Proteins exert anti apoptotic apoptotic programmed cell cell cycle. Medical search. Frequent questions

BCL-6 proteins repress genes involved in terminal differentiation and promote proliferation by blocking expression of a cell-cycle inhibitor (p27KIP1). (wikipedia.org)
miRNAs have been implicated as transcriptional regulators in a wide range of biological processes determining cell fate, stress response, proliferation, or death [ 5 ]. (hindawi.com)
Cell proliferation was examined by MTT and cell count assays. (biomedcentral.com)
Effects of Ganoderma lucidum spores on HepG2 cells proliferation and growth cycle. (springer.com)
At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
Effects of RAD001 and letrozole (alone and in combination) on the proliferation and survival of MCF7/Aro and T47D/Aro cells were evaluated using proliferation assays, flow cytometry, immunoblotting, and apoptosis analyses. (aacrjournals.org)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)
MTT assays were employed to determine the effect of cell proliferation. (biomedcentral.com)
Meanwhile, overexpression of ENDOD1 suppressed cell proliferation, induced G0/G1 cell cycle arrest and inhibited cell migration and invasion. (biomedcentral.com)
Conversely, siRNA-mediated silencing of ENDOD1 promoted cell proliferation, migration and invasion. (biomedcentral.com)
Multiple myeloma is a B-cell-dependent hematological malignancy caused by excessive clonal proliferation of terminally differentiated plasma cells in bone marrow. (protheragen.com)
RAS proteins generated from mutant KRAS constitutively activate their downstream signaling pathways, such as those involved in the growth, proliferation, and survival of cancer cells [8]. (cellphysiolbiochem.com)
The current study demonstrated that PD markedly inhibited PAC cell proliferation and triggered their apoptosis. (biomedcentral.com)
Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
Platinum compounds inhibit cell growth and proliferation. (medscape.com)
The ED 50 =1.0 -10 ng/ml, determined by the dose-dependant proliferation of human peripheral blood mononuclear cells. (egfie.com)

These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
Additional analysis on piceatannol provides revealed its excellent and powerful bioactive properties, including inhibitory results on platelet-derived development factor-BB (22), changed gene expression leading to the hold off of adipogenesis, and cell routine inhibition in colorectal tumor cells (23, 24). (bioskinrevive.com)
microRNAs (miRNAs) are important regulators of target messenger RNA translation by binding mainly to complementary sequences of the 3′ untranslated region of target messenger RNA transcripts thereby leading to RNA degradation and/or inhibition of protein synthesis [ 4 ]. (hindawi.com)
Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)
Previous studies have indicated that cancer cells rely heavily on proteasomes to meet the demand for turnover and are therefore more sensitive to proteasomal inhibition than normal cells. (protheragen.com)
The inhibition of cell wall β-glucan synthase leads to changes in the cell wall integrity and further cell damage [ 9 ] [ 10 ] . (encyclopedia.pub)
Interestingly, Dicer inhibition exerts more profound effects on processes like migration and viability of EC in comparison to Drosha inhibition. (uni-frankfurt.de)
Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. (oncotarget.com)
This is a heavy metal coordination complex that exerts its cytotoxic effect by platination of DNA, a mechanism analogous to alkylation, leading to interstrand and intrastrand DNA crosslinks and inhibition of DNA replication. (medscape.com)

Immunofluorescence staining, flow cytometry and western blot analysis were also used to determine apoptosis and the expression of proteins associated with apoptosis. (spandidos-publications.com)
In this study, we investigated the potential mechanism underlying the anti- C. albicans effects of AMP-17 using flow cytometry, transmission electron microscopy, fluorescent probes, fluorescence microplate reader, and confocal laser microscopy. (researchsquare.com)
Khz cytotoxicity was measured using an MTT assay and the mitochondrial membrane potential (MMP)-related, calcium-induced generation of reactive oxygen species (ROS) in A549 cells was measured by flow cytometry. (springer.com)
Flow cytometry analysis showed that the percentage of A549 cells in sub-G1 phase of the cell cycle increased in response to Khz treatment. (springer.com)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Flow cytometry was used to explore the cell cycle distribution and apoptotic effects. (biomedcentral.com)
Cell viability was estimated by cell counting kit-8 and cell apoptosis by flow cytometry. (karger.com)
The cell cycle distribution was analyzed through PI staining and flow cytometry analysis, while apoptotic cells were measured by double staining with Annexin V-FITC and PI. (biomedcentral.com)

When naïve B-cells encounter an antigen, one of the pathways that they can follow is through the germinal center environment. (wikipedia.org)
Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
Bioactive organic substances that exert affects on these pathways and suggestion the cellular stability and only apoptosis may possibly be helpful for book OVCA healing strategies. (bioskinrevive.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
FHND91 is 100% converted in aqueous solution to active molecules and results in tumor cell death through endoplasmic reticulum stress-dependent and mitochondria-mediated pathways. (protheragen.com)
However, preclinical trials of inhibitors of the downstream pathways of mutant RAS proteins have failed to achieve satisfactory results [9, 10]. (cellphysiolbiochem.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)

