• E proteins made by the viral genome promote the activation of host DNA replication mechanisms that can then be used by the virus during its own replication. (medscape.com)
  • We use a combination of cell-based and in vitro assays to show that the interface of the FluPol A dimer is required for vRNA synthesis during replication of the viral genome. (nature.com)
  • Our study provides high-resolution structures of medically relevant FluPol A , as well as insights into the replication mechanisms of the viral RNA genome. (nature.com)
  • Detailed analysis of the splicing junctions showed clusters of AS events occurred in two regions of the virus genome, demonstrating that transcriptome analysis could gain valuable insights into viral splicing. (nature.com)
  • The results of the genome test proved remarkably accurate: in 89 percent of the cases a viral signature showed itself to be distinct from a bacterial one, according to Zaas' Wednesday report in the Science Translational Medicine journal. (rt.com)
  • While genome-wide association studies (GWAS) have identified numerous disease-associated variants involved in gene expression, implicating the involvement of eQTLs, they are unable to show any causal relationships. (sanger.ac.uk)
  • The team identified 1,275 eQTLs within the genome which alter gene expression along the innate immune response between people, relevant for 40 immune-related diseases such as Crohn's disease and diabetes. (sanger.ac.uk)
  • HIV genome contains three main genes: gag, pol, and env. (proteopedia.org)
  • Genome annotation disclosed 29 SARS-CoV-2 gene products - including 16 non-structural proteins, 4 structural proteins and 9 accessory factors. (news-medical.net)
  • A) SARS-CoV-2 genome annotation, predicting 29 virus gene products. (news-medical.net)
  • This strategy saves valuable space in the viral genome and allows the virus to better hide from the host's immune system, according to an announcement from Rockefeller University. (feedstuffs.com)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • Viral integration into the host cellular genome is a hallmark of malignant progression. (medscape.com)
  • L genes encode viral capsid proteins. (medscape.com)
  • Three of these RNP segments encode the virus' surface proteins, i.e., the HA, NA and M proteins. (cdc.gov)
  • These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. (thermofisher.com)
  • SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. (thermofisher.com)
  • The vaccine uses lipid nanoparticles, or fat bubbles, to deliver bits of genetic material that encode instructions for making the SARS-CoV-2 spike protein-the red protuberances in the iconic virus image-which the coronavirus uses to enter human cells. (poz.com)
  • In spite of their broad abundance, viruses, in particular bacteriophages, remain largely unknown since only about 20% of sequences obtained from viral community DNA surveys could be annotated by comparison with public databases. (mdpi.com)
  • The transmembrane domain prediction also indicated that these viral gene products contain at least one transmembrane domain in their protein sequences - with the exception of ORF6, which is actually a short protein with only 61 amino acids. (news-medical.net)
  • For some pathogens, consideration may need to be given to the presence of mutations in targeted gene sequences or proteins. (who.int)
  • At least two mutations in the NRAS gene have been found to cause giant congenital melanocytic nevus. (medlineplus.gov)
  • The NRAS gene mutations that cause this condition are somatic, meaning that they occur during a person's lifetime and are present only in certain cells. (medlineplus.gov)
  • The mutations that cause this condition affect a single protein building block (amino acid) in the N-Ras protein. (medlineplus.gov)
  • These mutations lead to production of an N-Ras protein that is constantly turned on (constitutively active). (medlineplus.gov)
  • Somatic mutations in the NRAS gene are involved in the development of several types of cancer. (medlineplus.gov)
  • These mutations lead to an N-Ras protein that is constitutively active and can direct cells to grow and divide without control. (medlineplus.gov)
  • Studies suggest that NRAS gene mutations are common in the aggressive skin cancer melanoma, including individuals without giant congenital melanocytic nevus (described above). (medlineplus.gov)
  • Mutations in the NRAS gene have also been found in other types of cancer. (medlineplus.gov)
  • For reasons that are unclear, inherited mutations in the NRAS gene do not appear to increase the risk of cancer in people with Noonan syndrome. (medlineplus.gov)
