Proteins from cancer. Medical search. Frequent questions

A normal cell that has accumulated several mutations in particular genes becomes likely to turn into a cancer cell. (bcm.edu)
Activating mutations of Ras genes are often observed in cancer. (nature.com)
The protein products of the three Ras genes are almost identical. (nature.com)
Ras genes are mutated in ~20% of all human cancer cases [ 1 ]. (nature.com)
There are three Ras genes that generate four almost identical proteins: HRAS, NRAS, KRAS4A and KRAS4B [ 2 ]. (nature.com)
These algorithms use knowledge of modular structure of genes and proteins to separately study each region. (nih.gov)
The Ras family of proteins are enzymes that set in motion the growth, division and differentiation of many types of cells, and their genes have been identified as the most frequently mutated cancer-related genes in humans. (scienceblog.com)
A new study by Mark Bedford, Ph.D. , professor of Molecular Carcinogenesis , and colleagues published in Molecular Cell sheds light on the mechanism by which TDRD3 - a protein that 'reads' epigenetic marks on chromosomal proteins - turns on certain genes. (mdanderson.org)
Several types of chemical modifications of the five major histone protein families give rise to a complex 'histone code' that signals the transcriptional machinery to turn genes on or off. (mdanderson.org)
The researchers studied the two proteins in breast cancer cell lines, where they discovered that TDRD3 recruits TOP3B to active chromatin (where genes are turned on) that is marked by arginine methylation. (mdanderson.org)
In humans, only about 1.5 percent of the human genome or DNA consists of protein-coding genes. (indiavision.com)
Researchers have now presented a new proteogenomics method, which makes it possible to track down protein coding genes in the remaining 98.5 percent of the genome, something that until now has been an impossible task to pursue. (indiavision.com)
Many of the new proteins encoded by pseudogenes could also be traced in other cancer cell lines, and the next objective on the researchers' agenda is to investigate if these genes in the "junkyard" of the genome play a role in cancer or other diseases. (indiavision.com)
Dr Lethio said that their study challenges the old theory that pseudogenes don't code for proteins, asserting that their method allows for protein based genome annotation in organism with complex genomes and can lead to discovery of many novel protein coding genes, not only in humans but in any species with a known DNA sequence. (indiavision.com)
Signal transducers and activators of transcription (STATs) are a group of cytosolic proteins that regulate the expression of several genes associated with the uncontrolled growth and immortality of cancer cells. (selectscience.net)
While this protein is present in most cells, in cancer it is permanently switched on, driving the expression of genes that lead to uncontrolled cell growth and survival. (selectscience.net)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
According to the study, investigators identified the methyltransferase enzyme that controls the activity of the normal AML1 protein - also called RUNX1 - demonstrating its ability to regulate the function of transcription factors, proteins that control cell fate by turning genes on or off. (mskcc.org)
Together, Green said, the proteins made by these genes make up the body's melanoma defense pathway. (healthnewstrack.com)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
The variety of keratin genes differentially expressed suggests that these proteins may however have additional functions. (exposed-skin-care.net)
Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least two or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)
In hereditary nonpolyposis colorectal cancer (HNPCC), an inherited mutation in one of the DNA mismatch repair (MMR) genes appears to be a critical factor. (medscape.com)
MMR genes normally produce proteins that identify and correct sequence mismatches that may occur during DNA replication. (medscape.com)
We need to know more about the proteins that our genes produce. (lu.se)
A lot happens in a cell when information is transferred from the genes' coding to a protein", explains Ákos Végvári, a researcher at the Division of Electrical Measurements at Lund University. (lu.se)
We have around 20 000 genes that can produce at least 500 000 proteins. (lu.se)
This means taking different types of cancer, for example, as the starting point and trying to identify the genes and the different protein variants that differ between healthy and ill individuals. (lu.se)

A team led by researchers at Baylor College of Medicine and the University of Texas at Austin has applied an unconventional approach that used bacteria to discover human proteins that can lead to DNA damage and promote cancer. (bcm.edu)
To uncover these DNA "damage-up" proteins, the researchers took an unconventional approach. (bcm.edu)
When the researchers looked for human protein relatives of the DNA "damage-up" proteins they had found in bacteria, they identified 284. (bcm.edu)
When the researchers overproduced these proteins in human cells in the lab, half of the proteins triggered DNA damage and mutation. (bcm.edu)
The researchers based their work on the premise that it is proteins, and not mutations in DNA per se, that are ultimately responsible for changing somatic cells into cancerous ones. (genengnews.com)
The researchers used NCI-60 tumor cell lines which came from the U.S. National Cancer Institute. (genengnews.com)
However, the researchers also found some clearly distinguishable protein profiles between the tumor cells of different tissues. (genengnews.com)
For the first time, researchers have determined how bromodomain (BRD) proteins work in type 2 diabetes, which may lead to a better understanding of the link between adult-onset diabetes and certain cancers. (sciencedaily.com)
According to the researchers new small molecule BET inhibitors have been developed that block all three BET proteins in cancer cells, but they interfere with too many functions. (sciencedaily.com)
Researchers at The Ohio State University are the first to detect a section of this protein's structure that had previously been unobservable by standard lab tools, revealing features and interactions related to the protein's mutations that put cells into a state of perpetual division - a classic cancer characteristic. (scienceblog.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Researchers at Nottingham Trent University discovered that injecting the PAP 114 protein in the surrounding area of cancerous cells stimulates the body's immune system and "switches off" tumour growth. (ibtimes.co.uk)
Many Alzheimer's researchers have focused on amyloid beta alone, or connections between amyloid beta and another protein, tau. (news-medical.net)
Papers published by researchers at GlaxoSmithKline ($GSK)--which has a protein degradation team at its Stevenage, U.K. site--Yale University, Dana-Farber Cancer Institute and the University of Dundee have shifted perceptions of the potential of PROTACs. (fiercebiotech.com)
Researchers at the Queen Mary University of London have found a protein that had a previously unknown role in cell ageing. (worldhealth.net)
The researchers found that the short protein isoform of bone morphogenetic protein 1 (BMP1) occurred more frequently in NSCLC patients compared with healthy participants, and with even greater abundance in patients with late-stage cancer, suggesting that this isoform of BMP1 may play a role in NSCLC progression. (tmcnet.com)
And this difference is proving to be an Achilles' heel that allows researchers to target cancer stem cells without harming healthy cells - the approach has already proven effective in clinical trials against acute myeloid leukemia and holds promise for other cancers including breast, pancreatic, and liver. (newswise.com)
Washington - Researchers have found close to one hundred novel human gene regions that code for proteins and a number of these regions are so-called pseudogenes, which may be linked to cancer. (indiavision.com)
Researchers tested the compounds on breast cancer cells and found curcusone D to be extremely effective at shutting down cancer cells . (phys.org)
Already, researchers from other entities have reached out to test the compound on the cancers they study, bringing hope for renewed therapeutics for treating the disease. (phys.org)
A new study led by researchers at Memorial Sloan Kettering Cancer Center (MSKCC) reports on a novel mechanism that can enhance the function of a protein that is frequently impaired in patients with acute forms of leukemia. (mskcc.org)
The researchers found that the cellular pathways that regulate the activity of the normal AML1 protein through a process called arginine methylation cannot similarly regulate the activity of AML1-ETO, a protein associated with causing acute leukemia. (mskcc.org)
Researchers from the University of British Columbia (UBC) have identified a new protein that helps an oral bacterium thrive in other locations around the body. (lightsources.org)
Howard Hughes Medical Institute (HHMI) researchers have uncovered a protein that stops the growth of melanoma, a cancer that develops from pigment-producing cells in the skin called melanocytes. (healthnewstrack.com)
Researchers found that people with better oral health - those having natural teeth and more frequent dental visits - had better chances of surviving head and neck cancers. (medicaldaily.com)
Freiburg researchers demonstrate that the transport of molecules along the cell's skeleton plays a crucial role in cancer metastasis. (scitechdaily.com)
Mechanisms governing metastasis-a major cause of mortality in cancer patients-remain elusive, noted Y. Peng Loh of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and fellow researchers in their online report of their protein discovery ( The Journal of Clinical Investigation , www.jci.org/articles/view/40433/pdf ). (oncologynurseadvisor.com)
This is key, say researchers, to design therapies that adapt to each patient's type of cancer: the quest for personalised medicine , that is more effective and causes fewer side effects. (cnio.es)
One of the researchers who will focus on the role of chaperones in the correct folding of cellular proteins is Johannes Buchner, from the Technical University of Munich, Germany. (cnio.es)
There are unique circumstances where the SGK1 protein is critically important, so there might be a vulnerability that researchers can target and alter the way the cells process their nutrients, said Schafer. (medicalxpress.com)
By improving hospital care pathways, researchers from MD Anderson Cancer Center successfully reduced inpatient opioid use by 50% after pancreatic cancer surgery and cut the median opioid prescription volumes at discharge to zero. (cancerletter.com)
Within the research field of proteomics, researchers study the link between proteins and disease. (lu.se)
A few years ago, researchers believed that they would easily be able to identify individual biomarkers for different diseases, i.e. that one protein would be enough to diagnose a certain disease. (lu.se)
It is this unique sequence that researchers use to identify and quantify the protein. (lu.se)
By using three consecutive mass analysis units in mass spectrometry, the researchers can now filter out rare protein sequences. (lu.se)