XIAP (X-linked inhibitor of Cilomilast (SB-207499) manufacture apoptosis proteins), another determinant of chemoresistance in OVCA (7), blocks apoptosis signaling in its last levels by inhibiting caspases that could otherwise be turned on through the activities of pro-apoptotic mediators like NOXA. (bioskinrevive.com)
RAD001 (everolimus), a mammalian target of rapamycin (mTOR) pathway inhibitor in phase II clinical trials in oncology, exerts potent antiproliferative/antitumor activities. (aacrjournals.org)
FHND91 is a selective oral proteasome inhibitor that binds irreversibly to the β5 submit of the 20S proteasome to exert anti-cancer effects. (protheragen.com)
Rather, p53 accumulation by either knockdown of Mdm2 or addition of an Mdm2 inhibitor, Nutlin-3, before irradiation strongly attenuated the UV-induced DDR and increased cell survival. (rupress.org)
Preincubation with an autophagy inhibitor accelerated cell death. (cellphysiolbiochem.com)
Mice inoculated with control pancreatic cancer cells developed tumors, while those inoculated with CIRT/autophagy inhibitor-treated cells showed significant evasion. (cellphysiolbiochem.com)
Kaithwas, Gaurav 2019-10-24 00:00:00 Background: This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis. (sagepub.com)
Tadalafil is a known phosphodiesterase-5 Distinct metastasis and resistance development by self- (PDE-5) inhibitor, which have anti-cancer effects in vari- renewing nascent cancer cells in response with the ous types of cancer [2]. (sagepub.com)
Wilden JJ, van Krüchten A, Gieselmann L, Hrincius ER, Deinhardt-Emmer S, Haupt KF, Preugschas HF, Niemann S, Ludwig S, and Ehrhardt C. (2020) The influenza replication blocking inhibitor LASAG does not sensitize human epithelial cells for bacterial infections. (uni-muenster.de)

MP increased the mRNA expression of T-bet and the protein expression of Bcl-2 in the spleen and decreased the protein expression of caspase-3 and Bax. (hindawi.com)
C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
Real-time PCR data indicated that ENDOD1 mRNA expression was markedly increased in LNCaP and 22Rv1 cells and decreased in PC3 and DU145 cells compared to the normal epithelial cells RWPE1. (biomedcentral.com)

Taken at face value, senile cataract is intimately associated with the increased risk of oxidative stress, which levies irrevocable changes in the lenticular proteins that impel the lens epithelial cells to the apoptotic phase. (molvis.org)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
Real-time PCR and western blot were used to detect ENDOD1 mRNA and protein expression in normal prostatic epithelial and PCa cell lines. (biomedcentral.com)

Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
Lavage fluid from the lumen of the asthmatic airway contains numerous mediators including histamine, prostaglandins (predominantly PGD2 and PGF2), leukotrienes, kinins, kallikrein, and eosinophil derived major basic protein. (edu.pk)
The third step comprises the release of granule proteins, which occurs when eosinophils become exposed to soluble mediators for example PAF 10 , immuncomplexes 11 or solid particles 12 . (edu.pk)
The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. (frontiersin.org)

B-cells within the germinal center proliferate and undergo immunoglobulin somatic hypermutation (SHM) of IgV region genes to revise their antigen receptors. (wikipedia.org)
The rearranging of genes makes the cells capable of generating antibodies with a higher or lower affinity to the specified antigen. (wikipedia.org)
BCL-6 genes are involved in several cell processes that can affect the ability of the B-cell to differentiate and proliferate. (wikipedia.org)
BCL-6 genes produce BCL-6 proteins. (wikipedia.org)
In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
Chrysin regulated miR-18a, miR-21, and miR-221 genes in gastric cancer cell line [ 26 ]. (hindawi.com)
Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)
Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)
Finally, the Normal-like classified tumors show high expression levels of many genes expressed by adipose tissue and other nonepithelial cell types and are characterized by gene expression patterns that are similar to those of normal breast tissue. (biomedcentral.com)
Overexpression of the RNA-binding protein HuR (ELAVL1) occurs during colon tumorigenesis and is abnormally present within the cytoplasm, where it post-transcriptionally regulates genes through its interaction with 3'UTR AU-rich elements (AREs). (oncotarget.com)

