• These proteins are involved in the production of a molecule called ribosomal RNA (rRNA), a chemical cousin of DNA. (medlineplus.gov)
  • Variants in the TCOF1 , POLR1C , or POLR1D gene reduce the production of rRNA. (medlineplus.gov)
  • In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. (thermofisher.com)
  • Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. (nih.gov)
  • Together, these studies unravel unexpected gene regulation directly mediated by rRNA and how ribosome evolution drives translation of critical developmental regulators. (nih.gov)
  • Also repeats, transfer RNA (tRNA) and ribosomal RNA (rRNA) genes were annotated. (escholarship.org)
  • Some of the enzymes which generate aromatic radicals that break down most prominent bacterial strains found were isolated and tax- the complex linkages present in lignin to compounds of lower onomically identified using 16S ribosomal RNA (rRNA) se- molecular weight. (lu.se)
  • The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. (nih.gov)
  • Each time an amino acid is added to a growing polypeptide during protein synthesis, a tRNA anticodon pairs with its complementary codon on the mRNA molecule, ensuring that the appropriate amino acid is inserted into the polypeptide. (genome.gov)
  • In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)
  • A specific nuclear compartment, the nucleolus, and its involvement in ribosomal RNA synthesis, are highlighted. (eur.nl)
  • Interestingly, the 2-MIB synthesis gene was consistently expressed, regardless of the water temperature. (mdpi.com)
  • Evidence exists for telomerase dysfunction, ribosome deficiency, and protein synthesis dysfunction in this disorder. (medscape.com)
  • Before this information can be used for protein synthesis, however, an RNA copy (transcript) of the gene must first be made. (khanacademy.org)
  • For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
  • Of particular biological significance, the short arms of acrocentric chromosomes contain the genes required for the synthesis of ribosomes and ribosomal RNA. (stowers.org)
  • Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. (absoluteastronomy.com)
  • Reduction of ribosomal RNA synthesis and ribosomal RNA genes in a mutant of Xenopus laevis which organizes only a partial nucleolus. (wikidata.org)
  • Ribosomes are tiny particles made up of RNA and proteins that specialize in protein synthesis and are found free or bound to the endoplasmic reticulum within cells . (britannica.com)
  • It binds to the 50S subunit of the ribosome, thus inhibiting bacterial protein synthesis. (msdmanuals.com)
  • Quinupristin and Dalfopristin Quinupristin and dalfopristin are streptogramin antibiotics, which, like macrolides and lincosamides, inhibit the synthesis of bacterial proteins. (msdmanuals.com)
  • All inhibit protein synthesis by binding to the 50S ribosomal subunit. (msdmanuals.com)
  • All of the sequenced genomes have a group I intron in the large ribosomal subunit RNA gene, suggesting that this intron is fixed in these species. (umd.edu)
  • Now, using a combination of cutting-edge techniques in molecular and developmental genetics, genomics, and biochemistry, we will determine how TCS mutations target ribosomal RNA genes and how they alter the composition and formation of ribosome-assembling factories. (pewtrusts.org)
  • The work provided a detailed look at a complex, and until-now mysterious, part of E. coli ribosome assembly-the formation of an entire major component, or domain, of the E. coli ribosome, with assistance from eight protein partners that end up incorporated into the structure. (scripps.edu)
  • The team will now be able to extend this research further to study not only the rest of ribosome assembly, which involves multiple RNA strands and dozens of proteins, but also the many other types of RNA-folding and RNA-protein interaction in cells. (scripps.edu)
  • Ribosome shunting allows host translational machinery to engage polycistronic transcripts similar to RIBOSOMAL FRAMESHIFTING, and use of INTERNAL RIBOSOME ENTRY SITES. (bvsalud.org)
  • All cells use ribosomes to synthesize their proteins. (pewtrusts.org)
  • For example, mutations in a gene involved in the production of ribosomal RNA (a key component of ribosomes) underlie Treacher Collins syndrome (TCS), a condition that affects the development of the bones and tissues of the face. (pewtrusts.org)
  • This type of RNA is called a messenger RNA ( mRNA ), as it serves as a messenger between DNA and the ribosomes, molecular machines that read mRNA sequences and use them to build proteins. (khanacademy.org)
  • Ribosomes are required for manufacturing proteins, the workforce of a cell, and their formation is a cell's most energy intensive activity. (stowers.org)
  • LA JOLLA, CA - A team of scientists from Scripps Research and Stanford University has recorded in real time a key step in the assembly of ribosomes-the complex and evolutionarily ancient "molecular machines" that make proteins in cells and are essential for all life forms. (scripps.edu)