Most notably, this bacteria is prevalent in the tumors of colorectal cancer patients. (lightsources.org)
This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). (lu.se)
The present study aimed to investigate components other than phenolic compounds that may have antitumor effects against colorectal cancer (CRC). (spandidos-publications.com)
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. (medscape.com)
See Colorectal Cancer: Prevention, Diagnosis, and Therapeutic Options , a Critical Images slideshow, to help identify the features several types of colorectal cancers. (medscape.com)
In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in two extended kindreds and named it cancer family syndrome. (medscape.com)
Before molecular genetic diagnostics became available in the 1990s, a comprehensive family history was the only basis from which to estimate the familial risk of colorectal cancer. (medscape.com)

NRAS»HRAS protein expression in cells that correlate with the rank order of Ras mutation frequencies in cancer. (nature.com)
Precision is required when designing such drugs - interfering with a protein in the wrong way could do more harm than the disease caused by a mutation. (scienceblog.com)
While nevi are, by definition, non-cancerous, more than half the time the same mutation is at fault in melanoma and nevi: a single amino acid change in a protein called BRAF. (healthnewstrack.com)
The BRAF mutation found in nevi and melanoma increases the activity of the BRAF protein, prompting cells to multiply abnormally. (healthnewstrack.com)
In some melanocytes with this mutation, the proliferation cannot be stopped, and cancer develops. (healthnewstrack.com)
Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. (bepress.com)
[ 13 ] The presence of a second thrombophilic mutation such as factor V Leiden has been associated with a more severe phenotype in some protein C-deficient kindreds. (medscape.com)
Individuals who are homozygous or compound heterozygous for a mutation or other genetic defect affecting the protein C, typically due to the inheritance of abnormal alleles from both parents, can experience neonatal purpura fulminans, intracranial thromboembolism, and thrombosis. (medscape.com)
In HNPCC, a mutation that inactivates an MMR gene leads to the accumulation of cell mutations and greatly increases the likelihood of malignant transformation and cancer. (medscape.com)

Membrane proteins are critical mediators for tumor progression and present enormous therapeutic potentials. (mit.edu)
The database can accelerate therapeutic developments and biotechnological applications of cancer-related membrane proteins. (mit.edu)
GRP78 is a resident protein of the endoplasmic reticulum (ER) and mayassociate transiently with a variety of newly synthesized secretory and membrane proteins orpermanently with mutant or defective proteins that are incorrectly folded, thus preventing theirexport from the ER lumen. (exposed-skin-care.net)

The exact significance of this expression and the contribution, if any, of MDR-3 Pgp in the resistance of breast cancer or other solid cancers further investigation. (dcu.ie)
we found that the expression of cartilage protein COMP is associated with metastases and a poor prognosis for patients with various types of solid cancers. (lu.se)

While already found in breast, ovarian, lung and oral cancers, POLQ is believed to play a role in a number of additional cancers, so the impact of the group's finding could be far-reaching in terms of new therapies. (sciencedaily.com)
Scientists from Seer in collaboration with Luis Diaz, M.D. from Memorial Sloan Kettering Cancer Center found previously unknown associations between four protein isoforms and non-small cell lung cancer (NSCLC) progression, constituting potential novel, disease-relevant biomarkers, or therapeutic targets. (tmcnet.com)
The compound-curcusone D-has the potential to help combat a protein found in many cancers, including some forms of breast, brain, colorectal, prostate, lung and liver cancers, among others. (phys.org)
We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of p16 and Rb protein: 28/30 specimens that did not stain for p16 stained for Rb and 21/31 p16-positive specimens did not stain for Rb. (nih.gov)
Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice. (bvsalud.org)
Previously, we reported that orthotopic xenografts of Lewis lung carcinoma 1 in C57BL/6 mice caused them to develop lung cancer with albuminuria . (bvsalud.org)
This implies that these mice can be used as a model of human disease and suggests that Lewis lung carcinoma 1 cell -secreted proteins (LCSePs) contain nephrotoxic molecules and cause inflammation in renal cells . (bvsalud.org)
Therefore, in this mouse model of lung cancer , FAK signaling prompts podocyte FP effacement and proteinuria , indicative of PNS. (bvsalud.org)

In addition, the proteins' RNAs, an indicator of protein production, predicted mutagenesis in tumors and poor patient prognosis. (bcm.edu)
In particular, stage II and III tumors displayed enhanced PTPN2 protein expression in tumor-infiltrating T cells, and increased PTPN2 levels negatively correlated with expression of PD-1, CTLA4, STAT1, and granzyme A. In vivo, T cell- and DC-specific PTPN2 deletion reduced tumor burden in several CRC models by promoting CD44+ effector/memory T cells, as well as CD8+ T cell infiltration and cytotoxicity in the tumor. (jci.org)
Green said IGFBP7's ability to target melanoma tumors throughout the body may make it a powerful tool for cancer therapy. (healthnewstrack.com)
Signaling molecules released by the cancer cells drive both processes and thereby increase the malignancy of tumors. (scitechdaily.com)
The presence of high levels of a particular protein in tumors drives metastasis, providing a valuable biomarker for predicting the spread of cancer. (oncologynurseadvisor.com)
However, the team helped shed light on this process by finding that the carboxypeptidase E gene is alternatively spliced in human tumors to yield an N-terminal truncated protein that drives metastasis. (oncologynurseadvisor.com)
By measuring the protein's genetic material in human tumors and the genetic material from surrounding tissue, the investigators could predict at least 90% of the time whether a cancer would spread within 2 years, regardless of cancer stage. (oncologynurseadvisor.com)
One of these is CSMD1, a large transmembrane protein deleted in number of tumors but also acting as classical complement inhibitor targeting complement convertases. (lu.se)