Our results revealed that H2O2 increased the rate of apoptosis by stimulating various pro-apoptotic processes, such as the generation of intracellular reactive oxygen species (ROS), lipid peroxidation, DNA fragmentation and caspase-3 activation. (spandidos-publications.com)
In zebrafishes, forced expression of rat lcn2 gene increased the number and thickness of cellular processes in GFAP-expressing radial glia cells, suggesting that lcn2 expression in glia cells plays an important role in vivo . (jneurosci.org)
In this process, astrocytes proliferate to fill gaps and undergo a typical morphological change: a large cytoplasmic mass, long and branched processes, and increased expression of intermediate filaments such as glial fibrillary acidic protein (GFAP). (jneurosci.org)
The ultrastructural study of the cellular modifications (during the life cycle reversion of T. nutricula) showed the presence of both degenerative and apoptotic processes. (researchgate.net)
The significant presence of degenerative and apoptotic processes could be related to the occurrence of a sort of metamorphosis when an adult medusa transforms itself into a polyp. (researchgate.net)
nutricula ) showed the presence of both degenerative and apoptotic processes. (researchgate.net)
Recent studies have shown that in addition to necrosis and apoptosis, there are also other new programmed death modes, such as autophagy, necrosis and necrotic apoptosis, which have unique biological processes and pathophysiological characteristics. (nature.com)

We propose that lcn2 is an autocrine mediator of reactive astrocytosis based on the multiple roles of lcn2 in the regulation of cell death, morphology, and migration of astrocytes. (jneurosci.org)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)
Our results indicated that lcn2 is critical for cell death sensitization, stimulation of cell migration, and morphological changes of reactive astrocytes. (jneurosci.org)
Further, AMP-17 treatment resulted in an increase in reactive oxygen species (ROS) levels, depolarization of the mitochondrial membrane potential (MMP), and changes in the cell cycle, leading to the apoptosis and necrosis, which ultimately contributed to the death of C. albicans cells. (researchsquare.com)
Jacobson MD. Reactive oxygen species and programmed cell death. (springer.com)
Miyajima, A, Nakashima J, Yoshioka K. Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells. (springer.com)
Oxidative stress is a plethora of reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, hydroxyl radical, and inducible nitric oxide species that exert a constellation of aberrant changes in the oxidation-reduction status of the cell. (molvis.org)
In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)

Del Sarto J, Gerlt V, Friedrich ME, Anhlan D, Wixler V, Teixeira MM, Boergeling Y, Stephan Ludwig (2021) Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection. (uni-muenster.de)

Forced expression of lcn2 or treatment with LCN2 protein increased the sensitivity of astrocytes to cytotoxic stimuli. (jneurosci.org)
Iron and BIM (Bcl-2-interacting mediator of cell death) proteins were involved in the cytotoxic sensitization process. (jneurosci.org)

Gene expression profiling has revealed that diffuse large B-cell lymphoma (DLBCL) is composed of at least 3 different sub-groups, each having distinct oncogenic mechanisms that respond to therapies in different ways. (wikipedia.org)
Hypertrophy was estimated by measuring the cell surface area and the atrial natriuretic peptide (ANP) gene expression. (karger.com)
Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
Finally, we showed that decreasing NSMCE2 gene expression increases breast cancer cells' sensitivity to chemotherapy treatment. (biomedcentral.com)
Taken together, the present study revealed that MWCNTs exert epigenetic effects in the lungs of exposed animals, potentially driving the subsequent gene expression changes. (cdc.gov)

Breast tumors can be divided into subtypes using two parameters: (I) At the molecular level based on the protein expression of three receptors: estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) [ 2 ]. (biomedcentral.com)
Basal tumors are characterized by high expression of keratins 5 and 17, laminin, and fatty acid binding protein 7. (biomedcentral.com)

We hypothesize that piceatannol enhances CDDP awareness in OVCA cells by exerting particular influences on crucial Cilomilast (SB-207499) manufacture regulators of apoptosis. (bioskinrevive.com)
Our results reveal that piceatannol enhances the apoptotic actions of CDDP in OVCA through nuclear activation and stabilization of p53, proteasome-dependent XIAP down-regulation, as well as the improvement of Drp1-reliant mitochondrial fission. (bioskinrevive.com)
Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. (springer.com)
Fig. 2: Fructose metabolism enhances hypoxic cell survival and decreases pyruvate kinase activity. (nature.com)
Astragaloside IV might suppress autophagy initiation directly or indirectly through suppressing the oxidative stress and inflammatory response, which further enhances the cell viability and tight junction and reduces apoptosis in LPS-stimulated pulmonary endothelial ARDS cell model, thus exerting its therapeutic function in ARDS. (karger.com)
Its action enhances antigen-specific responses of immune cells. (egfie.com)

Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
little attention has been devoted to the mechanisms and other immune cells. (hindawi.com)
The article will then delve into the existing evidence on green tea consumption, the mechanisms of action by which it may exert its effects, and an overview of research studies and clinical trials. (greenteaadvice.com)
Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. (springer.com)
Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)
However, the bioactive ingredients and mechanisms underlying its anti-cancer effect remains unclear. (biomedcentral.com)
How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)

