AnatomyOrganismsChemicals and DrugsPhenomena and ProcessesInformation Science
Viral Matrix ProteinsMarburgvirusVirus ReplicationViral ProteinsExtracellular Matrix ProteinsVirus AssemblyVirionExtracellular MatrixCysteine Loop Ligand-Gated Ion Channel ReceptorsCartilage Oligomeric Matrix ProteinMatrilin ProteinsNuclear MatrixMatrix MetalloproteinasesFibronectinsMatrix Metalloproteinase 2Molecular Sequence DataBone MatrixAmino Acid SequenceCollagenCells, CulturedGlycoproteinsMatrix Metalloproteinase InhibitorsLamininRNA, ViralMatrix Metalloproteinase 1TenascinNuclear Matrix-Associated Proteins
CapsidGenomeNucleic acidsStructuralAntibodiesInfectionVirologyGlycoproteinsNeuraminidaseReceptorsEnvelope proteinsRecombinantRibonucleoproteinParticlesDistribution of proteinsVaccinesVirusesTumorPolymeraseReplicationBacterialVaccineInfectionsMembrane proteinNonstructuralRetroviralFusion proteinExtracellularAntigenDimericMRNAVirion envelopeNucleocapsidsMiceVP40GeneticsEbolaCleavageInteractsMammalianBindsCrucial roleCellEBOVGeneRespiratoryConformationSuppressionRegimen
Capsid8
  • A very common motif among viral capsid proteins is called the single jelly roll , made up of eight beta strands in two four-stranded sheets. (virology.ws)
  • The extra sequences at the N-termini of viral jelly roll capsid proteins, involved in recognizing the viral genome, likely evolved after the capture of these proteins from cells. (virology.ws)
  • Retroviral structural proteins also appear to have originated from cell proteins, with clear homologies with matrix, capsid, and nucleocapsid proteins. (virology.ws)
  • Given this information on the origin of viral capsid proteins, we can modify the three hypotheses for the origin of viruses into one. (virology.ws)
  • Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (proteopedia.org)
  • The core is constituted by capsid protein hexamer subunits. (proteopedia.org)
  • The capsid (from the Latin capsa for box) is the protein shell surrounding the nucleic acid genome. (virology.ws)
  • AAV is a nonhuman pathogen of the Parvoviridae family possessing a single-stranded DNA genome (4.7 kb) with two open reading frames, rep (for replication) and cap (encodes capsid proteins), flanked by two symmetric inverted terminal repeats. (molvis.org)
Genome7
  • The virus particle consists of an envelope, an underlying matrix, and the encapsulated genome. (hu-berlin.de)
  • The second function is to play a role in nuclear localization of the viral genome at the very start of cell infection. (proteopedia.org)
  • It binds in the cytoplasm the human BAF protein which prevent autointegration of the viral genome, and might be included in virions at the ration of zero to 3 BAF dimer per virion. (proteopedia.org)
  • Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that converts the viral RNA genome into dsDNA in the cytoplasm, shortly after virus entry into the cell. (proteopedia.org)
  • Genome Eight negative sense ssRNA molecules, each encoding one protein. (powershow.com)
  • Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. (virology.ws)
  • N is the major structural protein which tightly binds the RNA genome. (biomedcentral.com)
Nucleic acids4
  • We have previously discussed the idea that viruses originated from selfish genetic elements such as plasmids and transposons when these nucleic acids acquired structural proteins (see A plasmid on the road to becoming a virus ). (virology.ws)
  • Missing from these hypothesis is how nucleic acids became virus particles - that is, how they acquired structural proteins. (virology.ws)
  • These two terms describe two different ways that viral nucleic acids and proteins are arranged in virus particles. (virology.ws)
  • A film detection method for tritium-labeled proteins and nucleic acids in polyacrylamide gels. (microbiologyresearch.org)
Structural7
  • Viral matrix proteins are structural proteins linking the viral envelope with the virus core. (wikipedia.org)
  • I want to explore in more detail the idea that the structural proteins of viruses likely originated from cell proteins ( link to paper ). (virology.ws)
  • It seems likely that viral structural proteins originated from cellular genes. (virology.ws)
