Proteins show that agouti. Medical search. Frequent questions

GH activates agouti-related protein (AgRP) neurons and GH receptor (GHR) ablation in AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight loss. (nih.gov)
Agouti-related protein (AgRP) is a hypothalamic regulator of food consumption in mammals. (tau.ac.il)
show that hypothalamic AgRP1 neurons regulate feeding, pineal AgRP2 cells are retinal pigment epithelium-like bearing a unique secretory capability, and pre-optic AgRP2 neurons regulate the stress axis, possibly reflecting an ancestral role of the single agrp gene found in mammalians. (tau.ac.il)
In mammals, NPY neurons coexpress Agouti-related protein (AgRP) in the arcuate nucleus of the hypothalamus, and NPY/AgRP neurons activate orexigenic signaling to increase food intake. (korea.ac.kr)
Taken together, our results show that the zebrafish NPY/AgRP system is involved in appetite regulation. (korea.ac.kr)
In the present study we examined the diurnal patterns of agouti-related protein (AGRP) and proopiomelanocortin (POMC) mRNA expression in the arcuate nucleus and their relation to circulating glucocorticoids and food intake. (elsevierpure.com)
Acute alcohol exposure also increases both the activity of agouti-related protein (AgRP)-expressing neurons and AgRP immunoreactivity. (bvsalud.org)
Here, we show that adenosine receptor A2B signaling in the brain modulates the extent of alcohol-induced fatty liver in mice and that both the AgRP neuropeptide and the sympathetic nervous system are indispensable for hepatic steatosis induced by bingelike alcohol consumption. (bvsalud.org)
It contains Sf 21-expressed recombinant human AgRP and has been shown to accurately quantitate the recombinant factor. (novusbio.com)
Agouti-related Protein (AgRP), also known as the protein product of the Agouti-related Transcript (ART), is a neuropeptide and a functional antagonist of alpha-MSH on Melanocortin (MC)-3 and MC-4 receptors, both of which are implicated in obesity. (novusbio.com)
AgRP shares sequence and structural similarity with the Agouti protein and has similar expression patterns in both mouse and human. (novusbio.com)
Risperidone-induced weight gain is associated with a number of factors, including gene polymorphisms ( 12 - 14 ), exercise ( 15 - 17 ), peripheral molecules ( 18 ), and hyperphagia caused by regulating the expression of melanocortin-4 receptor (MC4R), neuropeptide Y (NPY), and agouti-related peptide (AgRP) ( 19 - 21 ). (frontiersin.org)
Neuropeptide Y (NPY), melanin-concentrating hormone (MCH), orexin, galanin, and agouti gene-related protein (AgRP) are typical orexigenic peptides, while α-melanocyte stimulating hormone (α-MSH), corticotropin-releasing hormone (CRH), cocaine- and amphetamine-regulated transcript (CART), neuropeptide W (NPW) and galanin-like peptide ( GALP ) have been described as anorexigenic peptides [ 7 - 14 ]. (walshmedicalmedia.com)
Increase of energy accumulation elicits leptin release and simultaneous inhibition of orexigenic neurons expressing neuropeptide Y (NPY) and agouti-related peptide (AgRP), as well as activation of the anorexigenic proopiomelanocortin (POMC) neurons within the hypothalamic arcuate nucleus (ARC). (frontiersin.org)
We have observed that suppression of ROS levels diminish pro-opiomelanocortin (POMC) cell activation and promote the activity of neuropeptide Y- (NPY)/ agouti related peptide- (AgRP) neurons and feeding, whereas ROS activates POMC neurons and reduces feeding. (grantome.com)
2014) and preliminary data generated during this funding period showed that mitochondrial size in AgRP and POMC neurons changes according to the metabolic state of the organism: while during negative energy balance, characterized by increased AgRP and decreased POMC neuronal activities, mitochondrial size decreases (fission), during positive energy balance (fed state) mitochondrial size increases in AgRP and POMC (fusion). (grantome.com)
While neurons that express the agouti-related protein (Agrp) increase appetite, those that produce POMC promote a feeling of fullness. (geneticobesitynews.com)
In the second study, the NIDDK researchers demonstrated that barr1 also modulated the activity of hypothalamic agouti-related protein (AgRP) neurons, which regulate food intake and maintain proper blood-glucose concentrations. (nih.gov)
In one study NIDDK researchers demonstrated that the signaling protein, barr1, modulates the activity of hypothalamic AgRP neurons, which regulate food intake and maintain proper blood-glucose levels. (nih.gov)

