Proteins sequence 3 phosphoinositide dependent protein kinases. Medical search. Frequent questions

Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. (rcsb.org)
This pathway involves the sequential activation of Phosphoinositide 3-kinase (PI3K), AKT, and mTOR. (ebrary.net)
Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)
These guanosine triphosphatases bind GTP causing the activation of mitogen activated protein kinase (MAPK), phosphoinositide-3-kinase (PI3K) and Ras-like (RAL) pathways [ 1 ]. (biomedcentral.com)
The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). (umbc.edu)

In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. (wikipedia.org)
The catalytic region is highly conserved among the different isoforms, as well as, to a lesser degree, among the catalytic region of other serine/threonine kinases. (wikipedia.org)
The pseudosubstrate region, which is present in all three classes of PKC, is a small sequence of amino acids that mimic a substrate and bind the substrate-binding cavity in the catalytic domain, lack critical serine, threonine phosphoacceptor residues, keeping the enzyme inactive. (wikipedia.org)
PDK1 contains an N-terminal serine/threonine kinase domain followed by a PH domain. (embl.de)
Non-specific serine/threonine protein kinase. (edu.pl)
To examine the involvement of interchromatin granule clusters (IGCs) in transcription and pre-mRNA splicing in mammalian cell nuclei, the serine-arginine (SR) protein kinase cdc2-like kinase (Clk)/STY was used as a tool to manipulate IGC integrity in vivo. (rupress.org)
The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine ,PTK) or serine/threonine ,STK) kinase catalytic domains. (insulin-receptor.info)

To understand the signal transduction required, we focused primarily on IL-6 induction by measuring mitogen-activated protein kinase activity and analyzing the effects of mutant or dominant negative forms of Vav, Rac1, and c-Jun N-terminal kinase-1 (JNK1). (aai.org)
Vav overexpression resulted in the constitutive activation of JNK1 with little or no effect on p38 mitogen-activated protein kinase and ERK2. (aai.org)
A major signaling pathway in eukaryotic cells is the mitogen-activated protein kinase (mapk) pathway which is implicated in regulating cell. (kgsepticsewer.com)

By monitoring pairwise disulfide conjugation between PIFtide and PDK1 cysteine mutants, we defined the PIFtide binding orientation in the PIF pocket of PDK1 and assessed subtle relationships between PIFtide positioning and kinase activation. (rcsb.org)
This entry represents the pleckstrin homology (PH) domain from 3-phosphoinositide-dependent protein kinase 1 (PDK1) type proteins. (embl.de)
Following binding of the PH domain to PtdIns(3,4,5)P3 and PtdIns(3,4)P2, PDK1 activates these enzymes by phosphorylating a Ser/Thr residue in their activation loop. (embl.de)
This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. (sdbonline.org)

The class I PI3Ks are activated by growth factor tyrosine kinase receptors (class IA), such as EGFR, or by G protein coupled receptors (GPCRs) (class IB). (ebrary.net)
Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
Epidermal Growth factor receptor ,EGFR) is the prototype member of the type 1 receptor tyrosine kinases. (insulin-receptor.info)
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases. (umbc.edu)
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. (umbc.edu)
Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing. (lu.se)

Thus, conventional and novel PKCs are activated through the same signal transduction pathway as phospholipase C. On the other hand, atypical (a)PKCs (including protein kinase Mζ and ι / λ isoforms) require neither Ca2+ nor diacylglycerol for activation. (wikipedia.org)
To define the localization of WDFY2 in the endocytic pathway, we transiently transfected hTERT-RPE1 cells with green flourescent protein (GFP)-WDFY2 and performed structured illumination microscopy (SIM) together with APPL1 and EEA1 visualized with antibodies (Fig. 1a ). (nature.com)
The ↑[Ca 2+ ] i activates a signaling cascade that involves, sequentially, calcium-calmodulin, nitric oxide synthase, guanylyl cyclase, and protein kinase G. This signal transduction pathway enables Cl − to pass through vesicular channels and act as a counterion for the transport of H + , so that the vesicles of secretogogue-stimulated cells become acidic. (jneurosci.org)
This novel trafficking/chaperoning pathway underpins neurotransmission, as secretory vesicles rely on the zippering of SNARE proteins such as syntaxin-1 to undergo fusion with the plasma membrane. (edu.au)
The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and myristoylated PKI(14-22) amide, indicating partial mediation via a cAMP/PKA pathway. (diabetesjournals.org)
Glucose metabolism activates this pathway by means of increasing [Ca 2+ ] i via L-type voltage-dependent calcium channels (VDCCs) by affecting the electrical activity of the cell. (diabetesjournals.org)