DNA is tightly packaged into chromosomes along with histone proteins. (mdanderson.org)
Findings from a study at The University of Texas MD Anderson Cancer Center revealed the leukemia-boosting abilities of ENL, which contains a protein component called YEATS that "reads" histone proteins. (mdanderson.org)
Histone proteins make up chromatin, large clusters of DNA- and RNA-containing molecules comprising our body's chromosomes. (mdanderson.org)

Reported in the journal Cell , the study also proposes biological mechanisms by which these proteins can cause damage to DNA, opening possibilities for future cancer treatments. (bcm.edu)
Although bacteria and people are different, their basic biological processes are similar, so with this approach we thought we might find common mechanisms of DNA damage that could be relevant to cancer," Rosenberg said. (bcm.edu)
We showed that E. coli can help to identify DNA damage-up proteins and mechanisms of action in human cells quickly and inexpensively. (bcm.edu)
Some of the proteins and their mechanisms were known to be involved in cancer, but many others were not suspected of being in the cancer-causing list," said co-corresponding author Dr. Christophe Herman , professor of molecular and human genetics and molecular virology and microbiology at Baylor College of Medicine and member of the Dan L Duncan Comprehensive Cancer Center. (bcm.edu)
The wide variety of kinases shows how different these mechanisms are in human cancers. (genengnews.com)
Finally, direct measurement of mutant versus wildtype KRAS protein abundance revealed a frequent imbalance that may suggest additional non-gene duplication mechanisms for optimizing oncogenic Ras dosage. (nature.com)
Protein 53 is known as the guardian of the genome since it is basic for the genome's integrity by preventing the accumulation of mutations originating either by the cell's own mechanisms or by the action of external agents. (scienceblog.com)
These findings demonstrate that distinct protein isoforms may differentially contribute to diverse biological mechanisms and to the pathogenesis of cancers, potentially paving the road to identify new diagnostic markers or new therapeutic targets," said Dr. Diaz, Head of the Division of Solid Tumor Oncology at Memorial Sloan Kettering Cancer Center. (tmcnet.com)
they showed quite potent anti-cancer activity and may lead to new mechanisms to combat cancer. (phys.org)
Although gene profiling can identify their cancer-specific signatures, systematic correlations between protein functions and tumor-related mechanisms are still unclear. (mit.edu)
Drug delivery mechanisms better able to target protein drugs to the disease site and provide localized, sustained release have the potential to transform therapeutic standards. (biorxiv.org)
Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. (lu.se)

