ReductaseNADHGeneGenesAcyl carrierEnzymeDonorsRecombinant proteinStructural ClassifiElectronCytochromeLipidsMolecularNADPHKinaseFlavoproteinsCharacterizationDomain-containHypothetical proteinActivityOxidationPyruvateSpeciesMacromoleculesInteractionsCatalyticMembrane proteinLund UniversityFattySynthaseIdentical Protein GroupsComplementOxidative StressOrganismsHumanFamilyCellularCytoplasm
Reductase7
- While redox (reductase, oxidative and isomerase) activities of SsPDO point to its central role in the biochemistry of cytoplasmic disulfide bonds, chaperone activities also on an endogenous substrate suggest a potential role in the stabilization of intracellular proteins. (cnr.it)
- β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
- The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase. (genome.jp)
- This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). (thermofisher.com)
- Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in Profiles. (umassmed.edu)
NADH5
- This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). (nih.gov)
- Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (nih.gov)
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (nih.gov)
- Complex I, or NADH:quinone oxidoreductase, catalyzes the first step in the respiratory chain. (lu.se)
- The NADH binding site, FMN and eight FeS clusters are located in the promontory part, whereas the seven membrane-spanning proteins are all encoded by mitochondrial DNA in eukaryotes, in fact the Complex I encoding genes make up half of the mtDNA in mammals. (lu.se)
Gene4
- Our method considers a variety of features including protein sequences, gene co-expression, functional association, and phylogenetic profiles. (nature.com)
- The POR gene provides instructions for making the enzyme cytochrome P450 oxidoreductase. (medlineplus.gov)
- Because cytochrome P450 oxidoreductase helps regulate the activity of these enzymes, researchers suspect that normal variations in the POR gene may influence a person's response to particular drugs (drug metabolism). (medlineplus.gov)
- More than 50 mutations in the POR gene have been found to cause cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
Genes4
- Here, we build large, intact carboxysome shells (over 90 nm in diameter) in the industrial microorganism Escherichia coli by expressing a set of carboxysome protein-encoding genes. (nature.com)
- The antioxidant response element, or ARE, present in the promoters of many antioxidant protein genes is a major regulatory lynchpin in this cellular response. (asbmb.org)
- Transcription factor Nrf2 is a key regulator of genes encoding phase II detoxification enzymes and antioxidant proteins in response to environmental chemical insults. (cdc.gov)
- We reported here that Cd induces cytoprotective genes NAD(P)H-quinone oxidoreductase I (Nq01) and heme oxygenase I (Ho-1) via the Nrf2/Keap1 pathway. (cdc.gov)
Acyl carrier1
- An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. (umassmed.edu)
Enzyme3
- Oxidoreductases (EC 1.x.x.x) are the first enzyme class in the Enzyme Commission Nomenclature. (medchemexpress.com)
- The classical Complex I enzyme is composed of seven membrane-spanning protein subunits and seven protein subunits protruding into the cytoplasm (in bacteria) or into the mitochondrial matrix (in eukaryotes). (lu.se)
- FAO is a complex enzyme which consists of two separate proteins that sequentially catalyze the oxidation of fatty alcohol to fatty aldehyde and fatty acid. (jci.org)
Donors3
- Oxidoreductases Acting on Sulfur Group Donors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Harvard Catalyst Profiles by year, and whether "Oxidoreductases Acting on Sulfur Group Donors" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Oxidoreductases Acting on Sulfur Group Donors" by people in Profiles. (harvard.edu)
Recombinant protein4
- E. coli-derived human WWOX recombinant protein (Position: M1-D245). (thermofisher.com)
- Full length human recombinant protein of human SPR(NP_003115) produced in HEK293T cell. (origene.com)
- As such, we provide services and make equipment available in the areas of recombinant protein production, crystallisation, biophysical characterization, and structure determination. (lu.se)
- LP3 is fully equipped for recombinant protein production in E. coli and insect cells (BEVS) and protein purification using state of the art chromatography systems. (lu.se)
Structural Classifi1
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Electron1
- Oxidoreductases are a large group of enzymes that catalyze the transfer of electrons from one molecule (the oxidant, the hydrogen or the electron donor) to another molecule (the reductant, the hydrogen or electron acceptor). (medchemexpress.com)