  • The unique synonymous mutations detected in the E and Non-structural 2a genes of Usutu-BONN strains may suggest an adaptive evolution. (cdc.gov)
  • The B.1.1.7 variant contains several mutations, including several in the gene that encodes the viral spike protein. (eurekalert.org)
  • the B.1.1.7 variant, due to its mutations, shows up as positive for two of those sites, but negative for the third site, which is within the virus's spike gene. (eurekalert.org)
  • The SGTF pattern can occur with other SARS-CoV-2 variants that have spike gene mutations, but the researchers found by sequencing every SGTF sample they had from December through February, 662 of the 986 samples (67 percent) contained the B.1.1.7 variant. (eurekalert.org)
  • For many questions in biology, we want to know how different genes interact, and for this we need to introduce mutations into multiple genes," says Rudolf -Jaenisch, a biologist at the Whitehead Institute in Cambridge Massachusetts. (technologyreview.com)
  • Some mutations in the S gene may lead to changes in the spike protein which result in inhibition of contact and entry of the virus into human cells, however in the case of the VOC, they contain mutations in the S gene that enhance the process of contact and entry into human cells, increasing transmissibility of the virus. (who.int)
  • To date, WHO has designated 4 SARS CoV-2 genotypes that meet the working definition of a VOC: i) contain mutations divergent from the Wuhan strain and ii) that the mutations impact one or more of the aspects of viral infection that have public health significance. (who.int)
  • Currently, manufacturers are focusing on and targeting assays to mutations in the S gene. (who.int)
  • This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. (nih.gov)
  • A viral structural protein is a viral protein that is a structural component of the mature virus. (wikipedia.org)
  • During assembly of the bacteriophage (phage) T4 virion, the structural proteins encoded by the phage genes interact with each other in a characteristic sequence. (wikipedia.org)
  • Maintaining an appropriate balance in the amounts of each of these structural proteins produced during viral infection appears to be critical for normal phage T4 morphogenesis. (wikipedia.org)
  • Phage T4 encoded proteins that determine virion structure include major structural components, minor structural components and non-structural proteins that catalyze specific steps in the morphogenesis sequence. (wikipedia.org)
  • Viral nonstructural protein Viral+Structural+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Ito N, Mossel EC, Narayanan K, et al. (wikipedia.org)
  • doi:10.2217/fmb.14.91 Wikimedia Commons has media related to Viral structural proteins. (wikipedia.org)
  • The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
  • One of these structural changes altered the protein so that it could no longer function for viral resistance. (usda.gov)
  • The other structural change allowed normal viral resistance to occur but affected the shape of the protein on the surface of cells. (usda.gov)
  • In this strain, 1 putative cleavage site of the viral polyprotein responsible for processing of structural proteins was changed. (cdc.gov)
  • Here, we used a gene therapy approach to directly overexpress APPsα in the brain using AAV-mediated gene transfer and explored its potential to rescue structural, electrophysiological and behavioral deficits in APP/PS1∆E9 AD model mice. (springer.com)
  • gag gene codes for structural proteins which forms the 'body' of the viral particle, among other proteins. (proteopedia.org)
  • The S gene is one of the structural genes of the virus which encodes for a protein that sits on the surface of the SARS CoV-2 virus. (who.int)
  • The cp gene from ZYMV encodes the coat protein (CP) gene from Zucchini yellow mosaic virus. (cbd.int)
  • The OAS1 gene encodes a protein involved in clearing viral RNA from the cell. (sanger.ac.uk)
  • E1 protein has helicase activity for replication, and E2 encodes DNA-binding protein for regulation of transcription. (medscape.com)
  • Crucially, some viral vectors (i.e., viruses specifically used to deliver genetic material into cells) have the potential to circumvent the blood-brain- (BBB) and blood-spinal cord barriers (BSCB) when intravenously injected. (frontiersin.org)
  • The largest, ORF-1, codes for the nonstructural proteins responsible for viral replication. (medscape.com)
  • The positive samples were further subjected to PCRs for the amplification of a partial segment of the Usutu virus envelope and nonstructural 5 gene. (cdc.gov)
  • The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. (nih.gov)
  • The mRNA of the DM2-cMyc gene was synthesized and injected into Xenopus oocytes. (cdc.gov)