  • The core proteins of alphaviruses (think Semliki Forest virus) has structural similarity with chymotrypsin-like serine proteases. (virology.ws)
  • At some point these genetic elements acquired structural proteins from the cells and became bona fide virus particles. (virology.ws)
  • Also cleaves Nef and Vif, probably concomitantly with viral structural proteins on maturation of virus particles (By similarity). (proteopedia.org)
  • The virion envelope surrounding the nucleocapsid contains the following structural proteins: S (spike), M (matrix), E (envelope) and N (nucleocapsid). (iucr.org)
Antibodies5
  • The cells of the adaptive system have their own proteins on the surface, formally referred to as immunoglobulins (Ig) but commonly known as antibodies. (hackaday.com)
  • This produces a population of antibodies with varying affinities for other proteins, depending on the size, shape, and electrostatic charge of the amino acids. (hackaday.com)
  • When the innate immune cells present the bits and pieces of an invader's proteins to the adaptive system, with any luck, one of the antibodies will randomly match and bind to the invader. (hackaday.com)
  • In this thesis we have produced proteins that are densely decorated with carbohydrate determinants in order to study the glycosylation capacity of cell lines (paper I) and generate efficient binders of antibodies (paper II), bacterial toxins (paper III) and virus receptors such as the influenza hemagglutinin (paper IV). (avhandlingar.se)
  • One way to find out is by testing your blood for the presence of antibodies against the viral nucleocapsid protein, which can only be encountered during natural infection. (virology.ws)
Infection6
  • Viral matrix proteins, like many other viral proteins, can exert different functions during the course of the infection. (wikipedia.org)
  • A study published by Cell Press on May 7th in the Biophysical Journal reveals how the most abundant protein making up the Ebola virus-viral protein 40 (VP40)-allows the virus to leave host cells and spread infection to other cells throughout the human body. (eurekalert.org)
  • To be able to present knowledge to assist reply this query, we, subsequently, investigated the consequences of endurance coaching on the degrees of host proteins concerned in SARS-CoV-2 an infection in mice. (aidstar-one.com)
  • The presence of ACE-2 in varied tissues might allow viral an infection. (aidstar-one.com)
  • As bacterial and viral infections can both cause the same kinds of symptoms, it can be difficult to distinguish which is the cause of a specific infection. (wikipedia.org)
  • Rotavirus infection of primary human pDCs provides a powerful experimental system for the study of mechanisms underlying pDC-mediated innate immunity to viral infection and reveals a potentially novel dsRNA-dependent pathway of IFNalpha induction. (stanford.edu)
Virology1
  • In 1983, Lamb joined the faculty at Northwestern as an associate professor, where his laboratory combined classic virology and molecular cell biology with reverse genetics, protein biochemistry, mass spectroscopy, electron microscopy, crystallography and electrophysiology to investigate the mechanisms underlying virus membrane biology. (northwestern.edu)
Glycoproteins3
  • An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins inserted in the host cell membrane on one side and affinity for the RNP complex molecules on the other side, which allows formation at the membrane of a complex made of the viral ribonucleoprotein at the inner side indirectly connected to the viral glycoproteins protruding from the membrane. (wikipedia.org)
  • This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. (nih.gov)
  • His lab produced detailed structure-function analyses of the entry glycoproteins of paramyxoviruses, including the visualization of the pre-fusion structure of a paramyxovirus fusion protein for the first time. (northwestern.edu)
Neuraminidase2
  • The viral spike proteins, hemagglutinin and neuraminidase, as well as the proton channel M2 are embedded into this membrane. (hu-berlin.de)
