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  • 2000
  • http://arabidopsis.org/blast/ http://arabidopsis.org/cgi-bin/fasta/TAIRfasta.pl New sequences : 145 Updated sequences : 0 Updated annotation : 113 ====================== New DNA Sequences ======================= AF238326 AF238326 633bp mRNA PLN 24-APR-2000 Arabidopsis thaliana putative TATA binding protein associated factor 24kDa subunit mRNA, complete cds. (bio.net)
  • AF238327 AF238327 552bp mRNA PLN 24-APR-2000 Arabidopsis thaliana putative TATA binding protein associated factor 21kDa subunit (TAFII21) mRNA, complete cds. (bio.net)
  • AF136588 AF136588 1256bp mRNA PLN 23-APR-2000 Arabidopsis thaliana leucine-rich repeat protein FLR1 (FLR1) mRNA, complete cds. (bio.net)
  • inhibitor
  • Ponatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy. (drugbank.ca)
  • Tafinlar is a kinase inhibitor that was initially indicated as a single agent for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test [FDA label]. (drugbank.ca)
  • Ceritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. (drugbank.ca)
  • Cdk1-cyclin complexes are also governed by direct binding of Cdk inhibitor proteins (CKIs). (wikipedia.org)
  • subunit
  • The Escherichia coli dihydroxyacetone (Dha) kinase is an unusual kinase because ( i ) it uses the phosphoenolpyruvate carbohydrate: phosphotransferase system (PTS) as the source of high-energy phosphate, ( ii ) the active site is formed by two subunits, and ( iii ) the substrate is covalently bound to His218 K * of the DhaK subunit. (pnas.org)
  • DhaM, the phosphotransferase subunit of Dha kinase, is phosphorylated by the small phospho-carrier protein HPr of the PTS ( 1 ). (pnas.org)
  • Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. (uniprot.org)
  • putative TATA binding protein associated factor 24kDa subunit. (bio.net)
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining it to discrete locations within the cell. (wikipedia.org)
  • This protein has a cell cycle-dependent interaction with the RII subunit of PKA. (wikipedia.org)
  • pyruvate
  • Dihydroxyacetone phosphate (Dha-P), an intermediate for the synthesis of pyruvate, can be generated in bacteria through glycerol fermentation by the sequential actions of glycerol dehydrogenase forming dihydroxyacetone and Dha kinase generating Dha-P. Dha kinases are divided into two classes, those using ATP as the phosphoryl donor or those using the PTS-dependent DhaM protein to provide the phosphoryl group ( 1 ). (pnas.org)
  • Differential expression between tumor-bearing and control mice was notable for peptides from novel variants of muscle pyruvate kinase, malate dehydrogenase 1, glyceraldehyde-3-phosphate dehydrogenase, proteoglycan 4, minichromosome maintenance, complex component 9, high mobility group box 2, and hepatocyte growth factor activator. (aacrjournals.org)
  • ubiquitin
  • Sildenafil treatment significantly increased myocardial PKG activity and significantly reduced myocardial accumulation of CryAB R120G , ubiquitin conjugates, and aberrant protein aggregates in mice with CryAB R120G -based desmin-related cardiomyopathy. (ahajournals.org)
  • The ubiquitin-proteasome system (UPS) mediates the degradation of most intracellular proteins and regulates diverse cellular processes, including protein quality control. (ahajournals.org)
  • HIPK2
  • The protein is also referred to as SIP or "stress inducible protein" TP53INP1 has been shown to interact with HIPK2 and p53. (wikipedia.org)
  • There is evidence to suggest that HIPKs including HIPK2 are evolutionarily conserved proteins across a wide array of species. (wikipedia.org)
  • The HIPK2 protein is 1198 amino acids in length and has a molecular weight of 130.97 kilodaltons. (wikipedia.org)
  • In addition to its kinase domain, HIPK2 has two nuclear localization signals, a SUMO interaction motif, an auto-inhibitory domain a transcriptional co-repression domain, and several interaction domains, including one for p53. (wikipedia.org)
  • residues
  • Our results provide a comprehensive picture of the roles of the highly conserved active site residues of dihydroxyacetone kinases. (pnas.org)
  • Unlike other low molecular weight messengers that bind to and activate target cellular receptors, NO signaling is mediated by a coordinating complex between NO and transition metals or target cellular proteins, often via S-nitrosylation of cysteine residues. (wikipedia.org)
