• Aquaporin 3 (AQP3) is a peroxiporin, a membrane protein that channels hydrogen peroxide in addition to water and glycerol. (bvsalud.org)
  • Therefore, we investigated whether disruption of the lipid raft harboring EGFR could affect AQP3 expression, and conversely, whether AQP3 silencing would affect the EGFR/phosphoinositide-3-kinase (PI3K)/Protein kinase B (PKB or Akt) signaling pathway in breast cancer cell lines with different malignant capacities. (bvsalud.org)
  • 수분통로단백질인 aquaporin 3 (AQP3)은 백반증, 건선 등 다양한 피부 관련 질병의 발현에 중요한 역할을 한다. (e-ajbc.org)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
  • Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. (scite.ai)
  • we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
  • However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
  • Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
  • Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature, especially in tubular epithelial cells. (biomedcentral.com)
  • PC1 and PC2 are found on the primary cilium, a hair-like structure present on the apical membrane of a cell, in addition to the cell membranes and cell-cell junctions of tubular epithelial cells. (basicmedicalkey.com)
  • The aim of this study was to determine AQP gene expression in pancreatic cancer tissues and to validate aquaporins as possible diagnosis and/or prognosis genes. (bvsalud.org)
  • We evaluated H2O2 uptake, cell migratory capacity, and expression of PI3K, pAkt/Akt in three breast cancer cell lines, MCF7, SkBr3, and SUM159PT, and in the nontumorigenic breast epithelial cell line MCF10A. (bvsalud.org)
  • Because of their relatively high transcript expression the present work addresses the cellular and subcellular location of AQPs 4, 7 and 9 proteins in CPECs and EP cells, using immunolabeling with validated antibodies and confocal immunofluorescence. (wright.edu)
  • Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (hopkinsmedicine.org)
  • Expression of Aquaporin-1 water channel protein in mouse erythro-leukemia cells: genetic regulation of corticosteroid and chemical induction. (hopkinsmedicine.org)
  • Genomic organization and developmental expression of aquaporin-5 in lung. (hopkinsmedicine.org)
  • Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). (hopkinsmedicine.org)
  • PURPOSE: We investigated the expression of the N-myc and STAT interactor (NMI) protein in invasive ductal carcinoma tissue and estimated its clinicopathologic significance as a prognostic factor. (koreamed.org)
  • Acutely and chronically, lithium salts produce a natriuresis that is associated with an impaired regulation of the expression of the epithelial sodium channel in the cortical collecting tubule. (medscape.com)
  • Western blot analysis was conducted to investigate protein expression related to EMT and apoptotic and MAPK signaling pathways. (jcpjournal.org)
  • Moreover, Sangju honey stimulated apoptosis by increasing the expression of p21, p53, cleaved caspase 3, and caspase 9. (jcpjournal.org)
  • SPARC (secreted protein,acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-matrix interactions, cellular proliferation and differentiation, and the expression of genes encoding extracellular matrix components. (silverchair.com)
  • Tissue or cell-specific expression of the Nek1 protein was never reported, since no anti-Nek1 antibodies were available then, and the association of Nek1 with pleiotropic abnormalities including PKD was not made in mice until later [ 4 ]. (biomedcentral.com)
  • Over-expression of PRDX6 enhances the migration and invasion of lung cancer cell line A549 [J]. Basic & Clinical Medicine, 2019, 39(3): 365-368. (magtechjournal.com)
  • Background: Aquaporin (AQP) expression has been investigated in various malignant neoplasms, and the overexpression of AQP is related to poor prognosis in some malignancies. (koreamed.org)
  • However, the expression of AQP protein. (koreamed.org)
  • These survival mechanisms include accumulation of organic osmolytes and increased expression of heat shock proteins through numerous pathways, resulting in osmotolerance. (biomedcentral.com)
  • REG4, S100P, SERPINB5 and REG1A protein expression was confirmed by immunohistochemistry (n=23). (bmj.com)
  • Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