  • Synthetic vaccinology uses information from viral gene sequencing to create DNA and mRNA molecules encoding viral proteins. (sciencedaily.com)
  • Through a process related to viral cross-protection, transgenic lines with this gene exhibit resistance to infection and subsequent disease caused by ZYMV. (cbd.int)
  • Here is the solution the Duke researchers came up with: photographing gene activity at the onset of infection. (rt.com)
  • But a viral infection is fought with a different set of genes than a bacterial one, for instance. (rt.com)
  • Because the cleave step results in infectious viral particles, Drugs called protease inhibitors can interfere with this step of the viral life cycle and further prevent HIV infection progressing. (proteopedia.org)
  • We are trying to understand the contribution of this family to virulence in C. glabrata by figuring out what the ligand specificity is of different family members, how genes are normally regulated during infection, and what mechanisms normally act to keep the genes transcriptionally silent and how that silence is regulated. (hopkinsmedicine.org)
  • Now, the same team - including researchers in the laboratories of Charles M. Rice, the Maurice R. & Corinne P. Greenberg professor and head of the Laboratory of Virology & Infectious Disease, and Robert B. Darnell, the Robert & Harriet Heilbrunn professor and head of the Laboratory of Molecular Neuro-oncology - has found evidence that another RNA virus - bovine viral diarrhea (BVD) virus, which infects cows and other livestock - also depends on miRNA for infection. (feedstuffs.com)
  • The viral S gene is important as it codes for the Spike protein which is the molecule that makes contact with, and allows entry of the virus into susceptible host cells, causing infection. (who.int)
  • A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
  • The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. (bvsalud.org)
  • In a first for the genetic toolset known as CRISPR, a recently discovered protein has been found to act as a kind of multipurpose self-destruct system for bacteria, capable of degrading single-stranded RNA, single-stranded DNA and double-stranded DNA. (sciencedaily.com)
  • Using a high-resolution imaging technique called cryo-EM, the team discovered that when this protein, named Cas12a2, binds to a specific sequence of genetic material from a potentially dangerous virus, called a target RNA, a side portion of Cas12a2 swings out to reveal an active site, similar to a sprung-open switchblade knife. (sciencedaily.com)
  • This is the first CRISPR protein that has been found to degrade such a wide range of genetic material. (sciencedaily.com)
  • In order to shed some light into this genetic dark matter we expanded the search of orthologous groups as potential markers to viral taxonomy from bacteriophages and included eukaryotic viruses, establishing a set of 31,150 ViPhOGs (Eukaryotic Viruses and Phages Orthologous Groups). (mdpi.com)
  • Virus-mediated gene therapy has the potential to deliver exogenous genetic material into specific cell types to promote survival and counteract disease. (frontiersin.org)
  • This also leads to differing RNA and protein formations, otherwise known as a genetic fingerprint. (rt.com)
  • These are like signposts in our DNA that indicate which genetic variations are linked to changes in the expression of certain genes, affecting how much or how little a gene is dialled up or down, leading to differences in the levels of proteins produced by that gene. (sanger.ac.uk)
  • The present findings suggest that local IFN production may interact with a genetic factor ( PTPN2 ) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased β-cell apoptosis via JNK activation and the intrinsic apoptotic pathway. (diabetesjournals.org)
  • Susceptibility to T1D is linked to genetic factors, but T1D-predisposing genes have low penetrance and only a small proportion of individuals genetically at risk will develop the disease. (diabetesjournals.org)
  • Precise and easy ways to rewrite human genes could finally provide the tools that researchers need to understand and cure some of our most deadly genetic diseases. (technologyreview.com)
  • Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes. (technologyreview.com)
  • Most conventional gene therapies crudely place new genetic material at a random location in the cell and can only add a gene. (technologyreview.com)
  • Projection of viral predicted peptides on the cyanobacterial PSI crystal structure suggested that the viral-PSI components might provide a unique way of funnelling reducing power from respiratory and other electron transfer chains to the PSI. (nih.gov)
  • Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. (nih.gov)
  • While nine spCas9 gene editing sites surround the Arc start codon, the accuracy of the editing was highly sequence-dependent, with only a single target resulting in an in-frame reporter integration. (lu.se)
  • A chicken gene that produces a protein important for viral disease resistance was obtained and its DNA sequence was determined. (usda.gov)
  • This technology could allow researchers to perform microsurgery on genes, precisely and easily changing a DNA sequence at exact locations on a chromosome. (technologyreview.com)
  • Additionally, adeno-associated virus-mediated gene delivery is a safe and effective method for modulating gene expression, and thus is a useful research tool for manipulating individual UPR markers in affected retinas and a promising delivery vector for gene therapy in retinal degenerative disorders. (molvis.org)
  • Before a person even feels the first symptoms of an illness, sets of genes are dispatched by the organism to battle it. (rt.com)
  • We also focus research on a family of genes--the EPA genes--that allow the organism to bind to host cells. (hopkinsmedicine.org)
  • This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. (origene.com)
  • Manipulation of UPR markers has been made possible by the use of knockout mice, pharmacological agents, and viral vector-mediated augmentation of gene expression. (molvis.org)
  • These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)
  • Expression of the L1 protein using recombinant DNA technology produces noninfectious virus-like particles (VLPs). (cdc.gov)
  • Assuming the same expression level in the Xenopus oocytes, DM2 without tag and influenza C virus M2 protein (CM2) were subjected to the TEVC method. (cdc.gov)
  • The tool, GASPACHO, captures dynamic changes in gene expression along the innate immune response, allowing researchers to identify genes and molecular pathways associated with disease risk that have previously been too complex to detect or interpret. (sanger.ac.uk)
  • The study, published in Nature Genetics (12 June), helps to unpick the relationship between specific genes, their expression levels, and their potential connection in disease susceptibility. (sanger.ac.uk)
  • The regions that affect gene expression are called expression quantitative trait loci (eQTLs). (sanger.ac.uk)
  • Unlike previous eQTL mapping attempts that aggregate single-cell data - measuring average gene expression over many cells - GASPACHO enables cell-specific resolution to track changes over time and across individual cells. (sanger.ac.uk)
  • The researchers found that when applying the tool to investigate variation in COVID-19 outcomes, lower expression of OAS1 gene variation occurred in those more likely to get COVID-19. (sanger.ac.uk)
  • In COVID-19 patients, the team found lower OAS1 expression in nasal epithelial cells as well as monocytes in blood - both viral target cell types - compared to a reference genotype group. (sanger.ac.uk)
  • Differences in mechanical and fatigue properties of diaphragm motor units are the result of expression of different contractile proteins and mitochondrial volume densities in corresponding muscle fiber types. (mayo.edu)
  • Dr. Sieck's team has also developed a novel targeted gene therapy approach to increase TrkB expression in phrenic motor neurons using an adeno-associated virus. (mayo.edu)
  • Furthermore, stable viral gene expression was done in cells and subsequently verified by immunoblotting technique. (news-medical.net)
  • The miRNAs are small stretches of RNA made by host cells to regulate gene expression. (feedstuffs.com)
  • Disruption of E1 and E2 allows for dysregulated downstream genes and the expression of E6 and E7 proteins, which are selectively maintained in virally induced tumors. (medscape.com)
  • Here we show evidence for the presence of photosystem I (PSI) genes in the genomes of viruses that infect these marine cyanobacteria, using pre-existing metagenomic data from the global ocean sampling expedition as well as from viral biomes. (nih.gov)
  • The seven cyanobacterial core PSI genes identified in this study, psaA, B, C, D, E, K and a unique J and F fusion, form a cluster in cyanophage genomes, suggestive of selection for a distinct function in the virus life cycle. (nih.gov)
  • To do this, we examine the non-redundant viral diversity stored in public databases, predict proteins in genomes lacking such information, and used all annotated and predicted proteins to identify potential protein domains. (mdpi.com)
  • Aptamers to components of the replication complex are therefore useful molecular tools for studying viral replication and also have potential as diagnostic molecules in the future. (whiterose.ac.uk)