Whereas the G s /G i -protein-dependent tuning of striatal neurons is fairly well known, the precise impact and underlying mechanism of G q -protein-dependent signals remain poorly understood. (jneurosci.org)
Here, using different experimental approaches, especially designer receptor exclusively activated by designer drug (DREADD) chemogenetic technology, we found that sustained activation of G q -protein signaling impairs the functionality of striatal neurons and we unveil the precise molecular mechanism underlying this process: a phospholipase C/Ca 2+ /proline-rich tyrosine kinase 2/cJun N -terminal kinase pathway. (jneurosci.org)
To analyze this effect anatomically, we manipulated G q -protein-dependent signaling selectively in neurons belonging to the direct or indirect striatal pathway. (jneurosci.org)
Acute G q -protein activation in direct-pathway or indirect-pathway neurons produced an enhancement or a decrease, respectively, of activity-dependent parameters. (jneurosci.org)
In contrast, sustained G q -protein activation impaired the functionality of direct-pathway and indirect-pathway neurons and disrupted the behavioral performance and electroencephalography-related activity tasks controlled by either anatomical framework. (jneurosci.org)
By ablation of AgRP1-expressing neurons and knockout of the agrp1 gene, we show that AgRP1 stimulates food consumption in the zebrafish larvae. (tau.ac.il)
Acts on hypothalamic neuropeptide y-expressing neurons and agouti-related protein-expressing neurons. (familytreecounseling.com)
Moreover, the levels of many neuropeptides are linked to the actions of leptin, in addition to which it has been shown that neurons containing feeding regulating neuropeptides interact with each other via synaptic inputs [ 15 , 16 ]. (walshmedicalmedia.com)
A protein known as the steroid receptor coactivator-1 (SRC-1) helps regulate body weight by controlling the function of neurons involved in eating impulses, a study reveals. (geneticobesitynews.com)

Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. (wikipedia.org)
The agouti-signaling protein (ASIP) is a competitive antagonist with alpha-Melanocyte-stimulating hormone (α-MSH) to bind with melanocortin 1 receptor (MC1R) proteins. (wikipedia.org)
Alleles of the Agouti Signaling Protein (ASIP) gene control the temporal and spatial expression of red-based phaeomelanin and black-based eumelanin pigments. (usask.ca)
Further genotype analysis showed that expression of the grizzle/domino pattern requires a genotype interaction involving ASIP, MC1R, and Canine Beta-Defensin 103 (DEFB103). (usask.ca)
This dark orange colour is caused by the Agouti Signaling Protein (ASIP) mutation, which is quite uncommon among Holland Lops. (pestclue.com)
Identification of Single Nucleotide Polymorphisms in the Agouti Signaling Protein (ASIP) Gene in Some Goat Breeds in Tropical and Temperate Climates. (rit.edu)

But in the yellow mice, it isn't methylated, meaning that these animals overexpress Agouti signaling protein in many tissues, leading to their yellow hue. (the-scientist.com)
We focused on two genes known to cause melanism in other taxa, Mc1r and its antagonist, the agouti signaling protein (Agouti). (gephebase.org)
In the first two papers, the researchers discovered two new roles that the signaling protein beta-arrestin-1 (barr1), plays in regulating important metabolic functions. (nih.gov)

RSV at a 10 µM concentration was entirely metabolized to resveratrol-3-sulfate after 24 and counteracted leptin resistance by increasing the protein levels of OBRb. (bvsalud.org)
Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV 1 and paraoxonase 3 was positively associated therewith. (lu.se)
Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. (lu.se)
Recombinant carp Leptin protein was shown to stimulate pituitary gtha, fsh beta, lh beta expression, and ovarian germinal vesicle breakdown in vitro. (onacademic.com)
Analysis showed that 14 of 15 variants found in severely obese children impaired the function of SRC-1, causing a reduction in leptin-mediated signaling. (geneticobesitynews.com)
Regulation of leptin by agouti. (nih.gov)