  • Silent forkhead box protein O1 inhibits H2O2-induced apoptosis of rat alveolar epithelial cells type II [J]. Basic & Clinical Medicine, 2019, 39(4): 519-523. (magtechjournal.com)
  • In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine. (koreamed.org)
  • Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. (thermofisher.com)
  • Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. (jcpjournal.org)
  • Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. (biomedcentral.com)
  • This protein complex has also been implicated in regulating a number of signaling pathways, including Wnt, mammalian target of rapamycin (mTOR), STAT3, cMET, phosphoinositide 3-kinase (PI3K)/AKT, G protein-coupled receptor (GPCR), and epidermal growth factor receptor (EGFR), as well as in the localization and activity of cystic fibrosis transmembrane conductance (CFTR). (basicmedicalkey.com)
  • Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
  • Choroid plexus epithelial cells (CPECs) secrete most of the CSF through poorly understood mechanisms that involve aquaporins (AQPs) and various solute transport proteins like the Na+-K+-2Cl- cotransporter 1 (NKCC1). (wright.edu)
  • The primary function of most aquaporins is to transport water across cell membranes in response to osmotic gradients created by active solute transport. (shadowebike.com)
  • Aquaporins (AQPs), a family of water channel proteins, have been linked to carcinogenesis. (bvsalud.org)
  • Aquaporins (AQPs), a family of small integral membrane proteins responsible for facilitating water fluxes through the cell membrane, offer potential promising drug targets for sepsis treatment due to their role in water balance and inflammation. (bvsalud.org)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • The mammalian aquaporins, which number about a dozen, are expressed in many cell types involved in fluid transport, including epithelia and endothelia in kidney, lung, exocrine glands, eye and gastrointestinal organs. (shadowebike.com)
  • The well-characterized mammalian proteins are found in renal (IIa isoform) and intestinal (IIb isoform) brush border membranes and are about 640 amino acyl residues long with 8-12 putative TMSs. (tcdb.org)
  • Mammalian porters of the PNaS family may catalyze cotransport of 3 Na + with 1 inorganic phosphate. (tcdb.org)
  • Here we report that Nek1 is expressed most strongly in the distinct subset of renal epithelial cells. (biomedcentral.com)
  • Effect of tolvaptan on aquaporin in inner medullary collecting duct cell line and renal tubule function [J]. Basic & Clinical Medicine, 2019, 39(8): 1163-1167. (magtechjournal.com)
  • As a result of FGF8 and Wnt4 secretion, Lhx1 activation initiates the mesenchymal-to-epithelial transition, causing the pretubular aggregates to form renal vesicles. (j-organoid.org)
  • In response to parathyroid hormone and dietary inorganic phosphate, the renal cotransporter is rapidly inserted into and retrieved from the renal brush border membrane in a fashion similar to that by which the glucose transporter (Glut4) (TC# 2.A.1.1) is regulated by insulin, and aquaporins 1 and 2 (TC# 1.A.8.1) are regulated by vasopressin (Levi et al. (tcdb.org)
  • PC2 and FPC both interact with kinesin 2 (KIF 3A/B). Localization of disease proteins in the cilium, the transition zone, and the basal body is color coded. (basicmedicalkey.com)
  • Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. (encyclopedia.pub)
  • Dr. King's research focus early in his tenure was the biology of aquaporin water channel proteins in the respiratory tract as well as other tissues. (hopkinsmedicine.org)
  • Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat. (hopkinsmedicine.org)
  • Aquaporins in complex tissues: II. (hopkinsmedicine.org)
  • Identify the properties of epithelial tissues that affect molecule movement. (msudenver.edu)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5. (nature.com)
  • Chemical injury induced by DSS leads to a loss of both Lgr5 + cells and Axin2 + cells and epithelial regeneration is driven by Axin2 − cells, including differentiated Krt20 + surface enterocytes. (nature.com)
  • We demonstrate that Rspo3 is essential for epithelial repair via induction of Wnt signaling in differentiated cells. (nature.com)