  • The molecular chaperone glucose-regulated protein 78 ( GRP78 ) or binding immunoglobulin protein (BiP), in addition to Ca 2+ binding and protein processing functions, possesses one more key role: master initiator of early UPR signaling. (molvis.org)
  • Proteins are separated in the first dimension based on their isoelectric point, and then in the second dimension by molecular weight. (learner.org)
  • Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. (hopkinsmedicine.org)
  • Over the past decade, the importance of hepatitis B identified for all 4 genes ( 2 ). (cdc.gov)
  • Most cases of acute viral hepatitis. (msdmanuals.com)
  • HBV mutant tase activity of the HBV polymerase protein lacks a proof- surveillance and understanding of HBV mutant impact on reading function, random mis-incorporation of bases into disease diagnosis will pose a challenge to global health the replicating DNA strand occurs. (cdc.gov)
  • It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals. (bvsalud.org)
  • Single nucleotide and copy number variants in the paired-like homeodomain transcription factor 2 (PITX2) and forkhead box C1 (FOXC1) genes are associated with Axenfeld-Rieger syndrome as well as other CNS malformations. (bvsalud.org)
  • The researchers discovered that, with a single mutation to the Cas12a2 protein, the active site degrades only single-stranded DNA -- a feature especially useful in developing new diagnostics tailored for any of a wide range of viruses. (sciencedaily.com)
  • It has been well demonstrated that viruses deploy host AS machinery for viral protein productions. (nature.com)
  • However, knowledge on viral AS is limited to a few disease-causing viruses in model species. (nature.com)
  • Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • Gene therapy viruses are non-replicating, but still hijack host cell machinery to express transgenes of interest in the nucleus. (frontiersin.org)
  • Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. (frontiersin.org)
  • Historically, vaccines against viral diseases have used live-attenuated (weakened) viruses or inactivated whole viruses to induce protective immune responses. (sciencedaily.com)
  • B surface antigen (HBsAg) mutants, their impact on viral to an amino acid change in the overlapping reading frame. (cdc.gov)
  • Genomic analysis revealed several unique amino acid substitutions among the polyprotein gene. (cdc.gov)
  • Mutational analysis of several of these amino acids both in pUL105 and pUL70, proved that they are crucial for viral replication. (frontiersin.org)
  • Using GASPACHO (GAuSsian Processes for Association mapping leveraging Cell HeterOgeneity), researchers at the Wellcome Sanger Institute, the National Center for Child Health and Development in Japan, Tel Aviv University and their collaborators have identified a gene variant that affects COVID-19 susceptibility. (sanger.ac.uk)
  • By conducting a state-of-the-art interactome study between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host cells, researchers from the University of Texas MD Anderson Cancer Center in Houston identified 437 human proteins as the high-confidence interacting proteins - with substantial implications for understanding coronavirus disease 2019 (COVID-19) pathology and potential treatments. (news-medical.net)
  • In this study, the researchers applied the two aforementioned strategies: tandem affinity purification with the SFB ( S-protein , FLAG epitope, and streptavidin-binding peptide) tag, as well as proximity labeling by using a second-generation biotin ligase, BioID2. (news-medical.net)
  • The researchers have also built an interaction network by utilizing the 437 identified virus-host protein-protein interactions, which enabled all the complex analyses that they have pursued. (news-medical.net)
  • In short, from a total of 437 high-confidence interacting proteins that bind to one or more SARS-CoV-2 genes, the researchers have identified several gene products, M protein, NSP6, ORF3a, ORF6 and ORF7b that interacted with host cell membrane proteins and complexes. (news-medical.net)
  • The N-Ras protein acts like a switch, and it is turned on and off by the GTP and GDP molecules. (medlineplus.gov)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous. (lu.se)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
  • A companion paper in the same issue of Nature describes the biological functions of Cas12a2, while the paper described in this news release describes the mechanisms by which the protein accomplishes them. (sciencedaily.com)
