Proteins sequester kinases. Medical search. Frequent questions

An inhibitory molecule of the IKB family interacts with NF-KB to sequester it in the cytoplasm. (medscape.com)
Displacement of DVL from the centrosome and its release into the cytoplasm on NEK2 phosphorylation is coupled to the removal of linker proteins, an event necessary for centrosomal separation and proper formation of the mitotic spindle. (muni.cz)
The inhibitory IkB proteins (alpha, beta, epsilon) complex with and sequester NFkB family members in the cytoplasm, rendering these transcription factors inactive. (rndsystems.com)
Wnt and Rho GTPase signaling Rabbit polyclonal to NGFR and their discussion In the canonical Wnt signaling pathway, most -catenin in the cytoplasm can be sequestered in a oligomeric complicated of casein kinase, axin, the adenomatous polyposis coli tumor suppressor proteins (APC) and glycogen synthase kinase 3 (GSK3) [16]. (exposed-skin-care.net)
In canonical Wnt signaling, most -catenin in the cytoplasm can be sequestered within an oligomeric complicated of glycogen synthase kinase 3 (GSK3), casein kinase (CK), axin and adenomatous polyposis coli tumor suppressor proteins (APC). (exposed-skin-care.net)
In unstimulated cells, p50:p65 is sequestered in the cytoplasm by inhibitory proteins known as NF-κB inhibitors (IκBs). (biomedcentral.com)
In cytoplasm, zinc mostly binds zinc-chelating proteins called metallothioneins (MTs). (frontiersin.org)
Subsequently, the inhibitory proteins that sequester NF-κB in the cytoplasm are phosphorylated, ubiquitinated, and degraded in the proteasome. (iucc.ac.il)
The experience of NF-κB is normally regulated with the NF-κB inhibitory proteins (IκB) that binds to and sequesters NF-κB family within the cytoplasm. (healthcarecoremeasures.com)
NF-κB proteins are inhibited by IκB proteins present in the cytoplasm. (abcam.com)
In most cell types, NF-jB is sequestered in the cytoplasm by association with IjBa [20]. (lsd1receptor.com)
For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. (medlineplus.gov)

We measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein (CREB). (nature.com)
Egan, J. J., Greenberg, A. S., Chang, M. K. & Londos, C. Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation. (nature.com)
This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. (creativebiolabs.net)
Proteins associated with PML bodies were examined by Western blot analysis, and pUL97 appeared to specifically affect the phosphorylation of RB in a kinase-dependent manner. (elsevierpure.com)
Three consensus RB binding motifs were identified in the UL97 kinase, and recombinant viruses were constructed in which each was mutated to assess a potential role in the phosphorylation of RB and the inhibition of nuclear aggresome formation. (elsevierpure.com)
We concluded from these studies that both UL97 kinase activity and the LxCxE RB binding motif are required for the phosphorylation and stabilization of RB in infected cells and that this effect can be antagonized by the antiviral drug maribavir. (elsevierpure.com)
Phosphorylation of the eIF2alpha subunit is a common mechanism for down-regulating protein synthesis under stress conditions. (nih.gov)
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. (biomedcentral.com)
Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses. (en-academic.com)

A key serine-threonine kinase involved in the induction of innate and acquired immune responses mediated by Toll-like receptors and NOD (nucleotide-binding oligomerization domain)-like receptors. (creativebiolabs.net)
The RIPK2 protein is a 61 kD kinase with a serine/threonine kinase domain at the N-terminus and a caspase activation and recruitment domain (CARD) at the C-terminus. (creativebiolabs.net)
The core of the Hippo pathway is composed of a kinase cascade that includes MST1/2 serine/threonine kinase (ortholog of Hpo in D. melanogaster ), WW45 scaffold protein (Sav), MOB (Mats) and LATS1/2 kinases (Wts). (oncotarget.com)
Following ionizing irradiation, IκB-kinases become activated and phosphorylate IκB at specific serine sites. (biomedcentral.com)
Low concentrations of heme activate Heme-Regulated Inhibitor Kinase, which phosphorylates the Serine-51 of eIF-2{alpha}, and makes its interaction with eIF-2B nonproductive(eIF-2{alpha} sequesters eIF-2B). (en-academic.com)
In human beings, three isoforms of TGF-have been explained, TGF-ligands is definitely transduced through cell surface area recaptor complexes of two unique types of transmembrane serine-threonine kinases, the sort I and type II receptors. (molecularcircuit.com)