  • The achievement, reported in Cell , reveals in unprecedented detail how strands of ribonucleic acid (RNA), cellular molecules that are inherently sticky and prone to misfold, are "chaperoned" by ribosomal proteins into folding properly and forming one of the main components of ribosomes. (scripps.edu)
  • Ribosomes are made of both RNA and proteins, reflecting a molecular partnership that is widely believed to go back nearly to the dawn of life on Earth. (scripps.edu)
  • Venki Ramakrishnan , byname of Venkatraman Ramakrishnan , (born 1952, Chidambaram , Tamil Nadu , India ), Indian-born physicist and molecular biologist who was awarded the 2009 Nobel Prize for Chemistry , along with American biophysicist and biochemist Thomas Steitz and Israeli protein crystallographer Ada Yonath , for his research into the atomic structure and function of cellular particles called ribosomes . (britannica.com)
  • There he continued to utilize neutron scattering, as well as another technique called X-ray crystallography , to elucidate the structure of ribosomes and other molecules, including chromatin and proteins known as histones . (britannica.com)
  • Viral mechanisms of translational programming in which ribosomes reach the start codon bypassing or shunting over large segments of the 5′ UTR of VIRAL RNA. (bvsalud.org)
  • The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. (thermofisher.com)
  • Still other RNA molecules, such as tiny microRNAs ( miRNAs ), act as regulators of other genes, and new types of non-protein-coding RNAs are being discovered all the time. (khanacademy.org)
  • G protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal. (absoluteastronomy.com)
  • The imaging feat clarifies how RNA molecules fold-and might one day translate into better medicines for a host of diseases. (scripps.edu)
  • More generally, the research offers biologists a powerful new approach to the study of RNA molecules, hundreds of thousands of which are active at any given time in a typical cell. (scripps.edu)
  • QIAseq Stranded RNA Library Kits use a unique protocol, which does not require actinomycin D to retain strand specificity or dUTP to ensure stranded library construction, thereby ensuring highly sensitive detection of low-expression RNA molecules with increased complexity and transcript coverage. (qiagen.com)
  • The sources of genome expansion include group I introns and accessory genes encoding putative homing endonucleases, DNA and RNA polymerases (presumed to be of plasmid origin) and hypothetical proteins. (umd.edu)
  • Variants (also known as mutations) in the TCOF1 , POLR1C , or POLR1D gene can cause Treacher Collins syndrome. (medlineplus.gov)
  • In the autosomal dominant form, mutations in the RNA component of telomerase ( TERC ) or telomerase reverse transcriptase ( TERT ) are responsible for disease phenotype. (medscape.com)
  • Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. (thebiogrid.org)
  • therefore, mutations on this gene cause both telomeric and nontelomeric causes of DKC. (medscape.com)
  • Analysis of 270 families in the DKC registry found that mutations in dyskerin ( DKC1 ), TERT , and TERC only account for 64% of patients, with an additional 1% due to NOP10 , suggesting that other genes associated with this syndrome are, as yet, unidentified. (medscape.com)
  • It encodes 39 protein coding genes, 25 tRNA genes, and two ribosomal RNA genes (rnl and rns). (usda.gov)
  • The tRNA genes encode transfer RNAs for 19 essential amino acids except threonine. (usda.gov)
  • Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)
  • This is the molecular gene . (blogspot.com)
  • I suspect they are thinking of a gene as coding sequences but you have to struggle to interpret their view of the molecular definition. (blogspot.com)
  • It's not clear they have even considered it since they rely on the work of other philosophers who have also ignored it [see Debating philosophers: The molecular gene ]. (blogspot.com)
  • The problem with this part of the book (the part about the molecular gene) is that the authors seem to be confused about the difference between a molecular gene and the view that "genes" are the only thing that count in genetics, evolution, metabolism etc. (blogspot.com)
  • They refuse to use critical thinking to unravel the meaning of the molecular gene -a meaning that is really quite simple even though it's not perfect. (blogspot.com)
  • This review focuses on recent progress in reconstruction of trypanosome phylogeny based on molecular data from ribosomal RNA, the miniexon and protein-coding genes. (scielosp.org)
  • This progression from DNA to RNA to protein is called the " central dogma " of molecular biology. (khanacademy.org)
  • A gene is a molecular unit of heredity of a living organism. (absoluteastronomy.com)
  • QIAseq Stranded RNA Library Kits are intended for molecular biology applications. (qiagen.com)
  • CTCF is a protein that mediates distinct processes of gene regulation, including transcription and the structural organization of the genome. (eur.nl)
  • While loss of wild-type p53 causes fatal damages to the genome, it is not surprising that the TP53 gene is mutated in more than 50% human cancers, and the functions of p53 are often impeded through various mechanisms in the remainder ( Levine and Oren, 2009 ). (elifesciences.org)