  • SH2 domains recognise specific amino acid sequences within proteins containing phosphotyrosine residues and SH3 domains recognise proline-rich sequences within specific peptide sequence contexts of proteins. (wikipedia.org)
  • 1999
  • Such oral use of MTX is in practice because of its fairly good intestinal absorption, which has been suggested to be mediated by a carrier-mediated transport system specific to folate and its analogs ( Sirotnak and Tolner, 1999 ). (aspetjournals.org)
  • mRNA
  • An important development in recent years is the substantial improvement in tandem mass spectrometry instrumentation for proteomics, allowing in-depth analysis and confident identifications even for proteins coded by mRNA transcript sequences expressed at low levels ( 6 - 8 ). (aacrjournals.org)
  • novel
  • We modified the ECgene database to include three-frame translations of the cDNA sequences ( 5 ) to determine the occurrence of novel splice variant proteins. (aacrjournals.org)
  • In this study, we have interrogated our modified ECgene database to identify both novel and known splice variants among circulating proteins. (aacrjournals.org)
  • mediates
  • In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. (uniprot.org)
  • regulation
  • Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. (semanticscholar.org)
  • Protein kinase C regulation of organic anion transport in renal proximal tubule. (semanticscholar.org)
  • Although the mechanisms through which PKD regulates protein trafficking have been well studied, little is known of the identity of transported cargo, and the relevance of this regulation to tumor development remains to be determined. (aacrjournals.org)
  • The protein is made up of several regions which directly relate to its function, regulation, and localization. (wikipedia.org)
  • plasma proteins
  • Here, we exploit this model to test the hypothesis that cancer-specific alternative splice variants can be identified by in-depth mass spectrometric analysis of plasma proteins from this mouse model of pancreatic cancer. (aacrjournals.org)
  • regulates
  • Conclusions- PKG positively regulates proteasome activities and proteasome-mediated degradation of misfolded proteins, likely through posttranslational modifications to proteasome subunits. (ahajournals.org)
  • Through this catabolic process, GSNOR regulates the cellular concentrations of GSNO and plays a central role in regulating the levels of endogenous S-nitrosothiols and controlling protein S-nitrosylation-based signaling. (wikipedia.org)
  • amino
  • Many studies have correlated characteristics of amino acids with crystallization propensity, as part of the effort to determine the factors that affect the propensity of protein crystallization. (biomedcentral.com)
  • Post-translational modification is a process where new functional group(s) are conjugated to the amino acid side chains in a target protein through reversible or irreversible biochemical reactions. (wikipedia.org)
  • The most abundant amino acids in the protein are serine, threonine and alanine, which make up approximately 30 percent of the proteins total amino acid count. (wikipedia.org)
  • The protein kinase domain is 330 amino acids long and is located near the N-terminus of the protein. (wikipedia.org)
  • structurally
  • Both ATP- and PTS-dependent Dha kinases display high structural similarity of their corresponding domains/subunits and are structurally distinct from other kinases. (pnas.org)
  • transmembrane
  • OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. (wikipedia.org)
  • Sodium-hydrogen exchange regulatory cofactor 2 has been shown to interact with SGK, Actinin alpha 4, Parathyroid hormone receptor 1, Phosphoinositide-dependent kinase-1, EZR, PODXL, Cystic fibrosis transmembrane conductance regulator and PLCB3. (wikipedia.org)
  • catalytic
  • In addition to this catalytic core, Cdk1, like other cyclin-dependent kinases, contains a T-loop, which, in the absence of an interacting cyclin, prevents substrate binding to the Cdk1 active site. (wikipedia.org)
  • enzymology
