Loading...
  • genes
  • By careful examination of the large amount of experimental information available about the genes, proteins and biochemical reactions involved in regulating the cell division of C. crescentus , we have developed a good understanding of the mechanism of cell division in this organism and a realistic, quantitative mathematical model of the molecular machinery that oversees Caulobacter's cell division cycle," said John Tyson. (eurekalert.org)
  • asymmetric cell div
  • The article "Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus" is by Genetics, Bioinformatics, and Computational Biology graduate student Shenghua Li, research scientist Paul Brazhnik, Professor and Director of VBI's Cyberinfrastructure Group Bruno Sobral, and University Distinguished Professor of Biological Sciences John Tyson. (eurekalert.org)
  • Molecular
  • The two cell types undergo different development programs but share the same core molecular regulatory system that controls whether the cell commits to a new round of DNA synthesis and to the cell division process. (eurekalert.org)
  • regulatory
  • This regulatory core comprises three key proteins - DnaA, GcrA, and CtrA - that act as control points or master switches for DNA replication and cell division. (eurekalert.org)
  • Tyson added: "We have been able to establish a wiring diagram that maps the essential regulatory steps for DNA replication and cell division in Caulobacter in a way that is similar to how you would define a computer process. (eurekalert.org)
  • sequence
  • With the model in place, the researchers confirmed that it correctly represents the sequence of physiological events that take place during cell division. (eurekalert.org)
  • regulator
  • For example, the math model predicts that if the master regulator CtrA cannot be properly phosphorylated, which is a key step in the activation of CtrA, then the cell replicates its DNA but cannot divide. (eurekalert.org)
  • mutations
  • Taking this one step further, they were also able to simulate the impact of specific known mutations on cell function. (eurekalert.org)
  • undergoes
  • Caulobacter normally undergoes a cell cycle that produces two different types of offspring: a motile "swarmer cell" with a flagellum, a slender thread-like structure that allows the bacterium to swim, and an immobile "sessile stalked cell" that lacks a flagellum. (eurekalert.org)