Activation of P2Y12 receptor first phosphorylates BAD through the PI3K Akt pathway, and the liquid acidified BAD binds to 14-3-3 protein to separate BAD from BAD Bcl-XL complex, thus releasing free Bcl-XL. (researchsquare.com)
As an important anti-apoptotic protein, dissociated Bcl-XL mainly binds to BAK or Bax and inhibits the pore-promoting activity of BAK or Bax [ 10 ] to achieve its anti-apoptotic function. (researchsquare.com)
Users from the TGF-superfamily are TGF-is secreted like a latent precursor: After secretion the pro-domain (latency connected proteins, LAP) binds and inactivate the ligand, permitting its association with inhibitory latent TGF binding protein (LTBPs) that focus on the complicated towards the ECM where in fact the latent TGF-is sequestered. (molecularcircuit.com)

In the field of molecular biology, receptor tyrosine kinase-like orphan receptors (RORs) are a family of tyrosine kinase receptors that are important in regulating skeletal and neuronal development, cell migration and cell polarity. (wikipedia.org)
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. (ucsf.edu)

Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, which are often spatially compartmentalized by anchoring proteins to increase signalling specificity 1 . (nature.com)
We also investigate stress-responsive protein kinases that phosphorylate eIF2alpha, viral regulators of these kinases, and how cellular phosphatases are targeted to dephosphorylate eIF2alpha. (nih.gov)
Cell cycle regulation is largely based on protein phospho-dephosphorylation events, catalyzed by cyclin dependent kinases (Cdks) and phosphatases (PPases), respectively. (encyclopedia.pub)

The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it is also stimulated by environmental stress conditions, such as starvation, oxidative stress, and the accumulation of misfolded proteins. (mdpi.com)
Disintegration of the inner membrane exposes the sequestered cytoplasmic cargo to lysosomal hydrolases, which break down the material into its constituent metabolites 1, 2 . (invivogen.com)
All IFNαs and IFNβ bind to the same receptor and as a result, the cytoplasmic kinases JAK1 and TYK2 become activated and phosphorylate the STAT1 and STAT2 molecules. (cdc.gov)

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
Here, we show that Mcl-1 down-regulation by the cyclin-dependent kinase (CDK) inhibitor roscovitine or Mcl-1-shRNA dramatically increases ABT-737 lethality in human leukemia cells. (aacrjournals.org)

Dishevelled (DVL) is a key scaffolding protein and a branching point in Wnt signaling pathways. (muni.cz)
However, autophagy can also be used to spatiotemporally regulate immune signaling pathways (e.g. by recycling activated proteins to limit cytokine production) and block inflammation (e.g. by removing damaged mitochondria before they can release harmful reactive oxygen species). (invivogen.com)
Among them are the Sprouty proteins which mainly act as inhibitors of growth factor-dependent neuronal and glial signaling pathways. (springer.com)
Recently, a book arm of TGF-signaling continues to be discovered where ALK5 activates the R-Smads, Smad1/5, resulting in TGF-can on the other hand activate the R-Smads, Smad1/5/8 via the Tcan also activate Smad-independent signaling pathways through the connection and association with option mediator protein [30]. (molecularcircuit.com)

The IKB is phosphorylated by a multiprotein complex with two kinases subunits. (medscape.com)
The first step of protein synthesis is binding of the initiator Met-tRNA to the small ribosomal subunit by the factor eIF2, which is composed of three subunits. (nih.gov)
AMP-activated protein kinase - 5 AMP activated protein kinase or AMPK consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans, that plays a role in cellular energy homeostasis. (en-academic.com)
The common regulatory step in both of these cascades is activation of an IκB kinase ( IKK ) complex consisting of catalytic kinase subunits (IKKα and/or IKKβ) and the regulatory non-enzymatic scaffold protein NEMO (NF-κB essential modulator also known as IKKγ). (abcam.com)
NF-κB activation leads to expression of the IκBα gene, which functions as a negative feedback loop to sequester NF-κB subunits, terminating signaling unless a persistent activation signal is present. (abcam.com)

Moreover, cells use autophagy to regulate the activity of specific signaling proteins, to prevent accumulation of damaged organelles or long-lived, aggregate-prone proteins, and to remove incoming threats such as intracellular pathogens. (invivogen.com)
In addition, most intracellular calcium is normally sequestered within organelles. (medscape.com)
The high intracellular calcium activates numerous calcium-dependent enzymes that further break down the cell membrane, leading to the release of intracellular contents such as myoglobin and creatine kinase into the circulation. (medscape.com)
In recent years, the search for intracellular signaling integrator downstream of receptor tyrosine kinases provided valuable novel substrates. (springer.com)

