• P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (broadinstitute.org)
  • P59 [also known as FK506 binding protein 59 (FKBP59) or heat shock protein 56 (hsp56)] and heat shock proteins 90 and 70 (hsp90 and hsp70) associate with steroid receptors and are believed to maintain the receptors in an inactive state. (broadinstitute.org)
  • This evidence that Hsp12 must have a protective function, together with its small molecular mass, led to its classification with other heat shock proteins (HSPs). (mytum.de)
  • The heat shock proteins are a highly conserved family of stress response proteins. (rndsystems.com)
  • The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
  • The DNA that makes up genes contains the instructions to synthesise proteins, but it's wrong to think that, for a given gene, these instructions are always the same for all parts of the organisms . (evolutionnews.org)
  • Indeed, FANTOM5's survey of 95 percent of protein-coding genes found near universal coverage by promoters, based on the first few bases of RNA transcripts. (evolutionnews.org)
  • Other genes are involved in the control of protein synthesis. (sheldrake.org)
  • Identifiable genes are switched on and particular proteins made at the beginning of new developmental processes. (sheldrake.org)
  • Otherwise biology will go on floundering, even drowning, in oceans of data, as yet more genomes are sequenced, genes are cloned and proteins are characterized. (sheldrake.org)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)
  • A FKBP59 homologue complexed with hsp90-hsp70 was also detected in yeast, which suggests that the immunophilin-heat shock protein association has been evolutionarily conserved. (broadinstitute.org)
  • The fish and mammalian sequences are also well conserved, particularly for zebrafish, to beyond the end of the hydrophobic sequence (identity 41-53%, 78 amino acids, zebrafish length). (nih.gov)
  • The researchers did find that the DNA sequences of other fungi code for proteins that could be considered Hsp12 "family members," and they identified one protein in human neurons that may have similar features. (mytum.de)
  • Although the amino acid sequences of these domains are very similar to each other, the predicted functional region for the Fe-S cluster assembly, the CXXC motif, exists only in domain I. The structure of the domain II of chloroplastic NifU-like protein OsNifU1A has an alpha-beta sandwich structure containing two alpha helices located on one side of the beta-sheet. (rcsb.org)
  • Diane Burgess and Michael Freeling sampled the genomes of a wide variety of plant species (e.g., rice, banana, cacao, the model plant Arabidopsis , and other flowering plants, both monocots and dicots) and found " numerous conserved non-coding sequences " (CNSs). (evolutionnews.org)
  • Phylogeny based on concatenated sequences of 125 conserved ORFs showed that this isolate clustered most closely with the Mkuzi 1979 isolate. (cdc.gov)
  • The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. (cdc.gov)
  • Autophagy is the "self-eating" process of degrading damaged proteins and organelles, as well as recycling intracellular energy to maintain cellular homeostasis under stress conditions. (hindawi.com)
  • The mammalian target of rapamycin (mTOR) is an evolutionarily highly conserved intracellular serine/threonine kinase family member. (hindawi.com)
  • Here, we used an affinity purification approach in two distantly related photosynthetic eukaryotes, the green alga Chlamydomonas reinhardtii and the plant Arabidopsis thaliana , to discover proteins that interact with VIPP1. (biorxiv.org)
  • Of the few known proteins involved in these processes, VIPP1 stands out due to its similarity to ESCRT-III, an integral component of the ESCRT machinery that is responsible for membrane remodeling and trafficking in the cytoplasm of eukaryotes. (biorxiv.org)
  • Oxr1p belongs to the group of TLDc domain containing proteins that are highly conserved in higher eukaryotes. (upstate.edu)
  • We report evidence from cDNA isolation and expression analysis as well as analyses of genome, expressed sequence tag (EST), cDNA and expression databases for a new gene named SPRN (shadow of prion protein). (nih.gov)
  • The gene is for a receptor called ACVR1 in the bone morphogenetic protein-signalling pathway (BMP). (brighthub.com)
  • In addition, KIN17 is a highly conserved gene across evolution. (spandidos-publications.com)
  • This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. (fishersci.com)
  • It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. (fishersci.com)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. (nih.gov)
  • The linear sequence of the A, T, C, and G bases in what is called coding DNA determines the particular protein that a short segment of DNA, known as a gene, will encode. (evolutionnews.org)
  • The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)
  • Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
  • Genotyping of ASFV isolates by partial sequencing of the B646L gene that encodes the major capsid protein p72 has identified 22 genotypes ( 6 ). (cdc.gov)
