Proteins canonical bipartite nuclear localization signals. Medical search. Frequent questions

Research suggests SPATS1 may play a role in the canonical Wnt Signaling pathway and in the first spermatogenic wave. (wikipedia.org)
Another study suggests that it acts as a negative regulator in the canonical Wnt signaling pathway. (wikipedia.org)
The canonical WNT-β-catenin pathway is essential for self-renewal growth and survival of AML stem/blast progenitor cells (BPCs). (researchassistantresume.com)
Deregulated canonical WNT-β-catenin pathway has also been documented to be essential for self-renewal growth and survival of the AML stem and blast progenitor cells (BPCs)2-5. (researchassistantresume.com)
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? (babraham.ac.uk)
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)

A general idea of its chemical structure, subcellular localization, expression, and conservation is known. (wikipedia.org)
The C2 domain is thought to be involved in calcium-dependent phospholipid binding [ ( PUBMED:8253763 ) ] and in membrane targetting processes such as subcellular localisation. (embl.de)

Citalopram Hydrobromide Due to inhibition of the phosphorylation of β-catenin by GSK3β the polyubiquitylation and proteasomal degradation of β-catenin is definitely often abrogated in the AML BPCs1 16 This enables the preservation nuclear translocation and transcriptional activity of β-catenin. (researchassistantresume.com)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
the ß-importin kap8 (pse1/kap121) is required for nuclear import of the cellulase transcriptional regulator xyr1, asexual sporulation and stress resistance in trichoderma reesei. (liverpool.ac.uk)

The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. (scienceopen.com)
In human cells infected with herpes simplex virus 1 the double-stranded RNA-dependent protein kinase (PKR) is activated but phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2) and total shutoff of protein synthesis is observed only in cells infected with gamma(1)z34.5- mutants. (scienceopen.com)
Taxonomy and function of C1 protein kinase C homology domains. (embl.de)
These domains were first discovered as the loci of phorbol ester and diacylglycerol binding to conventional protein kinase C isozymes, which contain 2 C1 domains (C1A and C1B) in their N-terminal regulatory regions. (embl.de)
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. (embl.de)
The atypical protein kinase C (PKC) member PKC-zeta has been implicated in several signal transduction pathways regulating differentiation, proliferation or apoptosis of mammalian cells. (embl.de)

The carboxyl-terminal 64 aa of gamma(1)34.5 protein are homologous to the corresponding domain of MyD116, the murine growth arrest and DNA damage gene 34 (GADD34) protein and the two domains are functionally interchangeable in infected cells. (scienceopen.com)
the filamentous fungus aspergillus oryzae is a well-known expression host used to express homologous and heterologous proteins in a number of industrial applications. (liverpool.ac.uk)

Spermatogenesis associated serine rich 1 (SPATS1) is a protein which in humans is encoded by the SPATS1 gene. (wikipedia.org)
Expression in the nucleus may be supported by the fact that the rat homolog of the SPATS1 gene was experimentally found to have a probable bipartite nuclear localization signal. (wikipedia.org)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
Here, we characterize the evolution and function of the SPATA31 gene family (former designation FAM75A ), which was previously shown to be among the gene families with the strongest signal of positive selection in hominoids. (biomedcentral.com)

These results indicate that in infected cells, gamma(1)34.5 interacts with and redirects phosphatase to dephosphorylate eIF-2alpha to enable continued protein synthesis despite the presence of activated PKR. (scienceopen.com)
The proposed mechanism for maintenance of protein synthesis in the face of double-stranded RNA accumulation is different from that described for viruses examined to date. (scienceopen.com)
Given their essential role in protein synthesis, they occur regularly and are unlikely to disappear from a viable genome. (fascea.pics)
For example, if the AARS of a pathogen is different enough from that of humans, an antibiotic could be developed that disrupts protein synthesis in the infectious agent. (fascea.pics)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)

Several microaary studies have studied the effects of knocking out different proteins and enzymes and the resulting effects on SPATS1 expression. (wikipedia.org)
That seems like a tall enough task for a class of enzymes, and when protein-based life began, it was. (fascea.pics)

