Proteins facilitate signal transduction through tumor. Medical search. Frequent questions

We have developed a rule-based model of crosstalk between the HMGB1 signaling pathway and other key cancer signaling pathways. (biomedcentral.com)
Moreover, the models also predict that mutations of RAS, ARF and P21 in the context of HMGB1 signaling can influence the cancer cell's fate - apoptosis or survival - through the crosstalk of different pathways. (biomedcentral.com)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
Many studies have found evidence of crosstalk between the two signaling pathways involving p53 and CyclinE [ 15 ]. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
The ligand-activated intracellular signalling pathways result in neutrophil migration to the site of inflammation. (rcsb.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
He has over 12 years of experience in the field of innate immunity with specific expertise in Toll-like receptor (TLR), inflammasome and cGAS-STING signalling pathways. (monash.edu)
The basic science studies focus on identifying signal transduction targets, critical molecular pathways that are distinct in various tumor types. (lsuhs.edu)
signal transduction pathways that control the availability of eIF4E, especially those involving mTOR The goal of this focus group is to better understand how cancer cells become active and how to interfere with that process, which will lead to more specific treatment modalities. (lsuhs.edu)
This review describes current knowledge about the expression of distinct ORs in cancers, as well as the canonical and non-canonical signaling pathways induced by these ORs. (bmbreports.org)
Ras proteins are membrane-bound small GTPases that act as molecular transducers, coupling cell surface receptors to intracellular effector pathways to regulate cellular processes such as cell proliferation, differentiation, migration, and apoptosis [ 3 ] [ 4 ] . (encyclopedia.pub)
Multiple disciplinary approaches integrated the bioinformatics, cellular, molecular and in vivo (mice and zebrafish models) platforms are applied to investigate tumorgenesis, signal transduction pathways and chemoprevention agents. (ncku.edu.tw)
Our results emphasize the need for new endocrine agents able to block widespread actions of estrogen without exerting any stimulatory activity on transduction pathways shared by the steroid and growth factor-signaling networks. (unical.it)
The GFRα and GFRα-mediated signaling pathways. (medsci.org)
Special considerations are given to the causal involvement of novel molecular pathways, including cytokines, growth factors, and intracellular signaling cascades in RA pathophysiology, and the emerging role of targeted therapeutic agents in the management of RA. (jscimedcentral.com)
Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

Recent findings have demonstrated that cooperativity goes beyond cell intrinsic mechanisms as the tumor interacts with the immediate cells of the microenvironment, the immune system and systemic organs to eventually facilitate malignant progression. (nih.gov)
Cancer-associated fibroblasts (CAFs) are one major type of component identified in the tumor microenvironment. (spandidos-publications.com)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
Collectively, the rising premise is certainly that heparanase portrayed by tumor cells, innate immune system cells, turned on endothelial cells and also other cells from the tumor microenvironment is certainly a get good at regulator from the intense phenotype of cancers, a significant contributor to the indegent outcome of cancers sufferers and a leading focus on for therapy. (nihvp.org)
2008). The pro-tumorigenic aftereffect of heparanase is certainly related to its HS degrading activity mainly, facilitating cell invasion and priming the tumor microenvironment. (nihvp.org)
Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
However, the mechanism through which RAD18 influences triple-negative breast cancer (TNBC), especially the interaction between tumor cells and the tumor microenvironment, remains elusive. (nature.com)
Tumor microenvironment (TME) remodeling is a critical process in primary tumor progression. (nature.com)

