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  • Diabetes
  • This review highlights the recent findings on beneficial effects of flavonoids in the management of diabetes with particular emphasis on the investigations that explore the role of these compounds in modulating glucose transporter proteins at cellular and molecular level. (ijbs.com)
  • Type 2 DM (T 2 DM) or non-insulin-dependent diabetes mellitus (NIDDM) is one of the most common types of DM, accounted for 90-95% of the diabetic cases worldwide. (ijbs.com)
  • Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). (genecards.org)
  • Among its related pathways are Type II diabetes mellitus and Regulation of beta-cell development . (genecards.org)
  • Hypoglycemia-associated autonomic failure (HAAF) constitutes one of the main clinical obstacles to optimum treatment of type 1 diabetes. (nih.gov)
  • Dr. Kibbey is interested in the mechanisms of insulin secretion by beta-cells and the pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus. (yale.edu)
  • The main symptoms of the diabetes mellitus type 2 are excessive thirst, excessive urination, weakness, fatigue and dry mucous membranes. (amazonaws.com)
  • For the treatment of diabetes mellitus type 2 the medicines, capable to reduce the level of blood sugar and insulin, are applied. (amazonaws.com)
  • The Institute of Cell Therapy developed and clinically tested the method of treatment of diabetes mellitus, the 1st and 2nd type, by means of hematopoietic stem cells transplantation. (amazonaws.com)
  • Treatment of diabetes mellitus type 2 with the use of stem cells does not only increase the effectiveness of treatment by traditional means and methods, but sometimes enables to refuse completely from them. (amazonaws.com)
  • Type 1 diabetes is an autoimmune condition, and the immune system attacks the cells of the pancreas. (amazonaws.com)
  • The exact mechanisms that lead to Type 2 diabetes are not fully understood, but an underlying genetic susceptibility is usually present. (amazonaws.com)
  • If people living with Type 1 diabetes don't receive treatment they can develop very high blood sugar levels - hyperglycaemia - within days. (amazonaws.com)
  • Type 2 diabetes tends to develop more gradually, which is one of the reasons why medical professionals think that so many cases go undiagnosed. (amazonaws.com)
  • Type 2 diabetes is characterized by obesity (particularly central deposition adiposity, or fat around the middle and deep in the abdominal cavity), cardiovascular disease, systemic inflammation, and the poor ability of muscles to store nutrients, which leads to muscle wasting and fat storage as well as nutrients circulating in the blood. (amazonaws.com)
  • Insulin resistance, and its associated metabolic syndrome, is a step along the road to type 2 diabetes. (amazonaws.com)
  • Type 2 diabetes mellitus (T2DM) is a growing worldwide epidemic. (springer.com)
  • 1 Type 2 diabetes mellitus (T2DM) is the most common form, accounting for approximately 85% of all cases. (springer.com)
  • The purpose of this study is to determine if self-monitoring in patients with type 2 diabetes not using insulin results in better glycemic control. (bioportfolio.com)
  • Primary: What is the effect of SMBG in patients with type 2 diabetes who are not using insulin on Glycemic control (as measured with glycosylated hemoglobin (HbA1c)? (bioportfolio.com)
  • A Study to assess if patients with Type 2 diabetes (T2D) who have suboptimal glycemic control using multiple oral agents are able to make lifestyle changes resulting in improved glycemic c. (bioportfolio.com)
  • Although the prevalence of all types of chronic conditions is increasing, diabetes is one of the few long-term metabolic disorders that individuals can successfully manage, monitor and control on a da. (bioportfolio.com)
  • Biological evaluation of (3 β )-stigmast-5-en-3-ol as potent anti-diabetic agent in regulating glucose transport using in vitro model," International Journal of Diabetes Mellitus , vol. 2, no. 2, pp. 101-109, 2010. (hindawi.com)
  • Targeting the AMPK pathway for the treatment of type 2 diabetes," Frontiers in Bioscience , vol. 14, no. 9, pp. 3380-3400, 2009. (hindawi.com)
  • Patients suffering from type-2 diabetes and/or obesity often develop insulin resistance and are unable to control their glucose homeostasis. (jove.com)
