• This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit. (uchicago.edu)
  • and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit ß by EPR Spectroscopy. (uchicago.edu)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
  • The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. (uchicago.edu)
  • The pathogenic oral spirochete bacterium Treponema denticola lacks a long-RSH homologue but encodes putative small alarmone synthetase (Tde-SAS, TDE1711) and small alarmone hydrolase (Tde-SAH, TDE1690) proteins. (bvsalud.org)
  • Our results also expand our general understanding of proteins that synthesize nucleotide-based intracellular signaling molecules in bacteria. (bvsalud.org)
  • Two alarmone (magic spot) second messengers, guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp), which are synthesized by RelA/SpoT homologue (RSH) proteins, play central roles in the stringent response. (bvsalud.org)
  • The tetrameric 410-amino acid (aa) Tde-SAS protein preferentially synthesizes ppGpp over pppGpp and a third alarmone, pGpp. (bvsalud.org)
  • The co-occurrence analysis of core concepts in this stringent response, i.e. the (p)ppGpp nucleotides with gene products was also inspected and suggest that besides the enzymes RelA and SpoT that control the basal levels of (p)ppGpp nucleotides, many other proteins have a key role in this response. (biomedcentral.com)
  • By characterizing the biochemical functions of the proteins putatively responsible for the stringent response in T. denticola, we may gain molecular insight into how this bacterium can survive within harsh oral environments and promote infection. (bvsalud.org)
  • A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. (uchicago.edu)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • GTP Phosphohydrolase-Linked Elongation Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
  • Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz01g27080.t1","No alias","Chromochloris zofingiensis","Solute-binding protein family 5 domain [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz02g09110.t1","No alias","Chromochloris zofingiensis","2-hydroxy-palmitic acid dioxygenase Mpo1-like [Interproscan]. (ntu.edu.sg)
  • protein_coding" "Cz03g01030.t1","No alias","Chromochloris zofingiensis","Rieske [2Fe-2S] iron-sulphur domain [Interproscan]. (ntu.edu.sg)
  • A family of GTP-binding proteins that were initially identified in YEASTS where they were shown to initiate the process of septation and bud formation. (nih.gov)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
  • Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
  • Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)
  • The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS. (lookformedical.com)
  • We approach this question using the minimum description length principle and illustrate its application by analyzing residues that distinguish translational initiation and elongation factor guanosine triphosphatases (GTPases) from other P-loop GTPases. (nih.gov)
  • This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
  • They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. (lookformedical.com)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
  • protein_coding" "AAC73572","dnaX","Escherichia coli","DNA polymerase III/DNA elongation factor III, tau and gamma subunits [Ensembl]. (ntu.edu.sg)
  • Within a structure of yeast elongation factor 1[Formula: see text], these residues form a significant cluster centered on a region implicated in guanine nucleotide exchange. (nih.gov)
  • Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of bacterial ribosomes by a process linked to hydrolysis of GTP to GDP. (lookformedical.com)
  • Interferon-induced DYNAMIN-like GTP-binding proteins localized in the cytoplasm, nuclear pore complex and nucleus. (nih.gov)
  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • protein_coding" "AAC74007","cmoM","Escherichia coli","putative S-adenosyl-L-methionine-dependent methyltransferase [Ensembl]. (ntu.edu.sg)
  • Regulatory proteins that act as molecular switches. (umassmed.edu)
  • Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis. (lookformedical.com)
  • We study a simple abstract problem motivated by a variety of applications in protein sequence analysis. (nih.gov)
  • GTP-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • GTP-Binding Proteins, in the D tree, were expanded with the addition of 16 specific proteins and many associated enzymes along with the rearrangement of closely related concepts. (nih.gov)
  • They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. (umassmed.edu)
  • It inhibits protein synthesis by binding to RNA. (lookformedical.com)
  • It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis. (lookformedical.com)
  • protein_coding" "AAC74207","potD","Escherichia coli","spermidine/putrescine ABC transporter periplasmic binding protein [Ensembl]. (ntu.edu.sg)
  • Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. (lookformedical.com)
  • protein_coding" "AAC73204","ftsQ","Escherichia coli","divisome assembly protein, membrane anchored protein involved in growth of wall at septum [Ensembl]. (ntu.edu.sg)
  • Previously, treatment of a disease with biological factors and products which are treed in D24, required coordination of the disease with /therapy rather than /drug therapy. (nih.gov)
  • PMID- 214395 TI - Chemical modification of peptide antibiotics : Part VII--Biological activity of derivatives of polymyxin B. PMID- 214396 TI - Temporal relations in phosphohydrolases of mouse testes. (nih.gov)
  • Computational analysis of the CB1 carboxyl-terminus in the receptor-G protein complex. (umassmed.edu)
  • Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
  • Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. (umassmed.edu)
  • Finally, using serum samples from COVID-19 patients, we highlighted strong concentrations of pro-inflammatory factors that did not perturb BBB integrity after short term exposure. (bvsalud.org)
  • This graph shows the total number of publications written about "GTP-Binding Proteins" by people in this website by year, and whether "GTP-Binding Proteins" was a major or minor topic of these publications. (umassmed.edu)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 16.8 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)