  • In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction CTP + dolichol ⇌ {\displaystyle \rightleftharpoons } CDP + dolichyl phosphate Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate. (wikipedia.org)
  • cellular
  • When expressed stably as a protein fused with green fluorescent protein (GFP-hPCFT/HCP1) in MDCKII cells, GFP-hPCFT/HCP1 was mainly localized at the apical membrane, and the cellular accumulation of MTX was higher from the apical side than from the basal side. (aspetjournals.org)
  • Studies of animal models have not been able to explain the disease mechanism of diabetes development in CEL-MODY ( 6 , 7 ), but cellular studies indicate that mutated CEL protein is misfolded ( 8 ). (diabetesjournals.org)
  • Activation of PKG increased proteasome peptidase activities, facilitated proteasome-mediated degradation of surrogate (enhanced green fluorescence protein modified by carboxyl fusion of degron CL1) and bona fide (CryAB R120G ) misfolded proteins, and attenuated CryAB R120G overexpression-induced accumulation of ubiquitinated proteins and cellular injury. (ahajournals.org)
  • German scientists Warburg and Christian discovered a yeast derived yellow protein required for cellular respiration in 1932. (wikipedia.org)
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • receptor
  • Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma. (drugbank.ca)
  • When gram-positive bacteria detect high concentration of AIP in the environment, AIP bind to a receptor to activate kinase. (wikipedia.org)
  • lipid
  • May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. (uniprot.org)
  • Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER). (wikipedia.org)
  • mammalian cells
  • Abgent has over fifteen years of experience producing recombinant proteins in E. coli and mammalian cells (CHO and HEK293, etc), and we have added a powerful yeast expression platform to our menu of services. (abgent.com)
  • coli
  • Here we report the crystal structure of the E. coli Dha kinase complex, DhaK-DhaL. (pnas.org)
  • The most studied representative of the PTS-dependent family is the Escherichia coli Dha kinase, which is composed of DhaK and DhaL subunits. (pnas.org)
  • Crystal structures for the two individual subunits of the E. coli PTS-dependent Dha kinase-DhaK ( 2 ) and DhaL ( 4 )-have been previously determined, as well as the structure of an ATP-dependent single chain, two-domain Dha kinase from Citrobacter freundii ( 5 ), which has 30% sequence identity to the E. coli kinase. (pnas.org)
  • fission
  • As a Golgi-resident protein, PKD has been shown to be essential for membrane fission and vesicle formation in the transport of cargo from the trans -Golgi network (TGN) to the plasma membrane ( 15-17 ). (aacrjournals.org)
  • apoptosis
  • It was particularly noteworthy that in cultured normal rat cholangiocytes, GSNO activated protein kinase B, protected against apoptosis, and enhanced UDCA-induced ATP release to the medium. (wikipedia.org)
  • metabolism
  • In biochemistry, flavin adenine dinucleotide (FAD) is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. (wikipedia.org)
  • human
  • Hence, to gain further insight into the disease mechanism, we further studied human CEL -mutation carriers using radiological methods and secretin-stimulated duodenal juice to examine the pancreatic proteome ( 9 ). (diabetesjournals.org)
  • Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C". Mol Cell Biol. (wikipedia.org)
  • peptides
  • Check out links to articles that cite our custom service antibodies, peptides, and proteins in major peer-reviewed journals, organized by research category. (abgent.com)
  • Isotopic labeling of cysteine-containing peptides from tumor-bearing mice and wild-type controls enabled relative quantification of the proteins. (aacrjournals.org)
  • pancreatic
  • In addition, our analysis of quantitative expression ratios reveals variant proteins that are differentially expressed in pancreatic cancer. (aacrjournals.org)
  • We therefore investigated nondiabetic and diabetic CEL -mutation carriers by pancreatic imaging studies and secretin-stimulated duodenal juice sampling. (diabetesjournals.org)
  • We identified multiple pancreatic cysts in all eight diabetic mutation carriers but not in any of the four nondiabetic mutation carriers or the six healthy controls. (diabetesjournals.org)