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  • Peptides
  • Self amd Foreign 60-Kilodalton Heat Shock Protein T Cell Epitope Peptides Serve As Immunogenic Carriers for a T Cell-Independent Sugar Antigen", J. Immunol. (patentgenius.com)
  • The selectivity of binding of low-molecular-weight constituents for different classes of carrier proteins was explored further (17,18), revealing that subsets of bound low-molecular-weight peptides and sequenced protein fragments associated with albumin were different from those bound to immunoglobulin, apolipoprotein, and transferrin (18). (thefreedictionary.com)
  • However, its signficantly better solubility provides greater flexibility in immunogen preparation protocols by allowing a broader range of buffer and pH conditions for coupling peptides, proteins and other haptens using classical crosslinkers such as glutaraldehyde, Sulfo-SMCC and EDC. (thermofisher.com)
  • Successful production of antibodies specific to small antigens (i.e., peptides or drug compounds) requires that these haptens be covalently conjugated to a larger, more complex molecule (usually a protein) to make them immunogenic. (thermofisher.com)
  • Because of their large size and molecular complexity, KLH and CCH hemocyanins are carrier proteins of choice for use as immunogens to produce antibodies against haptens and peptides. (thermofisher.com)
  • fatty acid syn
  • have devised a procedure to reconstitute E.Coli Fatty Acid Synthase using purified protein components ( including FabD) and reported a detailed kinetic analysis of this in-vitro reconstituted system. (wikipedia.org)
  • mammalian
  • A homologous protein, which can be rendered ineffective by the antibody to pure chicken riboflavin carrier protein, has been shown to occur in several mammalian species, including two species of monkeys, and also in humans. (wikipedia.org)
  • Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H. Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. (wikipedia.org)
  • Gene
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • ACPs
  • The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. (wikipedia.org)
  • The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. (wikipedia.org)
  • bound
  • Separate from this, the carrier can also flip between the two conformations when A is not bound, and the likelihood of one conformation or the other is not as dependent on the concentration of A inside or out. (madsci.org)
  • Without A bound, the "carrier out" conformation is probably favored, but even if the two states are pretty much equally likely the same concentration gradient that powers steps 1-3 will lead to the empty carrier flipping back to be open to the outside. (madsci.org)
  • This study examined the proportion of LMM biomarkers, which are bound to circulating carrier proteins. (hindawi.com)
  • Mass spectroscopic analysis of human serum following molecular mass fractionation, demonstrated that the majority of LMM biomarkers exist bound to carrier proteins. (hindawi.com)
  • Moreover, the pattern of LMM biomarkers bound specifically to albumin is distinct from those bound to non-albumin carriers. (hindawi.com)
  • Several insights emerged: a) Accumulation of LMM biomarkers on circulating carrier proteins greatly amplifies the total serum/plasma concentration of the measurable biomarker, b) The total serum/plasma biomarker concentration is largely determined by the carrier protein clearance rate, not the unbound biomarker clearance rate itself, and c) Examination of the LMM species bound to a specific carrier protein may contain important diagnostic information. (hindawi.com)
  • A diverse array of protein degradation fragments appear to accumulate in plasma, bound to carrier proteins such as albumin (18-20). (thefreedictionary.com)
  • 6) This is a significant number on its own, but the situation may be even worse when accounting for the fact that the majority of the hormone is bound to carrier proteins including sex hormone binding globulin (SHBG) and albumin and, as such, may not be available for tissues to use. (thefreedictionary.com)
  • Antigen
  • KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines. (hindawi.com)
  • subunits
  • Proteins 9, 10, 12, 22 and 54 are subunits of the TIM system that mediates import of multispanning carrier proteins into the inner membrane (IM). (gsf.de)
  • The CCH protein is composed of two very large polypeptide subunits (404/351 kDa) that form an extremely stable heterodidecameric structure even in the absence of divalent cations. (thermofisher.com)
  • transports
  • Kahn's group of researchers found 'RBP4, a protein that transports vitamin A in the blood may be a cause for insulin resistance' from animal studies. (medindia.net)
  • antibody
  • Antibody Responses to Haemophilus influenzae Type b and Diphtheria Toxin Induced by Conjugates of Oligosaccharides of the Type b Capsule with the Nontoxic Protein CRM",Infect. (patentgenius.com)
  • If this protein is rendered ineffective (e.g., by immuno-neutralization) by treatment of the bird with a specific antibody, then embryonic development ceases and the embryo dies. (wikipedia.org)
  • vitro
  • The stability, protein-loading rate, and in vitro release of BAY 55-9837 from CS-SeNPs were also quantified. (dovepress.com)
  • membrane
  • A carrier precursor exiting the TOM channel is captured by the 70 kDa Tim9/10-complex in the intermembrane space and transferred to the 300 kDa inner membrane complex that contains Tim9p, Tim10p, Tim12p, Tim22p and Tim54p. (gsf.de)
  • Binding to the Tim22-complex triggers the membrane potential dependent insertion of mulitspanning carrier into the inner membrane. (gsf.de)
  • Inner membrane proteins 11, 17, 23 and 44 are members of, or closely adjacent to, the second TIM system ( Tim17-complex )that mediates transport of precursors carrying a targeting presequence. (gsf.de)
  • membrane proteins that have a high affinity for particular solutes, e.g. glucose, and which facilitate the passage of these solutes through membrane barriers. (thefreedictionary.com)
  • The histidine rich desaturases tend to be integral membrane proteins. (wikipedia.org)
  • similar
  • If two conformations of a protein have similar energies and the energy barrier between the conformations is low enough, random thermal motions can convert the protein between the two conformations. (biology-online.org)