  • Bloom syndrome (BS) is a rare human autosomal recessive disorder cased by mutations in the gene (BLM) coding for Bloom syndrome protein. (lu.se)
  • The overall structure appears closely related to prion proteins (PrPs), although the C-terminal domains of Shos are quite different from those of PrPs, for which conformational changes in mammals are implicated in disease. (nih.gov)
  • We are interested in understanding the molecular mechanisms by which these proteins exert their neurodegenerative properties and in the case of prion proteins, gain their infectious properties. (edu.au)
  • It contains a conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by an adjacent glycine-rich region, and Arg-Asp and Arg-Glu dipeptide repeats rich domain, making U11/U12-35K a possible functional analog of U1-70K. (nih.gov)
  • The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
  • Protein S15 interacts in the minor groove with a G-U/G-C motif and a three-way junction. (unboundmedicine.com)
  • One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. (cdc.gov)
  • The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. (cdc.gov)
  • This suggests that the immunophilin-heat shock protein-steroid receptor interaction is ubiquitous and not limited to immune systems. (broadinstitute.org)
  • Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. (nih.gov)
  • ZIP4 is a ZMM protein involved in homologous recombination and may act as a hub through physical interactions with components of the chromosome axis and other ZMMs 19 . (nature.com)
  • Adenovirus protein- protein interactions: hexon and protein VI. (microbiologyresearch.org)
  • As the assembly was carried out in the absence of ATP, this suggests that formation of the holoenzyme from the individual subcomplexes is solely driven by protein-protein interactions at the interface. (upstate.edu)
  • Unlike reversible disassembly, which requires ATP hydrolysis on V 1 to break protein-protein interactions, Oxr1p mediated disassembly of V-ATPase is ATP independent and therefore a novel mode of activity regulation. (upstate.edu)
  • The latter is constrained by a conserved base triple and stacking interactions, and locked into place by magnesium ions and protein side chains, mainly through interactions with the unique three-dimensional geometry of the backbone. (unboundmedicine.com)
  • The oncoprotein c-Myc belongs to the IDP group of proteins and is an oncogenic master regulator overexpressed in more than half of human cancers, but characterizing its interactions are inherently difficult due to their short-lived nature. (lu.se)
  • Here, I will describe our recent progress in characterizing the structure and interactions of c-Myc focusing on MB0-II by nuclear magnetic resonance (NMR), small-angle x-ray scattering (SAXS) and protein crystallography. (lu.se)
  • We will present first molecular data showing how these boxes interact with critical transcription factors as well as with each other in a highly specific but also highly dynamic manner, and how these interactions can be interrupted. (lu.se)
  • It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. (prospecbio.com)
  • This subfamily corresponds to the RRM of U11/U12-35K, also termed protein HM-1, or U1 snRNP-binding protein homolog, and is one of the components of the U11/U12 snRNP, which is a subunit of the minor (U12-dependent) spliceosome required for splicing U12-type nuclear pre-mRNA introns. (nih.gov)
  • This result together with some common structural features led to the suggestive hypothesis of a possible functional link between mammalian PrP and Sho proteins. (nih.gov)
  • 100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. (novusbio.com)
  • Among several newly identified proteins, we focused on a highly conserved but uncharacterized protein (VIPP1-Associated protein 1, VIA1) that robustly interacts with VIPP1 in both systems. (biorxiv.org)
  • Here we report the discovery of VIA1, a conserved protein that interacts with VIPP1 and participates in thylakoid biogenesis and remodeling in two distantly related photosynthetic organisms. (biorxiv.org)
  • The endoplasmic reticulum membrane complex (EMC) is a highly conserved, multifunctional 10-protein complex related to membrane protein biology. (nih.gov)
  • For example, alkaline vacuole/lysosome are deficient in autophagy, Golgi pH regulates its ability to glycosylate proteins and failure to maintain endosomal pH perturbs with its ability to recycle receptors to the Plasma membrane or, the trans-Golgi. (upstate.edu)
  • The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. (fishersci.com)
  • This epitope encompasses a glycosylation site (N343) of the viral spike protein. (flutrackers.com)
  • The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response. (elifesciences.org)
  • These vesicles have been shown to contain many proteins associated with neurodegenerative diseases, including the prion protein (PrP), amyloid precursor protein (APP), Tau and α-synuclein. (edu.au)
  • BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