Our cells make protein carcinogens," said co-corresponding author Dr. Susan M. Rosenberg , Ben F. Love Chair in Cancer Research and professor of molecular and human genetics , of molecular virology and microbiology and of biochemistry and molecular biology at Baylor. (bcm.edu)
External factors such as tobacco smoke and sunlight can damage DNA, but most DNA damage seems to result from events that occur within cells and is mediated by cellular components, including proteins. (bcm.edu)
They searched for proteins that promote DNA damage in human cells by looking at proteins that, when overproduced, would cause DNA damage in the bacterium E. coli . (bcm.edu)
We uncovered an extensive and varied network of proteins that, when overproduced, alter cells in ways that lead to DNA damage," Rosenberg said. (bcm.edu)
A new kind of medicine that destroys specific proteins on the surface of cells could lead to better therapies for conditions such as cancer. (newscientist.com)
The approach, devised by Xin Zhou at the Dana-Farber Cancer Institute in Boston, Massachusetts, and her colleagues, involves using modified antibodies they call TransTACs to join a surface protein to another common protein that is involved in transporting iron into cells. (newscientist.com)
The team identified over 10,000 different proteins in cancer cells. (genengnews.com)
Identifying the protein portfolio of tumor cells increases our chances of finding new targets for drugs. (genengnews.com)
The TUM group also showed that the protein pattern of the cells determines the effectiveness of cancer drugs. (genengnews.com)
The findings, which appear in PLOS ONE , show that reducing levels in pancreatic beta cells of individual BRDs, called BET proteins, previously shown to play a role in cancer, may also help patients who are obese and diabetic. (sciencedaily.com)
Protein 53 is very important in protecting against cancer given that it prevents cancer-causing mutations from accumulating and its inactivation is closely linked to the proliferation of tumour cells. (scienceblog.com)
This causes the gene encoding the protein, which in humans is the TP53 gene, to be seen as a tumour suppressor since its inactivation can make it easier for many types of tumour cells to develop. (scienceblog.com)
Scientists at John van Geest Cancer Research Centre, Nottingham Trent University, have found a protein which subdues prostate cancer by stimulating immune response against the tumour cells. (ibtimes.co.uk)
The only vaccine for prostate cancer available as of now uses the blood of the patient to isolate his or her immune system cells, which are cultured with a different protein, PAP-GM-CSF, similar to PAP. (ibtimes.co.uk)
The cultured complex of the patient's immune cells and protein are then put back in the patient's body to stimulate the immune system response to cancer. (ibtimes.co.uk)
Cancer cells try to avoid the overproduction of reactive oxygen species by metabolic rearrangements. (hindawi.com)
Cancer cells demand high energy production to sustain their pathological increase in proliferation rate. (hindawi.com)
In cancer cells, ROS production is mainly due to overexpression of the NADPH oxidase [ 3 ]. (hindawi.com)
While a balance between enhanced ROS production and detoxification can be maintained, cancer cells will proliferate and survive. (hindawi.com)
Commonly used radio- and chemotherapies are prooxidant strategies that alter cancer cells through ROS modulation and induce cell death [ 5 , 6 ]. (hindawi.com)
Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
The biological functions of HMGB1 are diverse in normal cells and during the start and progression of cancer. (hindawi.com)
Originally discovered for its effect on ovarian cancer metastasis and stem cell metabolisms, Wong's group found the OCIAD1 protein in human brain cells--and determined it impairs neurons and damages synapses in the brain, contributing to neurodegeneration in Alzheimer's disease. (news-medical.net)
New treatments for aging and early cancer may result from the discovery of protein found to have a previously unknown role in the ageing of cells. (worldhealth.net)
A slew of "abnormal" cells were identified in tissues from older individuals who were in the preliminary stages of cancer. (worldhealth.net)
Senescent cells do not proliferate yet they exchange information with adjacent cells through the transmission of inflammatory proteins. (worldhealth.net)
Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults. (mdanderson.org)
Shi's team employed CRISPR, a gene-editing tool, to deplete ENL and suppress cancer gene expression, which was crucial given that cancer cells often co-opt chromatin regulatory pathways. (mdanderson.org)
They have found a previously undetected trigger point on a naturally occurring "death protein" that helps the body get rid of unwanted or diseased cells. (medindia.net)
The research team suggests that the newly discovered 'trigger point' called BAX can help design new drugs that would force malignant cancer cells to commit suicide. (medindia.net)
Because BAX lies at the crossroads of the cell's decision to live or die, drugs that directly activate BAX could kill diseased cells like in cancer and BAX-blocking drugs could potentially prevent unwanted cell death, such as in heart attack, stroke, and neurodegeneration," Walensky added. (medindia.net)
Sometimes they rip apart fats, and in a pinch, cells can even metabolize protein. (newswise.com)
Cancer cells do things a little differently. (newswise.com)
First, most cancer cells continue to depend on glucose, but switch over from "cellular respiration" (which requires oxygen), to "glycolysis" (which can happen with or without oxygen). (newswise.com)
A University of Colorado Cancer Center study published today in the journal Cancer Cell shows that cancer stem cells take a third approach: They stick with cellular respiration, but switch from metabolizing sugar to metabolizing protein, or more precisely amino acids, which are the building blocks of protein. (newswise.com)
Healthy cells don't need to metabolize protein. (newswise.com)
In acute myeloid leukemia, we've gotten pretty good at killing the bulk of cancer cells, but a small population of cancer stem cells are uniquely equipped to resist these therapies, and these stem cells often survive to restart the condition later. (newswise.com)
We've needed a way to specifically target cancer stem cells, and it looks like this might be it," says Craig Jordan, PhD, investigator at University of Colorado Cancer Center, division chief of the Division of Hematology and the Nancy Carroll Allen Professor of Hematology at the University of Colorado School of Medicine. (newswise.com)
In fact, Jordan has spent more than 20 years laying the scientific groundwork for this attack against cancer stem cells, and now just in the past six months, with a flurry of important publications, the work from his team has led not only to increased understanding of these tenacious cells, but to treatments that may change the standard of care for acute myeloid leukemia and perhaps other cancers as well. (newswise.com)
Very basically, a series of studies performed by first author Courtney Jones, PhD, and others in the Jordan lab showed that leukemia stem cells do not (or are perhaps unable) to switch from cellular respiration to glycolysis like more mature cancer cells. (newswise.com)
When those patients were subsequently treated with venetoclax, the drug killed the cancer stem cells that continued to depend on amino acid metabolism, but was ineffective against cancer stem cells that had switched to lipid metabolism. (newswise.com)
The protein they were targeting, BRAT1, regulates DNA damage response and DNA repair in cancer cells. (phys.org)
Cancer cells grow very fast and make a lot of DNA. (phys.org)
If scientists can damage cancer cells' DNA and keep them from repairing it, they can stop cancer cells from growing. (phys.org)
Our compound can not only kill these cancer cells, it can stop their migration," Dai said. (phys.org)
For killing cancer cells and stopping migration, there are other compounds that do that," Dai said. (phys.org)
Gunning highlights the BioTek Cytation™ cell imaging multi-mode reader as playing a crucial role in this research by enabling the visualization of STAT proteins and the effects of inhibitors in cancer cells, adding another dimension to the team's research. (selectscience.net)
When they also examined in lab experiments how breast cancer triggers high levels of von Willebrand Factor, they found breast tumour cells cause the release of the clotting protein from endothelial cells, the cells which form the inside lining of blood vessels. (b-s-h.org.uk)
Anticoagulant medication (low-molecular weight heparin) could inhibit this effect by reducing levels of von Willebrand Factor and also preventing the migration of cancer cells across an endothelial cell layer in the lab. (b-s-h.org.uk)
Dr Jamie O'Sullivan, of the Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI, said: "Our findings now show, for the first time, that this blood clotting may be caused by increased levels of a key pro-clotting protein, von Willebrand Factor, and that the breast tumour cells directly interact with the blood vessel wall to promote release of this protein. (b-s-h.org.uk)
Interestingly, this not only increases risk of blood clotting for these patients, but may also promote breast cancer cells spreading throughout the body via the circulation. (b-s-h.org.uk)
2022) "Breast cancer cells mediate endothelial cell activation, promoting von Willebrand Factor release, tumour adhesion and transendothelial migration. (b-s-h.org.uk)
The protein, called AML1, plays a critical role in the development of the blood system and in the production of platelets and immune cells. (mskcc.org)
With the help of the CMCF beamline at the Canadian Light Source (CLS), located at the University of Saskatchewan, Wolthers and her colleagues determined that the new protein they identified enables the bacteria to take essential nutrients, such as iron, from our blood cells. (lightsources.org)
Some of the cells progressed to cancer, while others did not. (healthnewstrack.com)
The "cargo carriers," or endosomes, of certain brain cancer cells contain overactive NHE9 proteins (blue), which pump out too many protons (orange), changing the endosomes' acidity and slowing their "shipping speed. (medicaldaily.com)
Metastasis occurs when cancer cells break free from a primary tumor and spread throughout the body, requiring them to sever connections with neighboring cells and migrate to other tissues. (scitechdaily.com)
The dynamics of the actin-network enable the locomotion of cells, for example during development or wound closure, but also that of spreading cancer cells. (scitechdaily.com)
For their study, they used high-resolution microscopy to track the movement of individual transport vesicles within living cancer cells. (scitechdaily.com)
Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. (bepress.com)
In this study, we present evidence for increased DNA damage and instability in cancer cells with RB pathway defects when RB1 mutations are induced. (bepress.com)
RB1 deletion in retinoblastoma protein pathway-disrupted cells results in DNA damage and cancer progression" Molecular and Cellular Biology Vol. 39 Iss. (bepress.com)
Scientists at Memorial Sloan Kettering Cancer Center (MSK) have glimpsed never-before-seen details of the human androgen receptor - the protein inside of cells that responds to male-typical hormones like testosterone. (mskcc.org)
Heat shock proteins make it possible for cells to survive under conditions of stress. (cnio.es)
We now know that the cold, UV radiation, changes in pressure, and other types of damage also enable stressed cells to produce these proteins. (cnio.es)
As explained by Paul Workman, president of The Institute of Cancer Research (ICR) - one of the main cancer drug research centres in the world - cancer cells present specific types of damage due to their very nature, and chaperone proteins are precisely what enable them to survive that damage. (cnio.es)
More basic issues will also be addressed, such as our understanding of exactly how chaperone proteins carry out their functions in cells and what their role in cancer and other ageing processes are. (cnio.es)
Chaperone proteins play an essential role in protein folding, stability, and activity in healthy and pathological cells, including cancer cells", explains Djouder. (cnio.es)
One specific protein may be a master regulator for changing how cancer cells consume nutrients from their environments, preventing cell death and increasing the likelihood the cancer could spread, a study from the University of Notre Dame has shown. (medicalxpress.com)
Non-cancerous cells often die after detaching from the extracellular matrix , but SGK1 activity promotes survival and therefore increases the chances that the cancer could spread, or metastasize. (medicalxpress.com)
If you better understand precisely how cancer cells that are potentially metastatic survive in these sorts of foreign environments, then you can potentially antagonize those survival pathways and selectively cause those cells to die," said Schafer, also an affiliate member of Notre Dame's Harper Cancer Research Institute. (medicalxpress.com)
More than 90 percent of cancer deaths are caused by metastasis of cancer cells from one location to another, Schafer said. (medicalxpress.com)
For instance, breast cancer can metastasize to the brain, and metastatic cancer cells need to adapt to the new environment there. (medicalxpress.com)
This discovery appears to be broadly relevant across many different types of cancer, Schafer said, with research in this paper focused on breast and colon cancer cells grown in cultures under different conditions. (medicalxpress.com)
If you can kill those cells that are potentially metastatic, then potentially you can get to a point where you can block cancer dissemination," Schafer said. (medicalxpress.com)
Can a vitamin transform natural killer cells into a cancer therapy? (medicalxpress.com)
Keratins are a large family of proteins which form the intermediate filament (IF) cytoskeleton of epithelial cells and their appendages hairs and nails (reviewed in references 8 and 15). (exposed-skin-care.net)
PODS are efficiently taken up by phagocytic cells with the cargo protein subsequently released in a bioactive form. (biorxiv.org)
Since blood-circulating phagocytic cells, including monocytes, are actively recruited into diseased and inflamed tissue, such as the tumour microenvironment, we postulated that monocyte/macrophage-mediated PODS delivery could be used as a molecular "Trojan horse" to efficiently deliver therapeutic proteins to target cells. (biorxiv.org)
Castro-Puyana M, Pérez-Sánchez A, Valdés A, Ibrahim OHM, Suarez-Álvarez S, Ferragut JA, Micol V, Cifuentes A, Ibáñez E and García-Cañas V: Pressurized liquid extraction of Neochloris oleoabundans for the recovery of bioactive carotenoids with anti-proliferative activity against human colon cancer cells. (spandidos-publications.com)
Proteins are made from amino acids and are important parts of all cells and tissues. (medlineplus.gov)
function of several poorly characterized proteins expressed in tumor cells and which are structurally related to known complement inhibitors but also suggested to act as tumor suppressors. (lu.se)
2019) Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling. (lu.se)
HER2 is found in large amounts on the surface of some cancer cells where it stimulates their growth. (who.int)
The same protein can exist in different forms and different concentrations in different cells. (lu.se)