They are derived by a targeted mechanism from the cell endocytic compartment and are formed and stored within the intracellular multivesicular bodies (MVBs). (spandidos-publications.com)
The proteasome functions as an ATP-dependent degradation of intracellular proteins, and its specificity depends on interactions only with the proteins that are labelled by polyubiquitin chain or contain a specific amino acid sequence. (protheragen.com)
The proteasome plays an important role in the ubiquitin-protein pathway (UPP), which is a key pathway for intracellular protein degradation, regulation of antigen presentation, cell cycle, NF-kB metabolism, etc. (protheragen.com)

Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
Microvesicles have a diameter ranging from 100 nm to 1 µm and are released by cell membrane budding. (spandidos-publications.com)
2016). In a subsequent study, we found that AMP-17 can impair cell wall integrity, destroy cell membrane structure, and increase cell membrane permeability in C. albicans (Ma et al. (researchsquare.com)
The Rg1 treatment also abolished H 2 O 2 -induced morphological changes, including cell rounding, membrane blebbing, neurite retraction and nuclei condensation, which were generated by myosin IIA-actin interaction. (ijbs.com)
AuNPs interact with cell wall macromolecules, damaging them and affecting membrane proteins [ 9 ] . (encyclopedia.pub)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)

This T(14,18) translocation places the BCL-2 gene close to the heavy chain gene enhancer and results in the overexpression of the Bcl-2 protein. (wikipedia.org)
Lactate production and the expression of galectin-9, a critical immunosuppression molecule, were detected after PKM2 knockdown and overexpression in HNSCC cells. (researchsquare.com)

These compounds have been shown to have antioxidant and anti-inflammatory effects, which may contribute to Chaga's potential health benefits. (chagamushrooms.net)
Antioxidants are compounds that help protect the body against the damaging effects of free radicals, which are unstable molecules that can damage cells and contribute to aging and disease. (chagamushrooms.net)
Furthermore, Chaga has been shown to have anti-inflammatory effects, which may help reduce inflammation in the body. (chagamushrooms.net)
Honey is a natural product known for its varied biological or pharmacological activities-ranging from anti-inflammatory, antioxidant, antibacterial, antihypertensive to hypoglycemic effects. (mdpi.com)
These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
In this study, we examined the cytoprotective effects of cyanidin-3-glucoside (C3G) isolated from mulberry fruit against pancreatic β-cell apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress. (spandidos-publications.com)
The MIN6 pancreatic β-cells were used to investigate the cytoprotective effects of C3G on the oxidative stress-induced apoptosis of cells. (spandidos-publications.com)
Recent studies have suggested that anthocyanins isolated from mulberry fruit exert anti-aging, anti-hyperlipidemic and anti-cancer effects ( 11 - 13 ). (spandidos-publications.com)
In the present study, we investigated the protective effects of C3G isolated from mulberry fruit against the H 2 O 2 -induced apoptosis of MIN6N pancreatic β-cells. (spandidos-publications.com)
The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. (hindawi.com)
To test this hypothesis, we attempted to investigate whether TFs can exert its cardioprotective effect and the effects of TFs on miR-21 in H9c2 cells. (hindawi.com)
In addition to inhibiting pathogens such as bacteria and fungi, AMPs also have varying degrees of killing effects on viruses, tumor cells, and parasites (Falanga et al. (researchsquare.com)
Compared with traditional antibiotics, AMPs have a broader spectrum of antimicrobial effects, better thermal stability, and less toxicity toward human cells. (researchsquare.com)
This article examines the existing evidence surrounding green tea's potential anti-cancer effects, shedding light on the scientific discoveries and providing a comprehensive overview of its potential benefits. (greenteaadvice.com)
This study aimed to investigate the anti-proliferative effects of Khz on A549 lung cancer cells. (springer.com)
The anti-proliferative and pro-apoptotic effects of Khz suggest that this extract shows great promise as a potential chemotherapeutic agent. (springer.com)
Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. (springer.com)
Silibinin has been reported to exert therapeutic effects in various cancer models. (jcancer.org)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
No apoptotic effects occurred upon manipulation of ENDOD1 expression. (biomedcentral.com)
Because of their pin-point dose distribution owing to the Bragg peak, carbon ion beams provide cancer cells with a peak dose radiation without exerting any adverse effects on normal tissues in the vicinity [11]. (cellphysiolbiochem.com)
The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. (biomedcentral.com)
Obviously, our data do not formally exclude effects of antagomir-92a on perivascular and other cell types, but surely include effects on EC. (uni-frankfurt.de)
The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. (egfie.com)