  • In addition to genes, there are many other functional parts of the genome. (blogspot.com)
  • Scientists know what they are talking about when they say that the human genome contains about 20,000 protein-coding genes and at least 5,000 genes for non-coding RNAs. (blogspot.com)
  • They are comfortable with the idea that our genome has lots of other functional regions that lie outside of the genes. (blogspot.com)
  • Then they confuse themselves by thinking that knowledgeable experts use the word "gene" as a synonym for all functional sequences in the genome. (blogspot.com)
  • In terms of the distribution of identified genes in a specific category relative to the whole genome, only the categories of PE/PPE and conserved hypotheticals have statistical significance. (hindawi.com)
  • The two smallest sequenced genomes (A. terreus and P. chrysogenum) do not contain introns in protein-coding genes, whereas the largest genome (T. stipitatus), contains a total of eleven introns. (umd.edu)
  • The presumed gene count of 100,000 for human genome drastically went down to around 20,000 after the completion of Human Genome Project. (tripod.com)
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • Information regarding gene content, polycistronic transcription units, sequence insertion or deletion, transition or transversion, and nucleotide repeats may help resolve evolutionary relationships in the kingdom Plantae (Viridiplantae) 6 , 7 , 8 . (plos.org)
  • An amino acid is the fundamental molecule that serves as the building block for proteins. (genome.gov)
  • An anticodon is a trinucleotide sequence located at one end of a transfer RNA (tRNA) molecule, which is complementary to a corresponding codon in a messenger RNA (mRNA) sequence. (genome.gov)
  • The team used an advanced imaging technology called "zero-mode waveguide single-molecule fluorescence microscopy," which they have adapted in recent years for real-time tracking of RNAs and proteins. (scripps.edu)
  • A key finding was that the ribosomal protein partners guide the folding of the RNA strand through multiple temporary interactions with the strand, well before they nestle into their final places in the folded RNA-protein molecule. (scripps.edu)
  • Human 18 S ribosomal RNA sequence inferred from DNA sequence. (wikipedia.org)
  • The variant isolates we ana- only source of available sequence for the cytochrome b lyzed were ST243 (Rakhine State) and MC53 (Tanintharyi ( cyt b ) gene (16). (cdc.gov)
  • Sequence features of the 13 protein-coding genes, two ribosomal RNAs and 22 transfer RNAs are described. (unboundmedicine.com)
  • A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
  • A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)
  • A gene is a DNA sequence that is transcribed to produce a functional product. (blogspot.com)
  • Finally, they misunderstand the term "gene-centric" where the word "gene" is used metaphorically to refer to any DNA sequence that functions in population genetics and evolution. (blogspot.com)
  • Many genes encode protein products, meaning that they specify the sequence of amino acids used to build a particular protein. (khanacademy.org)
  • In individuals without an identified variant in one of these genes, the genetic cause of the condition is unknown. (medlineplus.gov)
  • With the recognition that DNA was the genetic material, the word "gene" took on an additional meaning as a physical unit of function. (blogspot.com)
  • Some viruses use RNA, not DNA, as their genetic material, but aren't technically considered to be alive (since they cannot reproduce without help from a host). (khanacademy.org)
  • Using genetic approaches we identified several genes that may be involve in the ability of a vector to transmit disease. (usda.gov)
  • This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. (thebiogrid.org)
  • Dyskenin is composed of 514 amino acids and has a role in ribosomal RNA processing and telomere maintenance. (medscape.com)
  • This study also includes a phylogenetic analysis based on 14 concatenated core mitochondrial proteins. (umd.edu)
  • Despite the conservation of the core genes, the mitochondrial genomes of Aspergillus and Penicillium species examined here exhibit significant amount of interspecies variation. (umd.edu)
  • Most of this variation can be attributed to accessory genes and mobile introns, presumably acquired by horizontal gene transfer of mitochondrial plasmids and intron homing. (umd.edu)
  • A heterozygous mutation was found on the conserved telomere maintenance component 1 gene ( CTC1 ). (medscape.com)
  • Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. (nih.gov)
  • It gives an introduction to gene regulation and how this process is influenced by chromatin modifications, nuclear organization and compartmentation. (eur.nl)
  • For information on therapeutic regulation of gene expression, see therapeutic gene modulation.Regulation of gene expression includes the processes that cells and viruses use to regulate the way that the information in genes is turned into gene products. (absoluteastronomy.com)
  • Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. (rupress.org)
  • Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
  • Transcription is controlled by regulatory sequences such as promoters, operators, and enhancers but these are not part of the gene. (blogspot.com)
  • This involved the transcription, or copying out from its corresponding gene, of a ribosomal RNA, and initial interactions of this RNA strand with a ribosomal protein. (scripps.edu)
  • In the new study, the team extended this approach by tracking not only the transcription of a ribosomal RNA but also its real-time folding. (scripps.edu)
  • Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled. (absoluteastronomy.com)
  • These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA. (absoluteastronomy.com)
  • Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
  • Bases include the pyrimidine bases (cytosine, thymine in DNA, and uracil in RNA, one ring) and the purine bases (adenine and guanine, two rings). (khanacademy.org)
  • They talk about "structural genes" and imply that the discovery of "regulatory genes" altered our concept of the gene but these terms were never used by experts in the way that the authors imagine (p. 66). (blogspot.com)
  • SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
  • Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin. (elifesciences.org)
  • Six among the 42 genes identified in this study are on the list of the top 100 persistence targets selected by the TB Structural Genomics Consortium. (hindawi.com)
  • Collagen is the main structural protein found in skin and other connective tissues. (nutritionaloutlook.com)
  • This shows that we now can examine in detail how RNAs fold while they are being synthesized and proteins are assembling on them," says first author Olivier Duss, PhD, a postdoctoral research fellow in the Department of Integrative Structural & Computational Biology at Scripps Research. (scripps.edu)
  • ribosomal RNA identification of the isolates showed high score similarity with Pseudomonas spp. (lu.se)
  • all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes. (medscape.com)
  • They seem to think that the gene-centric view requires that everything be attributed to DNA sequences that encode proteins. (blogspot.com)
  • The presence of CTCs in 43 blood samples from patients with metastatic melanoma was evaluated using a combination of immunocytochemistry and transcript analyses of five genes by RT-PCR and 19 genes by droplet digital PCR (ddPCR), whereby a CTC score was calculated. (nature.com)
  • Defects in the NOP10 gene were found in association with autosomal recessive DKC. (medscape.com)
  • The proteins produced from the TCOF1 , POLR1C , and POLR1D genes all appear to play important roles in the early development of bones and other tissues of the face. (medlineplus.gov)
  • Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. (elifesciences.org)
  • There are two types of genes: protein-coding genes and those that specify a functional noncoding RNA (i.e ribosomal RNA, lincRNA). (blogspot.com)
  • Thus, when they recognize that important functional elements exist outside of genes, they conclude that the gene-centric view is fatally flawed. (blogspot.com)
  • Living beings depend on genes, as they specify all proteins and functional RNA chains. (absoluteastronomy.com)
  • An intronic mutation may well result in a non-functional gene (like the splicing site mutation in CYP21A2 ). (tripod.com)
  • In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. (thermofisher.com)
  • Highly polymorphic regions (such as HLA genes) are not represented either due to difficulty with designing primers because of the lack of constant regions flanking the variants. (tripod.com)
  • MMPs are a group of enzymes that can break down proteins such as collagen and elastin (another connective tissue protein in the skin). (nutritionaloutlook.com)
  • Finally, genes of B. retrofracta and 6 other Brassicaceae species were used for phylogenetic tree reconstruction. (escholarship.org)
  • The other one is that mutation is any variation in the gene that causes an obvious change in phenotype whereas polymorphisms do not cause any obvious phenotypic variation. (tripod.com)
  • three different genes may cause the same phenotype). (tripod.com)
  • Enrichment analyses indicated significant differential expression of 24 pathways in AUDs, including those implicated in protein targeting to membrane and viral gene expression. (cdc.gov)
  • DNA and RNA are polymers (in the case of DNA, often very long polymers), and are made up of monomers known as nucleotides . (khanacademy.org)
  • The aim of this thesis is to investigate the different functions of CTCF by a combined analysis of CTCF-interacting proteins and by deletion of CTCF in vivo and in vitro. (eur.nl)
  • Non-experts may not be familiar with the topic and they may have many misconceptions about genes and DNA sequences but we don't base our science on the views of non-experts. (blogspot.com)
  • Though most chloroplast genes are believed to have been transferred to the nucleus during evolution, their genomes have maintained fairly conserved structures and gene contents throughout their evolutionary lineage 1 . (plos.org)