As revealed by the results of this study, GGTase-I shows a correlation with the proliferation of SACC through the regulation of cell cycle and may take on vital significance in the migration and invasion of SACC by regulating RhoA/ROCK1/MLC signaling pathway. (bvsalud.org)
In this work, we construct a simple model of HMGB1 signal transduction to investigate tumorigenesis on the basis of known signaling pathway studies [ 16 - 21 ]. (biomedcentral.com)
With its E3 ubiquitin-protein ligase activity via interaction with several proteins such as RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, BCL10 etc., c-IAP2 can regulate NFkB signaling - positive regulation of canonical and negative regulation of non-canonical pathway. (novusbio.com)
Based on the findings, the inhibition of miR-543 was found to play a tumor suppressive role in PA through the down-regulation of Wnt/β-catenin pathway by negatively regulating Smad7. (cancerindex.org)
The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. (cancerindex.org)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
Accumulating evidence indicates that aberrant activation of the Hedgehog (Hh) signalling pathway by Glioma-associated oncogene (Gli) transcription factors is involved in the aggressive progression of cancers, including ovarian cancer. (jcancer.org)
Using gene-silencing experiments and specific pharmacological inhibitors, we have ascertained that EGF and TGFÎ± induce GPR30 expression through the EGFR/ERK transduction pathway, and the recruitment of c-fos to the activator protein-1 site located within GPR30 promoter sequence. (unical.it)
High expression of RAD18 facilitated a highly stem-cell phenotype through the Hippo/YAP pathway, which supports the proliferation of TNBC. (nature.com)
Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)

c-IAP2 (inhibitor of apoptosis protein-2) belongs to IAPs family and besides exerting antiapoptotic effects through its interaction with multiple cytokines, it participates in inflammation, immunity and mitogenic kinase signal transduction, cell proliferation, invasion and metastasis also. (novusbio.com)
The translational research group investigators are working with an array of solid tumor model systems to understand the molecular events that drive, and are critical for tumor progression and metastasis, and resistance to therapy. (lsuhs.edu)
The long-term goals of this group are to identify novel targets that are critical for solid tumor progression and metastasis. (lsuhs.edu)
The underlying hypothesis that the group is collectively testing is that despite distinct origins, there are common targets among various solid tumor malignancies that could be explored to prevent tumor progression, tumor metastasis and therapeutic resistance. (lsuhs.edu)
Indeed, for both human and canine cancer patients afflicted with osteosarcoma, the most common primary tumor of bone, metastasis to the lungs is the most common cause of death. (vin.com)
First metastasis is a verb that describes the process of cancer progression from a primary tumor site to a distant secondary site. (vin.com)
To define genes and or proteins that contribute to the metastatic phenotype of metastasis in osteosarcoma, we have utilized a cross-species comparative approach that includes murine, canine, and human systems for gene identification and evaluation. (vin.com)
Ras proteins are essential mediators of a multitude of cellular processes, and its deregulation is frequently associated with cancer appearance, progression, and metastasis. (encyclopedia.pub)
Matrix metalloproteinase-7 (MMP-7) facilitates degradation of the extracellular matrix, promoting the invasion of tumour cells, and is associated with cancer progression and metastasis. (jcancer.org)
Aberrant activation of the Hh-Gli-MMP-7 signalling axis is essential for acceleration of the progression and metastasis of human ovarian cancer, implicating its use as a novel therapeutic target of ovarian cancer. (jcancer.org)
2016). Many clinical association research have consistently confirmed that upregulation of heparanase appearance correlates with an increase of tumor size, tumor angiogenesis, improved metastasis and poor prognosis (Hammond et al. (nihvp.org)
A causal function of heparanase in tumor metastasis was confirmed by the elevated lung, Mouse monoclonal antibody to Protein Phosphatase 3 alpha bone tissue and liver organ colonization of cancers cells pursuing overexpression from the heparanase gene, and by a proclaimed reduction in the metastatic potential of cells put through heparanase gene silencing. (nihvp.org)
The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)

