Proteins or glycoproteins structurally carrier proteins. Medical search. Frequent questions

Here we discuss two approaches currently used to investigate the global dynamics of phosphorylation based on the isolation of phosphorylated proteins or peptides. (acs.org)

Although present also in other key regulatory proteins of cholesterol biosynthesis, uptake, and signaling, the structure and mechanism of action of the SSD are unknown. (duke.edu)
However our demonstration of glycoprotein biosynthesis in the model bacterium Escherichia coli, through the activity of a novel C. jejuni oligosaccharyltransferase (CjPglB), is a significant advance (Wacker et al, Science 2002). (ukri.org)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
My additional independent research on ER localisation and splicing in auxin biosynthesis showed for the first time ER-localisation for an auxin biosynthetic protein. (brookes.ac.uk)

Rifampin (an organic anion-transporting peptide 2 inhibitor) or GG918 [GF120918 ( N -(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide)] (a potent P-glycoprotein inhibitor) were used to estimate effects of uptake or efflux transporters on digoxin metabolism. (aspetjournals.org)
Many of the well studied efflux transporters, such as P-glycoprotein (P-gp), MRP2, and BCRP are members of the ATP-binding cassette transporter superfamily. (aspetjournals.org)
These pumps have broad drug specificity and belong to a family of ATP-binding cassette (ABC) transporters, of which P-glycoprotein (PGP) is one of the most important members. (savedelicious.com)
In our studies on neurotransmitter metabolism we have focused our efforts on transporters, a functional class of proteins that move neurotransmitters and other small molecules across membranes in cells. (stanford.edu)

The hydrophobic part is located towards the inside, while the hydrophilic regions are located towards the outside of the membrane, which is why they are called glycoproteins. (scienceasker.com)
As I have explained before, there are two polar R groups, an area of the protein that is outside the bilayer (hydrophilic bond), while the non-polar R groups, an area of the protein that is in contact with the bilayer (hydrophobic bond). (scienceasker.com)
Wnt-3a is a highly conserved lipid-modified, secreted hydrophobic glycoprotein with conserved 24 cysteine residues that is essential for cell signaling. (biolegend.com)
In biological macromolecules like proteins, the hydrophobic residues tend to clump together in the interior of the folded structure. (cheap-essay.org)

Transcriptomic analysis of the two recombinant strains in comparison with the control strain showed that the correct folding of proteins assisted by molecular chaperones played a key role in the improvement of FumDM expression and its enzyme activity. (inra.fr)

The former are membrane-spanning proteins. (scienceasker.com)

However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
P-gp shows resistance to a wide range of structurally, chemically, and functionally diverse compounds. (japsonline.com)

As MKs require they appear route( protein) and Membrane of initial storage to embryogenesis drugs larger than 50-100 genes, and synthesis dissociates up to 128 N. As MK's mature, the autosomal codon is covalent, the platelet is, and bile languages and the knowledge pathway checkpoint are characterized. (familie-vos.de)
We have recently identified and characterised a gene cluster (pgl) which is responsible for the synthesis of glycoproteins in the bacterial food-borne pathogen, Campylobacter jejuni. (ukri.org)
These are called so, because they are not dependent upon nuclear DNA and cytoplasmic ribosomes for the synthesis of proteins, while other organelles are dependent. (psebsolutions.com)
This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
present structures of a protein complex in which protein E of bacteriophage φX174 functions to inhibit host peptidoglycan synthesis, thereby inducing lysis. (x-mol.com)
Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)

MDR1 codes for P-glycoprotein (P-gp), a member of the ABC transporter superfamily of proteins that promote cellular efflux of chemotherapeutic agents. (sphingolipidclub.com)
AtDTX1 (At2g04040) has been identified as a detoxifying efflux carrier for plant-derived antibiotics and other toxic compounds, including CD2+. (or.jp)

Cancer cells are constantly using a variety of tools, involving genes, proteins, and altered pathways, to ensure their survival against antineoplastic drugs. (wikipedia.org)
Wnt-3a belongs to Wnt family of proteins that consist of structurally related genes encoding highly conserved cysteine rich secreted glycoproteins. (biolegend.com)
Intracellular accumulation of beta-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to promote expression of Wnt target genes. (biolegend.com)
We have been able to transfer the segment of DNA containing the pgl genes into E. coli to produce recombinant glycoproteins, thus opening up the field of glycoengineering. (ukri.org)

Nano-DESI MSI is an ambient ionization technique that has been previously used for imaging of metabolites, lipids, and proteins in biological tissue samples without special sample pretreatment. (bvsalud.org)

Uptake and degradation is facilitated if the protein is structurally modified. (eclinpath.com)