When the hosts are infected or subject to immune stimulation, AMPs can be quickly synthesized in some tissues and cells. (researchsquare.com)
There are numerous types of cancer, each originating from specific cells or tissues in the body. (greenteaadvice.com)
In this study, we determined the protein expression of ENDOD1 in PCa tissues by immunohistochemistry (IHC) and explored its correlations with clinicopathological parameters. (biomedcentral.com)
Abnormal myeloma cells produce a mutated form of immunoglobulin protein called M-protein, which accumulates in tissues and blood vessels. (protheragen.com)
Instead, miR-92a expression is specifically upregulated in ischemic tissues and appears to cell-autonomously repress the angiogenic potential of EC. (uni-frankfurt.de)

After nuclear activation, p53 up-regulates multiple pro-apoptotic elements including NOXA, which localizes towards the mitochondria and interacts with anti-apoptotic Bcl-2 family (12). (bioskinrevive.com)
The next launch Cilomilast (SB-207499) manufacture of pro-apoptotic elements including SMAC (second mitochondria-derived activator of caspases) and cytochrome takes on a major part in caspase-dependent apoptosis (13, 14). (bioskinrevive.com)
However, the excessive generation of ROS, such as super oxide anions (O 2 − ) and hydrogen peroxide (H 2 O 2 ) due to environmental stress results in significant oxidative damage to cell structures, such as DNA, the mitochondria and cell membranes ( 3 , 4 ). (spandidos-publications.com)
Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)

In response to a brain injury, astrocytes proliferate and become hypertrophic with an increased expression of intermediate filament proteins. (jneurosci.org)
Protein expression of ER stress and apoptosis factors was analyzed using Western Blot analysis. (karger.com)
Our study suggests that TFs can decrease cell apoptosis, which may be mediated by altering the expression of miR-21, PTEN/Akt, and Bcl/Bax. (hindawi.com)
We have previously produced the recombinant AMP-17 protein in a prokaryotic expression system and showed that it possesses excellent antifungal activity (Guo et al. (researchsquare.com)
Finally, MAC was found to trigger apoptotic death pathway (based on expression levels of cleaved-caspase 3, Bax/Bcl-2 balance, p53 and p21). (biomedcentral.com)
The expression of p53, Bax, Bcl-2, and actin proteins was analyzed by western blotting. (springer.com)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Western blot showed that androgen-sensitive LNCaP cells had the highest protein expression level of ENDOD1, whereas castration-resistant PCa cell lines PC3 and DU145 had significantly lower protein levels. (biomedcentral.com)
This protective effect of preaccumulated p53 was mediated, at least in part, by the increased expression of CDKN1A/p21, subsequent down-regulation of BRCA1, and impaired JNK activation accompanied by decreased association of replication protein A with chromatin. (rupress.org)
The expression of tumour necrosis factor (TNF)-α, interleukin (IL)-6, zonula occludens (ZO)-1, Beclin-1 and autophagy-related (atg) 5 mRNA was evaluated by quantitative PCR, and the expression of ZO-1, microtubule-associated proteins 1A/1B light chain 3B (LC3B) I and, LC3B II protein by Western blot. (karger.com)
LPS effectively inhibited cell viability and LC3B I expression and enhanced LC3B II, Beclin-1 and atg5 expressions in MLE-12 cells. (karger.com)
3-methyladenine promoted cell viability and ZO-1 expression, down-regulated Beclin-1 and atg5 expression, while Rapamycin (Rap) had an opposite effect. (karger.com)
Astragaloside IV suppressed cell viability and ZO-1 expression after the Rap treatment. (karger.com)

CIRT reduced the survival fraction of pancreatic cancer cells and induced apoptotic and necrotic alterations, along with autophagy. (cellphysiolbiochem.com)

Fission can be an integral event occurring before the induction of apoptosis and requires cleavage from the organelle in response to different stimuli, including cell tension. (bioskinrevive.com)
Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. (springer.com)
In patients who are eligible for autologous stem cell transplantation (ASCT), drugs are administered as induction and maintenance therapy. (protheragen.com)
β-peltatin initially arrested PAC cells at G2/M phase, followed by apoptosis induction. (biomedcentral.com)

Taken together, our results suggest that C3G isolated from mulberry fruit has potential for use as a phytotherapeutic agent for the prevention of diabetes by preventing oxidative stress-induced β-cell apoptosis. (spandidos-publications.com)
Recent studies have demonstrated that antioxidants present in natural products protect cells by reducing H 2 O 2 -induced oxidative stress in vitro and in vivo ( 5 - 7 ). (spandidos-publications.com)
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause of cell apoptosis or death in the central nervous system (CNS) diseases, such as neurodegenerative and psychiatric diseases. (ijbs.com)