Protein kinases are these enzymes found inside our body which are responsible for catalyzing phosphorylation reactions. (kgsepticsewer.com)

Here we report the discovery of a non-malignant somatic KRAS variant using whole exome sequencing in a minimally symptomatic then-8-year-old girl with unexplained massive splenomegaly. (biomedcentral.com)
Assessment of DNA repair susceptibility genes identified by whole exome sequencing in head and neck cancer. (parp4.com)

While AKT phosphorylates multiple downstream targets (see above), the emerging picture is that the ability of AKT to coordinate mitogenic and nutrient-sensing pathways controlling protein synthesis is a key mechanism by which AKT regulates cell proliferation. (ebrary.net)
It phosphorylates and activates several downstream kinases, including AMP-dependent kinase, AMPK . (sdbonline.org)
Downstream signalling is controlled by both RAS-intrinsic GTP hydrolysis, guanine nucleotide exchange factors (GEFs) that catalyse hydrolysis and GTPase-activating proteins (GAPs) [ 2 ]. (biomedcentral.com)

Acanthamoeba -mediated brain endothelial cell death was abolished using LY294002, a phosphatidylinositol 3-kinase inhibitor. (asm.org)
Significantly, the actions of both GLP-1 and forskolin were abolished by the selective Ca 2+ /calmodulin-dependent phosphatase 2B (calcineurin) inhibitor, FK506, as well as by the chelation of intracellular Ca 2+ by BAPTA (bis(2-aminophenoxy)ethane- N,N,N ′ ,N ′-tetraacetate). (diabetesjournals.org)
SMA-RL71 was extremely steady and experienced a diameter of 181.6 nm in buffer and 275.1 nm in serum as measured by dynamic light scattering and a near neutral charge of ?0.0432 mV.30 We first examined the tissue distribution pattern LGK-974 kinase inhibitor of SMA-RL71 and compared it to free RL71. (insulin-receptor.info)
Open up in another screen LGK-974 kinase inhibitor Amount 1 Medication deposition in tissue following treatment with SMA-RL71 and RL71. (insulin-receptor.info)
Records: Tumor-bearing mice had been treated with (A) an individual iv dosage of 10 mg/kg of either RL71 or SMA-RL71 and euthanized 6 h afterwards or (B) intravenously implemented 10 mg/kg of RL71 or SMA-RL71 LGK-974 kinase inhibitor on times 4, 7, 11, and 14 and euthanized 3 times afterwards. (insulin-receptor.info)

AKT prevents cell death by inactivating proapoptotic factors including BAD, procaspase-9 and Forkhead transcription factor family proteins (FOXOs), activates transcription factors that upregulate antiapoptotic genes, including NF-kB, inactivates p53 through Mdm2, and phosphorylates the cell cycle inhibitors p21 CIP1/WAF1 and p27 KIP1 , thus increasing cell proliferation (Hennessy et al. (ebrary.net)
moreover, PI3′-kinase inhibitors (wortmannin and LY294002) antagonized secretion. (jneurosci.org)
The vast majority of protein kinase inhibitors bind at the adenosine. (kgsepticsewer.com)

Furthermore, CETP females exhibited increased aortic relaxation to 17ß-estradiol (E2) and upregulation of heat shock protein 90 (HSP90) and caveolin-1, proteins that stabilize estrogen receptor (ER) in the caveolae. (bvsalud.org)
More specifically, substrates with certain FYVE domains (named after the first four proteins in this motif, Fab1, YotB, Vac1p, and EEA1) bind PIP, and these pathways have been implicated in vesicular trafficking or receptor-mediated endocytosis ( 5 ). (asm.org)
Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca 2+ receptor (CaR) by increased extracellular Ca 2+ (↑[Ca 2+ ] e ). (jneurosci.org)
EphRs comprise the largest subfamily of receptor tyr kinases (RTKs). (umbc.edu)

To date, it is well known that lncRNAs participate in chromatin modifications and transcriptional and translational regulation of protein-encoding genes or regulate protein function and activity through specific binding [ 3 - 5 ]. (jcancer.org)
60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
RNA polymerase II mainly transcribes microRNA genes as primary miRNA transcripts (pri-miRNAs) that contain 5′cap and 3′poly(A) tails ( 28 ). (frontiersin.org)
Gain-of-function variants in the three RAS genes have been found in 27 % of human cancers [ 3 ]. (biomedcentral.com)
This domain occurred 367 times on human genes ( 852 proteins). (umbc.edu)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)

By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. (insulin-receptor.info)

