receptor, and T-cell antigen. (duke.edu)
Immunoreactivities with anti-tenascin and anti-glioma-associated antibodies were variable in these cell lines. (duke.edu)

I demonstrated that tumor cells secreted proteins that drove the recruitment and/or expansion of pulmonary TAMs, Tregs, and granulocytic-MDSCs (G-MDSCs), resulting in increased primary lung tumor growth and pulmonary metastasis of mammary carcinoma cells, respectively. (ubc.ca)

Scholars@Duke publication: Biochemical and structural studies of tenascin/hexabrachion proteins. (duke.edu)
The predominant form of tenascin observed by electron microscopy is a six-armed oligomer, termed a hexabrachion. (duke.edu)

Immunostaining for basic fibroblast growth factor (bFGF) markedly decreased in striatal astrocytes after both lesions, despite an increased staining for glial fibrillary acidic protein (GFAP). (jneurosci.org)
In summary, the detection of neurofilament proteins and synaptophysin and the absence of glial fibrillary acidic protein provide strong evidence for a neuronal phenotype of D384 Med, D425 Med, and D458 Med. (duke.edu)

We highlight alterations in global proteins involved in metabolic processes, maintaining cellular structure, trafficking, and neuronal processes. (bvsalud.org)

In the central nervous system of rodents, the extracellular matrix glycoproteins tenascin-C and tenascin-R are expressed predominantly by astrocytes and oligodendrocytes respectively. (researchgate.net)

CAA is characterized by the misfolding and excessive vascular deposition of amyloid-β (Aβ) peptides, which are generated by multiple proteolytical processing of the β-amyloid precursor protein (APP) [ 60 ]. (biomedcentral.com)

The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, which is strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. (bdbiosciences.com)

Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. (embl.de)

These protein modules are lined up like beads on a string and give rise to long and extended molecules. (wikipedia.org)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

Tenascin C is an oligomeric glycoprotein composed of individual polypeptides with molecular weights ranging from 180 to ~300kDa. (wikipedia.org)

Tenascin-C mRNA was not detectable at any time in the unlesioned or lesioned inferior olivary nucleus by in situ hybridization. (researchgate.net)

The Tenascin family of proteins shares a similar structural pattern. (wikipedia.org)
3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)

Type III modules are present in both extracellular and intracellular proteins. (embl.de)
Calcitriol induces a number of non-genomic responses including rapid intestinal absorption of calcium, release of calcium from intracellular stores, opening of voltage-gated calcium and chloride channels, and the activation of protein kinase C, protein kinase A, phosphatidylinositol-3 kinase (PI3K) and phospholipase C ( 4 ). (jcancer.org)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)

Sedimentation in a cesium chloride gradient gave a higher buoyant density for human tenascin than for fibronectin, suggesting that it has a higher degree of glycosylation. (duke.edu)
Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. (kactusbio.com)
Little attention, however, has been paid to glycosylation of the ECM components that constitute the majority of glycosylated protein mass and presumed biological properties. (bu.edu)
Protein glycosylation is the enzymatic addition of carbohydrates to proteins, which can influence many protein attributes including folding, stability, function, and subcellular localization. (bvsalud.org)
We then showed changes in O-linked glycosylation of individual proteins in the diabetic retina. (bvsalud.org)

Receptor-type protein tyrosine phosphatase alpha (PTPα is a widely expressed transmembrane-bound protein that has been implicated in integrin signaling, focal adhesion formation, and normal cell migration. (ubc.ca)

The thickness and density of tenascin, lumican, and procollagen III in the reticular basement membrane (RBM) were quantified immunohistochemically by confocal microscopy. (jci.org)
They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)

The proteomic profile of CAA type 1 was characterized by massive enrichment of multiple predominantly secreted proteins and showed significant overlap with the recently reported brain microvascular proteome of patients with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary cerebral small vessel disease (SVD) characterized by the aggregation of the Notch3 extracellular domain. (biomedcentral.com)

NDN odes for the protein Necdin, which, in rodents, interacts with neurotrophin receptors in a way that is not completely understood to promote normal cognitive development. (bartleby.com)
Protein translation (PT) declines with age in invertebrates, rodents, and humans. (bvsalud.org)

Extracellular matrix proteins play a role in promoting exercise responses, leading to adaptation, regeneration, and repair. (lu.se)

Here, we show that amyloid fibrils of Aβ1-40 peptide can effectively initiate amyloid formation in different globular proteins and metabolites, converti. (shengsci.com)

Methods: We used liquid chromatography/mass spectrometry-based proteomics and high throughput screening to identify proteins differentially expressed and proteins differentially O-glycosylated in the retinas of wildtype and diabetic mice. (bvsalud.org)

Congratulations to Kristen Segars, an MD/PhD candidate in Dr. Trinkaus-Randall's lab, for her receipt of an F30 grant for her work, "Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication. (bu.edu)
By examining changes in various proteins involved in the wound healing response at the cellular level, Segars hopes to understand why the corneas of diabetic patients fail to heal effectively. (bu.edu)
While recent advances in the field have identified major cellular signaling contributing to DR pathogenesis, little has been reported on the protein post-translational modifications (PTM) - known to define protein localization, function, and activity - in the diabetic retina overall. (bvsalud.org)
With a critical need to expedite the discovery of PTMomics in diabetic retinas, we identified both global changes in protein levels and the retinal O-glycoproteome of control and diabetic mice. (bvsalud.org)