Bcl-2 proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis). (wikipedia.org)
However, C3G reduced the H2O2-induced cell death in the MIN6N pancreatic β-cells. (spandidos-publications.com)
However, the precise role of lcn2 in the cell survival and death has yet to be determined. (jneurosci.org)
Programmed cell death and Bcl-2 protection in very low oxygen. (springer.com)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)
What is the relationship between ferroptosis and other types of cell death? (nature.com)
Whether under physiological or pathological conditions, cell death is an unavoidable and important link in the process of life and marks the end of the life of a cell. (nature.com)
Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)
The identification of PEox-protein adducts during ferroptosis suggests that they are participants in the ferroptotic process preventable by 2-mercaptoethanol and may contribute to a point of no return in the ferroptotic death process. (cdc.gov)

Transwell migration and invasion assays were done to evaluate changes in the ability of cell migration and invasion. (biomedcentral.com)

Cellular senescence is a programmed response that prevents a cell from dividing after some number of cell divisions. (wikipedia.org)
The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
The ultrastructural study of the cellular modiﬁcations (during the life cycle re version of T. (researchgate.net)

Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
In addition, we confirmed that H2O2 activated mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK) and p38 MAPK. (spandidos-publications.com)

In particular, isothiocyanates (ITCs) exerting anti-cancer properties, have received great interest as potential chemotherapeutic agents. (biomedcentral.com)

Cell viability was examined by MTT assay and lipid peroxidation was assayed by thiobarbituric acid (TBA) reaction. (spandidos-publications.com)
In LPS-induced ARDS cell model, astragaloside IV up-regulated cell viability, SOD activity and ZO-1 and LC3B I expressions but down-regulated cell apoptosis, TNF-α, IL-6, LC3B II, Beclin-1 and atg5 expressions and LDH and MDA levels. (karger.com)
Cell viability was determined using Cell Counting Kit-8 assay. (biomedcentral.com)

The ability of fructose to promote cell survival through an allosteric metabolite thus provides additional insights into the excess adiposity generated by a Western diet, and a compelling explanation for the promotion of tumour growth by high-fructose corn syrup. (nature.com)

Furthermore, Chaga has been found to induce autophagy via the AMPK-mTOR signaling pathway in breast cancer cells, suggesting that it may have potential as an adjuvant therapy for cancer treatment. (chagamushrooms.net)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)

Germinal Center B-Cell like (GCB) DLBCLs appear to arise from normal germinal center B cells, while Activated B-cell like (ABC) DLBCLs are thought to arise from postgerminal center B cells that are arrested during plasmacytic differentiation. (wikipedia.org)
Follicular dendritic cells and T cells help to select the B-cells that have a high affinity to the antigen for further differentiation into plasma cells and memory cells. (wikipedia.org)
Normal germinal center B-cells appear to be poised for apoptosis unless they are selected to progress to the next stage of differentiation. (wikipedia.org)
citation needed] Blocking the differentiation of germinal center B cells is dangerous because the cells are programmed to divide rapidly at this stage. (wikipedia.org)

One of the unexpected findings of the Human Genome Project was that over 98% of the human genome does not encode for proteins. (pharmaceuticalintelligence.com)

14-3-3 proteins exert anti-apoptotic activity by interfering with the function of BH3-only proteins and has been validated as a potential molecular target for anticancer therapeutic development in other types of cancers. (wikipedia.org)
The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
We aim to explore whether astragaloside IV is effective for ARDS treatment in a lipopolysaccharides (LPS)-induced cell model and whether autophagy is involved in the therapeutic function of astragaloside IV. (karger.com)

This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
MNU 47 mg/kg, i.v.) and group IV (Tada- activate protein kinase G and map kinase pathway of lafil 4 mg/kg, p.o. (sagepub.com)

DLBCL patients are at higher risk when they relapse early after R-CHOP chemotherapy and have a poor response to second-line rituximab-containing treatments even when these regimens involve high-dose therapy and autologous stem cell transplant. (wikipedia.org)
Approximately half of DLBCL patients develop CHOP-resistant cells. (wikipedia.org)
A study of DLBCL cell lines indicated that 14-3-3ζ proteins may play a role in mediating resistance of DLBCL cells to CHOP. (wikipedia.org)

The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
Insect hormones such as ecdysteroids and juvenoids play a key role in accessory gland development and protein synthesis but little is known about underlying molecular players and their mechanism of action. (sdbonline.org)

We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
Masemann D, Meissner R, Schied T, Lichty BD, Rapp UR, Wixler V, and Ludwig S. (2021) Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancers. (uni-muenster.de)

In vitro studies have demonstrated that Chaga extracts and small phenolic compounds derived from the mushroom exhibit cytotoxicity against various cancer cell lines. (chagamushrooms.net)
Four herbal PD formula was then disassembled into 15 combinations of herbal ingredients and a cytotoxicity assay showed that the Pulsatillae chinensis exerted the predominant anti-PAC effect. (biomedcentral.com)
Cytotoxicity is cell-cycle nonspecific. (medscape.com)
Cytotoxicity can occur at any stage of the cell cycle, but cell is most vulnerable to action of these drugs in G1 and S phase. (medscape.com)