  • HA), neuraminidase (NA), and matrix (M2) protein embedded in a lipid bilayer derived from the host cell and covers the matrix (M1) protein that surrounds the viral core. (powershow.com)
Receptors1
  • Integrin receptors are involved in cell-cell and cell-extracellular matrix interactions, serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in thrombosis and haemostasis. (embl.de)
Envelope proteins1
  • It interacts with the genetic material, with the envelope proteins and with the lipid bilayer of the envelope. (hu-berlin.de)
Recombinant4
  • In this study, we constructed a recombinant Alphavirus Semliki Forest virus (SFV) replicon vector DREP to express EBOV GP and matrix viral protein (VP40). (frontiersin.org)
  • The mucin - type protein was used as a probe to analyze the O - glycosylation capacity of the se cell lines, which today are used for the commercial production of recombinant proteins and vaccine co mponents. (avhandlingar.se)
  • Here, we have evaluated the immunogenicity of recombinant PvDBPII formulated with the adjuvants Matrix-M and GLA-SE in mice. (bvsalud.org)
  • Recombinant viral vaccines using chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) vectors as well as a protein and adjuvant formulation (PvDBPII/Matrix-M) were tested in both a standard and a delayed dosing regimen. (bvsalud.org)
Ribonucleoprotein2
  • The genetic material is organized as bundle of eight ribonucleoprotein complexes that encode for eleven proteins. (hu-berlin.de)
  • The ribonucleoprotein complex making up the core consists of at least one of each of the eight single-stranded RNA segments associated with the nucleoprotein (NP) and the three polymerase proteins (PB2, PB1, PA). (powershow.com)
Particles4
  • When the researchers mutated the C-terminal domain of VP40, the protein was much less effective at binding to and bending membranes and forming virus-like particles that could escape from host cells. (eurekalert.org)
  • Glycoprotein (GP) is the major protective antigen of EBOV, and can generate virus-like particles (VLPs) by co-expression with matrix protein (VP40). (frontiersin.org)
  • Many cell proteins have jelly role motifs, and some form 60-subunit virus-like particles in cells. (virology.ws)
  • Selection of particles and proteins for use as human cytomegalovirus subunit vaccines. (microbiologyresearch.org)
Distribution of proteins1
  • Taxonomic distribution of proteins containing DISIN domain. (embl.de)
Vaccines3
  • These include messenger ribonucleic acid (mRNA) vaccines, protein subunit and virus-like particle (VLP) vaccines, and non-replicating viral vector vaccines. (canada.ca)
  • An authorized viral vector COVID-19 vaccine may be offered to individuals 18 years of age and over, without contraindications to the vaccine, when all other authorized COVID-19 vaccines are contraindicated. (canada.ca)
  • We conducted two phase 1/2a clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II (PvDBPII). (bvsalud.org)
Viruses5
  • The matrix Z proteins of arenaviruses are related to cellular RING domain proteins, and the matrix proteins of some negative strand RNA viruses are related to cellular cyclophilin. (virology.ws)
  • There are many more examples, providing support for the hypothesis that viruses evolved on multiple instances by recruiting different cell proteins. (virology.ws)
  • Now, the question if of course - is it of viral origin or is it a cellular protein co-opted by viruses? (virology.ws)
  • Oncomodulatory viruses, such as human cytomegaloviruses (HCMV), are known to release over 200 proteins, many of which can alter tumor behavior [ Table 1 ]. (surgicalneurologyint.com)
  • Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)
Tumor1
  • In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
Polymerase2
  • The individual RNPs each contain a binding site for the viral polymerase, as seen by the immunogold labeling of the end of the RNP segment (C). The external view of the virions (D) illustrates the pleomorphic appearance and the surface spikes. (powershow.com)
  • Using an existing clone of the trout-avirulent VHSV-IVb strain MI03 (pVHSVmi), eight chimeric VHSV clones were constructed in which the coding region(s) of the glycoprotein (G), non-virion protein (NV), G and NV, or G, NV and L (polymerase) genes together, were exchanged between the two clones. (biomedcentral.com)