To ascertain if the specificity of the natural and mutated PglBs have been altered we will test separate capsular polysaccharides from the important pathogens Streptococcus pneumoniae and Burkholderia pseudomallei to determine if the respective capsules can now be coupled/conjugated to an appropriate carrier protein. (ukri.org)
Recently, along with our collaborators we have demonstrated that CjPglB has a relaxed specificity enabling transfer of diverse polysaccharides, including lipopolysaccharide and capsules, to proteins with appropriate D/E-X-N-Z-S/T consensus sequons. (ukri.org)

Subsequently, thyroglobulin (Tg), a large glycoprotein containing multiple tyrosine residues, is synthesized in the rough endoplasmic reticulum of thyroid follicular cells. (myendoconsult.com)

The 334 amino acid recombinant protein has a predicted molecular mass of approximately 37.4 kD. (biolegend.com)
Why choose BioLegend recombinant proteins? (biolegend.com)

A family of transmembrane proteins that function primarily as calcium-activated chloride channels. (bvsalud.org)
Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. (bvsalud.org)

The eucaroite cell is much more complex than the prokaryotic cell since, in addition to structurally differentiating, there are also many more cellular organelles than in the prokaryotic cell. (scienceasker.com)
Ubiquitins and ubiquitin-like proteins participate in diverse cellular functions, such as protein degradation and HEAT-SHOCK RESPONSE , by conjugation to other proteins. (nih.gov)

It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)

We will seek to identify or engineer alternative PglB proteins that will have a modified specificity for different glycostructures. (ukri.org)

In order to evoke an appropriate immune response, vaccines against these bacteria consist of capsule linked to a protein carrier forming a glycoprotein or glycoconjugate. (ukri.org)

I took up a position at Oxford Brookes University in 2012 investigating the role of reticulon proteins in ER tubulation and viral trafficking in order to develop my international reputation in ER research and advanced imaging. (brookes.ac.uk)

Active Transport: As the polar molecules cannot pass through the nonpolar lipid bilayer, they require a carrier protein of the membrane to facilitate their transport across the membrane. (psebsolutions.com)
Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)

The latter processes enhance degradation of albumin, which likely occurs within macrophages via scavenger receptors (e.g. glycoprotein 18). (eclinpath.com)
Wnts bind Frizzled receptors and forms complex with low-density lipoprotein receptor-related protein (LRP5 or LRP6) which results in the stabilization of intracellular beta-catenin levels. (biolegend.com)

Albumin is a globular protein with a molecular weight of 66-69,000 daltons (66-69 kDa). (eclinpath.com)
Albumin makes a large contribution to plasma colloid osmotic pressure due to its small size and abundance (35-50% of total plasma proteins by weight). (eclinpath.com)
Aside from being a carrier for molecules, albumin is also thought to be an anti-oxidant protein by scavenging reactive oxygen species, protecting bound substances from oxidant injury, and binding free copper, which acts as an oxidant ( Merlot et al 2014 ). (eclinpath.com)
Most thyroxine is bound to carrier proteins, such as thyroxine-binding globulin (TBG), transthyretin, and albumin in circulation, with only a tiny fraction (approximately 0.03%) present as free thyroxine (FT4)[3]. (myendoconsult.com)
T3 circulates bound to carrier proteins (mainly TBG and albumin), with a small fraction (approximately 0.3%) existing as free triiodothyronine (FT3). (myendoconsult.com)

Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine arm of its donor substrate and weakly binds the acyl carrier protein. (du.ac.in)
It is disclosed herein that the HIV-1 envelope protein gp120 binds to α4β7 integrin on CD4+ T-cells, natural killer (NK) cells and CD8+ T-cells. (justia.com)

The leads of download tarih and power peptide are within a ER pore where proteins, reactions and expression rafts are neurological factors( Avecilla et al. (familie-vos.de)

7 Remoxipride also increases expression of the protein Fos in the nucleus accumbens but not the dorsolateral striatum, which may be responsible for a reduced incidence of extrapyramidal symptoms. (drugbank.com)
In which organelle the proteins required for functioning of nucleus are formed? (psebsolutions.com)

The vast majority of proteins entering the secretory pathway are synthesized on ribosomes docked at ER translocons and are co-transationally translocated into the ER lumen. (stanford.edu)

Remoxipride is approximately 80% protein bound, mainly to α-1-acid glycoprotein. (drugbank.com)
Structurally, T4 comprises four iodine atoms bound to a tyrosine-derived backbone. (myendoconsult.com)

Characteristics of resistant cells include altered membrane transport, enhanced DNA repair, apoptotic pathway defects, alteration of target molecules, protein and pathway mechanisms, such as enzymatic deactivation. (wikipedia.org)
N-linked glycans are released from glycoproteins using an established enzymatic digestion with peptide N-glycosidase F, and their spatial localization is examined using nano-DESI MSI. (bvsalud.org)

This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)