Next, we observed that Acanthamoeba specifically activates phosphatidylinositol 3-kinase. (asm.org)
Protein kinase a (pka) exists as a tetrameric holoenzyme which activates with increase of camp and plays an important role in many. (kgsepticsewer.com)
The g protein dissociates and one subunit interacts with and activates an enzyme - adenylate cyclase- which converts atp into a second messenger. (kgsepticsewer.com)

This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
Using tobacco pollen tubes as a model, we addressed the signaling effects of PA by probing the functions of three most relevant enzymes that regulate the production and degradation of PA, namely, phospholipases D (PLD), diacylglycerol kinases (DGKs), and lipid phosphate phosphatases (LPPs). (frontiersin.org)

There is significant interest in identifying and characterizing allosteric sites in enzymes such as protein kinases both for understanding allosteric mechanisms as well as for drug discovery. (rcsb.org)
Protein kinases belong among the most intensively studied classes of enzymes. (kgsepticsewer.com)
In cell biology, protein kinase a (pka) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic amp (camp). (kgsepticsewer.com)
Phosphoinositides (PPIs) together with various kinases and phosphatases were described as specific lipids and enzymes with signaling functions earlier ( Martin, 1998 ). (frontiersin.org)
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. (insulin-receptor.info)

The majority of inositol lipids reside in membranes and serve as substrates for kinases, phosphatases, and phospholipases. (asm.org)

WDFY2 localizes to actin-stabilized endosome tubules positive for the small GTPase RAB4 and shows a preference for highly curved membranes enriched for the lipid phosphatidylinositol 3-phosphate (PtdIns3P). (nature.com)
Specific distribution of PI lipids is regulated, either by the localization of a kinase-phosphatase pair or, by vesicular and non-vesicular lipid transport. (upstate.edu)
Only the lysosome/vacuole possesses a low abundant signaling lipid PI(3,5)P2. (upstate.edu)
The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition. (nih.gov)

Conversely, overexpression of a catalytically inactive mutant, Clk/STY(K190R), causes retention of hypophosphorylated SR proteins in nuclear speckles. (rupress.org)

These studies show that disulfide trapping is useful for characterizing allosteric sites on kinases and that a single allosteric site on a protein kinase can be exploited for both activation and inhibition by small molecules. (rcsb.org)
This was dependent on Vav-mediated activation of Rac1 as a Dbl domain-mutated Vav, inactive Rac N17, and inactive JNK1 down-regulated the Vav-induced JNK1 or IL-6 responses. (aai.org)
ADP-ribosylation factors (ARFs) are approximately 20-kDa guanine nucleotide-binding proteins recognized as critical components in intracellular vesicular transport and phospholipase D activation. (embl.de)
The inhibitory effect of metformin was mimicked by disruption of the MID1-α4/PP2A protein complex by siRNA knockdown of MID1 or α4 whereas AMPK activation was not required. (biomedcentral.com)
This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. (umbc.edu)

Intracellular calcium ([Ca 2+ ] i ) appears to be an important mediator of this process ( 3 , 6 - 10 ). (diabetesjournals.org)
Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members. (lu.se)

These data suggest that the synergistic action of glucose and GLP-1 to promote insulin gene transcription is mediated through NFAT via PKA- and calcineurin-dependent pathways in pancreatic β-cells. (diabetesjournals.org)

The N-terminal C2a domain has been shown to bind phospholipids in a Ca2+-dependent manner (Fukuda, 1996 and Fukuda, 1997), while the role of the C2b domain remains unclear. (sdbonline.org)
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

Moreover, we showed that Acanthamoeba produces severe HBMEC cytotoxicity by secreting extracellular proteases, as well as using contact-dependent mechanisms such as phagocytosis ( 12 ), which may play an important role in blood-brain barrier perturbations. (asm.org)
and (3) the level of tumor-derived extracellular miRNAs might vary with the age of the patient and the status of disease, so their value as non-invasive biomarkers are reduced. (frontiersin.org)
More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. (umbc.edu)

Both the ATP-binding protein (ATP)- and the substrate-binding sites are located in the cleft formed by these two terminal lobes. (wikipedia.org)
PI3Ks are grouped into three classes (I-III) according to their substrate preference and sequence homology (Cantley 2002). (ebrary.net)

3. Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine. (jcancer.org)

We have previously identified NFAT (nuclear factor of activated T-cells) as a key regulator of insulin gene transcription in pancreatic β-cells that is activated by the calcium/calmodulin-dependent protein phosphatase 2B (calcineurin) in response to increased [Ca 2+ ] i ( 10 ). (diabetesjournals.org)
Functional groups contained in this DE gene list include metabolic proteins (including opposing patterns ofCA3andCA4), mitochondrial proteins (CKMT1A), oxidative status (SEPP1,HIG2A) and cholesterol homeostasis (APOA1,INSIG1). (1library.net)