  • New insights into the mechanisms of insulin resistance may provide new treatment strategies for type-2 diabetes. (jove.com)
  • Methods and Results- Thirteen patients with type 2 diabetes mellitus received both intravenous reconstituted HDL (rHDL: 80 mg/kg over 4 hours) and placebo on separate days in a double-blind, placebo-controlled crossover study. (ahajournals.org)
  • These findings suggest a role for HDL-raising therapies beyond atherosclerosis to address type 2 diabetes mellitus. (ahajournals.org)
  • 1 Type 2 diabetes mellitus and the cluster of pathologies including glucose intolerance/insulin resistance, obesity, and high plasma triglycerides that constitute the metabolic syndrome are associated with low and dysfunctional HDL. (ahajournals.org)
  • Given the high and escalating prevalence of type 2 diabetes mellitus, obesity, and the metabolic syndrome and the associated marked elevation in cardiovascular morbidity and mortality, this is an important area of investigation. (ahajournals.org)
  • Recent studies have demonstrated that infusions of recombinant and reconstituted HDL (rHDL) have modest effects on coronary plaque morphology and volume 10,11 and improve endothelial function in type 2 diabetes mellitus. (ahajournals.org)
  • The introduction of the eBalance device will bring to market the first non-invasive treatment option to capitalize on our understanding of how central microcurrents are to both treatment and potential reversal of type 2 diabetes. (science20.com)
  • This does not, however, explain systematic changes, such as a diminished junctional conductance in type 2 diabetes. (science20.com)
  • Inhibitor
  • Male 20-week-old type 2 diabetic rats (OLETF) were randomly divided into 3 groups: sedentary control, resistance training (3 times a week on alternate days for 8 weeks), or resistance training with continuous infusion of a 5α-reductase inhibitor (n = 8 each group). (nih.gov)
  • The purpose of this study was to examine the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of L-type amino acid transporters, on the cell growth suppression in KB human oral cancer cells and to study the roles of cell cycle regulatory factors in the BCH-induced growth inhibition. (biomedsearch.com)
  • islet
  • We've known for some time that the islet is sensitive to a glucose demand in secreting insulin and uses gap junctions as a tuning parameter in this adaptation. (science20.com)
  • Modulation
  • The normal functions of the hair cells require high levels of ATP and consequently glucose for the modulation and maintenance of F-actin and related cytoskeletal proteins [ 1 ]. (hindawi.com)
  • fructose
  • The GLUT family members 1, 2, 3, 4, and 5 have been studied in various tissues and cell types with regard to glucose and/or fructose transport [ 5 ]. (hindawi.com)
  • amino acid
  • The encoded protein has an amino acid length of 496 and a mass of 53.9 kDa. (biocompare.com)
  • GLUTs generally comprise a 500-amino acid protein backbone and they have a single N-linked oligosaccharide and 12 transmembrane domains. (hindawi.com)
  • nuclear
  • said glucose response element comprises a hepatic nuclear factor-4 (HNF-4) binding site and a glucose responsive site. (google.com)
  • Glucose uptake rate, as determined by 31 P-nuclear magnetic resonance spectroscopy measuring 2-deoxyglucose conversion to 2-deoxyglucose-6-phosphate, was measured in isolated perfused hearts obtained from banded rabbits when M/V ratio had increased by 15% from baseline (compensated hypertrophy) and by 30% from baseline (early-decompensated hypertrophy). (ahajournals.org)
  • Sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • the sequence of said HNF-4 binding site and said glucose responsive site is in a native orientation. (google.com)
  • said glucose response element comprises a nucleotide sequence set forth in SEQ ID NO.: 1. (google.com)
  • said insulin-sensitive element comprises a nucleotide sequence set forth in SEQ ID NO.: 2. (google.com)
  • 100% sequence identity with primate protein, 93% sequence identity with rat, cow, and rabbit proteins. (covalab.com)
  • anti-diabetic
  • These antioxidants have been proposed as potential anti-diabetic drugs by acting as biological targets involved in T 2 DM development. (ijbs.com)
  • Moreover, we highlighted the anti-diabetic effects of the flavonoids in the management of T 2 DM, through modulating glucose transporters, with particular emphasis on the investigations and recent findings. (ijbs.com)