Cytochrome3
- Most of the mutations that cause cytochrome P450 oxidoreductase deficiency change single protein building blocks (amino acids) in cytochrome P450 oxidoreductase. (medlineplus.gov)
- Reduced activity of cytochrome P450 oxidoreductase can also disrupt the production of cholesterol, which likely impairs normal bone formation in severe cases of cytochrome P450 oxidoreductase deficiency. (medlineplus.gov)
- if a shortage of cytochrome P450 oxidoreductase prevents retinoic acid from being broken down, the resulting excess of that molecule can stimulate the abnormal growth and fusion of bones. (medlineplus.gov)
Lipids4
- Unlike protein localization, identification of critical differences in membrane content has not yet been expanded to lipids, due to the difficulty of isolating domain-specific samples. (nih.gov)
- We have overcome this by using SMA to coimmunopurify membrane proteins and their native lipids from two regions of photoreceptor ROS disks. (nih.gov)
- Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins or DNA. (asbmb.org)
- LP3 is colocalised with and closely collaborates with the DEMAX platform of the ESS on production of deuterium labeled biomolecules (proteins, lipids) for neutron scattering experiments and the development of methods for crystal growth for neutron crystallography. (lu.se)
Molecular4
- Therefore, in the lab we working with molecular biological approaches such as making mutants and fusion proteins but also purely biochemical/biophysical projects, purifying proteins for reconstitution into liposomes, where the ion translocation activities can be measured by Na+ NMR using a shift reagent or by a pH sensitive, membrane-impermeable dye denoted Glu3. (lu.se)
- In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of enzymes with oxidoreductase activity. (wikipedia.org)
- It is a monomeric protein with a molecular mass of 60 kDa and high reactivity at neutral pH. (sigmaaldrich.com)
- And there tended to be a low-molecular-weight protein that was always induced. (asbmb.org)
NADPH1
- These antioxidant enzymes include glutathione S -transferase, or GST, NADPH:quinone oxidoreductase 1, thioredoxin and hemeoxygenase-1. (asbmb.org)
Kinase1
- Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
Flavoproteins1
- The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases. (wikipedia.org)
Characterization1
- LP3 and PPS offer services for the entire process chain of production, purification, characterization, protein crystallisation and protein structure determination and structure refinement, or each individual step in the chain. (lu.se)
Domain-contain1
- 25637 PKD domain containing protein CP001857 CDS Arcpr_0030 complement(25624. (go.jp)
Hypothetical protein15
- 9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
- 10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
- 13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
- 13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
- 19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
- 21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
- 23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
- 29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
- 29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
- 36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
- 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
- 43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
- 47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
- 52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
- 53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
Activity6
- Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. (betalifesci.com)
- High-resolution profiling of the ROS disk lipid composition gives new insights into how intricate membrane structure and protein activity are balanced within the ROS, and provides a model for future studies of other complex cellular structures. (nih.gov)
- Predicted to enable oxidoreductase activity. (mcw.edu)
- Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. (yeastrc.org)
- Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts. (jci.org)
- Sjögren-Larsson syndrome (SLS) is an inherited disorder associated with impaired fatty alcohol oxidation due to deficient activity of fatty alcohol:NAD+ oxidoreductase (FAO). (jci.org)
Oxidation2
- Oxidoreductases are a fundamental class of enzymes responsible for the catalysis of oxidation-reduction reactions, crucial in most bioenergetic metabolic pathways. (medchemexpress.com)
- Oxidoreductases with specificity for oxidation or reduction of SULFUR COMPOUNDS. (harvard.edu)
Pyruvate1