Replication3
  • pDC activation and maturation were observed independently of viral replication and were enhanced in cells in which virus replicates. (stanford.edu)
  • Production of IFNalpha by pDCs following RRV exposure required viral dsRNA and surface proteins, but neither viral replication nor activation by trypsin cleavage of VP4. (stanford.edu)
  • However, the effect of rotavirus NSP1 on viral replication is not well defined. (stanford.edu)
Bacterial1
  • [12] Distinguishing the two is important, since viral infections cannot be cured by antibiotics whereas bacterial infections can. (wikipedia.org)
Vaccine2
  • It is recommended that an authorized protein subunit COVID-19 vaccine (Novavax Nuvaxovid) should be offered to individuals in the authorized age groups without contraindications to the vaccine who are not able or willing to receive an mRNA COVID-19 vaccine. (canada.ca)
  • PvDBPII/Matrix-M, given in a delayed dosing regimen, elicited the highest antibody responses and reduced the mean parasite multiplication rate after CHMI by 51% (n = 6) compared with unvaccinated controls (n = 13), whereas no other vaccine or regimen affected parasite growth. (bvsalud.org)
Infections1
Membrane protein2
  • We show that the EBV-encoded latent membrane protein 1 (LMP1) induces the expression of miR-146a via NFkappaB. (nih.gov)
  • The E1 viral membrane protein is required for formation of the viral envelope and is transported via the Golgi complex. (nih.gov)
Nonstructural2
  • Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
  • Although increased levels of systemic type I interferon (IFNalpha and beta) correlate with accelerated resolution of rotavirus disease, multiple rotavirus strains, including rhesus rotavirus (RRV), have been demonstrated to antagonize type I IFN production in a variety of epithelial and fibroblast cell types through several mechanisms, including degradation of multiple interferon regulatory factors by a viral nonstructural protein. (stanford.edu)
Retroviral1
  • One example is syncytin , a retroviral protein used for the construction of the mammalian placenta. (virology.ws)
Fusion protein3
  • There is also the phenomenon of HAP2 - a fusion protein that is used by many different eucaryotic organisms "all over" the phylogenetic tree (from Chlamydomonas to Bees) for mediating cell-cell fusion, predominantley of gametes. (virology.ws)
  • Turns out, that this protein look exactly like a class II viral fusion protein. (virology.ws)
  • PSGL - 1 genetically fused to mouse IgG 2b Fc forms a dimeric PSGL - 1/mIgG 2b mucin - type fusion protein. (avhandlingar.se)
Extracellular4
  • Carbohydrates are ubiquitous on the surface of all cells in mammals where they are involved in interactions with the surroundings (extracellular matrix), other cells (including self and non - self) and microbes (bacteria and virus). (avhandlingar.se)
  • Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. (embl.de)
  • To determine whether the co-injection of extracellular matrix degrading enzymes improves retinal transduction following intravitreal delivery of adeno-associated virus-2 (AAV2). (molvis.org)
  • One potential limit to the efficacy of intravitreal viral injection stems from the physical barriers formed by the vitreous, internal limiting membrane (ILM), retinal extracellular matrix (ECM), and cell surface proteoglycans. (molvis.org)
Antigen2
  • A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. (microbiologyresearch.org)
  • The invasion of reticulocytes by Plasmodium vivax merozoites is dependent on the interaction of the Plasmodium vivax Duffy Binding Protein (PvDBP) with the Duffy antigen receptor for chemokines (DARC). (bvsalud.org)
Dimeric1
  • Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. (proteopedia.org)
MRNA2
  • NS5A upregulates Beclin 1 mRNA and protein expression in a HCV NS5A-transactivated protein 9 (NS5ATP9)-dependent manner ( 15 ). (spandidos-publications.com)
  • MMP-9 mRNA and protein were detected at high levels in ETOH-RSV mice compared to RSV. (cdc.gov)
Virion envelope1
Nucleocapsids1