  • Austin SA, Combs CK (2008) Mechanisms of microglial activation by amyloid precursor protein and its proteolytic fragments. (springer.com)
  • We may in the future be able to use OAS1 and other genes on the same cascade in drug discovery or as therapeutic targets, but more research is needed to understand the specific mechanisms by which OAS1 or related genes may contribute to COVID-19. (sanger.ac.uk)
  • However, the mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)
  • We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
  • However, these genes only account for part of interindividual differences in disease predisposition or phenotypic diversity, and the pathophysiologic mechanisms by which most candidate genes predispose to T1D remain unclear. (diabetesjournals.org)
  • Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. (bvsalud.org)
  • With thousands of clinical trials to date, gene therapy is a flourishing strategy with great promise for the treatment of diseases impacting the nervous system. (frontiersin.org)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • Several transcript variants encoding different isoforms have been found for this gene. (origene.com)
  • Many human illnesses, including heart disease, diabetes, and assorted neurological conditions, are affected by numerous variants in both disease genes and normal genes. (technologyreview.com)
  • Wuhan strain will continue to arise, yet not all viral variants generated through mutation of the virus are important or have immediate public health relevance. (who.int)
  • Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective. (cdc.gov)
  • The HCMV helicase-primase complex (pUL105-pUL102-pUL70) is essential for viral DNA replication and could thus be a relevant antiviral target. (frontiersin.org)
  • Almkvist O, Basun H, Wagner SL, Rowe BA, Wahlund LO, Lannfelt L (1997) Cerebrospinal fluid levels of alpha-secretase-cleaved soluble amyloid precursor protein mirror cognition in a Swedish family with Alzheimer disease and a gene mutation. (springer.com)
  • Anderson JJ, Holtz G, Baskin PP et al (1999) Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. (springer.com)
  • Barger SW, Harmon AD (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881. (springer.com)
  • The two candidate substrates are the amyloid precursor protein (APP) in axons and tumor necrosis factor receptor 1 (TNFR1) on macrophages , which infiltrate injured nerves and clear the inhibitory myelin debris. (hopkinsmedicine.org)
  • These studies aid in understanding how genes determining cell surface proteins can affect interactions between cells and confer viral disease resistance. (usda.gov)
  • The number of viral particles generated in some infected persons can be as high as 1011 viral particles per day. (cdc.gov)
  • The new viral particles cannot enter the host cell without maturation which require HIV-encoded protease. (proteopedia.org)
  • Additionally, we describe how neuropathology can negatively influence these pathways, and conclude by discussing opportunities to optimize the intramuscular administration route to maximize gene delivery and thus therapeutic potential. (frontiersin.org)
  • When the interactomes of NSP1 and N protein (i.e., two key SARS-CoV-2 proteins) were compared with other human coronaviruses , host pathways manipulations and divergent protein-protein interactions responsible for differences in disease pathology were uncovered. (news-medical.net)
  • His focus on understanding these proteins has led to the development of new techniques for studying cell-selective activities and advances with novel pathways that induce programmed cell death in cancer. (wpi.edu)
  • The N-Ras protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. (medlineplus.gov)
  • To transmit signals, the N-Ras protein must be turned on by attaching (binding) to a molecule of GTP. (medlineplus.gov)
  • Support vector machines are the classifier which has a potential to make a classification of the discriminatory genes and non-discriminatory genes. (researchgate.net)
  • The study found evidence of SARS-CoV-2 replication in all analyzed human autopsy coronaries regardless of their pathological classification, although viral replication was highest in early-stage lesions that progress to more advanced atherosclerotic plaques. (medscape.com)
  • May 10, 2021 Scientists are researching a new COVID-19 vaccine that would target only a small portion of the virus's spike protein. (sciencedaily.com)
  • Floor E. Interaction of morphogenetic genes of bacteriophage T4. (wikipedia.org)
  • Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin. (nih.gov)
  • Finally, we recorded mCherry-Arc interaction with presynaptic protein Bassoon in mCherry-negative surrounding neurons at close proximity to mCherry-positive spines of edited neurons. (lu.se)