The primary immunologic abnormality resulting from infection by human immunodeficiency virus (HIV) is the progressive depletion and functional impairment of T lymphocytes expressing the CD4 cell surface glycoprotein. (justia.com)

They underlie genetic disease in roughly 15% of patients with multiple congenital abnormalities and/or mental retardation (MCA/MR). In genetic diagnostics, the pathogenicity of chromosomal aberrations in these patients is typically assessed based on criteria such as phenotypic similarity to other patients with the same or overlapping aberration, absence in healthy individuals, de novo occurrence, and protein coding gene content. (biomedcentral.com)
However, with early diagnosis of active disease, identification of asymptomatic protoporphyrinogen oxidase gene mutation carriers, and avoidance of drugs and other factors known to induce or worsen clinical expression, symptomatology among those at risk can be minimized. (medscape.com)

Each follicle is composed of a rim of simple cuboidal epithelial cells encircling a mass of colloidal storage protein named thyroglobulin. (myendoconsult.com)
Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. (mdpi.com)

Screening of a phage-display library demonstrated that two glycoprotein-specific mAbs recognized a conserved sequence, WxxxDI, which aligned between aa 14 and 19 of the mature glycoprotein. (microbiologyresearch.org)

It is used in protein biochemistry. (lookformedical.com)

The key enzyme in the C. jejuni pathway that couples proteins to sugars is the oligosaccharyltransferase protein termed CjPglB. (ukri.org)
Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)

If an integrin protein is mutated what cell function might be affected? (cheap-essay.org)

As new SARS-CoV-2 variants emerge and displace circulating virus strains, we recommend that standardized binding antibody assays that include spike protein-based antigens be utilized to estimate antibody concentrations correlated with protection from COVID-19. (cdc.gov)

I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)

Also the main mechanism of resistance to these drugs will be explored, particularly focusing on the role of P-glycoprotein and how it can be modulated to reverse drug resistance. (savedelicious.com)

Wnt family proteins have been implicated in oncogenesis and in multiple developmental processes including regulation of cell fate and patterning during embryogenesis. (biolegend.com)
Its crystal structure reveals a previously unknown outward-facing state of the protein family. (nature.com)
A family of proteins that are structurally-related to Ubiquitin. (nih.gov)

Iodide ions are then transported to the apical membrane of the thyroid follicular cells by the action of pendrin, an anion exchanger protein. (myendoconsult.com)
However, despite the success of these glycoconjugate vaccines they have major drawbacks in terms of the technical difficulties in purifying the capsule material from bacterial cells and then conjugating the capsule to carrier proteins. (ukri.org)
IFN-γ was measured in supernatants after in vitro stimulation of peripheral blood mononuclear cells with collagen type II (CII), purified protein derivative or influenza virus. (biomedcentral.com)

The ER is the 'port of entry' for proteins destined for the cell surface and beyond. (stanford.edu)

It also serves as a carrier protein for many insoluble organic substances (e.g., unconjugated bilirubin, long chain fatty acids) and drugs. (eclinpath.com)

The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)
These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)

Identification of type-specific domains within glycoprotein G of herpes simplex virus type 2 (HSV-2) recognized by the majority of patients infected with HSV-2, but not by those infected with HSV-1. (microbiologyresearch.org)
Here we report a crystal structure of a large fragment of human NPC1 at 3.6 Å resolution, which reveals internal twofold pseudosymmetry along TM 2-13 and two structurally homologous domains that protrude 60 Å into the endosomal lumen. (duke.edu)

Antigenic structure of rabies virus glycoprotein: ordering and immunological characterization of the large CNBr cleavage fragments. (microbiologyresearch.org)

Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
Instead, damaged or incorrectly synthesized proteins must be rapidly and efficiently destroyed lest they form toxic aggregates. (stanford.edu)

Identification of amino acids controlling the low-pH-induced conformational change of rabies virus glycoprotein. (microbiologyresearch.org)

The DTT-reduced protein migrates at approximately 41 kD. (biolegend.com)

Anatomy15

Organisms18

Chemicals and Drugs148

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes47

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science5

Health Care2

Peptides1

Biosynthesis4

Transporters4

Hydrophobic4

Assisted by molecular chaperones1

Membrane-spanning1

Functionally2

Synthesis6

Efflux2

Genes4

Biological1

Uptake1

Polysaccharides2

Residues1

Recombinant2

Transmembrane2

Cellular2

Conformation1

Specificity1

Consist1

Viral1

Lipid bilayer2

Receptors2

Albumin5

Binds2

Pore1

Nucleus2

Ribosomes1

Bound2

Enzymatic2

Molecular1

Functional1

Gene2

Colloidal2

Conserved sequence1

Biochemistry1

Pathway2

Integrin1

Assays1

Membranes1

Resistance1

Family3

Cells3

Cell surface1

Substances1

Highly2

Domains2

Large1

Form2

Identification1

Approximately1