  • The majority of epithelial cells are therefore short-lived, in contrast to a limited number of long-lived stem cells in the base of the crypts. (nature.com)
  • While Lgr5 + cells are long-lived and act as stem cells during homeostatic conditions, experimental models have demonstrated that Lgr5 + stem cells per se are not essential for maintaining epithelial integrity 3 . (nature.com)
  • This has been studied mainly in the small intestine, where different cell types such as enterocyte progenitors 4 , more differentiated secretory Bmi1 + cells 3 , or even fully differentiated Paneth cells can repopulate crypts upon injury. (nature.com)
  • Rspo proteins are secreted and can stabilize the effects of Wnt ligands by preventing ubiquitination and turnover of the Wnt receptor frizzled 9 , thereby dictating the size of the Lgr5 + stem cell pool by regulating self-renewal of Lgr5 + cells 10 . (nature.com)
  • Thus, we find that endogenous Rspo3 signaling is a critical determinant of cellular fate within the crypt and stimulates rapid recruitment of differentiated cells for epithelial wound healing and crypt regeneration through induction of Wnt signaling. (nature.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • CPs are composed of a monolayer of cuboidal epithelial cells, derived from ependymal cells (EPCs), joined by tight junctions, and surrounding a core of fenestrated capillaries. (wright.edu)
  • Aquaporins are found in a high concentration in the epithelial cells that produce aqueous humor (as well as other epithelial cells that allow water to move readily across their membrane, e.g., epithelial cells in the kidney). (shadowebike.com)
  • Orai1 proteins form the major ion conducting units mediating the Ca 2+ release activated Ca 2+ current (I CRAC ) in immune cells among many other cell types. (nature.com)
  • Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
  • by 3 months, all the fiber cells appeared swollen to a marked degree. (silverchair.com)
  • Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
  • HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
  • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. (jceionline.org)
  • miR-17-5p induces podocytes apoptosis and inhibits glomerular epithelial protein 1 in mice [J]. Basic & Clinical Medicine, 2019, 39(7): 973-977. (magtechjournal.com)
  • Hepatitis B virus X protein inhibits the proliferation and promotes the apoptosis of mouse foot cell line MPC5 [J]. Basic & Clinical Medicine, 2019, 39(5): 617-622. (magtechjournal.com)
  • The first three types in the Fig. 2 are common forms in integral membrane proteins, such as, transmembrane α-helix protein, transmembrane α-helical protein and transmembrane β-sheet protein. (shadowebike.com)
  • these are called transmembrane proteins. (shadowebike.com)
  • Some (more…) Many integral membrane proteins (called transmembrane proteins) span the lipid bilayer, with portions exposed on both sides of the membrane. (shadowebike.com)
  • Here we combine experimental and theoretical approaches and show that oxidation of Orai1 leads to reduced subunit interaction, slows diffusion and that either oxidized C195 or its oxidomimetic mutation C195D located at the exit of transmembrane helix 3 virtually eliminates channel activation by intramolecular interaction with S239 of transmembrane helix 4, thereby locking the channel in a closed conformation. (nature.com)
  • The inhibition is mainly mediated through the reactive cysteine C195 at the exit of transmembrane region 3 (TM3) of Orai1, a residue that is not conserved in the paralogue Orai3, which currents are not inhibited by oxidation 22 . (nature.com)
  • Identify the 3 domains of a transmembrane receptor. (msudenver.edu)
  • PC1 is a large 11-transmembrane protein that functions like a G protein-coupled receptor. (basicmedicalkey.com)
  • PC2 is a calcium-permeable six-transmembrane protein that structurally belongs to the transient receptor potential (TRP) cation channel family. (basicmedicalkey.com)
  • HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
  • Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. (thermofisher.com)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • Bauer EM, Shapiro R, Billiar TR, Bauer PM. High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s). (jceionline.org)