  • DNA is the molecule that encodes the genetic instructions enabling a cell to produce the thousands of proteins it typically needs. (evolutionnews.org)
  • Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)
  • The binding site for allosteric inhibitor (amino acid) is highly conserved between human liver pyruvate kinase (hL-PYK) and the rabbit muscle isozyme (rM 1 -PYK). (figshare.com)
  • 14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide. (prospecbio.com)
  • In addition, we found that the FKBP59-hsp complexes are more complicated than previously thought, involving other proteins such as actin and a 63-kDa protein, p63. (broadinstitute.org)
  • In higher organisms DNA is bound with proteins in complexes called the nucleosome. (sciencedaily.com)
  • It mainly forms the catalytic subunits of two protein complexes, including mTOR complex 1 (mTOR complex1, mTORC1) and mTOR complex 2 (mTOR complex2, mTORC2). (hindawi.com)
  • Mature frataxin (81-210) is a critically important protein because it facilitates the assembly of mitochondrial iron-sulfur cluster protein complexes such as aconitase, lipoate synthase, and succinate dehydrogenases. (nih.gov)
  • There were no differences in the amino acid lengths of any of their viral proteins. (usda.gov)
  • Temperature sensitivity of processing of viral proteins. (microbiologyresearch.org)
  • Silks are composed principally of proteins with a predominance of alanine, serine and glycine and silk proteins are able to undergo irreversible transformations from soluble protein to insoluble fibres. (bioone.org)
  • All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. (novusbio.com)
  • Further experiments will be required to uncover the physiological role of the interaction suof Oxr1 with the V-ATPase, and whether the observations obtained for the yeast system are conserved in higher organisms, including humans. (upstate.edu)
  • APOE is also involved in the formation of chylomicrons and VLDL and affects the activity of other lipid metabolism-associated proteins and enzymes, such as hepatic lipase and lipoprotein lipase. (dovepress.com)
  • The dense packing allows DNA molecule with a length of about two meters to fit into a microscopic cell nucleus, but it makes significant surfaces of the DNA inaccessible for the repair enzymes -- the proteins that manage the "repair" of damaged DNA regions. (sciencedaily.com)
  • Allergen avoidance strategies including personal protective equipment, engineering controls, protein encapsulation, and reduction of airborne enzyme concentrations are required to mitigate occupational exposure to fungal enzymes. (cdc.gov)
  • The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
  • Furthermore, these pathways are essential for cellular dynamics and build a highly regulated cellular signalling network. (mdpi.com)
  • Much remains to be understood about how the normal cellular isoform of the prion protein undergoes structural changes to become the disease associated form. (edu.au)
  • The vacuolar ATPase (V-ATPase) is a highly conserved rotary motor proton pump that plays an essential role in cellular housekeeping functions. (upstate.edu)
  • HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. (rndsystems.com)
  • Ribosomal protein S15 is of particular interest because it binds primarily to 16S rRNA and is required for assembly of the small subunit and for intersubunit association, thus representing a key element in the assembly of a whole ribosome. (unboundmedicine.com)
  • The high diagnostic potential of peptides and proteins from cells, tissues, and biological fluids is unquestionable. (genengnews.com)
  • As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
  • Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
  • The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. (novusbio.com)
  • This finding is inconsistent with the idea that allosteric pathways are conserved between homologues of a protein family. (figshare.com)
  • The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. (prospecbio.com)
  • The 14-3-3gamma, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. (prospecbio.com)
  • The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. (novusbio.com)
  • Alternative translocations include EWS-ERG t(21;22), EWS-ETV t(7;22), and EWS-FEV t(2;22), all of which involve the ETS family protein. (medscape.com)
  • Such treatments may eventually be combined with highly active antiviral drugs to end the pandemic. (forbes.com)
  • Quantitative peptide analysis by mass spectrometry (MS) has become indispensable for interrogation of proteins in complex biological samples. (genengnews.com)
  • The production of 27 of these putative proteins was confirmed by mass spectrometry analysis. (frontiersin.org)
  • The rapid evolution of SARS-CoV-2 viruses, such as the Omicron variants which are highly transmissible and immune evasive, underscores the need to develop therapeutic antibodies with broad neutralizing activities. (flutrackers.com)
  • 14-3-3 proteins are highly conserved and ubiquitously expressed. (prospecbio.com)