Prostate cancer associated transcript 18 (non-protein coding) is a protein that in humans is encoded by the PCAT18 gene. (wikipedia.org)
This gene was described by Crea et al as a prostate cancer-specific transcript activated by the androgen receptor. (wikipedia.org)
Histological slide showing prostate cancer. (ibtimes.co.uk)
The efficacy of the protein lies in triggering the body's immune response to prostate cancer. (ibtimes.co.uk)
The breakthrough paves the way for the development of new and improved vaccines for late stages of prostate cancer. (ibtimes.co.uk)
In the UK, more than 10,000 men die as a result of prostate cancer, while on an average about 40,000 are diagnosed with the disease each year. (ibtimes.co.uk)
Ecancer, a leading oncology journal, reports that the average age for men to be diagnosed with prostate cancer is 70-74 years, but positive diagnosis of men above 50 is on rise in recent years. (ibtimes.co.uk)
Dr McArdle believes that the study will lead to the development of vaccine which will generate a more specific, more efficient, faster and longer-lasting protective immune response against prostate cancer. (ibtimes.co.uk)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
Their research, published April 20, 2022, in the journal Molecular Cell , identifies unique features of the receptor that distinguish it from other hormone receptors and provide clues to how androgen signaling goes awry in prostate cancer . (mskcc.org)
We know a lot about the androgen receptor from studies conducted at the level of about 10,000 feet," says Charles Sawyers , Chair of the Human Oncology and Pathogenesis Program at MSK who researches the biology and treatment of prostate cancer. (mskcc.org)
Current methods, which are based on immunochemical methodology, for example to identify prostate cancer, are often not very sensitive and can only be used to point out a previously known biomarker. (lu.se)

Further research is necessary to validate the utility of these protein isoforms as novel biomarkers for NSCLC, or even new therapeutic targets. (tmcnet.com)
Ultimately, our long-term goal is to develop biomarkers for cancer and resistance to chemotherapy, and to provide a basis for the development of novel treatments. (lu.se)

Interestingly, they determined that these human proteins are linked to cancer more often than random sets of proteins. (bcm.edu)
Scientists at VCU Massey Cancer Center discovered a previously unrecognized relationship between two sets of proteins that operate in tandem to fend off the growth of pancreatic cancer. (cancerletter.com)

There is often a whole network of proteins involved and that also changes in the different stages of the disease", says Ákos Végvári. (lu.se)

Scientists have discovered a new protein which inhibits prostate tumour growth even in advanced stages. (ibtimes.co.uk)
Unfortunately for most cancers, the specific targets against which vaccination strategies can be based are sometimes weak and relatively poor at inducing robust, protective anti-tumour immune responses," said Dr Stephanie McArdle, who led the research team at Nottingham Trent's John van Geest Cancer Research Centre. (ibtimes.co.uk)
In other words, a tumour cell needs chaperone proteins to survive and proliferate. (cnio.es)
During the course of this thesis the expression of a panel of MDR associated proteins was correlated with patient and tumour characteristics and relapse and overall survival in a series of invasive breast carcinomas. (dcu.ie)
In an attempt to identify new breast cancer drug resistance associated antigens, MAb 5C3 was generated using paraffin wax embedded formalin fixed archival breast tumour tissue from a biopsy showing no P-170 or MRP-1 expression, as an immunogen. (dcu.ie)
You have metastatic breast cancer (breast cancer that has spread beyond the original tumour) with high levels of HER2. (who.int)

A peculiar family of proteins that could become the target of a new generation of cancer drugs, some of which are already undergoing clinical trials, are molecular chaperones. (cnio.es)

We investigated how the cell lines react to 108 different cancer drugs and found that there are indeed proteins that indicate whether a cell will respond to certain therapeutic agents, or whether it will be resistant to the drug," explains Hannes Hahne, Ph.D. a TUM expert in mass spectrometry techniques. (genengnews.com)
Despite existing knowledge about K-Ras and its key functional relationships with molecules related to cell health, the protein has been deemed "undruggable" because its configuration - both in normal and mutated forms - hides sites in its structure that would be most promising as therapeutic targets. (scienceblog.com)
Our finding suggests another known protein may be coming into play here, which could help us identify a new therapeutic target one day. (news-medical.net)
With RNAi screens identifying proteins such as the bromodomain and extraterminal (BET) domain family as playing a role in cancers, respiratory diseases and other conditions, PROTACs are seen as a platform technology with the potential to be applied across a range of therapeutic areas. (fiercebiotech.com)
Dutta S, Mahalanobish S, Saha S, Ghosh S and Sil PC: Natural products: An upcoming therapeutic approach to cancer. (spandidos-publications.com)

However, for reasons that remain unclear, KRAS is far more frequently mutated than the other Ras isoforms in cancer and RASopathies. (nature.com)
Importantly, the identified NSCLC-associated protein isoforms comprise structural variants of proteins that arise from distinct but related mRNAs produced from the same gene through the process of alternative splicing. (tmcnet.com)
Different protein isoforms can have distinct roles in biology, influencing disease predisposition and progression. (tmcnet.com)
What is especially encouraging here is that these protein isoforms were detected in plasma, a readily accessible sample type, enabling cancer detection and monitoring through liquid biopsy evaluation of patients. (tmcnet.com)
The study analyzed 188 plasma proteomes from NSCLC patients and controls to identify disease-associated protein isoforms. (tmcnet.com)
In addition to BMP1, the analysis revealed three other protein isoforms with significant diffeential behavior in NSCLC when compared to healthy controls: complement component 4a (C4a), complement component 1r (C1r) and lactate dehydrogenase B (LDHB). (tmcnet.com)
This study, which found disease-associated protein isoforms in NSCLC, could only have been achieved using an unbiased peptide-level approach that provides a deeper, more nuanced view of the human proteome," said Asim Siddiqui, Senior Vice President of Research at Seer. (tmcnet.com)

The Cancer3D database provides access to the results of such analyses based on data from The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE). (nih.gov)
Associate Professor and study leader Janne Lehtio's team found evidence for almost one hundred new protein-coding regions in the human genome. (indiavision.com)
Green, his postdoctoral fellow Narendra Wajapeyee, and their colleagues did a genome-wide search for the proteins involved. (healthnewstrack.com)
This study offers evidence that late-arising RB1 mutations can facilitate genome instability and cancer progression that are beyond the preexisting proliferative control deficit. (bepress.com)
Workman, under whose leadership the ICR has tested a score of new cancer drugs, has coined the expression Drugging the cancer genome to highlight the need to "discover innovative drugs that act on orphan proteins, instead of developing 'me too' type drugs, which simply mimic the effect of already known drugs", he says. (cnio.es)