Recent studies have found that overexpression of the High-mobility group box-1 (HMGB1) protein, in conjunction with its receptors for advanced glycation end products (RAGEs) and toll-like receptors (TLRs), is associated with proliferation of various cancer types, including that of the breast and pancreatic. (biomedcentral.com)
HMGB1 can activate a series of signaling components, including mitogen-activated protein kinases (MAPKs) and AKT, which play an important role in tumor growth and inflammation, through binding to different surface receptors, such as RAGE and TLR2/4. (biomedcentral.com)
CXCR1 is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumour growth. (rcsb.org)
CXCR1 is a class A, rhodopsin-like G-protein-coupled receptor (GPCR), the largest class of integral membrane proteins responsible for cellular signal transduction and targeted as drug receptors. (rcsb.org)
Recent structural determination of GPCRs has advanced by modifying the receptors with stabilizing mutations, insertion of the protein T4 lysozyme and truncations of their amino acid sequences, as well as addition of stabilizing antibodies and small molecules that facilitate crystallization in cubic phase monoolein mixtures. (rcsb.org)
This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. (bmbreports.org)
Odorant receptors (ORs) are G protein-coupled receptors (GPCRs) that are essential for detecting and distinguishing among odorants. (bmbreports.org)
Ras signaling is activated by cellular receptors including receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), cytokines receptors, and extracellular matrix receptors [ 12 ] . (encyclopedia.pub)
Interestingly, we show that functional cross talk of GPR30 with both activated EGFR and ERÎ± relies on a physical interaction among these receptors, further extending the potential of estrogen to trigger a complex stimulatory signaling network in hormone-sensitive tumors. (unical.it)

In this work, we have demonstrated that the non-toxic LPS from Rhodobacter capsulatus PG blocks the synthesis of pro-inflammatory cytokines during the activation of blood cells by Streptococcus pyogenes LTA through binding to the CD14 receptor, resulting in the signal transduction to TLR2/TLR6 being blocked. (actanaturae.ru)

By integrating metabolome and transcriptome analysis, the proliferation effects of ATZ and PCB153 were induced at low doses in MCF-7 cells through potential interference with the downstream transcription signaling of CYP19A1. (bvsalud.org)
Our simulations show that, if HMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpressed, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. (biomedcentral.com)
CyclinE is a cell cycle regulatory protein which regulates the G1-S phase transition during cell proliferation. (biomedcentral.com)
To the best of the authors' knowledge, no computational model has been proposed to investigate the importance of HMGB1 in tumor proliferation. (biomedcentral.com)
tumor model and how it has contributed to our understanding of how these initial simple genetic insults cooperate within the tumor cell to set in motion the malignant transformation program leading to tumor growth through cell growth, cell survival and proliferation, dismantling of cell-cell interactions, degradation of basement membrane and spreading to other organs. (nih.gov)
Inhibition of YAP or TGF-β breaks this loop and suppresses cancer stemness and proliferation In nude mice, RAD18 promoted subcutaneous transplanted tumor growth and M2-type TAM recruitment. (nature.com)

The Oncology group incorporates and adopts translational research from fundamental basic study to clinical application on several types of tumors, including hepatocellular carcinoma, bladder cancer, urothelial carcinoma and leukemia. (ncku.edu.tw)
TAMs are the major inflammatory cells in the TME, and are closely related to poor outcomes in several types of tumors [ 11 ]. (nature.com)

The protein p53 is one of the most important tumor suppressor proteins: its activation can lead to cell cycle arrest, DNA repair, or apoptosis. (biomedcentral.com)
In this paper, we ask the following questions: How do these proteins and their mutations change the cell's fate - apoptosis or survival - when HMGB1 signal transduction is activated? (biomedcentral.com)
By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. (insulin-receptor.info)
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)

The crosstalk is regulated by tumor suppressor proteins, including ARF, P21 and FBXW7, which are also frequently mutated in many cancers. (biomedcentral.com)

Almost two decades after the landmark discovery of cooperative oncogenesis between oncogenic Ras V12 and the loss of the tumor suppressor scribble in flies, this and other tumor models have provided new concepts and findings in cancer biology that has remarkable parallels and relevance to human cancer. (nih.gov)
The Program in Tumor Virology seeks to increase understanding of the roles played by oncogenic viruses in tumor development, thus stimulating novel approaches to prevention, diagnosis, treatment and cures for cancer. (lsuhs.edu)
Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. (medsci.org)

Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. (bmbreports.org)

