• With additional research and clinical studies, doctors could refine treatment protocols so that patients at higher risk are treated appropriately, but patients at lower or no risk of metastasis are not over-treated. (medindia.net)
  • Among several nuclear interacting protein partners suggested for S100A4, the tumor suppressor protein p53 has attracted particular interest, and previous studies suggest direct and indirect modes of interaction between the two proteins. (springer.com)
  • In conclusion, S100A4 and p53 were shown to be colocalized in individual nuclei of CRC cells, and it might be speculated whether the proteins interact in this subcellular compartment. (springer.com)
  • In addition, our studies demonstrated that MUC4 up-regulates the EGFR family of proteins, and augments downstream Erk1/2, PKC-γ, and FAK mediated oncogenic signaling. (sigmaaldrich.com)
  • MTA1, the founding member of the MTA family, a component of the nucleosome remodeling and histone deacetylation (NuRD) complex [ 8 ], exhibits effects on contributing to the DNA damage response, controlling the steady state of proteins via protein ubiquitination, and maintaining expressed states in a wide variety of human epithelial malignancies [ 9 , 10 ]. (hindawi.com)
  • Paradoxically, for localized disease, higher MTA1 protein expression was associated with lower rates of prostate specific antigen recurrence after radical prostatectomy for localized disease. (aacrjournals.org)
  • MTA1 increased the expression of HIF-1α protein, but did not increase the expression of its mRNA. (spandidos-publications.com)
  • Pancreatic ductal adenocarcinomas (PDAs) are desmoplastic and can undergo epithelial-to-mesenchymal transition to confer metastasis and chemoresistance. (jci.org)
  • We think that these peptides have a high potential for tumor therapy, above all for the treatment of pancreatic cancer with its aggressive metastases,' Véronique Orian-Rousseau of the Institute of Toxicology and Genetics (ITG) of KIT says. (scienmag.com)
  • Moreover, already existing metastases regressed or disappeared completely: 'This is the most remarkable result with respect to pancreatic cancer, the diagnosis of which mostly is possible after the formation of metastases only,' Orian-Rousseau says. (scienmag.com)
  • Conversely, knockdown of these proteins using respective siRNAs reversed the invasiveness of the lung cancer cells. (ovid.com)
  • We also demonstrated in this study, for the first time, that knockdown of MUC4 was associated with reduced expression of EGFR and ErbB3 (EGFR family proteins) in TNBC cells, suggesting that MUC4 uses an alternative to ErbB2 mechanism to promote aggressiveness. (sigmaaldrich.com)
  • Additionally, the group looked downstream from KDM3A to show that another protein known as Melanoma Cell Adhesion Molecule (MCAM) may be another essential link in the chain of events that leads to metastasis. (coloradocancerblogs.org)
  • The interacting partner and downstream target of Tid1-interacting client protein were determined. (thno.org)
  • Recent work from our laboratory suggests that inhibiting the upregulation of cytoskeletal signaling could offer potential therapeutic targets for metastasis control. (arvojournals.org)
  • While genetic deletion of FAP did not affect primary tumor weight in advanced disease, FAP deficiency increased tumor necrosis and impeded metastasis to multiple organs. (jci.org)
  • Together, our data suggest that miR-144 suppression may be the cause of the increased levels of AP4, as well as the augmented cancer metastases, in NSCLC. (springer.com)
  • In the present study, we investigated the function and potential molecular mechanism of KHSRP in non-small cell lung cancer (NSCLC) metastasis and elucidated its clinical significance. (springer.com)
  • Isobaric tags for relative and absolute quantitation and the SWATH™ approach were combined with nanoliquid chromatography-tandem mass spectrometry analysis to identify metastasis-associated nucleoproteins in NSCLC. (springer.com)
  • Specifically, the group used global gene expression profiling to show that the presence of KDM3A up-regulates pathways known to be involved in migration and metastasis. (coloradocancerblogs.org)
  • TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. (wikipedia.org)
  • MDA-MB-231 cells transfected with the cDNA for human preproPTH-rP secreted a tenfold greater amount of PTH-rP and caused significantly greater bone metastases when inoculated into the left cardiac ventricle of female nude mice compared with parental cells. (nih.gov)
  • Treatment of mice with a neutralizing monoclonal antibody to human PTH-rP resulted in a decrease in the development and progression of bone metastasis due to the parental MDA-MB-231 cells. (nih.gov)
  • Mice inoculated into the left cardiac ventricle with MDA/TbetaRIIdeltacyt had fewer and smaller bone metastases as assessed radiographically and histomorphometrically compared with controls. (nih.gov)
  • Ambartsumian NS, Grigorian MS, Larsen IF, Karlstrom O, Sidenius N, Rygaard J, Georgiev G, Lukanidin E (1996) Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene. (springer.com)
  • Keratinocyte-specific Tid1-deficient mice with 4-nitroquinoline-1-oxide (4NQO) treatment exhibited increased protein levels of Galectin-7 and had a poor survival rate. (thno.org)
  • EZH2 silences gene expression by attaching a methyl group, which consists of one carbon and three hydrogen atoms, to a histone protein that is intertwined with DNA and other proteins to compose chromosomes. (medindia.net)
  • Parathyroid hormone-related protein and bone metastases. (nih.gov)
  • Clinical evidence supports another important role for PTH-rP in malignancy as a mediator of the bone destruction associated with osteolytic metastasis. (nih.gov)
  • To investigate the role of PTH-rP in the pathophysiology of breast carcinoma metastasis to bone, the human breast carcinoma cell line MDA-MB-231 was studied in a murine model of human breast carcinoma metastasis to bone. (nih.gov)
  • The role of bone-derived TGF-beta in the development and progression of bone metastasis was studied by transfecting MDA-MB-231 cells with a cDNA encoding a TGF-beta type II receptor lacking a cytoplasmic domain, which acts as a dominant negative to block the cellular response to TGF-beta. (nih.gov)
  • Taken together, these data suggest that PTH-rP expression by breast carcinoma cells enhance the development and progression of breast carcinoma metastasis to bone. (nih.gov)
  • Bronckart Y, Decaestecker C, Nagy N, Harper L, Schafer BW, Salmon I, Pochet R, Kiss R, Heizman CW (2001) Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins. (springer.com)
  • Understanding the molecular basis by which metastasis of HNSCC is promoted may contribute to the development of a better treatment for decreasing the mortality of this cancer. (thno.org)
  • We performed the scratch-wound assay to investigate cellular migration and Western blot analyses for protein expression and phosphorylation of paxillin. (arvojournals.org)
  • The TFD (Thomsen-Friedenreich disaccharide) antigen in the fish protein is hidden in normal human cells but is exposed on the surface of cancer cells and is believed to play a key role in how cancer spreads. (innovations-report.com)
  • Fibroblast activation protein-expressing (FAP-expressing) cells act to enhance PDA progression, while α-smooth muscle actin myofibroblasts can restrain PDA. (jci.org)
  • We have devised a new light switch to turn off and back on specific proteins within seconds inside living cells using light. (statnews.com)
  • We think this is a broadly useful tool to figure out how proteins make cells work. (statnews.com)
  • Because we are interested in how the microtubule cytoskeleton helps cells accomplish complex tasks, such as change their shape, move or divide, we chose a protein as proof-of-principle that controls how microtubules interact with other structures inside cells. (statnews.com)
  • The team's basic research findings provide a rationale for developing an EZH2 inhibitor or a drug that mimics the protein that deactivates it as new cancer drugs. (medindia.net)