In this study, we set out to uncover proteins that, when overproduced by the cell, cause damage to DNA in ways that can lead to cancer. (bcm.edu)
For instance, some of the DNA damage-up proteins participate in the transport of molecules across the cell membrane. (bcm.edu)
Scientists from the Technical University of Munich (TUM) have decoded the proteome of 59 tumor cell lines and say that they have found new ways to explain why cancer drugs do not have the same effect on all patients suffering from the disease. (genengnews.com)
More than 5,000 of the 10,000 proteins identified are present in varying abundances in tumor cell lines of all types of tissue. (genengnews.com)
He believes this discovery shows the need for deeper analysis of individual BET proteins in all human cell types, starting with boosting insulin and improving metabolism in the pancreas of adults who are obese. (sciencedaily.com)
We have quantified HRAS, NRAS, KRAS4A and KRAS4B protein abundance across a large panel of cell lines and healthy tissues. (nature.com)
Over the past few decades it has become increasingly clear that epigenetic changes - heritable changes in the cell that do not result from DNA sequence alteration - may be just as important as gene mutations in cancer development. (mdanderson.org)
Chemical modification of these histones is one way that the cell regulates the packing and unpacking of the DNA and its associated proteins (collectively called chromatin), which in turn helps to determine whether a given gene is activated or repressed. (mdanderson.org)
The authors set out to find clues to TDRD3's function by looking for physical interactions between TDRD3 and other proteins in the cell. (mdanderson.org)
HMGB1 is an abundant protein, 10 6 molecules per cell [ 7 ], which has been postulated as a redox sensor [ 8 ]. (hindawi.com)
It is a major advantage as heightened cell proliferation creates a risk for cancer. (worldhealth.net)
The activated BAX proteins congregated inside the cell's power plants, the mitochondria and caused cell death. (medindia.net)
When analyzing the function of potential STAT inhibitors, it is important to know the location of the STAT protein within the cell. (selectscience.net)
HHMI investigator Michael Green and colleagues at the University of Massachusetts Medical School reported their identification of the genetic underpinnings of a new way to thwart one of the deadliest forms of cancer in the February 8, 2008, issue of the journal Cell. (healthnewstrack.com)
The cell has sensed this oncogenic influence-activated BRAF-and that induces an anti-cancer mechanism to throw the cell into this frozen state," he said. (healthnewstrack.com)
Evidence of this process was seen in human metastatic colon, breast, liver, and head and neck cancer cell lines. (oncologynurseadvisor.com)
and Xiaohong Helena Yang (Cancer Cell, Cambridge, USA). (cnio.es)
The study, published in Cell Reports , was completed in the laboratory of Zachary Schafer, the Coleman Foundation Associate Professor of Cancer Biology in the Department of Biological Sciences. (medicalxpress.com)
Schafer and collaborators found a protein called SGK1, known to be activated in a variety of cancer cell types, signals the cell to take up nutrients. (medicalxpress.com)
These nutrients include glucose, which allows the cell to survive after it detaches from the scaffold of proteins it had been attached to, called the extracellular matrix. (medicalxpress.com)
GRP78 is a highly conserved protein that is essential for cell viability.The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78and other resident ER proteins including glucose regulated protein 94 (GRP 94) and proteindisulfide isomerase (PDI). (exposed-skin-care.net)
Using different approaches we also found that the molecular system where these keratins modulate cell development appears to be associated with pRb as well as the molecular equipment controlling cell routine development during G1 which regarding K10 this function resides in the nonhelical termini from the protein. (exposed-skin-care.net)
Michael Jones, Robert Smith, Simon Rudge and Jonathan Best are employees of Cell Guidance Systems which owns patents related to the use of PODs technology to treat cancer. (biorxiv.org)
One important nutrient is protein, which is essential to the human body because it is part of every cell, issue, and organ, allowing them to grow and repair. (cdc.gov)
The projects feature state-of-the-art methods for the investigation of cell biology, such as flow cytometry and confocal microscopy, protein interaction analyses using the proximity-ligation assay and Biacore, and genetic manipulation employing the Cas9/CRISPR system. (lu.se)
We are now trying to look at the whole proteome, i.e. all the proteins in a certain type of cell at a certain time. (lu.se)
Clear cell renal cancer is the most common form of kidney cancer, with approximately 1 000 new cases in Sweden every year. (lu.se)

Understanding the behavior of the enzymes defending these assaults helps determine how -- and where -- cancer gets its foothold and flourishes. (sciencedaily.com)
New research published in an Advance Online Publication of Nature Structural & Molecular Biology shows that one of these enzymes -- human DNA polymerase theta (POLQ) -- may be a promising drug therapy target for inhibiting breast cancer. (sciencedaily.com)
This is accomplished by a class of enzymes called protein arginine methyltransferases (PRMTs). (mdanderson.org)

Among other things, the research shows that some pseudogenes produce proteins indicating that they indeed have a function. (indiavision.com)

Our work helps to better understand why patients with breast cancer have increased risk of blood clots and also why this may contribute to worse disease, cancer progression and spread throughout the body which will have a huge impact on the treatment of breast cancer and the outcomes for patients worldwide. (b-s-h.org.uk)
The fairly high rate of progression to muscle-invasive disease (30%) in patients with high-risk NMIBC require more frequent monitoring by urine cytology and cystoscopy, the gold standard for detection of bladder cancer recurrence. (medscape.com)

The important functions of the liver, the development of liver cancer and it's symptoms are presented in this interactive. (medindia.net)
Protein C is a 62-kD, vitamin K-dependent glycoprotein synthesized in the liver. (medscape.com)