The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine ,PTK) or serine/threonine ,STK) kinase catalytic domains. (insulin-receptor.info)
Records: Tumor-bearing mice had been treated with (A) an individual iv dosage of 10 mg/kg of either RL71 or SMA-RL71 and euthanized 6 h afterwards or (B) intravenously implemented 10 mg/kg of RL71 or SMA-RL71 LGK-974 kinase inhibitor on times 4, 7, 11, and 14 and euthanized 3 times afterwards. (insulin-receptor.info)

The effects of GGTase-I silencing on the migration, invasion, and spread of cells were examined, the messenger RNA levels of GGTase-I and RhoA genes of SACC cells after GGTase-I knockdown were determined, and the protein levels of RhoA and RhoA membrane of SACC cells were analyzed. (bvsalud.org)
This group studies the mechanism and regulation of protein synthesis in eukaryotic cells, with particular emphasis on how dysregulation of protein synthesis can lead to malignant transformation and progression to more aggressive forms of cell growth and invasion. (lsuhs.edu)
Zhang H, Wang Y, Chen T, Zhang Y, Xu R, Wang W, Cheng M, Chen Q. Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells. (jcancer.org)
MMP-7 facilitated the invasion and migration of ovarian tumour cells, indicating its key function in ovarian cancer progression. (jcancer.org)
In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)

The intracellular loops of GPCRs are crucial for G-protein interactions, and activation of CXCR1 involves both amino-terminal residues and extracellular loops. (rcsb.org)
Features important for intracellular G-protein activation and signal transduction are revealed. (rcsb.org)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. (cipsm.de)

Mutations in cis-acting splicing elements or changes in the activity of constitutive or alternative splicing could have a profound regulatory proteins that compromise the accuracy of either impact on human pathogenesis, in particular in tumor development and progression. (biologists.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
Additionally, Ras proteins are recognized as major oncogenes, as mutations in all three Ras genes occur in approximately 30% of human cancers [ 10 ] . (encyclopedia.pub)

Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)

A cDNA microarray was utilized to identify potential downstream targets of Hh signalling. (jcancer.org)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)

Finally, lncRNAs regulated expression of key proteins, thereby mediating development of a malignant phenotype. (oncotarget.com)
In addition, the cytokine byproduct TGF-β activates macrophages to have an M2-like tumor-associated macrophage (TAM) phenotype. (nature.com)

By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
In humans, three Ras genes ( H-ras , N-ras, and K-ras ) encode four distinct Ras proteins: H-Ras, N-Ras, K-Ras4A, and K-RasS4B, the latter 2 resulting from alternative RNA splicing of the K-ras gen. (encyclopedia.pub)
In previous reports, we identified a set of genes regulated by Hh signalling in ovarian tumour cells among which MMP-7 was identified as a potential Hh target gene candidate. (jcancer.org)
tumor suppressor genes. (upstate.edu)
To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)

Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)
TNF-α - tumor necrosis factor α. (actanaturae.ru)

miRNAs regulate proteins expressions by arresting or degrading the mRNAs. (cancerindex.org)
We demonstrate that epidermal growth factor (EGF) and TGFÎ± transactivate the GPR30 promoter and accordingly up-regulate GPR30 mRNA and protein levels only in endometrial and tamoxifen-resistant breast cancer cells. (unical.it)

They're examining signal transduction and experimental therapeutics, tumor immunology and immunotherapy, gene regulation and epigenetics, and stem cell biology. (luc.edu)

These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
This idea is certainly reinforced by research indicating a proclaimed inhibition of tumor development in mice treated with heparanase-inhibiting heparin-like substances (i.e. (nihvp.org)
2016). A proclaimed inhibition of tumor development and dissemination was also exerted by heparanase neutralizing monoclonal antibodies in xenograft types of lymphoma and myeloma, emphasizing the importance from the enzymatic activity of heparanase to advertise tumorigenesis (Weissmann et al. (nihvp.org)