Autophagy is one of the three principal mechanisms used by cells to sequester, remove and recycle waste, the others being proteasomal degradation and phagocytosis. (invivogen.com)
Upon stimulation, IκB is phosphorylated by an upstream IκB kinase (IKK), which leads to its ubiquitination and proteosomal degradation. (biomedcentral.com)
This tags IκB for poly-ubiquitination and subsequent degradation through the 26S proteasome [ 5 ], a multi-catalytic, ATP-dependent protease complex, responsible for posttranslational control of all short-lived and many long-lived proteins. (biomedcentral.com)
this goals it for polyubiquitination by way of a proteins complex filled with von Hippel-Lindau proteins (pVHL) and degradation. (healthcarecoremeasures.com)
32 and 36 by IjBa kinase, resulting in the conju-gation of ubiquitin that targets the proteins for pro-teasome-mediated degradation. (lsd1receptor.com)

Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
Heme-regulated inhibitor (HRI) kinase is a member of the eIF-2{alpha} kinase family. (en-academic.com)

At the same time, RIPK2 interacts with a variety of proteins, participates in the signal transduction of multiple receptors, and exerts physiological functions. (creativebiolabs.net)
The polyubiquitinated protein interacts with MAP3K7/TAK1. (creativebiolabs.net)
As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)
Under normal cellular conditions, eIF-2{alpha} productively interacts with eIF-2B, giving rise to guanine-nucleotide exchange activity that is essential for protein translation. (en-academic.com)
This led us to propose that wild-type Ataxin-1 might take on a conformation that resists clearance or interacts strongly with other proteins and that such conformation is favored by the expanded polyglutamine tract. (bcm.edu)

Seven type I receptors (Activin-recaptor like kinases, ALKs, 1C7) and five type II receptors are known in vertebrates. (molecularcircuit.com)

We previously used structural, molecular, and biochemical studies to define how the eIF2alpha kinases recognize their substrate. (nih.gov)

The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
Studies of human genome demonstrate that protein-coding genes only occupy less than 2% of the entire genome [ 1 ]. (ijbs.com)
Consequently, while Smad protein are intrinsically transcriptional activators, the transcriptional end result of buy BV-6 their focus on genes often depends upon the transcriptional companions connected with Smads [24]. (molecularcircuit.com)

Feliciello, A., Rubin, C. S., Avvedimento, E. V. & Gottesman, M. E. Expression of a kinase anchor protein 121 is regulated by hormones in thyroid and testicular germ cells. (nature.com)
Low expression of CDK6 protein in ZR-75-1, Neuro-2a, and INS-1 cells is consistent with the predicted expression pattern. (cellsignal.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
A transient expression assay suggested that pp71 and IE1 were also involved in this process, and this suggestion was significant, since both proteins have been reported to interact with components of promyelocytic leukemia (PML) bodies (ND10) and also interact functionally with retinoblastoma pocket proteins (RB). (elsevierpure.com)
In disorders such as leukemia, increased expression of antiapoptotic proteins, such as Bcl-2, is required for disease maintenance ( 3 ), confers drug resistance ( 4 ), and is associated with poor clinical outcome ( 5 ). (aacrjournals.org)
This was independent of the increase in reactive oxygen species, p38MAPK phos-phorylation and expression of NF-jB target proteins. (lsd1receptor.com)
To better understand the cellular components controlling alphavirus vector specificity, a cell culture model system of the anopheline restriction of CHIKV was developed along with a protein expression strategy. (cdc.gov)

DVL accumulates during the cell cycle and associates with NIMA-related kinase 2 (NEK2), which is able to phosphorylate DVL at amultitude of residues, as detected by a set of novel phospho-specific antibodies. (muni.cz)
The mutation of either the conserved LxCxE RB binding motif or the lysine required for kinase activity impaired the ability of the virus to stabilize and phosphorylate RB. (elsevierpure.com)
Four distinct kinases phosphorylate eIF2alpha on Ser51 under different cellular stress conditions: GCN2 responds to amino-acid limitation, HRI to heme deprivation, PERK to ER (endoplasmic reticulum) stress, and PKR to viral infection. (nih.gov)
Consistent with their common activity to phosphorylate eIF2alpha on Ser51, the kinases show strong sequence similarity in their kinase domains. (nih.gov)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
Recognizing the importance of protein interactions for mediating SCA1 pathogenesis, and given that SCA1 shares clinical and pathological features with several other inherited ataxias, we proposed that understanding the interactions of Ataxin-1 as they relate to the interactions of proteins implicated in other ataxias might provide better insight about molecular mechanisms leading to Purkinje cell degeneration and ataxia. (bcm.edu)