The BET proteins provide a new pathway to connect adult-onset diabetes with cancer, so properly targeting BET proteins may be helpful for both," explained Denis, who is the corresponding author of the study. (sciencedaily.com)
Formed by an international research team, the study served to discover that this protein played an unexpected physiological role: it also becomes activated during the formation process of ova and spermatozoids. (scienceblog.com)
The results of the study, published in Science, are revealing and help to understand more about the functions of this essential protein which stops the formation of tumours and therefore could open the door to new approaches in the study of cancer. (scienceblog.com)
Scientists have breathed new life into the study of a protein with an outsized link to human cancers because of its dangerous mutations, using advanced research techniques to detect its hidden regions. (scienceblog.com)
The subject of this study, the K-Ras protein, is linked to 75% of all Ras-associated cancers. (scienceblog.com)
The study revealed two "switch" regions - tellingly, both located near a protein loop where the most dangerous mutations occur - in the K-Ras structure that had not been visible before. (scienceblog.com)
One of 15 different polymerases tasked with copying our genetic material, POLQ is singled out in this study for its unique role -- captured in an X-ray crystallography visual -- in DNA repair pathways linked to breast cancer, and therefore, potential as a drug target. (sciencedaily.com)
The study establishes a link between TDRD3 and an enzyme that unwinds DNA at regions of active gene expression, and provides evidence that this partnership can prevent DNA breakage and chromosomal translocations - two of the hallmarks of cancer. (mdanderson.org)
There was a past study done in Scandinavia of 6,200 women with breast implants and they had a lower rate of breast cancer than that in the normal population. (newbeauty.com)
In 1997, there was a study from published in the Journal of Plastic and Reconstructive Surgery with a similar finding of a 37 percent reduction in the incidence of breast cancer in a group of women that had been followed for over 14 years. (newbeauty.com)
In a study published online in the journal EBiomedicine , Wong and his team at the Ting Tsung and Wei Fong Chao Center for BRAIN of Houston Methodist, reported on a new role of OCIAD1 (ovarian cancer immune-reactive antigen domain containing 1). (news-medical.net)
Research results, which build upon a previous MD Anderson study of histone-reading proteins, are published in the March 1 online issue of Nature . (mdanderson.org)
High levels of blood-clotting proteins can result in poor outcomes for breast cancer patients, according to an Irish study. (b-s-h.org.uk)
The new study uncovers a relatively unknown protein that regulates the melanocyte's "decision" to ward off cancer by either entering a programmed hibernation or committing suicide. (healthnewstrack.com)
The $800,000, three-year grant is the first DoD award to Sylvester to study pancreatic cancer. (cancerletter.com)
David Wheeler, member of the Cancer Prevention and Control research program at VCU Massey Cancer Center, was awarded a five-year, $1.7 million R01 grant from NCI to study thelong-term effects of neighborhood exposures and racial segregation on cancer risk through the use of innovative statistical models and analysis. (cancerletter.com)
This study provides proof-of-concept for the utility of intravenously administered PODS to provide a generalised and widely applicable mechanism to effectively deliver protein drugs for the therapy of cancer and potentially other diseases. (biorxiv.org)
We study how these proteins are related to tumor development in breast, prostate and melanoma cancer models. (lu.se)
ABSTRACT A case-control study investigated the association between dietary fat and breast cancer in Saudi Arabian women attending a specialist hospital in Riyadh. (who.int)

Houston Methodist scientists identified a protein found in ovarian cancer that may contribute to declining brain function and Alzheimer's disease, by combining computational methods and lab research. (news-medical.net)
A potential target for developing new cancer drugs has been identified by scientists at Dana-Farber Cancer Institute. (medindia.net)
Molecules that target and inhibit STAT protein function are therefore of great interest to scientists developing new cancer therapeutics. (selectscience.net)
Scientists have now come up with a new technology that involves cancer diagnosis through a simple urine test using a strip of paper, making diagnosis simple and affordable for people. (medicaldaily.com)

The Bedford lab studies one such modification, the methylation of arginine amino acids in histones and other chromatin-associated proteins. (mdanderson.org)
Proteins are formed of only 20 different amino acids, but almost all proteins are composed in such a way that part of the sequence is unique. (lu.se)

K-Ras is the holy grail of cancer research - probably one of the most studied biological molecules worldwide because it plays such a key role in many cancers," Brüschweiler said. (scienceblog.com)
The experiments also added clarity to how the normal protein and its mutated forms differ: Under normal circumstances, K-Ras is more active when it is bound to the first of two partner molecules and maintains proper control of multiple cellular functions, including the return to an inactive state. (scienceblog.com)
Doublié and Zahn's coauthor Richard Wood, Ph.D., of the Department of Epigenetics & Molecular Carcinogenesis at the University of Texas MD Anderson Cancer Center, and colleagues are in the process of examining candidate drug-like molecules that might act specifically on POLQ without inhibiting other necessary polymerases to limit side effects in cancer patients. (sciencedaily.com)
Boehringer Ingelheim has teamed up with the University of Dundee to develop proteolysis-targeting chimeric molecules (PROTACs), a new class of drugs designed to degrade proteins. (fiercebiotech.com)
Certain molecules are always present at very high levels, while other, pathogenic proteins may only be present at very low levels and thus be difficult to detect. (lu.se)

We discovered that simply putting implants into young, otherwise healthy patients seems to generate antibodies to specific breast cancer antigens. (newbeauty.com)
Monoclonal antibodies attach to specific proteins or antigens. (who.int)

The hope is that these findings could soon lead to breakthrough treatments for early stages of cancer and aging. (worldhealth.net)
One difficulty in studying curcusones as potential cancer treatments is that, while the shrub they come from is common and inexpensive, it takes massive amounts of the shrub to yield even a small amount of the compounds. (phys.org)
BT-ON014 trade name] may be combined with other cancer medicines, and is usually part of a sequence of treatments that may also include surgery or radiotherapy. (who.int)
BT-ON014 trade name] may be given with another cancer medicine, paclitaxel or docetaxel, as first treatment for metastatic breast cancer, or it may be used alone if other treatments have proved unsuccessful. (who.int)

One way proteins can cause DNA damage is by being overproduced, which is a relatively frequent cellular event," said Rosenberg, who also is leader of the Cancer Evolvability Program at the Dan L Duncan Comprehensive Cancer Center at Baylor. (bcm.edu)
Nearly all anti-tumor drugs are targeted against cellular proteins," says Bernhard Küster, Ph.D., TUM chair of proteomics and bioanalytics. (genengnews.com)
Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) is a Src family kinase substrate which takes part in a range of cellular events such as migration, survival, transformation, and invasion. (neuromics.com)

They found that TDRD3 forms a complex with a protein called topoisomerase 3B (TOP3B), an enzyme that unwinds DNA and, in so doing, prevents DNA structures from forming that impede gene transcription. (mdanderson.org)
Cdk4-mediated phosphorylation of Rb protein is inhibited by p16, a product of a possible tumor suppressor gene. (nih.gov)
[ 7 , 8 ] The gene for protein C is located on the long arm of chromosome 2 and nearly 200 pathogenic mutations of this gene have been described. (medscape.com)
A range of causative genetic alterations within the protein C promoter region and splice sites as well as in the coding sequence of the protein C gene itself have been reported. (medscape.com)
Type II protein C deficiency is less common than type I disease and is associated with decreased functional activity and normal immunologic levels of protein C. A number of point mutations within the protein C gene giving rise to this disorder have been described. (medscape.com)

The results presented show that MRP-1 protein at diagnosis is an independent prognostic factor for overall survival in node positive breast cancer patients treated with CMF based chemotherapy, absence o f MRP-1 expression at diagnosis was significantly associated with increased overall survival. (dcu.ie)
Analysing the composition of proteins using mass spectrometry could be the future of medical diagnosis. (lu.se)

In addition, you will have the opportunity to learn microbiologic and immunologic techniques and to express and purify recombinant proteins. (lu.se)
Within the past 2 years, investigational peptide- and recombinant protein-based serologic assays that can more easily differentiate the antibodies to HTLV-I and HTLV-II have been developed (8,9). (cdc.gov)

Gunning, whose work focuses on developing small molecule inhibitors for targeting and treating cancer, explains that STAT3 is hyperactivated in over 70% of all human cancers - making it a major target for drug discovery. (selectscience.net)
Based on analysis of non-fractionated, directly labeled, whole human serum proteomes we have identified a protein signature based on 19 non-redundant analytes, that discriminates between cancer patients and healthy subjects. (lu.se)
We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)

C-reactive protein is considered one of the best measures of the acute-phase response to an infectious disease or other cause of tissue damage and inflammation. (cdc.gov)