  • Other common primary cancers that metastasize to the liver include lung, melanoma, breast, pancreatic, and gastric cancer, each with high incidences for this type of disease progression [ 3 ] . (encyclopedia.pub)
  • Proteins are the second major component of plasma membranes. (shadowebike.com)
  • Background and Objectives: Cholesteatomatous chronic otitis media acquires epithelial proliferation and differentiation characteristics, which render it able to erode the underlying bone and cause complications. (koreamed.org)
  • 2007). We discover that ISWI is certainly a RanGTP-dependent microtubule-associated proteins (MAP) in vitro. (researchensemble.com)
  • It modulates transcriptional silencing and protein stability through deacetylation of target proteins. (koreamed.org)
  • The PC1/2 protein complex serves as a mechanosensor or chemical sensor and regulates calcium and G-protein signaling. (basicmedicalkey.com)
  • Aquaporins are channels, i.e. passive transporters where water always moves down its water potential gradient. (shadowebike.com)
  • Etiology and Pathogenesis ( Fig. 339-1 ) ADPKD is characterized by progressive formation of epithelial-lined cysts in the kidney. (basicmedicalkey.com)
  • FIGURE 339-1 Scheme of the primary cilium and cystic kidney disease proteins. (basicmedicalkey.com)
  • Topology of autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) proteins polycystin-1, polycystin-2, and fibrocystin/polyductin (FPC) are shown. (basicmedicalkey.com)
  • In addition, epithelial growth factor receptor (EGFR) plays an important role in breast cancer. (bvsalud.org)
  • Although NOD-like receptor protein 3 (NLRP3) inflammasome activation is known to. (koreamed.org)
  • Sjögren's syndrome (SjS) is a common autoimmune disorder associated with epithelial inflammation and exocrine gland dysfunction [ 5 ]. (biomedcentral.com)
  • In addition to lipids, membranes are loaded with proteins. (shadowebike.com)
  • PC1 also interacts with other proteins such as components of the BBSome and NPHP1. (basicmedicalkey.com)
  • Signals that regulate epithelial regeneration upon stem cell injury are largely unknown. (nature.com)
  • This Rspo3-driven regeneration program is supported by injury-induced stromal remodeling, and is essential for epithelial recovery. (nature.com)
  • Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
  • Aquaporins are membrane-channel proteins that are present at all levels of life, from bacteria to mammals. (shadowebike.com)
  • The PNaS family includes several functionally characterized, sodium-dependent, inorganic phosphate (P i ) transporter (NPT2 or NptA) proteins from mammals. (tcdb.org)
  • By forming a continuous protein pathway across the membrane, these proteins enable specific hydrophilic solutes to cross the membrane without coming into direct contact with the hydrophobic interior of the lipid bilayer. (shadowebike.com)
  • The N- and C-termini are in the cytoplasm, and a large hydrophilic loop is localized between TMSs 3 and 4. (tcdb.org)
  • Aquaporins ("water channels") 2003 Nobel Prize in Chemistry. (shadowebike.com)
  • He was elected to the American Society for Clinical Investigation in 2006 for work on aquaporin water channels. (hopkinsmedicine.org)
  • Lithium can substitute for sodium in several sodium channels, particularly the sodium-hydrogen exchanger in the proximal tubule (NHE3), the sodium/potassium/2chloride exchanger in the thick ascending limb of the loop of Henle (NKCC2), and the epithelial channel of the cortical collecting tubule (ENaC). (medscape.com)
  • A membrane protein is a protein molecule that is attached to, or associated with, the membrane of a cell or an organelle. (shadowebike.com)
  • The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. (gu.se)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)
  • High mobility group box 1 protein (HMGB1) is a non-histone chromosomal protein with dual activity. (jceionline.org)
  • Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene. (wikipedia.org)
  • AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • ICC is an aggressive epithelial malignancy of the bile ducts within the liver that is often locally advanced to metastatic disease and has an extremely poor prognosis. (encyclopedia.pub)