Different classes of dietary flavonoids exhibit anti-oxidative, anti-inflammatory, anti-mutagenic, anti-aging, cardioprotective, anti-viral/bacterial and anti-carcinogenic properties. (mdpi.com)

In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)

Antimicrobial peptides (AMPs) are a class of small, biologically active proteins produced by a variety of organisms as a first line of defense against pathogens. (researchsquare.com)
Consequently, saliva not merely consists of several antimicrobial peptides and protein, but offers buffering capability also, which is essential in the dental defense against attacks. (exposed-skin-care.net)

Drinking grape juice 30 minutes before meals for a week following each cycle of chemotherapy doesn't seem to reduce nausea or vomiting caused by chemotherapy. (medlineplus.gov)

In cells stimulated to undergo ferroptosis we identified PE-truncated species with sn-2 truncations ranging from 5 to 9 carbons. (cdc.gov)
Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)

3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

The histone acetyltransferase Tip60 regulates the apoptotic response to ultraviolet (UV) irradiation. (rupress.org)

The process of ubiquitination is divided into three steps regulated by ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2) and ubiquitin ligase (E3), in which E1 activates ubiquitin, E2 accepts the transfer of activated ubiquitin, and finally E3 selectively recognizes the substrate protein. (protheragen.com)

The phytoalexin resveratrol can be a stilbene within grapes and mulberry, well known because of its anti-cancer properties in burgandy or merlot wine extract (18). (bioskinrevive.com)
In particular, a representative of the anthocyanins isolated from mulberry fruit, cyanidin-3-glucoside (C3G), is present in high quantities in mulberry fruit and is considered a phytotherapeutic agent due to its anti-oxidant properties ( 11 , 14 ). (spandidos-publications.com)

Ergosterol peroxide, a bioactive compound found in Chaga, has also been shown to exhibit anti-cancer activity by down-regulating the β-catenin pathway in colorectal cancer. (chagamushrooms.net)
Astrocytes, the most abundant glial cell type in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. (jneurosci.org)
Moreover, we have found that TFs can increase the activity of superoxide dismutase (SOD) and reduce the level of malonaldehyde (MDA) together with lactate dehydrogenase (LDH) in H9c2 cells. (hindawi.com)
by inhibiting the production of virulence factors such as exopolysaccharides and metabolic activity such as surface hydrophobicity playing an important role in bacterium-host cell interactions and biofilm architecture in microbes, respectively [ 7 ] . (encyclopedia.pub)
Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, causing subsequent cytocydal activity. (medscape.com)
Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. (egfie.com)

In addition, we identified miR-92a as a novel endogenous repressor of the angiogenic program in EC, which impairs their angiogenic functions in vitro and in vivo. (uni-frankfurt.de)

These compounds have been found to have anti-tumor, anti-inflammatory, and antioxidant properties. (chagamushrooms.net)
Overall, while more research is needed to fully understand the potential health benefits of Chaga, the available evidence suggests that it may have antioxidant, immune-boosting, and anti-inflammatory properties that could promote health and wellbeing. (chagamushrooms.net)
Melatonin (N-acetyl-5-methoxytryptamine), the main product of the pineal gland, is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties [ 6 ] . (encyclopedia.pub)

GCB DLBCL shows amplification of the oncogenic mir-17-92 microRNA cluster and deletion of the tumor suppressor PTEN but these events have not been found in ABC DLBCL B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. (wikipedia.org)
Like a grasp regulator of cell routine progression, DNA restoration, and apoptosis, the tumor suppressor p53 takes Cilomilast (SB-207499) manufacture on a central part in this technique (9C11). (bioskinrevive.com)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)

Degeneration was prevalent during the unhealthy medusa and four-leaf clover stages, while the apoptotic rate was higher during the healthy medusa and cyst stages. (researchgate.net)

These proteins work with other transcription factors (BLIMP1, PAX5, XBP1) to form a regulatory circuit that controls the progression of germinal center B cells to plasma cells. (wikipedia.org)
pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)

Using Argonaute CLIP-seq data, Dr. Rigoutsos and colleagues showed that similar percentages of the two sets of microRNAs were in complex with Argonaute proteins. (pharmaceuticalintelligence.com)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
A HuProt microarray composed of 17,225 human full-length proteins with N-terminal glutathione S-transferase (GST) tags was used to identify protein-protein interactions. (molvis.org)
The protein-protein interactions may help CRYAA carry out multifaceted functions. (molvis.org)
To understand the functions of CRYAA and how these are regulated, protein-protein interactions need to be investigated. (molvis.org)