Mice with wildtype agouti will be grey, with each hair being partly yellow and partly black. (wikipedia.org)
In mice, the agouti gene encodes a paracrine signalling molecule that causes hair follicle melanocytes to synthesize the yellow pigment pheomelanin instead of the black or brown pigment eumelanin. (wikipedia.org)
In mice, the wild type agouti allele (A) presents a grey phenotype, however, many allele variants have been identified through genetic analyses, which result in a wide range of phenotypes distinct from the typical grey coat. (wikipedia.org)
In wild-type mice agouti is only expressed in the skin during hair growth, but these dominant yellow mutations cause it to be expressed in other tissues as well. (wikipedia.org)
While AND-34 is widely expressed in wild type mice, histologic analysis of multiple organs in AND-34 −/− mice is unremarkable and analyses of lymphocyte development show no overt changes. (molvis.org)
A small percentage of AND-34 −/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. (molvis.org)
ABOVE: Agouti Viable Yellow mice share the same DNA sequence, but have different methylation patterns. (the-scientist.com)
The mice are Agouti Viable Yellow, naturally occurring mutants, which, though genetically identical, have coats that vary in color-a phenomenon that researchers have long studied as an example of epigenetic inheritance. (the-scientist.com)
All of the mutant mice have a gene, Agouti , that influences coat color, and an adjacent transposable element-a DNA sequence that can move about the genome, creating or reversing mutations-that promotes the gene's expression. (the-scientist.com)
In a series of experiments examining the T cells and B cells of multiple generations of Agouti Viable Yellow mice, the researchers screened the animals' genomes searching for transposable elements that were methylated similarly to the one that sits next to the Agouti gene. (the-scientist.com)
Figure 2 shows two mice with identical genetic codes (as with identical twins). (cdc.gov)
When pregnant mice are exposed to BPA along with a vitamin B cocktail (including B12 and folic acid) which increase methylation of the Agouti gene, the offspring are no longer predominantly yellow and obese. (cdc.gov)
Thomas, Bolaji N. "Ethanol Extract of Blighia Sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice. (rit.edu)
In 2000, researchers at Duke University showed that the agouti gene in mice, which usually codes for ravenous, yellow rodents who are more susceptible to diabetes and cancer, can be completely turned off with a simple adjustment in the diet of the pregnant mothers. (kriskonaturopathic.com)
The steroid receptor coactivator-1 protein is known to play a key role in the regulation of body weight, shown in a previous study where mice without SRC-1 became obese . (geneticobesitynews.com)
One example of how environment can influence gene expression is the case of agouti mice. (scienceoxygen.com)

Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
Members of the 'O' class of FOX proteins provide the instructions for genes responsible for regulating cellular replication and senescence, resistance to oxidative stress, metabolism, and DNA repair. (foundmyfitness.com)
The agouti gene is probably the best known of the genes in the cat breeding world (the cat fancy). (pictures-of-cats.org)
These results show that melanism has evolved independently in these populations through mutations in the same gene, and suggest that melanism produced by mutations in genes other than Mc1r may be more common than previously thought. (gephebase.org)
Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
This happens because BPA decreases DNA methylation so that more offspring have unmethylated Agouti genes. (cdc.gov)
Genetic Polymorphism of Plasmodium Falciparum Merozoite Surface Protein-1 and 2 and Diversity of Drug Resistance Genes in Blood Donors from Bamako, Mali. (rit.edu)
Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni. (rit.edu)
As genes code for proteins in our bodies and the estimate was that each human being required over 120,000 proteins to perform the daily tasks of life, researchers expected to find a comparable 120,000+ genes. (kriskonaturopathic.com)

Agouti signalling peptide adopts an inhibitor cystine knot motif. (wikipedia.org)
Along with the homologous Agouti-related peptide, these are the only known mammalian proteins to adopt this fold. (wikipedia.org)
The message (signal) to create these two different types of pigment is effected by the action of a protein molecule called the agouti peptide and a hormone called the Melanocyte Stimulating Hormone (MSH). (pictures-of-cats.org)
Based on crystal structure of AdipoR1, we designed AdipoR1's peptide agonists using protein-peptide docking simulation and screened their receptor binding abilities and biological functions via surface plasmon resonance (SPR) and biological analysis. (phoenixpeptide.com)
Also, SPR and virtual screening techniques utilized in this study may potentially be applied to other peptide-drug screening processes against membrane receptor proteins. (phoenixpeptide.com)
at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)

Melanism in peromyscus is caused by independent mutations in agouti. (gephebase.org)

Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). (wikipedia.org)

We also found that ADP-1 activates AMP-activated protein kinase (AMPK) in an adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)-dependent pathway and stimulates glucose uptake in rat skeletal muscle cells (L-6 myotubes). (phoenixpeptide.com)

2014) showed that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. (grantome.com)

The coding exons of agouti are placed under the control of the Raly promoter, initiating ubiquitous expression of agouti, increasing production of pheomelanin over eumelanin and resulting in the development of a yellow phenotype. (wikipedia.org)
While variation in the Mc1r coding region does not correlate with melanism in any population, in a New Hampshire population, we find that a 125-kb deletion, which includes the upstream regulatory region and exons 1 and 2 of Agouti, results in a loss of Agouti expression and is perfectly associated with melanic color. (gephebase.org)