Emblematic of this clinical problem is the biology associated with progression in the pediatric solid tumor, osteosarcoma. (vin.com)

If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
Our findings shed new light on the molecular mechanisms of cGAS-STING signalling and have important implications for the effective therapeutic targeting of STING-related diseases. (monash.edu)
In the Politi Laboratory, we study mechanisms of lung tumorigenesis and in particular, the molecular features of tumors that determine response and resistance to targeted drugs. (yale.edu)

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate mRNA expression, and immunoblotting (IB) was conducted to evaluate protein expression. (jcancer.org)
Intensive study has demonstrated interactions with host-cell signal transduction and possibly eukaryotic transcription. (cdc.gov)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. (cancerindex.org)

Given that EGFR/HER2 overexpression is associated with tamoxifen resistance, our data may suggest that ligand-activated EGFR could contribute to the failure of tamoxifen therapy also by up-regulating GPR30, which in turn could facilitates the action of estrogen. (unical.it)

ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (wikipedia.org)

In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of the cell cycle and cell growth . (wikipedia.org)
The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)

The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells. (wikipedia.org)
Moreover, the potential underlying mechanism of silencing GGTase-I on the above-mentioned aspects in SACC cells was assessed by examining the protein expression of ROCK1, MLC, p-MLC, E-cadherin, Vimentin, MMP2, and MMP9. (bvsalud.org)
Advances in research techniques since then have shown the mitochondria in cancer cells to be functional across a range of tumour types. (researchgate.net)
The response of cells to environmental signals, as well as their differentiation, death or malignant transformation, involves changes in gene expression. (biologists.com)
Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
The invasive and migratory capabilities of tumour cells were tested with the transwell and wound healing assays, respectively. (jcancer.org)
Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
This was followed by repeated selection for increasingly aggressive tumor formation from cells recovered from xenograft tumors in immuno-compromised mice, generating the MCF-10CA1a cell line. (biomedcentral.com)
When inoculated subcutaneously into the flanks of immuno-compromised mice, MCF-10AT cells occasionally form tumors, whereas MCF-10CA1a cells invariably form tumors with a shorter latency than MCF-10AT derived tumors. (biomedcentral.com)
MCF-10CA1a cells grown in three-dimensional basement membrane culture form large, hyper-proliferative masses, that retain few characteristics of MCF10A acini and more closely resemble tumors. (biomedcentral.com)
In the present study, we evaluated the regulation of G protein-coupled receptor (GPR)30 expression in estrogen receptor (ER)-positive endometrial, ovarian, and estrogen-sensitive, as well as tamoxifen-resistant breast cancer cells. (unical.it)
We are especially interested how interstitial cells facilitate tubular epithelial cell survival and prevent CKD. (yale.edu)
The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)

Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
However, establishing an association between Hh signalling activation and MMP-7 expression requires further validation, and the function of this regulation remains unknown. (jcancer.org)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)

In addition, OR expression pattern in various cancers were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas (TCGA), and the associations between patient survival outcomes and OR levels were analyzed to determine the clinical relevance and significances of OR expression in tumors. (bmbreports.org)
On this floor Cardiovascular researchers facilitate high-impact, collaborative research across a wide spectrum of basic, translational, and clinical research in areas such as heart failure, cardiac proteins, blood clotting, and more. (luc.edu)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Heparanase neutralizing monoclonal antibodies are getting examined in pre-clinical research, and heparanase-inhibiting little substances are getting developed predicated on the resolved crystal MX1013 framework from the heparanase proteins recently. (nihvp.org)

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
The blood LBP protein, which binds to LPS and transfers it as a monomer to the membrane-bound receptor CD14, then to MD-2 and TLR4, is involved in the delivery of LPS to the receptor [ 8 ]. (actanaturae.ru)

tumor/stroma interactions. (nih.gov)
Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)

Reciprocally, TGF-β from TAMs activated RAD18 in TNBC to enhance tumor stemness, forming a positive feedback loop. (nature.com)

Their advantage lies in the ability to perceive tumors with a low mutation load, thus establishing the first line of defense against pathogens. (explorationpub.com)