  • For example, in rhabdoviruses, binding of M proteins to nucleocapsids is accountable for the formation of its "bullet" shaped virions. (wikipedia.org)
Mice3
  • Vaccination of BALB/c mice with DREP-GP, DREP-VP40, or DREP-GP+DREP-VP40 vectors, followed by immediate electroporation resulted in a mixed IgG subclass production, which recognized EBOV GP and/or VP40 proteins. (frontiersin.org)
  • AAV2 containing cDNA encoding enhanced green fluorescent protein (GFP), under the control of a chicken β-actin promoter, was delivered by intravitreal injection to adult mice in conjunction with enzymes including collagenase, hyaluronan lyase, heparinase III, or chondroitin ABC lyase. (molvis.org)
  • Previously, chronic ethanol consumption was shown to prolong inflammation and delay viral clearance in respiratory syncytial virus (RSV)-infected mice. (cdc.gov)
VP401
  • The Ebola virus is made up of seven proteins, including VP40, which plays a key role in enabling the virus to leave host cells and infect other cells in the human body. (eurekalert.org)
Genetics1
  • This study describes molecular characterization and construction of an infectious clone of the virulent VHSV-Ia strain DK-3592B from Denmark, and application of the clone in reverse genetics to investigate the role of selected VHSV protein(s) in host-specific virulence in rainbow trout (referred to as trout-virulence). (biomedcentral.com)
Ebola1
  • The Ebola Virus Matrix Protein Deeply Penetrates the Plasma Membrane: An Important Step in Viral Egress. (eurekalert.org)
Cleavage1
  • The viral core protein retains protease activity, needed for cleavage from a protein precursor. (virology.ws)
Interacts1
Mammalian1
  • Beclin l, the mammalian counterpart of the yeast Atg6 gene, is an essential protein in autophagy ( 10 ). (spandidos-publications.com)
Binds1
  • A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. (proteopedia.org)
Crucial role1
Cell9
  • Matrix protein p17 has two main functions: in infected cell, it targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (proteopedia.org)
  • Taken collectively, endurance coaching altered the degrees of host proteins concerned in SARS-CoV-2 cell entry in an organ-dependent method. (aidstar-one.com)
  • This protein serves as a transcriptional activator of cell growth. (spandidos-publications.com)
  • The glycosylation of PSGL - 1/mIgG 2b may be tailored by producing the protein in genetically engineered cell lines. (avhandlingar.se)
  • It remains to be shown if PSGL - 1/mIgG 2b can competitively inhibit and sterically block toxin and viral attachment to the cell surface. (avhandlingar.se)
  • Simplified illustration of a cell, pointing out some of the important mechanisms of viral oncomodulation. (surgicalneurologyint.com)
  • NCMV proteins and their oncogenic effects on cell mechanisms. (surgicalneurologyint.com)
  • We hypothesize that alcohol alters anti-viral immunity by disrupting immune cell chemotaxis in the lung. (cdc.gov)
  • Immune cell recruitment is necessary for viral clearance. (cdc.gov)
EBOV1
  • Through viral load suppression, we may be able to prolong a patient's survival in order to provide a better chance for the patient to develop natural immune defense against the EBOV. (biomedcentral.com)
Gene4
  • In herpesviruses, the viral matrix is usually called viral tegument and contains many proteins involved in viral entry, early gene expression and immune evasion. (wikipedia.org)
  • The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
Respiratory2
  • The blockage of interplay between angiotensin-converting enzyme 2 (ACE2) and S protein is taken into account an important goal for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medication. (aidstar-one.com)
  • The N-terminal domain of the nucleocapsid protein from Middle East respiratory syndrome coronavirus (MERS-CoV NP-NTD) contains many positively charged residues and has been identified to be responsible for RNA binding during ribonucleocapsid formation by the virus. (iucr.org)
Conformation1
Suppression2
Regimen1
  • We propose a therapeutic regimen to supplement the current supportive therapy aiming to reduce viral load, the most important factor in the determination of mortality. (biomedcentral.com)