Keywords: acute myeloid leukemia Beta Catenin Intro β-catenin functions as a co-activator for the T-cell Citalopram Hydrobromide element (TCF) 4/lymphoid enhancer element (LEF) 1 bipartite transcription element in the promoters of the WNT-β-catenin target genes and is implicated in malignancy transformation1. (researchassistantresume.com)
Therefore in the nucleus of AML stem/BPCs the β-catenin-TCF4/LEF1 complex increases manifestation of the pro-growth and pro-survival genes including cyclin D1 c-MYC and survivin while reducing Axin 2 levels1 3 15 In AML stem/BPCs Citalopram Hydrobromide multiple mechanisms are known to deregulate WNT signaling. (researchassistantresume.com)
In addition, cells can produce more than 300 different protein variants from AARS genes through alternative splicing of their mRNAs or post-translational protein fragmentation. (fascea.pics)
The primate SPATA31 genes also acquired new protein domains that suggest an involvement in UV response and DNA repair. (biomedcentral.com)

Note that these proteins have not been experimentally confirmed to interact with SPATS1. (wikipedia.org)
When both proteins are overexpressed, Gadd34 can interact with EBNA3C in both nuclear and cytoplasmic compartments. (scienceopen.com)
Furthermore, they have specific amino acid binding sites ready to interact with other proteins. (fascea.pics)

here, we investigated the nucleo-cytoplasmic shuttling mechanism that transports xyr1 across the nuclear pore complex. (liverpool.ac.uk)

functional characterization of nat/ncs2 proteins of aspergillus brasiliensis reveals a genuine xanthine-uric acid transporter and an intrinsically misfolded polypeptide. (liverpool.ac.uk)

EBNA3C is an EBV-encoded nuclear protein, essential for proliferation of EBV infected B-lymphocytes. (scienceopen.com)
In 2008 our lab was the first to report that tumor cells that acquired resistance to cetuximab exhibited dramatic up regulation of the EGFR, secondary to loss of ubiquitination, which led to enhanced signals to other EGFR family members (HER and HER3) that promoted proliferation and survival. (wisc.edu)

Bioinformatic analysis suggests that the protein does not have transmembrane structure and is composed of both alpha helixes and beta sheets. (wikipedia.org)

Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). (embl.de)

In addition, bioinformatic tools have identified a bipartite nuclear localization signal with high probability in the human protein at amino acids 174 - 191. (wikipedia.org)
Using EBNA3C amino acids 365-545 in a yeast two hybrid screen, we found an interaction with the Growth Arrest and DNA-damage protein, Gadd34. (scienceopen.com)
For some amino acids there are two variants with a separate enzyme for use in protein translation, which takes place in the mitochondria. (fascea.pics)
The amino acid sequence for this part of the protein resembled that of a human cytokine, EMAP II, which recruits circulating immune cells in tissues to promote inflammation. (fascea.pics)

Automatic Classification of signal regions in 1 H Nuclear Magnetic Resonance Spectra G. Fischetti, N. Schmid, S. Bruderer, G. Caldarelli, A. Scarso, A. Henrici, D. Wilhelm Frontiers Artificial Intelligence https://doi.org/10.3389/frai.2022.1116416 (2023). (guidocaldarelli.com)

These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. (babraham.ac.uk)

These special synthetases have been around since the dawn of protein-based life and are available for evolutionary modification. (fascea.pics)

It is also known by the aliases Dishevelled-DEP domain interacting protein (DDIP), Spermatogenesis Associated 8 (SPATA8), and serin-rich spermatogenic protein 1 (SRSP1). (wikipedia.org)
But Wakasugi went further and, in fact, the TyrRS carboxyl domain behaved exactly like EMAP II, inducing cultured phagocytes and leukocytes to migrate and release inflammatory signals. (fascea.pics)
The C2 domain is a Ca 2+ -dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. (embl.de)
Regions with significant homology [ ( PUBMED:7559667 ) ] to the C2-domain have been found in many proteins. (embl.de)
Taxonomic distribution of proteins containing C2 domain. (embl.de)
The complete taxonomic breakdown of all proteins with C2 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing C2 domain in the selected taxonomic class. (embl.de)
Many C1 domains and C1 domain-containing proteins bind phorbol esters, but many others do not. (embl.de)

The expression of this protein has been found to greatly decline in adulthood, compared to expression levels measured in fetuses. (wikipedia.org)
Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)