Can sequestering of mitotic spindle proteins cause aneuploidy? (ku.dk)

NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)
For instance, familial AD is linked to mutations in the amyloid precursor protein (APP), presenilin 1, and presenilin 2, all of which lead to increased levels of Aβ. (jneurosci.org)
Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al. (stanford.edu)
Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. (medlineplus.gov)
Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. (medlineplus.gov)

Cells infected with human cytomegalovirus in the absence of UL97 kinase activity produce large nuclear aggregates that sequester considerable quantities of viral proteins. (elsevierpure.com)
PML bodies have been linked to the formation of nuclear aggresomes, and colocalization studies suggested that viral proteins were recruited to these structures and that UL97 kinase activity inhibited their formation. (elsevierpure.com)
The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. (stainingkit.com)
These proteins also elicit immune responses that prevent infection or independently reduce viral replication. (stainingkit.com)
The regulatory activities of this viral protein play a major role in the pathogenicity of influenza virus and appear partially responsible for the ability of influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic viruses in humans. (cdc.gov)

Additionally, defective autophagy has been implicated in neurologic disorders characterized by accumulation of protein aggregates, including Parkinson's disease. (invivogen.com)
Our analysis of SCA1 transgenic mice revealed that the mutant protein aggregates in the nuclei of cerebellar Purkinje cells and that these aggregates stain positively for ubiquitin, the proteasome, and some chaperones. (bcm.edu)

ROR proteins (ROR1 and ROR2 in humans) can modulate Wnt signaling by sequestering Wnt ligands. (wikipedia.org)
The TGF-superfamily contains a lot more than 30 proteins ligands split into subfamilies predicated on series similarity and function. (molecularcircuit.com)

The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
What does this gene/protein do? (cancerindex.org)
In nucleated cells, BAD is an important target gene downstream of Akt [ 9 ] and belongs to the pro-apoptotic Bcl-2 family of proteins. (researchsquare.com)
Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA's primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. (biomedcentral.com)
The CDKN1B gene provides instructions for making a protein called p27. (medlineplus.gov)
Furthermore, the Smad complicated recruits co-activators, such as for example p300 and CREB binding proteins, or co-repressors, such as for example retinoblastoma-like 1 proteins, to modify gene transcription [18,20,23]. (molecularcircuit.com)

The activated receptor transmits the signal through downstream proteins to activate different kinases. (iucc.ac.il)
Together with this unique set of proteins in the cascade, Ub chains form the platform for the binding of downstream interacting partners. (iucc.ac.il)
PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (biomedcentral.com)
We further demonstrate that PTPRD has a tumor suppressor function in neuroblastoma through dephosphorylating and destabilizing AURKA, leading to a downstream decrease of MYCN protein. (biomedcentral.com)

Once the NF-κB pathway is normally activated ME0328 IκB is normally phosphorylated by IκB kinase (IKK) which phosphorylates IκB. (healthcarecoremeasures.com)

The pro-apoptotic function of bcl-XL is realized by binding to anti-apoptotic protein Bcl-XL and inhibiting its anti-apoptotic activity. (researchsquare.com)

The increase in FLT1/sFLT1 protein levels upon miR-10 knockdown in zebrafish and in HUVECs inhibited the angiogenic behavior of endothelial cells largely by antagonizing VEGF receptor-2 signaling. (ca.gov)
On the contrary, knockdown of Sprouty proteins increases proliferation of activated astrocytes and, consequently, reduces secondary brain damage in neuronal lesion models such as kainic acid-induced epilepsy or endothelin-induced ischemia. (springer.com)

This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)

This model predicts that most proteins that interact with wild-type Ataxin-1 should interact with the mutant protein and that modifications of Ataxin-1 that might alter its conformation are critical to pathogenesis. (bcm.edu)
We found that 14-3-3 proteins interact with Ataxin-1 in a S776-dependent manner and that 14-3-3 augments levels of Ataxin-1 when phosphorylated at S776 by Akt kinase. (bcm.edu)
Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity. (cdc.gov)