  • Every ~200 base pairs are organized in nucleosomes, consisting of eight histone proteins, which, like the thread on the bobbin, wound double helix of DNA, which is coiled into two supercoiled loops. (sciencedaily.com)
  • Cardiac alpha actin is a filamentous protein extending from a complex mesh with cardiac alpha-actinin (ACTN2) at Z-lines towards the center of the sarcomere. (wikipedia.org)
  • One of the few known critical regulators of this process, VIPP1 (Vesicle-Inducing Protein in Plastids 1), was recently shown to be structurally similar to ESCRT-III proteins - the first evidence for ESCRT-like (Endosomal Sorting Complex Required for Transport) machinery in chloroplasts. (biorxiv.org)
  • Previous studies have indicated that KIN17 is involved in global genome repair, DNA replication, transcription and regulation of the cell cycle as part of a multi-protein complex. (spandidos-publications.com)
  • Here we report the 2.8 ¿ resolution crystal structure of the highly conserved S15-rRNA complex. (unboundmedicine.com)
  • Just making the right proteins at the right times cannot explain the complex skeletons of such structures without many other forces coming into play, including the organizing activity of cell membranes and microtubules. (sheldrake.org)
  • This is the most abundant protein in the yeast S. cerevisiae under stress -- not only heat, but different kinds of stress -- and we found that it does not protect other proteins from unfolding or aggregation as other HSPs do. (mytum.de)
  • The essential ATP-binding cassette protein ABCE1 splits 80S ribosomes into 60S and 40S subunits after canonical termination or quality-control-based mRNA surveillance processes. (nature.com)
  • Each of the three is composed of two subunits: S1, the membrane distal region, including the receptor-binding and N-terminal domains, and S2, the membrane-proximal protein. (forbes.com)
  • The recently discovered broadly neutralizing monoclonal antibodies provide near-term hope effective for variant-independent prevention and treatment as we await the discovery of highly active antiviral drugs. (forbes.com)
  • These antibodies have been directed at the Spike protein on the virus's exterior. (forbes.com)
  • This is a favored target, as studies show that greater than ninety percent of naturally-occurring antibodies that neutralize SARS-CoV-2 are directed against the Spike protein. (forbes.com)
  • Structural organization of essential iron-sulfur clusters in the evolutionarily highly conserved ATP-binding cassette protein ABCE1. (nature.com)
  • Structural analyses reveal glycosaminoglycan binding sites on Notum, which probably help Notum to co-localize with Wnt proteins. (rcsb.org)
  • The role of adenovirus structural proteins in the regulation of adenovirus infection. (microbiologyresearch.org)
  • This study reports the function of CmNAC1, a stress-responsive pumpkin NAC domain protein. (frontiersin.org)
  • In addition, NAC domain proteins have become a popular research topic for different plant species. (frontiersin.org)
  • VIA1 is predicted to contain a winged-helix domain, a characteristic feature of ESCRT-II proteins that mediates the interaction with ESCRT-III proteins. (biorxiv.org)
  • Because VIA1 contains a predicted winged-helix domain, a hallmark feature of ESCRT-II proteins that mediates the interaction with ESCRT-III proteins, our data support the hypothesis that universal, mechanistic principles govern membrane remodeling across all living organisms. (biorxiv.org)
  • Chloroplastic NifU-like proteins have tandem NifU like domains, named domain I and domain II. (rcsb.org)
  • The cryo-EM structure of SW186 bound to the receptor-binding domain (RBD) of the viral spike protein showed that SW186 interacted with an epitope of the RBD that is not at the interface of its binding to the ACE2 receptor but highly conserved among SARS coronaviruses. (flutrackers.com)
  • The targets in the Spike protein are the primary receptor-binding domain (RBD) and the secondary N-terminal domain (NTD). (forbes.com)
  • Here, we show that human Abs can induce increased Fn-binding affinity in M proteins, likely by enhancing the weak A-B domain binding. (lu.se)
  • TATA-box binding protein is not required for RNA Polymerase II transcription in mouse embryonic stem cells. (elifesciences.org)
  • As expected, the genomic termini, possessing initiation signals for viral transcription and replication, were highly conserved. (usda.gov)
  • Located within the intrinsically disordered N-terminus part of c-Myc are the highly conserved so-called Myc boxes (MB0-IV), which are crucial for Myc function and interaction with other transcription factors. (lu.se)
  • Alpha cardiac actin is the major protein of the thin filament in cardiac sarcomeres, which are responsible for muscle contraction and generation of force to support the pump function of the heart. (wikipedia.org)
  • Cardiac alpha actin is a 42.0 kDa protein composed of 377 amino acids. (wikipedia.org)