We found that the use of engineered pegRNA (epegRNA), along with the combination of introducing a V223A mutation into the M-MLV RT and updating the architecture of the PE protein by varying the SpCas9 activity and nuclear localization signals (NLSs), synergistically and significantly increased the efficiency of prime editing in wheat. (biomedcentral.com)

SPATS1 protein is conserved in species as early as Oxytricha trifallax. (wikipedia.org)

These results also suggest the coupling of RACK1 to muscle unfolded protein response during SC activation. (sdbonline.org)

Despite the recent advancements by deep learning methods such as AlphaFold2, \textit{in silico} protein structure prediction remains a challenging problem in biomedical research. (academ.us)

Many AARS have been linked to human diseases caused not by defects in protein assembly but by these other non-canonical functions. (fascea.pics)

No orthologues have been found for this protein in archaea or bacteria. (wikipedia.org)
While other proteins have taken on supporting roles, the number and variety of byproducts found in AARS are remarkable, Schimmel says. (fascea.pics)

Here, we share our perspective on how to create a framework for systematically selecting protein structure prediction problems that are amenable for quantum advantage, and estimate quantum resources for such problems on a utility-scale quantum computer. (academ.us)

A protein abundance histogram, which compares the abundance of a desired protein to other proteins, shows that SPATS1 is on the lower level of expression. (wikipedia.org)
The acquisition of new SPATA31 protein functions and its broadening of expression may be related to the evolution of the diurnal life style in primates that required a higher UV tolerance. (biomedcentral.com)

Then, beginning in the 1990s, Schimmel and others began to discover non-canonical functions in higher eukaryotes, beginning with unexpected roles in angiogenesis. (fascea.pics)
to facilitate higher yields of proteins of interest, we constructed the pasop vector to express heterologous proteins in a. oryzae. (liverpool.ac.uk)

The GADD34 protein may have a similar function in eukaryotic cells. (scienceopen.com)
We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

β-catenin is also required for the HOXA9 and MEIS1-mediated transformation of the hematopoietic stem cells MLL-AF9-mediated transformation of the committed myeloid progenitor cells as well as necessary for the development and growth of MLL fusion protein-transformed leukemia stem cells2-5. (researchassistantresume.com)

Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (scienceopen.com)

There are 169765 C2 domains in 106000 proteins in SMART's nrdb database. (embl.de)
Proteins containing typical C1 domains are predicted to be regulated by diacylglycerol, whereas those containing only atypical domains are not. (embl.de)

The discovery of new functions for these ancient proteins was "a big surprise," he says. (fascea.pics)

June 18, 2010, Essentials of Trademarks P suas base for Mr. The development fact' of nuclear weapons does that they appreciate never complete Cold comprehensive P5+1. (shenservice.com)

and non-LTR retrotransposons, including long interspersed nuclear elements (LINEs, such as the L1 element [ 7 ] ) and short interspersed nuclear elements (SINEs, such as the Alu element [ 8 ] ). (encyclopedia.pub)

email of Paracoccidioides t amplitude chapter making tree in essence pass history signal by complexities: information with pharmacological T. IL-12 sets of F in vectors swords: a little file. (plywoodskyscraper.com)

We generated antibodies and show that the protein is re-localized from the nucleolus to the whole nucleus upon UV-irradiation suggesting a UV damage response. (biomedcentral.com)

F o For as long as living things have been building proteins based on the code of messenger RNA molecules, there have been aminoacyl-tRNA synthetases. (fascea.pics)

The protein in its longest form has 8 exons. (wikipedia.org)
form, signal, articles. (plywoodskyscraper.com)

Anatomy16

Organisms3

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes34

Disciplines and Occupations1

Information Science3

Pathway7

Subcellular2

Transcriptional5

Kinase6

Homologous2

Gene4

Synthesis4

Translocation1

Regulate1

Enzymes2

Genes4

Interact3

Cytoplasmic1

Functional1

Proliferation2

Transmembrane1

Motif1

Amino4

Classification1

Mechanisms1

Evolutionary1

Domain8

Levels2

Activity1

Species1

Unfolded protein1

Recent1

Human1

Found2

Structure1

Expression2

Higher2

Function2

Cells1

Translation1

Domains2

Functions1

Development1

Element1

Tree1

Damage1

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