The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
Mitochondrial biology, stress signaling and aging-related degenerative diseases. (upstate.edu)

Alterations in Ras signaling are implicated in the development of different diseases, such as neurological disorders, developmental disorders, and autism. (encyclopedia.pub)

Many of the biological effects of flavonoids appear to be related to their ability to modulate a number of cell-signaling cascades. (oregonstate.edu)

Tumor recurrence is a major issue for many cancer types, such as glioblastoma multiforme (GBM) patients after receiving Temador treatments. (aporc.org)

Dr Dominic De Nardo is leader of the Innate Immune Signalling Group in the Department of Biochemistry & Molecular Biology within the Monash Biomedicine Discovery Institute . (monash.edu)
Exploring how innate immune processes contribute to host defence against pathogens, disease pathologies and anti-tumour immunity. (monash.edu)

Despite its importance, the molecular mechanism of CXCR1 signal transduction is poorly understood owing to the limited structural information available. (rcsb.org)
Alternative splicing is a crucial mechanism for generating protein diversity. (biologists.com)

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. (wikipedia.org)
Ras proteins are the founding members of the Ras superfamily of GTPases, which in humans is composed of more than 150 members [ 1 ] [ 2 ] . (encyclopedia.pub)
The agents documented and list- ed that carcinogens commonly show tween tumour sites in humans and ed as carcinogenic to humans one or more of 10 key characteristics experimental animals. (who.int)

Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Studies have focused on the genetic and epigenetic status of CAFs, since they are critical in tumor progression and differ phenotypically and functionally from normal fibroblasts. (spandidos-publications.com)
For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)

Geranylgeranyltransferase type I (GGTase-I) significantly affects Rho proteins, such that the malignant progression of several cancers may be induced. (bvsalud.org)
The group studies herpesviruses such as cytomegalovirus and the Epstein Barr Virus, which is causally associated with lymphomas, gastric carcinomas, and head and neck cancers, as well as small DNA tumor viruses such as polyoma and human papilloma viruses, which are responsible for cervical and anogenital cancers and head and neck cancers. (lsuhs.edu)
Additionally, immunohistochemistry (IHC) was performed in multiple ovarian cancers, benign tumours and normal tissues to evaluate Gli2 and MMP-7 protein expression. (jcancer.org)
However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)

Thus, the role of GFRα is more complicated than originally assumed, and it is necessary to revisit and review the role played by this versatile molecule in tumors. (medsci.org)

However, viruses have evolved numerous strategies to hinder the cGAS-STING signal transduction, promoting their immune evasion. (frontiersin.org)

Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)

This observation resulted in the development of 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (PET) to detect glucose uptake and lactate production for tumor imaging. (hindawi.com)
Development and application of carbohydrate array is actively implemented and also facilitates the research in the branches of infectious disease and cancer. (ncku.edu.tw)
Iozzo and Sanderson, 2012), highlighting the idea that nonenzymatic actions of heparanase play a substantial function in heparanase-driven tumor development (Fux et al. (nihvp.org)

Anatomy19

Organisms15

Diseases33

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes61

Disciplines and Occupations1

Information Science4

Health Care1

Pathways19

Microenvironment9

Pathway11

Metastasis13

Receptors9

Cytokines1

Proliferation6

Several types of tumors2

Apoptosis4

Suppressor proteins1

Oncogenic3

Expressed by tumor cells1

Kinase2

Invasion5

Intracellular4

Mutations4

Rapidly proli1

Downstream3

Phenotype2

Genes5

Necrosis factor2

Regulate2

Experimental Therapeutics1

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Solid tumor1

Mechanisms3

Transcription6

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Regulation3

Clinical4

Membrane2

Interactions2

TNBC1

Mutation1

Mitochondrial2

Alterations1

Cascades1

Recurrence1

Innate2

Mechanism2

Humans3

Immunity1

Genetic2

Cancers4

Molecule1

Immune1

Proteases1

Development3