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  • fetal
  • Recently, another group of TAAs was described that include antigens overexpressed by neoplastic and fetal cells, and was weakly expressed in a phase-specific way in a few normal cells ( 14 , 15 ). (aacrjournals.org)
  • Our prediction is that at least some of the CSC antigens will match proteins already known to serve as TAAs and expressed by embryo-fetal tissues (e.g., survivin, telomerase, cancer/testis antigens) reflecting common functions between embryonic stem cells and CSCs, i.e., multipotent differentiation, plasticity, and self-renewal. (aacrjournals.org)
  • glycoprotein
  • The virus consists of a host derived lipid bilayer membrane, membrane glycoprotein spikes, and the C protein which together with viral RNA forms the icosahedral nucleocapsid. (ubc.ca)
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • gene
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • recognize
  • The risk is calculated by comparison of the recent advent of prenatal ultrasonography, an increasing number of mature t cells that recognize phosphotyrosine (or phosphoserine phosphothreonine) adaptor proteins to rss regions. (arrowheadpharma.com)
  • immunodominant
  • Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. (freepatentsonline.com)
  • HLA-DM-mediated editing contributes significantly to immunodominance and is exploited in discovering immunodominant epitopes from novel or previously uncharacterized antigens, particularly antigens associated with pathogens, tumors or autoimmune diseases. (freepatentsonline.com)
  • The nonstructural proteins NS3 and NSl.2a appear to be immunodominant and should be considered when designing subunit vaccines for dengue. (umassmed.edu)
  • responses
  • Immune responses targeting these proteins could thus result in a limited or no generation of antigen-loss variants and, therefore, they may efficiently control in vivo tumor growth, thus meeting the requirements for an ideal TAA set forth above. (aacrjournals.org)
  • The HLA diversity between North American Caucasians and populations where dengue is a serious health problem, calls for the analysis of immune responses in people who have been infected with natural circulating strains of the virus. (umassmed.edu)
  • In CRS patients E2 was the dominant antigen to which both cellular and humoral immune responses were elicited. (ubc.ca)
  • These results indicate that keratinocyte expression of HLA-DR enhances inflammatory skin responses to SAg's. (smokershistory.com)
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • An effective tumor vaccine may be required to induce both CTLs and T-helper (Th) responses against tumor-associated antigens. (aacrjournals.org)
  • membrane
  • Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer and thus is a potential target for prostate cancer immunotherapy. (aacrjournals.org)
  • PBMC
  • In all four patients analyzed, CTLs were detected in bulk culture PBMC against nonstructural dengue proteins. (umassmed.edu)
  • Expression
  • The HLA-DRB4 promoter polymorphism is associated with differential expression of this locus 4 and this occurs at the level of mRNA production 3 . (dorak.info)
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Using expression of these three phenomena are reduced by the purified x-box binding protein (creb). (arrowheadpharma.com)
  • Immunohistochemical studies revealed significantly higher HLA-DR expression in keratinocytes from psoriatics than from controls. (smokershistory.com)
  • respectively
  • Numerous CD4 + and CD8 + CTL lines were generated from the bulk cultures of two patients, KPP94-037 and KPP94-024, which were specific for the NSl.2a and NS3 proteins respectively. (umassmed.edu)
  • frequency
  • As for HLA-DQ, the frequency of HLA-DQB1*0501 was significantly lower in the patient group. (healthdocbox.com)
  • In this study, the frequency of s of HLA-DR, HLA-DQ, and HLA-DP antigens was evaluated by means of the PCR- RFLP method. (healthdocbox.com)
  • Intensity (concentration) and duration of exposure to the antigen, frequency of exposure, particle size, and antigen solubility may influence disease latency, prevalence, severity and course [6, (worldallergy.org)
  • CTLs
  • For one donor, CTLs specific for E, NSl.2a and NS3 proteins were all HLA-B44 restricted. (umassmed.edu)
  • These results demonstrate that after symptomatic secondary natural dengue infections in Thai patients, CTLs are mainly directed against nonstructural proteins and are broadly crossreactive. (umassmed.edu)
  • occur
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • HP develops as a result of the immunologically mediated events and the physiologic consequences that occur in the lung after inhalation of the responsible antigen in a sensitized individual. (worldallergy.org)
  • specific
  • The CD8 + NS1.2a specific lines from patient KPP94-037 were HLA-B57 restricted and the CD8 + NS3 specific lines from patient KPP94-024 were HLA-B7 restricted. (umassmed.edu)
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • common
  • Not only typical symptoms but some atypical symptoms like enamel defects in adult celiacs have also been reported and was obvious since gliadin and enamel proteins shared common antigenic motifs [ 5 ]. (omicsonline.org)