Their unique hourglass-shaped architecture is highly conserved among different bacterial membrane proteins and other biological channels. (ibecbarcelona.eu)
P2Y12 receptor (P2YR) is a G-coupled7-membrane-spanning proteins. (researchsquare.com)
The ubiquitinated cargo is then dragged and bound to the isolation membrane via LC3 by one of various sequestosome-like proteins (SLRs) such as p62, optineurin, Parkin or PINK1. (invivogen.com)
It translocates to the nuclear membrane upon stimulation, where it co-localizes with 5-LOX activating protein (FLAP) and cytosolic phospholipase A 2 (cPLA 2 ) [ 5 ]. (biomedcentral.com)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)

Based on this function, p27 is described as a tumor suppressor protein. (medlineplus.gov)

Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)

In genetic and biochemical studies, we found that the mutation disrupts eIF2 complex integrity, impairs general translation, alters translational control of mRNAs encoding key regulatory proteins, and reduces the fidelity of translation start codon selection. (nih.gov)

Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
The NEMO protein is required for the activation of the kinase complex. (medscape.com)
Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
Furthermore, in tumour necrosis factor alpha (TNFa)-stimulated Ewing's sarcoma (ES) cells, NF-jB is reported to prevent activation of an apoptotic cascade through inhibition of c-Jun N-terminal kinase (JNK) [23] and upregulation of anti-oxidant enzymes [24]. (lsd1receptor.com)

The Rho category of GTPases contains 20 members, that are 'Ras-like' proteins. (exposed-skin-care.net)
We study the mechanism and regulation of protein synthesis, focusing on GTPases and protein kinases that control this fundamental cellular process. (nih.gov)

The release of myoglobin from muscle cells is often associated with an increase in levels of creatine kinase (CK), aldolase, lactate dehydrogenase (LDH), serum glutamic-pyruvic transaminase (SGPT), and other enzymes. (medscape.com)
Hundreds of phages in these three and other families are shown to encode catalases and iron-sequestering enzymes that can be predicted to enhance cellular tolerance to reactive oxygen species. (biomedcentral.com)

We performed in-vitro lipolysis research of 3T3 L1 adipocytes using DS1, DS2, o-r DS1DS2 mAIM purified proteins, to ascertain whether N glycosylation variation might influence the lipolytic function of AIM. (aurorakinaseb.com)

Myoglobin is a dark-red, 17,8-kDa, monomeric heme protein that contains iron in its ferrous (Fe+2) form. (medscape.com)

On day 7 after maturation induction by insulin, dexamethasone, and 3 isobutyl 1 methylxanthine, cells were challenged with each alternative AIM protein for two days, and the different results of lipolysis were examined. (aurorakinaseb.com)
As shown in Fig. 3A, the down-regulation of lipid droplet coating meats including Fat particular protein 27 and Perilipin, a trademark of AIM induced lipolysis, was induced more by DS1DS2 than DS1, GW0742 DS2, or WT mAIM. (aurorakinaseb.com)

Our lab has previously reported that UVA irradiation may increase the appearance of message is stabilized, we used a artificial 3-untranslated area (UTR) to fully capture RNA-binding protein. (careersfromscience.org)

Through its BH1?3 domains, Bcl-XL can bind and sequester proapoptotic substances possessing the BH-3 domain (23). (careersfromscience.org)

An important signaling "code" in the multiple-step NF-κB activating cascade consists of different ubiquitin (Ub) chains that are assembled on the different effector proteins through different lysine residues in the Ub molecule. (iucc.ac.il)

Cdc14 is kept sequestered in the nucleolus by its binding to the nucleolar protein Net1 during most of the cell cycle. (encyclopedia.pub)

Binding to dsRNA by these proteins may result in initiation of helicase activity, concomitant with a conformational change that leads to recruiting additional cellular factors, including the recently identified IPS-1/MAVS protein ( 5 , 6 ). (cdc.gov)
As a result, different cellular kinases, including the IRF3 kinases TBK1 and IKKε, become activated. (cdc.gov)

Within the last several years, many therapeutic strategies have already been created to inhibit TGF-receptor kinase inhibitors, buy BV-6 TGF-neutralizing antibodies, soluble receptor decoys (Fc fusions) and TGF-antisense oligonucleotides [12]. (molecularcircuit.com)

In influenza viruses, the nonstructural protein 1 inhibits the interferon-mediated antiviral response. (cdc.gov)
Previous work indicated that the nonstructural protein 3 (nsP3) of these alphaviruses was partially responsible for this vector specificity. (cdc.gov)

Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
There are currently seven identified IκB family members: IκBα, IκBβ, Bcl-3, IκBε, IκBγ, and the precursor proteins p100 and p105, which are characterized by the presence of ankyrin repeats. (abcam.com)
The "Gratiaviridae" phages encode a HipA-family protein kinase and glycosyltransferase, suggesting these phages modify the host cell wall, preventing superinfection by other phages. (biomedcentral.com)

Neuronal microtubule-associated protein 2D is a dual A-kinase anchoring protein expressed in rat ovarian granulosa cells. (nature.com)
Protein tyrosine phosphatase receptor delta ( PTPRD ) is an important regulator of axon growth and guidance and is highly expressed in the central nervous system where it functions as a transmembrane homophilic neuronal cell adhesion molecule [ 1 ]. (biomedcentral.com)

Finally, we evaluate a functional interaction between Fry and NDR1 kinase, providing evidence of an evolutionarily conserved complex required for morphogenesis. (nature.com)
When phosphorylated by an active IkB kinase (IKK) complex, IkB proteins are degraded by proteasomes, resulting in the release and nuclear translocation of active NFkB. (rndsystems.com)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
Vesicle nucleation depends on a class III phosphatidylinositol-3-OH kinase (PI(3)K) complex formed by Beclin 1, Vps34 and other proteins. (invivogen.com)
The Atg5-Atg12 conjugate forms a large complex with the Atg16L1 protein. (invivogen.com)
Derailed and SRC64B form a complex, which contains catalytically active SRC64B, the formation or stability of which requires SRC64B kinase activity. (biologists.com)

In this fundamental process of life, the ribosome builds proteins according to the information encoded on the mRNA. (en-academic.com)

We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)

this interaction sequesters RIPK2 from the NOD2 signaling pathway. (creativebiolabs.net)
Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. (medlineplus.gov)

PKA: a portrait of protein kinase dynamics. (nature.com)

We found that miR-10 functions, in part, by directly regulating the level of fms-related tyrosine kinase 1 (FLT1), a cell-surface protein that sequesters VEGF, and its soluble splice variant sFLT1. (ca.gov)
Lack of one duplicate of IGF-1 receptor, which lengthens life-span, was been shown to be protecting by advertising faster aggregation of the and raising the denseness of amyloid plaques, therefore sequestering poisonous soluble A oligomer varieties into amyloid fibrils (Cohen et al. (ampkpathway.com)

However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. (medlineplus.gov)

Immunoprecipitation of CDK6 protein from Jurkat cell extracts. (cellsignal.com)
HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
The Hippo kinase pathway is emerging as a conserved signaling pathway that controls cell proliferation, apoptosis, contact inhibition, cell migration, cell differentiation, stem cell self-renewal, genetic stability, and epithelial-to-mesenchymal transition (EMT). (oncotarget.com)
Additionally, we handled cells with WT or DS1DS2 mAIM protein for 6 h, and addressed whether the cells included the extra AIM protein by immunoblotting using cell lysates and the culture supernatants. (aurorakinaseb.com)
As shown in Supplementary Fig. After the 6 h incubation was detected 2b, no loss of AIM proteins in the supernatant o-r no increase of AIM signal in cell lysate. (aurorakinaseb.com)
studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division. (medlineplus.gov)

Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP Sw ), resulting in high β-amyloid (Aβ) levels in the brain. (jneurosci.org)

Anatomy12

Organisms8

Chemicals and Drugs179

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes39

Information Science3

Cytoplasm12

Phosphorylation11

Serine6

Binds3

Receptor tyrosi2

Phosphatases3

Cytoplasmic3

Cyclin-depend3

Pathways4

Subunits5

Intracellular4

Degradation5

Inhibitor2

Interacts5

Receptors1

Substrate1

Genes3

Expression7

Phosphorylate4

Molecular2

Mitotic1

Mutations6

Viral5

Aggregates2

Ligands2

Gene7

Downstream4

Phosphorylates1

Anti-apoptotic1

Knockdown2

Oxidative stress1

Interact3

Membrane5

Tumor1

Lipids1

Regulatory proteins1

Activation4

GTPases2

Enzymes2

Adipocytes1

Heme1

Lipolysis2

Irradiation1

Proapoptotic1

Lysine1

Nucleolus1

Cellular2

Antibodies1

Nonstructural protein2

Family3

Neuronal2

Complex6

Ribosome1

Humans1

Interaction2

Dynamics1

Soluble2

Regulation1

Cell6

Precursor1