We performed carbon ion radiotherapy (CIRT) in human pancreatic cancer cell lines and analyzed their survival, apoptosis, necrosis, and autophagy. (cellphysiolbiochem.com)
To investigate the role of CIRT-induced autophagy, autophagy inhibitors were added to cells prior to CIRT. (cellphysiolbiochem.com)
CIRT effectively killed the pancreatic cancer cells by inhibiting their autophagy-inducing abilities. (cellphysiolbiochem.com)

Monoclonal antibodies are made by injecting human cancer cells into mice so that their immune systems create antibodies against foreign antigens. (wikipedia.org)
Monoclonal antibodies target specific antigens on cancer cells and may enhance the patient's immune response. (wikipedia.org)
Mouse monoclonal p53 antibodies (Perform-1), MDM2, and PARP had been from Santa Cruz Biotechnology (Santa Cruz, CA). Rabbit monoclonal anti-Ser(P)15-p53, anti-poly(ADP-ribose) polymerase (PARP) antibodies and siRNA constructs had been from Cell Signaling Technology (Beverly, CA). Rabbit polyclonal anti-NOXA and anti-XIAP antibodies, aswell as mouse monoclonal anti-GAPDH and anti-caspase-3 antibodies had been from Abcam (Cambridge, MA). (bioskinrevive.com)
The characteristic features of myeloma include increased plasma cells in the bone marrow and extramedullary sites, elevated monoclonal M-protein in serum and urine, osteolytic bone lesions, renal insufficiency, anemia, and immunodeficiency. (protheragen.com)

Recent scientific studies have investigated the potential health benefits of Chaga and its active compounds, including its potential anti-cancer properties. (chagamushrooms.net)
Chaga has gained popularity as a supplement due to its potential health benefits, including its anti-cancer properties. (chagamushrooms.net)
In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
Recent high-impact research has shown the genomic/genetic differences between cancer and normal cells using methods such as next-generation sequencing [ 1 , 2 ]. (intechopen.com)
Cancer is a complex and multifaceted disease characterized by the uncontrolled growth and spread of abnormal cells. (greenteaadvice.com)
Khz, a naturally occurring compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia, inhibits the growth of cancer cells. (springer.com)
The role of the mTOR pathway in estrogen response was evaluated in aromatase-expressing MCF7/Aro breast cancer cells by immunoblotting. (aacrjournals.org)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Our computational findings were experimentally confirmed in breast cancer cells by pharmacological SE disruption and gene silencing techniques. (biomedcentral.com)
To evaluate tumor formation, we inoculated CIRT-treated murine pancreatic cancer cells on the flank of syngeneic mice and measured tumor weight. (cellphysiolbiochem.com)
The traditional Chinese medicine formula Pulsatilla Decoction (PD) has been clinically used to treat inflammatory diseases for millennia and recently as a supplementary anti-cancer treatment in China. (biomedcentral.com)
MNU 47 mg/kg, i.v). Tadalafil was ad- apoptosis and also simultaneously affect cancer cell ministered from 7th to 110th day at the dose specified growth and adhesion, mitochondrial energy homeostasis, above. (sagepub.com)
It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)

Type 1 diabetes, classified as insulin-dependent diabetes mellitus, is caused by the loss of insulin secretion due to the destruction of pancreatic β-cells ( 1 ). (spandidos-publications.com)
Therefore, the protection of pancreatic β-cells is crucial for preventing the onset of type 1 diabetes. (spandidos-publications.com)

Our results demonstrate that Pulsatillae chinensis and particularly its bioactive ingredient β-peltatin suppress PAC by triggering cell cycle arrest at G2/M phase and apoptosis. (biomedcentral.com)

Anatomy25

Organisms12

Diseases6

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes73

Disciplines and Occupations1

Information Science3

Health Care1

Proliferation20

Inhibition10

Flow cytometry8

Pathways8

Inhibitor9

MRNA expression3

Epithelial3

Mediators4

Genes11

Processes7

Reactive9

Phosphorylation1

Cytotoxic2

Gene expression5

Tumors2

Enhances6

Mechanisms12

Intracellular3

Membrane6

Overexpression2

Effects24

Tissues5

Mitochondria4

Expression14

Necrotic1

Induction4

Oxidative stress3

Death13

Transwell1

Cellular3

Extracellular3

Isothiocyanates1

Viability3

Metabolite1

Induce2

Differentiation4

Encode1

Therapeutic3

Kinase3

CHOP3

Mechanism2

Cancers2

Cytotoxicity4

Cardioprotective1

Apoptosis of cells1

Antimicrobial2

Chemotherapy1

Ferroptosis2

Hematopoietic1

Accumulation1

Regulates1

Ubiquitination1

Mulberry2

Activity7

Vitro and in vivo1

Antioxidant3

Tumor suppressor3

Prevalent1

Transcription2

MicroRNAs1

Interactions4

Autophagy3

Monoclonal4

Cancer14

Pancreatic2

Bioactive1