- The pulse of acetogenesis appears to have been collectively catalyzed by a number of different organisms and metabolisms, most prominently pyruvate:ferredoxin oxidoreductase. (frontiersin.org)
Species2
- Other representative plant species cover even less protein involved in known PPIs. (nature.com)
- Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARAE1_ARATH . (yeastrc.org)
Macromolecules1
- LP3 is the only academic protein production platform in Sweden providing specialisation in protein production using the baculovirus expression vector system (BEVS, insect cells) and perdeuteration of biological macromolecules. (lu.se)
Interactions4
- The comparatively few differences between the two rim samples likely reflect specific protein-lipid interactions. (nih.gov)
- Protein-protein interactions (PPIs) play essential roles in many biological processes. (nature.com)
- Identification of protein-protein interactions (PPIs) is important for understanding how proteins work together in a coordinated fashion in a cell to perform cellular functions. (nature.com)
- Even for Arabidopsis , known PPI data cover interactions with only about 34.55% of proteins. (nature.com)
Catalytic1
- The naturally designed architecture, semi-permeability, and catalytic improvement of carboxysomes have inspired rational design and engineering of new nanomaterials to incorporate desired enzymes into the protein shell for enhanced catalytic performance. (nature.com)
Membrane protein1
- This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. (nih.gov)
Lund University1
- Lund Protein Production Platform (LP3) is a cross-faculty expert center and user facility of Lund University (LU). (lu.se)
Fatty1
- Important cytoprotective mechanisms activated by oxidative inflammatory conditions are mediated by nitrated fatty acids that covalently modify proteins to limit inflammation and oxidant stress. (aspetjournals.org)
Synthase1
- 38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
Identical Protein Groups1
- See the results of this search (89 items ) in our new Identical Protein Groups database. (nih.gov)
Complement10
- 6097 beta-lactamase domain protein CP001857 CDS Arcpr_0005 complement(6094. (go.jp)
- 30270 beta-lactamase domain protein CP001857 CDS Arcpr_0037 complement(30271. (go.jp)
- 32303) chromosome segregation and condensation protein%2C ScpB CP001857 CDS Arcpr_0039 complement(32287. (go.jp)
- 32898) chromosome segregation and condensation protein ScpA CP001857 CDS Arcpr_0040 complement(32907. (go.jp)
- 36314) chromosome segregation protein SMC CP001857 CDS Arcpr_0041 complement(36316. (go.jp)
- 40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
- 43228) protein of unknown function UPF0153 CP001857 CDS Arcpr_0051 complement(43225. (go.jp)
- 44065 protein of unknown function UPF0047 CP001857 CDS Arcpr_0053 complement(44048. (go.jp)
- 45260 protein of unknown function DUF121 CP001857 CDS Arcpr_0055 complement(45235. (go.jp)
- 55699) Ribosomal protein L15e CP001857 CDS Arcpr_0066 complement(55738. (go.jp)
Oxidative Stress1
- Many of these proteins are commonly expressed in cells exposed to oxidative stress. (asbmb.org)
Organisms1
- A potential role in disulfide bond formation in the intracellular proteins of thermophilic organisms has recently been ascribed to a new family of protein disulfide oxidoreductases (PDOs). (cnr.it)
Human4
- Catalase Protein, Human is an approximately 60.0 kDa human catalase protein expressed in E.coli . (medchemexpress.com)
- Our protein products do not contain carrier protein or other additives (such as bovine serum albumin (BSA), human serum albumin (HSA) and sucrose, etc., and when lyophilized with the solution with the lowest salt content, they often cannot form A white grid structure, but a small amount of protein is deposited in the tube during the freeze-drying process, forming a thin or invisible transparent protein layer. (betalifesci.com)
- Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2. (harvard.edu)
- The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. (thermofisher.com)
Family5
- 1251 orc1%2Fcdc6 family replication initiation protein CP001857 CDS Arcpr_0002 1251. (go.jp)
- 9195) PhoH family protein CP001857 CDS Arcpr_0008 9278. (go.jp)
- 41666) ExsB family protein CP001857 CDS Arcpr_0048 41748. (go.jp)
- 45756) PEBP family protein CP001857 CDS Arcpr_0056 45795. (go.jp)
- 47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
Cellular2
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. (thermofisher.com)
- PPIs are essential for individual protein functions, forming various cellular pathways, and are also involved in the development of diseases. (nature.com)
Cytoplasm1
- Both proteins were ubiquitinated in the cytoplasm. (cdc.gov)