  • The cp genomes of land plants usually contain approximately 110-120 genes, which mostly participate in photosynthesis or gene expression 4 , 5 . (plos.org)
  • As of the July 2013, the total number of genes (including pseudogenes and non-coding RNA genes) is around 58,000 with the total number of transcripts reaching almost 200,000 ( Gencode ). (tripod.com)
  • In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
  • When Treacher Collins syndrome results from variants in the TCOF1 or POLR1D gene, it is considered an autosomal dominant condition, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
  • In the remaining autosomal dominant cases, a person with Treacher Collins syndrome inherits the altered gene from an affected parent . (medlineplus.gov)
  • Autosomal recessive inheritance means both copies of the gene in each cell have variants. (medlineplus.gov)
  • The parents of an individual with an autosomal recessive condition each carry one copy of the altered gene, but they typically do not show signs and symptoms of the condition. (medlineplus.gov)
  • Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
  • By contrast, an autosomal recessive disorder requires two copies of the mutated gene (one from each parent) to cause the disorder. (genome.gov)
  • By contrast, an autosomal dominant disorder requires only a single copy of the mutated gene from one parent to cause the disorder. (genome.gov)
  • Humans have 23 pairs of chromosomes -the DNA/protein complex with two arms extending from the centromere, a region approximately at the center of the arms where duplicated chromosomes are held together prior to cell division. (stowers.org)
  • Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. (nih.gov)
  • Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (thermofisher.com)
  • it still remains to be determined if there are more proteins that can regulate the RPs-MDM2-p53 pathway. (elifesciences.org)
  • 4 Apparently, collagen peptides down-regulate those genes that express (i.e., produce) and activate MMPs. (nutritionaloutlook.com)
  • Since there are way too many nutrient/gene interactions to discuss, I'll limit my examples to collagen peptides and resveratrol. (nutritionaloutlook.com)
  • Collagen peptides refer to a small collagen protein chain. (nutritionaloutlook.com)
  • The significance of this is that smaller protein chains-or peptides-tend to be easily absorbed and distributed in the body. (nutritionaloutlook.com)
  • In this study, we performed a new bioinformatics analysis on microarray-based gene expression data obtained from the public domain to explore genes that were differentially induced by drugs between the group of capreomycin and PA-824 and the group of mainly the first-line TB drugs. (hindawi.com)
  • This study explores the use of a simple human neurosphere-based in vitro model to characterise the pharmacological and toxicological effects of LiCl and VPA using gene expression changes linked to phenotypic alterations in cells. (plos.org)
  • Treatment with VPA and LiCl resulted in the differential expression of 331 and 164 genes respectively. (plos.org)
  • According to the International Society of Nutrigenetics/Nutrigenomics, 2 the way to explain nutrigenomics is to say that dietary substances can influence gene expression. (nutritionaloutlook.com)
  • The expression of these gene products can have some very specific effects on our health and wellbeing. (nutritionaloutlook.com)
  • For applications such as gene expression, fusion gene or mutation detection, QIAseq Stranded mRNA Select Kits include an optimized mRNA enrichment protocol with all the reagents and components required to build high-quality RNA-seq libraries. (qiagen.com)
  • Alcohol use disorders are associated with a unique impact on airway epithelial cell gene expression. (cdc.gov)
  • Smoking-related alterations on airway gene expression are well described, but little is known about the impact of AUDs. (cdc.gov)
  • We measured gene expression in human airway epithelial cells (AECs), hypothesizing that AUDs would be associated with novel differences in gene expression that could alter risk for CAP. (cdc.gov)
  • RNA was extracted from AECs, and mRNA expression data were collected on an Agilent micro-array. (cdc.gov)
  • After adjustment for smoking, AUDs were associated with significant differential expression of 520 AEC genes, including genes for ribosomal proteins and genes involved in protein folding. (cdc.gov)
  • Smoking-associated AEC gene expression differences mirrored previous reports, but differed from those associated with AUDs. (cdc.gov)
  • Conclusions: AUDs have a distinct impact on AEC gene expression that may influence proximal airway function independent of smoking. (cdc.gov)
  • Data from ITS rDNA and the genes coding for translation elongation factor 1-α and DNA replication licensing factor mini-chromosome maintenance complex 7 support the distinctness of Mycoblastus s. str. (cambridge.org)
  • Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. (plos.org)
  • Find data in MPD that are associated with a particular mouse gene or chromosomal region. (jax.org)