Adult-onset diabetes has been known for decades to increase the risk for specific cancers. (sciencedaily.com)
Our data provide support for the model of a sweet-spot of Ras dosage mediating isoform-specific contributions to cancer and development. (nature.com)
How does a family of Ras proteins that share a common set of activators and effectors generate isoform-specific engagement with cancer-associated signaling networks? (nature.com)
This is currently best expressed in the Ras "sweet-spot" model that suggests that Ras dosage (expression and signaling strength imparted by specific mutations) will be a major factor in influencing the availability of individual Ras family members to engage cancer pathways [ 4 ]. (nature.com)
The protein becomes activated in response to specific signals such as breaks in DNA. (scienceblog.com)
This specific protein is expressed at an egregiously high level while senescence occurs. (worldhealth.net)
Histone modifications like acetylation serve as docking sites for reader proteins which recognize specific modifications, influencing downstream biological outcomes. (mdanderson.org)
Native and redesigned proteins exhibited highly similar characteristics, predicted structures and binding pockets, and slightly different docking poses against known ligands, although task-specific designs are still required for proteins more susceptible to internal hydrogen bond formations. (mit.edu)
Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect management, and new developments in specific cancers. (oncologynurseadvisor.com)
The members from the large keratin family of cytoskeletal proteins are expressed in a carefully regulated tissue- and differentiation-specific manner. (exposed-skin-care.net)
The specific combination of proteins in the blood reveals whether or not you are ill. (lu.se)

VCU Massey Cancer Center has changed its name to VCU Massey Comprehensive Cancer Center in recognition of its recent comprehensive status from NCI (The Cancer Letter, May 31, 2023). (cancerletter.com)

The idea is to leverage the cell's own disposal system to eliminate proteins involved in the development of diseases including cancer. (fiercebiotech.com)

Three-hundred-seventy-five of the 10,000 proteins belong to the kinase group. (genengnews.com)

Current work in the group includes studies of platinum-, gold- and ruthenium-based anticancer active drugs and their influence on nucleic acid structure, transcription and protein translation. (lu.se)

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. (jci.org)
Our in vivo results identify PTPN2 as a key player in controlling the immunogenicity of CRC, with the strong potential to be exploited for cancer immunotherapy. (jci.org)

We measured carbonyl content and while Cr(VI) shows an increase in protein oxidation, Cr(III) did not. (cdc.gov)
When only 0.4mmol hexavalent chromium was used and held constant, protein oxidation increased over time with carbonyl content increasing from .001 to .006 mmol carbonyl/mg protein in a one hour time span. (cdc.gov)

Stopping cancer from spreading throughout the body-metastasizing-is key to preserving a cancer patient's life. (phys.org)
Once cancer starts to migrate from its original organ into different body systems, new symptoms start to develop, often threatening the patient's life. (phys.org)
Partner with us to treat your patient's cancer. (mskcc.org)

Arabia showed that per capita energy intake studies of the relationship between diet and in Saudi Arabia rose from 1801 kcal in 1971 breast and colon cancers suggested there to 3082 kcal in 1992 [ 14,15 ]. (who.int)
HNPCC is divided into Lynch syndrome I (familial colon cancer) and Lynch syndrome II (HNPCC associated with other cancers of the gastrointestinal [GI] or reproductive system). (medscape.com)

Without better targeted drugs, some ongoing cancer clinical trials for BET inhibitors are premature. (sciencedaily.com)
BT-ON014 trade name] is also used in combination with medicines called aromatase inhibitors with patients with high levels of HER2 and hormone receptor-positive metastatic breast cancer (cancer that is sensitive to the presence of female sex hormones). (who.int)

76% of Ras-mutant cancer patients harbor KRAS mutations versus only 7% with HRAS mutations [ 1 ]. (nature.com)
Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
Reviewing clinical population studies from the U.S., Canada, and Europe, Francol and her colleagues found there may be a lower incidence of breast cancer in patients with implants than in control populations. (newbeauty.com)
La Jolla, CA plastic surgeon Robert Singer, MD says this is not the first article that's shown a lower risk for breast cancer in some patients with breast implants. (newbeauty.com)
New research from RCSI University of Medicine and Health Sciences, Dublin, found that patients with breast cancer had very high levels of von Willebrand Factor in their blood and that individuals with the highest levels had the poorest outcomes. (b-s-h.org.uk)
Writing in the Journal of Thrombosis and Haemostasis , they say analysing von Willebrand Factor levels may be useful to help predict clinical outcomes in patients with breast cancer. (b-s-h.org.uk)
Despite the recent advances in the detection, treatment and management of breast cancer, with an increasing range of hormonal, cytotoxic and more recently MAb targeted drug regimes available in the clinic, between 40% and 50% o f patients diagnosed will eventually die from this disease. (dcu.ie)
Identification of biological factors which can function as reliable markers of both prognosis and chemoresponsiveness will allow for more precise targeting of treatment for individual breast cancer patients. (dcu.ie)
Perform the first surveillance cystoscopy within 3 to 4 months after completion of the initial evaluation and treatment of patients with non-muscle-invasive bladder cancer (NMIBC). (medscape.com)
Paraneoplastic nephrotic syndrome (PNS) is a complication seen in cancer patients . (bvsalud.org)
Ultrastructural examination shows the accumulation of proteins and the presence of foot process (FP) effacement in the glomeruli of PNS patients . (bvsalud.org)

Targeting epigenetic readers represents a class of anti-cancer therapy that we believe holds clinical promise," said Hong Wen, Ph.D., research assistant professor of Epigenetics and Molecular Carcinogenesis and co-first author of the paper. (mdanderson.org)
A team of clinical psychologists at VCU Massey Cancer Center received a four-year, $1.5 million grant from the U.S. Department of Defense to help treat insomnia among military members, veterans, their beneficiaries and the general public who have been diagnosed with brain cancer. (cancerletter.com)

However, mapping all our proteins, which is the initial goal of the new research field known as proteomics, will take a long time. (lu.se)

This effort has paid off, leading to the creation of Janpix Inc. , an oncology-focused startup co-founded by Gunning that launched with $22 million in funding to advance STAT-targeting cancer therapies. (selectscience.net)
Mariza Daras was named chief of the Division of Neuro-Oncology at VCU Massey Cancer Center and the Department of Neurology at VCU School of Medicine. (cancerletter.com)

Our results indirectly support the theory that p16 expression is negatively regulated by the functional Rb protein. (nih.gov)
In order to address the multifactorial nature o f this disease, expression of individual proteins was analysed in relation to other markers. (dcu.ie)

Machine learning was used to extract key functional descriptions for protein visualization in the 3D-space, where spatial distributions provide function-based predictive connections between proteins and cancer types. (mit.edu)

Jashodeep Datta, a researcher with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has been awarded a grant from the U.S. Department of Defense's Congressionally Directed Medical Research Program to target chemotherapy resistance in pancreatic cancer. (cancerletter.com)

Anatomy12

Organisms3

Diseases57

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena3

Humanities1

Information Science7

Named Groups2

Health Care31

Geographicals4

Genes28

Researchers35

Colorectal cancer7

Mutation9

Membrane proteins3

Solid cancers2

Lung8

Tumors8

Histone proteins3

Mechanisms12

Cells85

Prostate cancer12

Biomarkers2

Sets of proteins2

Network of proteins1

Tumour6

Family of proteins1

Therapeutic5

Isoforms7

Genome5

Cell27

Enzymes3

Produce proteins1

Progression2

Liver2

Study19

Scientists4

Amino2

Molecules5

Antigens2

Treatments4

Cellular3

Gene5

Diagnosis2

Recombinant2

Human3

Acute1

Specific11

20231

Cell's1

10,0001

Nucleic1

Immunotherapy2

Content2

Patient's3

Colon2

Inhibitors2

Patients11

Clinical2

Proteomics1

Oncology2

Expression2

Visualization1

Pancreatic cancer1