An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)

Blocking the early-life PT elevation robustly improves life-/health-span and prevents age-related protein aggregation, whereas transiently inducing an early-life PT surge in long-lived fly strains abolishes their longevity/proteostasis benefits. (bvsalud.org)
Aβ1-40 mediated aggregation of proteins and metabolites unveils the relevance of amyloid cross-seeding in amyloidogenesis. (shengsci.com)

The purity of Mouse Tenascin is greater than 95% as determined by SEC-HPLC. (kactusbio.com)

TN-C is classified as an adhesion-modulating protein, because it has been found to inhibit cellular adhesion to fibronectin. (wikipedia.org)
The numerous involvements with cellular functioning and signaling make TN-C a popular protein to study in developing new therapies and detection methods. (wikipedia.org)
On the basis of these observations it has been suggested that tenascin-C and tenascin-R may be relevant in determining the cellular response after injury in the adult rodent central nervous system. (researchgate.net)

On reducing polyacrylamide gel electrophoresis (SDS-PAGE), human tenascin showed a single prominent band at 320 kDa and minor bands of 220 and 230 kDa. (duke.edu)
Upon treatment with neuraminidase, the apparent molecular weights of all human and chicken tenascin subunits on reducing SDS-PAGE were decreased by about 10 kDa. (duke.edu)

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (azolifesciences.com)

The growth associated protein GAP-43, a molecule present in axons and growth cones, decreased in the dorsolateral striatum after aspiration but not after thermocoagulatory lesions. (jneurosci.org)
Activation of toll-like receptor 4 (TLR4) by tenascin-C, a matrix molecule persistently expressed at high levels in people with RA, drives chronic inflammation in models of rheumatoid arthritis (RA). (bmj.com)

This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)

Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis. (shengsci.com)

Tenascin-R mRNA was expressed by distinct neural cell types in the unlesioned olivocerebellar system. (researchgate.net)

After a lesion, the density of cells containing tenascin-R transcripts increased significantly in the inferior olivary nucleus and in the white matter of the cerebellar cortex. (researchgate.net)

The early-life PT elevation triggers proteostatic dysfunction, silences stress responses, and drives age-related functional decline via juvenile hormone-lipid transfer protein axis and germline signaling. (bvsalud.org)

Recent work has shown that TN-C inhibits HIV infection in immune cells by binding to a chemokine coreceptor site on the HIV-1 envelope protein, blocking the virus' entry into the host cells. (wikipedia.org)
In Chapter 2, I examined how proteins secreted by cancer cells can promote a tumor-permissive microenvironment through the recruitment of suppressive innate and adaptive immune cells to the lungs. (ubc.ca)
Targeting tumor-secreted proteins, or the suppressive immune cells that are expanded in response to said proteins, led to a decrease in primary and metastatic pulmonary disease. (ubc.ca)

[ 12 ] Genetic alterations in dysplastic (atypical, Clark) melanocytic nevi appear complex and include loss of tumor suppressor genes and altered function of oncogenes, housekeeping genes, growth factors, and extracellular matrix proteins. (medscape.com)

We found this overlap to be largely attributable to the accumulation of high-temperature requirement protein A1 (HTRA1), a serine protease with an established role in the brain vasculature, and several of its substrates. (biomedcentral.com)

Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). (shengsci.com)

Therefore eosinophils may contribute to tissue remodeling processes in asthma by regulating the deposition of ECM proteins. (jci.org)
They caution that Tenascin-C might not do it all-some samples with relatively low levels still neutralized the threat-and they've only tested it on tissue samples. (newser.com)
Each tissue and organ system has an array of connective proteins. (medscape.com)

Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)

Here, I investigate the role of one intrinsic factor (receptor-type protein tyrosine phosphatase alpha) and one extrinsic factor (ionizing radiation) in facilitating cancer cell invasion. (ubc.ca)

In particular, prenatal cannabinoid treatment reduced the phosphorylated levels of ERK1/2 in selected subcellular compartments of hippocampus, frontal and prefrontal cortex, whereas no changes were observed in the total levels of these proteins. (researchgate.net)
Results Tenascin-C is expressed early in the development of RA, even before disease diagnosis, with higher levels in the joints of people with synovitis who eventually developed RA than in people whose synovitis spontaneously resolved. (bmj.com)
Degradation of crystallins and MIP 26, or changes in the levels of these proteins, were not detected. (silverchair.com)
Mesangial cells are the major extracellular matrix (ECM)-producing cells in the kidney glomerulus and, when exposed to elevated glucose levels, they up-regulate assembly of fibronectin (FN) and other ECM proteins. (princeton.edu)

Proteoglycans4

Gene8

Collagen7

Extracellular matrix glycoprotein2

Expression14

Antibodies3

Tumor Cells1

Hexabrachion2

Glial fibrill2

Neuronal1

Glycoproteins1

Peptides1

Monoclonal1

Fibronectin type1

Molecules2

Glycoprotein composed1

Situ hybridization1

Structural2

Intracellular3

Glycosylation5

Integrin1

Basement membrane2

Predominantly1

Rodents2

Regeneration1

Globular1

Differentially1

Diabetic4

High-molecular-weight1

Aggregation2

Purity1

Cellular3

Human2

Alters1

Molecule2

Differentiation1

Bone1

Neural1

Nucleus1

Functional1

Immune3

Alterations1

Accumulation1

Mitotic1

Tissue3

Kinase1

Investigate1

Levels4