  • Many of these diseases are associated with the misfolding of certain proteins into aberrant forms that are found in the brain tissues of individuals with these diseases. (edu.au)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • KIN17, which is known as a DNA and RNA binding protein, is highly expressed in numerous types of human cancers and was discovered to participate in several vital cell behaviors, including DNA replication, damage repair, regulation of cell cycle and RNA processing. (spandidos-publications.com)
  • Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase. (rcsb.org)
  • We assessed the effect of the frameshift variant on EMC10 RNA and protein expression and evaluated EMC10 expression in normal human brain tissue using immunohistochemistry. (nih.gov)
  • Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. (lu.se)
  • It is known that for the synthesis of a protein, information written in the genetic code, which could be imagined as the manual for its assembly where triples of nucleotides match certain amino acids, should be taken out of the nucleus into the cytoplasm of the cell. (sciencedaily.com)
  • in particular, what varies is the point in the "string" of code at which protein synthesis starts . (evolutionnews.org)
  • RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development. (elifesciences.org)
  • SPRN comprises two exons, with the open reading frame (ORF) contained within exon 2, and codes for a protein of 130-150 amino acids named Shadoo (Japanese shadow), predicted to be extracellular and GPI-anchored. (nih.gov)
  • BLM protein comprises of 1417 amino acids. (lu.se)
  • 2 In the blood, APOE protein could interact with lipids, resulting in lipoproteins, including very-low-density lipoproteins (VLDL). (dovepress.com)
  • A single protein may be required to interact with several hundred different partners, with maintained specificity but with built-in versatility in the response. (lu.se)
  • Intrinsically disordered proteins (IDPs) proteins lack stable folded structure under native conditions but can interact simultaneously with multiple partners and/or binding sites, thus facilitating rapid biological response to transient signals. (lu.se)
  • Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • U11/U12-35K is highly conserved among bilateria and plants, but lacks in some organisms, such as Saccharomyces cerevisiae and Caenorhabditis elegans. (nih.gov)
  • But in many organisms, there is much more DNA in a cell than is needed to code for all the necessary proteins . (evolutionnews.org)
  • They enable organisms to make particular proteins. (sheldrake.org)
  • Approximately, 200 biotic (organisms or particles mixtures of many proteins [4, 6]. (cdc.gov)
  • How highly conserved and how widely spread is the newly discovered protective mechanism of Hsp12? (mytum.de)
  • ATP-BINDING CASSETTE PROTEINS that are highly conserved and widely expressed in nature. (bvsalud.org)
  • Experimental research found a markedly decreased expression of autophagy-related proteins such as Beclin-1, Atg12-Atg5, and LC3-II in a diabetic mouse model and in a high glucose-induced podocyte injury model [ 4 ]. (hindawi.com)
  • Autophagy is a highly conserved and lysosome-dependent bulk degradation process. (hindawi.com)
  • These bacteriophages appear to be most similar to bacteriophages that infect Pseudomonas and Ralstonia rather than Enterobacteriales bacteria by protein similarity, however, we were only able to detect infection of Erwinia and the closely related strains of Pantoea . (frontiersin.org)
  • After washing away unbound material, a biotinylated detection antibody is used to detect both phosphorylated and unphosphorylated protein, utilizing a standard Streptavidin-HRP format. (rndsystems.com)
  • These results demonstrated that SW186 neutralizes diverse SARS coronaviruses by binding to a conserved RBD epitope, which could serve as a target for further antibody development. (flutrackers.com)
  • Antibody responses targeting the M protein have been shown to favor the conserved C region. (lu.se)
  • In bacterial ribosomes, the small (30S) ribosomal subunit is composed of 16S rRNA and 21 distinct proteins. (unboundmedicine.com)
  • The S protein, due to its exposure on the outside of the virus is also one of the parts of the virus that is recognised as foreign by the immune system. (who.int)
  • GAS' M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. (lu.se)
  • The results provide evidence that Glu-68 , a highly conserved residue located 0.47 nm from the catalytic zinc ion, may intermittently coordinate to the zinc ion. (lu.se)
  • All missense mutations are in the highly conserved DEAH or RecQ C-terminal helicase domains. (lu.se)
  • Highly conserved regions are less likely to mutate, therefore there is a high likelihood that the diagnostic test will remain accurate in the presence of variants. (who.int)
  • Genomic analysis of highly virulent isolate of African swine fever virus. (cdc.gov)
  • Yet an exhaustive investigation led by Munich-based researchers has revealed that Hsp12 is structurally and functionally different from every other stress protein that has been studied before. (mytum.de)