  • This is the first indication of a direct interaction between a candidate gene for T1D and the activation of a specific downstream proapoptotic pathway in β-cells. (diabetesjournals.org)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • All of the previously known CRISPR immune systems protect bacteria by deactivating genes from an invading virus. (sciencedaily.com)
  • Now, a recently discovered CRISPR protein, called Cas12a2, has been found to act as a kind of multi-purpose self-destruct system for bacteria, capable of degrading single-stranded RNA, single-stranded DNA and double-stranded DNA. (sciencedaily.com)
  • CRISPR is the name for a set of tools that occur naturally in bacteria, but which scientists have adapted for use in gene editing. (sciencedaily.com)
  • After harvesting blood cell precursors called hematopoietic stem cells from the bone marrow of a sickle-cell patient, scientists would use CRISPR to correct the defective gene. (technologyreview.com)
  • The Worcester Business Journal covered a WPI forum on the gene-editing technology known as CRISPR. (wpi.edu)
  • The encoded protein is secreted and binds hydroxyapatite with high affinity. (origene.com)
  • HIV-1 protease cleaves an human immunodeficiency virus (HIV) precursor proteins, such as cleaving the env protein , glycoprotein (GP) 160 , into gp41 and gp120 . (proteopedia.org)
  • Recently, core photosystem II (PSII) genes were identified in cyanophages and proposed to function in photosynthesis and in increasing viral fitness by supplementing the host production of these proteins. (nih.gov)
  • Here we report a novel approach to characterizing viral AS using whole transcriptome dataset from host species. (nature.com)
  • RNA splicing plays important roles in viral replication and virus-host interactions 38 . (nature.com)
  • One of the key facets of SARS-CoV-2 lifecycle is host-virus protein-protein interactions. (news-medical.net)
  • We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. (hopkinsmedicine.org)
  • If a virus can co-opt one, it can manipulate its host without having to make its own protein. (feedstuffs.com)
  • This protein is a critical in the linking of the virus to a host cell it can infect. (who.int)
  • Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes. (cdc.gov)
  • To provide a basis for developing novel ion channel-blocking compounds, we investigated the properties of influenza D virus M2 protein (DM2) as a drug target. (cdc.gov)
  • Conclusion: The M2 protein from newly isolated influenza D virus showed ion channel activity similar to that of CM2. (cdc.gov)
  • Such a diagnostic would still require separate work and probably involve collecting saliva or a nasal sample from a patient to be mixed with the team's modified Cas12a2 protein, the piece of guide RNA that acts like a mugshot to identify a specific virus, and a fluorescent probe designed to light up when its single-stranded DNA gets cut. (sciencedaily.com)
  • The Tekmira drug targets three of the seven genes of the Ebola virus. (forbes.com)
  • HIV-1 Protease is a viral aspartic protease that responsible for maturation of human immunodeficiency virus (HIV) . (proteopedia.org)
  • An influenza virus' RNP is composed of both RNA and protein. (cdc.gov)
  • Every influenza virus has eight RNP segments, corresponding to the virus' eight total gene segments. (cdc.gov)
  • The virus' hemagglutinin (HA) and neuraminidase (NA) surface proteins, were displayed in semi-transparent blue, sticking out of the surface of the virus. (cdc.gov)
  • His disciplinary research focuses on the discovery and characterization of novel virus proteins that have onco-selective toxicity. (wpi.edu)
  • The S protein, due to its exposure on the outside of the virus is also one of the parts of the virus that is recognised as foreign by the immune system. (who.int)
  • In other words, HIV-1 protease is responsible for maturation of the virion by cleaving proteins into their mature form. (proteopedia.org)
  • Yet scientists have until recently remained largely ham-fisted when they've tried to directly modify genes in a living cell. (technologyreview.com)
  • The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. (thermofisher.com)
  • These proteins play important roles in cell division, cell differentiation, and the self-destruction of cells (apoptosis). (medlineplus.gov)
  • The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. (nih.gov)
  • The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. (nih.gov)
  • RNA alternative splicing (AS) is an important post-transcriptional mechanism enabling single genes to produce multiple proteins. (nature.com)