When agouti is expressed, production of pheomelanin dominates, a melanin pigment that produces yellow or red colored hair. (wikipedia.org)
Single-cell sequencing of pineal agrp2-expressing cells revealed molecular resemblance to retinal-pigment epithelium cells, and anatomic analysis shows that these cells secrete peptides, possibly into the cerebrospinal fluid. (tau.ac.il)
The agouti gene signals the on-off creation of eumelanin a pigment produced in a cell called a melanocyte. (pictures-of-cats.org)
When the agouti gene has not signalled the creation of eumelanin a pigment called phaeomelanin is produced in the melanocyte. (pictures-of-cats.org)

Agrp1 (agouti-related protein 1) and sla (somatolactin a), which are related to appetite and lipid catabolism, are significantly higher in GH-transgenic carp. (onacademic.com)

This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as an inverse agonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. (wikipedia.org)

Furthermore, uncoupling protein 2 (UCP2), a mitochondrial protein inducing proton leak and highly expressed in the arcuate nucleus, reduces ROS production. (grantome.com)

This ectopic expression of the agouti gene is associated with the yellow obese syndrome, characterized by early onset obesity, hyperinsulinemia and tumorigenesis. (wikipedia.org)
It is essential to develop novel antidiabetic and anti-obesity drugs that are endowed with increased efficacy and show few side effects. (nih.gov)

This complex organization of the gene reflects the complex nature of the protein receptor it produces. (creation.com)
Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)

One of the main benefits of capybara meat is its high protein content. (priceofmeat.com)
On average, capybara meat contains around 22% protein, which is comparable to conventional sources of meat such as beef and chicken. (priceofmeat.com)
This makes capybara meat an excellent alternative protein source for those looking to diversify their diet. (priceofmeat.com)
In addition to being high in protein, capybara meat is also rich in polyunsaturated fatty acids (PUFAs). (priceofmeat.com)

In the past, researchers suggested that the epigenetically regulated Agouti trait was the tip of the iceberg for DNA methylation-based epigenetic inheritance, he says. (the-scientist.com)
The screen did identify one transposable element that, like the element abutting the Agouti gene, displayed a bit of memory, Ferguson-Smith says, "but our data suggested that memory is not being conferred by DNA methylation. (the-scientist.com)
The change occurred because the environmental exposure altered the methylation pattern in the mouse genome, silencing the agouti gene responsible for yellow fat cell formation. (scienceoxygen.com)

In a second population from Alaska, we find that a premature stop codon in exon 3 of Agouti is associated with a similar melanic phenotype. (gephebase.org)

The viable yellow (Avy) mutation is due to a change in the mRNA length of agouti, as the expressed gene becomes longer than the normal gene length of agouti. (wikipedia.org)
In contrast, POMC mRNA levels did not show a significant fluctuation across the diurnal cycle, although there was a tendency for levels to decrease after the onset of the dark cycle. (elsevierpure.com)

To illustrate the dramatic impact of epigenetics and the influence of modifiable environmental factors, let us look briefly at the example of the Agouti mouse . (cdc.gov)

AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)

In other species such as horses, agouti signalling is responsible for determining which parts of the body will be red or black. (wikipedia.org)
But data sets based on commercial hunting booms throughout the 20th century tell a different story, showing that many terrestrial Amazonian species have proven more resilient than most experts expected. (sapiens.org)

This interaction is responsible for making distinct light and dark bands in the hairs of animals such as the agouti, which the gene is named after. (wikipedia.org)
Alternately the non-agouti gene ( a/a ) signals the creation of solid colored hairs. (pictures-of-cats.org)

The most widely studied allele variants are the lethal yellow mutation (Ay) and the viable yellow mutation (Avy) which are caused by ectopic expression of agouti. (wikipedia.org)
This protein signals the distribution of melanin pigments in epithelial melanocytes located at the base of hair follicles with expression being more sensitive on ventral hair than on dorsal hair. (wikipedia.org)
[3] FOXO proteins translate these cues into changes in gene expression that modulate and coordinate an organism's longevity and overall health. (foundmyfitness.com)
Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
The protein expression study revealed that T 3 administration in fish creates hypermetaolic state. (i-scholar.in)
The expression of gys (glycogen synthase) and igfbp1 (insulin-like growth factor binding protein) as well as blood glucose concentrations are lower in GH-transgenic carp. (onacademic.com)

In the third study, Wess's group demonstrated that the presence of Gi-type G proteins expressed by fat cells is essential for maintaining normal blood-glucose concentrations. (nih.gov)

Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling. (nih.gov)
The core of the Hippo pathway is composed of a kinase cascade that includes MST1/2 serine/threonine kinase (ortholog of Hpo in D. melanogaster ), WW45 scaffold protein (Sav), MOB (Mats) and LATS1/2 kinases (Wts). (oncotarget.com)

FOXO proteins are regulated by the insulin/PI3K/Akt signaling pathway, a complex biological signaling system conserved across multiple organisms, from worms to mammals. (foundmyfitness.com)

The lethal yellow (Ay) mutation is due to an upstream deletion at the start site of agouti transcription. (wikipedia.org)
This is caused by the insertion of a single intracisternal A particle (IAP) retrotransposon upstream to the start site of agouti transcription. (wikipedia.org)

Researchers saw that SRC-1 activated the POMC gene , which provides the instructions to make the POMC protein. (geneticobesitynews.com)

If a cat has banded or ticked hair strands the cat carries the dominant agouti gene symbolized by the letter A . This gene signals the creation of the dark and light agouti banding on each hair. (pictures-of-cats.org)

Agouti is not directly secreted in the melanocyte as it works as a paracrine factor on dermal papillae cells to inhibit release of melanocortin. (wikipedia.org)

Bob Herschbach discovered the Mini Lop breed at a German National Rabbit Show in Essen, Germany in 1972, where it was known as a Klein Widder.These first Mini Lops were originated from the German Big Lop and the small Chinchilla.These two breeds came originally in Agouti and white colors. (ireggae.com)

Cardiac enlargement is caused in part by elevated IGF (insulin like growth factor) due to a reduction in IGF binding protein under conditions of elevated insulin. (robbwolf.com)

The environment of the cell determines which proteins are necessary and that message is conveyed through complex interactions to trigger the DNA to respond. (kriskonaturopathic.com)

Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease-and metabolism-linked proteins in relation to FEV 1 , FVC (both % predicted). (lu.se)

This deletion causes the genomic sequence of agouti to be lost, except the promoter and the first non-encoding exon of Raly, a ubiquitously expressed gene in mammals. (wikipedia.org)

FOXO proteins' ability to shuttle between sites within the cell places them at the nexus of essential cellular processes. (foundmyfitness.com)
The genetic code is the sequence of DNA (base pairs) that tells a cell how to build proteins, the essential building blocks of life. (cdc.gov)

The murine agouti gene locus is found on chromosome 2 and encodes a 131 amino acid protein. (wikipedia.org)

Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
In particular, we show that ITCH enhances epithelial-to-mesenchymal transition (EMT) through boosting YAP oncogenic function. (oncotarget.com)

This means where and while agouti is being expressed, the part of the hair that is growing will come out yellow rather than black. (wikipedia.org)
In the yellow mouse, a region of the DNA is unmethylated which makes the nearby Agouti gene turned on all the time, while in the brown mouse, the region is methylated and the Agouti gene is turned off. (cdc.gov)

Barr1 is a widely expressed cytoplasmic protein that regulates cellular responses to extracellular stimuli. (nih.gov)

To investigate the potential role of 18kDa Translocator protein (TSPO) in mediating homeostatic changes in food intake and body weight. (exeter.ac.uk)

Capybaras raised in environments with access to ponds show even higher levels of PUFAs and lower levels of saturated fatty acids (SFAs), making their meat even more nutritious. (priceofmeat.com)

[ 4 ] Analysis on a cohort of 902 schoolchildren showed higher waist circumference and disproportionate weight gain over a 12-month follow-up period in those children with low cardiorespiratory fitness. (medscape.com)

Orthologous to human MTMR9 (myotubularin related protein 9). (nih.gov)

Dr. Cochran's translational interests span protein-based drug discovery and development for applications in oncology and regenerative medicine, and the development of new technologies for high-throughput protein analysis and engineering. (stanford.edu)

Organisms1

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes10

Information Science3

AgRP19

Neurons9

ASIP6

Signaling Protein3

Leptin6

Mice16

Genes9

Peptide6

Mutations1

Melanocortin 1 recept1

Activates1

Regulation1

Exons2

Pigment4

AgRP11

Pigmentation1

Arcuate nucleus1

Obesity2

Receptor2

Capybara4

Methylation3

Phenotype1

MRNA2

Epigenetics1

Adaptor1

Species2

Hairs2

Expression6

Blood glucose concentrations1

Kinase2

Pathway1

Upstream2

POMC1

Signals1

Melanocyte1

Breeds1

Insulin1

Interactions1

Relation1

Mammals1

Essential2

Chromosome1

Epithelial2

Yellow2

Cellular1

Food intake1

Fatty1

Cohort1

Human1

Medicine1