The master kinase LKB1 is a key regulator of several cellular processes, including cell proliferation, cell polarity and cellular metabolism. (sdbonline.org)
It disrupted the AR translational MID1 regulator complex leading to release of the associated AR mRNA and subsequently to downregulation of AR protein in AR positive cell lines. (biomedcentral.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)

The term "protein kinase C" usually refers to the entire family of isoforms. (wikipedia.org)
It is expressed in different isoforms in various tissues and interacts with TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. (bvsalud.org)

3- 5 Therefore, during severe hypoxia or anoxia, the cell initiates a cascade of events that leads to apoptotic cell death, thereby preventing the accumulation of cells with hypoxia induced mutations. (bmj.com)

No mass spectrometry results found for this protein. (yeastrc.org)

Level of PI(3,5)P2 elevates by 20X its basal level, under hyperosmotic stress, helping cells to sustain salt toxicity, the mechanism of which is incompletely understood. (upstate.edu)
The disease mechanism underlying these variants is dependent on the specific defect, as some reduce intrinsic GTP hydrolysis, while others result in an insensitivity to GAP-mediated GTP hydrolysis [ 2 ]. (biomedcentral.com)

The GAP function of the amino-terminal extension of ARD1 required two arginines, an intact zinc finger motif, and a group of residues which resembles a sequence present in Rho/Rac GAPs. (embl.de)

Oxr1p belongs to the group of TLDc domain containing proteins that are highly conserved in higher eukaryotes. (upstate.edu)
The RAS family consists of three proteins all sharing a highly conserved N-terminus region: Harvey RAS (HRAS), Kirsten RAS (KRAS) and neuroblastoma RAS (NRAS). (biomedcentral.com)

In addition, downregulation of the V-ATPase subunit VhaPPA1-1 reduces Akt and Tor-dependent signaling and restores clearance. (sdbonline.org)
Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). (nih.gov)

2005). AKT also phosphorylates and inhibits glycogen synthase kinase-3 (GSK3), thus enhancing p-catenin and cyclin D1 stabilization (Vivanco and Sawyers 2002). (ebrary.net)
Subsequently, mTOR phosphorylates key eukaryotic translation regulators, including p70-S6 kinase (p70S6K) and the eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (Hay and Sonenberg 2004). (ebrary.net)

These proteins contain a characteristic zinc finger motif (Cys-x2-Cys-x(16,17)-x2-Cys) which displays some similarity to the C4-type GATA zinc finger. (embl.de)

Int J Immunogenet 2006(3): 205-9 [ PubMed abstract ]. (lu.se)
Eur J Pediatr 2006(3): 165-7 [ PubMed abstract ]. (lu.se)

J Cell Biol (2002) 156 (3): 425-436. (rupress.org)

For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)

EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. (umbc.edu)

WDFY2 localizes to endosomal tubules by binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns3P). (nature.com)
and phosphatidylinositol-3-phosphate biosynthetic process. (nih.gov)

OMIM: 190,070) encodes one of three small guanosine triphosphatase proteins belonging to the RAS family. (biomedcentral.com)
Atg18/WIPIs belong to the PROPPIN family of proteins. (nature.com)

As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
The camp-dependent protein kinase (pka) holoenzyme is composed of two regulatory and two catalytic subunits, designated pka r and pka c, respectively. (kgsepticsewer.com)

The cryo-EM analysis also revealed a population of free V 1 bound to Oxidation Resistance 1 (Oxr1p), a poorly characterized protein that has been implicated in protecting cells from oxidative stress. (upstate.edu)
shown in red), a poorly characterized protein implicated in oxidative stress response. (upstate.edu)

Phosphatidylinositol 3-kinases (PI3Ks) are important signaling molecules that phosphorylate the 3′ OH position of the inositol ring of phosphoinositides (PIs), generating the second messengers PI(3)P, PI(3,4)P 2 , and PI(3,4,5)P 3 ( 4 , 17 ). (asm.org)

As depicted in Fig. 7.1, AKT phosphory- lates and inactivates the tumor-suppressor protein tuberous sclerosis complex protein 2 (TSC2), which forms a complex with tuberous sclerosis complex protein 1 (TSC1), and act together as a GTPase activating protein (GAP) for the small GTPase Rheb1 (Inoki et al. (ebrary.net)
Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. (embl.de)
Classical GAP proteins accelerate GTPase activity by supplying an arginine finger to the active site. (embl.de)
Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). (embl.de)
Both guanine nucleotide-exchange proteins and GTPase-activating proteins (GAPs) for ARFs have been cloned recently. (embl.de)

Here, we have studied the function of WDFY2, a cytosolic protein that has been described to reside on endocytic vesicles close to the plasma membrane 6 . (nature.com)
Organelles are also identified by the presence of specific Phosphoinositide (PI) lipids on the cytosolic leaflet of their membrane. (upstate.edu)
LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)
We demonstrated that the protein Munc18-1 was responsible for the transport of syntaxin-1 to the plasma membrane. (edu.au)
We demonstrated that Munc18-1 and syntaxin-1A and are organised in nanodomains on the plasma membrane of neurons and neurosecretory cells that control SNARE-dependent neuroexocytosis through lateral trapping in these nanoclusters. (edu.au)

The inositol trisphosphate (IP 3 ) generated by PI-PLC mobilizes Ca 2+ from internal stores ([Ca 2+ ] i ). (jneurosci.org)
An inositol-1,3,4,5-tetrakisphosphate (IP4)-sensitive extended PH domain is essential for Gap1 activity, while Ca2+-sensitive C2 domains and a glutamine-rich region contribute equally to full activity in vivo. (sdbonline.org)

We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
The GTP-bound form of ARF is essential for the maintenance of normal Golgi morphology, it participates in recruitment of coat proteins which are required for budding and fission of membranes. (embl.de)

This group of proteins is responsible for cell proliferation, differentiation and inhibition of apoptosis. (biomedcentral.com)
A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. (bmj.com)
Apoptosis regulatory proteins are delicately balanced. (bmj.com)

the E-value for the PH_3 domain shown below is 1.3e-46. (embl.de)
The ARFGAP domain display no obvious similarity to other GAP proteins. (embl.de)
The ARFGAP domain is clearly unrelated to the other GAP proteins structures which are exclusively helical. (embl.de)
Taxonomic distribution of proteins containing ArfGap domain. (embl.de)
The complete taxonomic breakdown of all proteins with ArfGap domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing ArfGap domain in the selected taxonomic class. (embl.de)
We had reported that the ARF domain of ARD1 binds specifically GDP and GTP and that the amino-terminal extension acts as a GAP for the ARF domain of ARD1 but not for ARF proteins. (embl.de)

PF cells were found to express regulatory (p85) and catalytic (p110α and p110β) subunits of phosphatidylinositol 3′-kinase (PI3′-kinase). (jneurosci.org)

Previous studies have shown the mitogen-activated protein kinases (mapks) to be activated in macrophages upon infection with. (kgsepticsewer.com)

A nuclear protein and tumor suppressor that contains a C-terminal PHD ZINC FINGER. (bvsalud.org)

Matrix metalloproteinases (MMPs) play a critical role in progression of cancer by degrading and remodeling ECM, enabling cells to overcome tissue barriers, travel within the circulatory system before extravasating to produce a secondary tumor 3 , 4 . (nature.com)
These results were further confirmed using brain microvascular endothelial cells expressing dominant negative forms of phosphatidylinositol 3-kinase. (asm.org)
Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
Effects of activating protein kinase c int cells a. (kgsepticsewer.com)
Glucose and GLP-1 also synergistically activated NFAT (nuclear factor of activated T-cells)-mediated transcription from a minimal promoter construct containing tandem NFAT consensus sequences. (diabetesjournals.org)

Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)

Anatomy20

Organisms12

Chemicals and Drugs149

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes52

Disciplines and Occupations1

Information Science9

PI3K5

Serine7

Mitogen-activa3

PDK15

Tyrosine6

Pathway6

Phosphorylation1

Whole exome2

Downstream3

Inhibitor5

Inhibitors3

Receptor4

Genes7

Signal Transduction1

Activates3

Degradation2

Enzymes5

Substrates1

Lipid4

Overexpression1

Activation5

Intracellular2

Pathways1

Bind3

Extracellular4

Substrate2

Cell biology1

Gene2

Regulator3

Isoforms2

Mutations1

Mass spectrometry1

Mechanism2

Residues1

Highly conserved2

Subunit2

Phosphorylates2

Motif1

Abstract2

20021

Regulates1

Transmembrane1

Phosphatidylinositol 3-phospha2

Family2

Holoenzyme2

Oxidative2

PI3Ks1

GTPase5

Membrane5

Inositol2

Participates2

Apoptosis3

Domain7

Subunits1

Infection1

Tumor-suppressor1

Cells5

Hydrolysis1