Proteins called dynein. Medical search. Frequent questions

Dyneins are a family of cytoskeletal motor proteins that move along microtubules in cells. (wikipedia.org)
In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport. (wikipedia.org)
Cytoplasmic dynein positions the spindle at the site of cytokinesis by anchoring to the cell cortex and pulling on astral microtubules emanating from centrosome. (wikipedia.org)
Dynein pulls the microtubules and chromosomes to one end of the cell. (wikipedia.org)
When the end of the microtubules become close to the cell membrane, they release a chemical signal that punts the dynein to the other side of the cell. (wikipedia.org)
Budding yeast have been a powerful model organism to study this process and has shown that dynein is targeted to plus ends of astral microtubules and delivered to the cell cortex via an offloading mechanism. (wikipedia.org)
During transport, BICD2 stabilizes the dynein complex along a track-like system of small tubes called microtubules, similar to a conveyer belt. (medlineplus.gov)
Axonemal dynein causes sliding of microtubules in the axonemes of cilia and flagella and is found only in cells that have those structures. (wikipedia.org)
The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal band. (scivee.tv)
reveal that, upon platelet activation, the motor protein dynein slides microtubules apart, inducing marginal band coiling and the conversion of platelets to a spherical shape. (scivee.tv)
They also show that the motor protein dynein and so called 'microtubules' which are part of the cytoskeleton are involved in this process. (embl.org)
Microtubules - cellular components along which materials needed for nuclear growth are transported - are known to work together with dynein, the motor protein that enables that transportation. (embl.org)
The most important of these is a protein called dynactin1, which interacts with microtubules, enabling the dynein motor to move along microtubules. (mit.edu)
Outer dynein arms (ODAs) are arranged along the cytoskeletal scaffold of cilia and pull on microtubules to make them slide and bend, thereby driving the cilia waving motion. (cam.ac.uk)
Molecules can be transported around a cell by so-called motor proteins that move along a network of filaments called microtubules. (elifesciences.org)
The head of the non-motor protein cannot bind to ATP, although it can bind to microtubules. (elifesciences.org)
2001). The assembly and the functions of the spindle apparatus are tightly regulated by the orchestrated interplay of dynamic microtubules and motor proteins (Wittmann et al. (uni-konstanz.de)
2005). Kif18A is a member of the kinesin-8 protein family characterized by its unique dual functionality, which couples a highly processive motor activity with the ability to destabilize microtubules by specifically depolymerizing them at their plus end (Mayr et al. (uni-konstanz.de)
The G/LGN/NuMA complicated binds to dynein, which in turn generates microtubule tugging pushes toward the cell cortex through minus-end-directed dynein motion in colaboration with depolymerizing microtubules (Body 1A, middle). (researchassistantresume.com)
2011). Longer astral microtubules after that bind even more cytoplasmic dynein to create greater pulling drive and therefore orient department along the much longer cell axis (Minc et al. (researchassistantresume.com)
Fusion and division are regulated by dynein motors, which not only transport mitochondria along microtubules, but constantly remodel membranes. (jonlieffmd.com)
We propose a model in which the cooperation of dynein-mediated microtubule transport and oMAP4-mediated zippering of microtubules drives formation of a paraxial microtubule array that provides critical support for the polarisation and elongation of myotubes. (elifesciences.org)
Within the myoblasts, long filaments called microtubules are arranged in an overlapping linear pattern. (elifesciences.org)
A family of microtubule-associated proteins (or 'MAPs' for short) bind to microtubules and assist in organising the filaments, but it is not clear how they work. (elifesciences.org)
The microtubules in cells that make smaller amounts of this protein were more disorganised, and these cells were unable to fuse with each other to form muscle cells. (elifesciences.org)
The experiments also found that oMAP4 can create links between different microtubules and act as a brake to prevent the filaments being moved excessively by motor proteins. (elifesciences.org)
A flagellum (plural, flagella ) is a long, whip-like projection or appendage of a cell composed of microtubules (long, slender, protein tubes) and used in motility. (newworldencyclopedia.org)
Centrioles also exhibit this nine-way pattern of microtubules and related proteins in a regular configuration. (risingacademy.org)
In other eukaryotes, HOOK homologs form the FHF complex with FTS and FHIP to activate dynein-mediated trafficking of endosomes along microtubules. (bvsalud.org)
It walks along microtubules, with the job of transporting proteins that are essential to the health of the cell. (satnavmag.com)
u003cbr /\u003e In the present study,Ishowed that a movement of autophagosome along microtubules is required for its targeting to lysosomes, and that IL3, an autophagosome binding protein,is a key molecule in assembly of autophagosome, dynein motor, and microtubules. (soken.ac.jp)
Dynein drives the cargo to minus-end of microtubules, while kinesin drives to plus-end of microtubules. (soken.ac.jp)
Considering that autophagosomes were often directed to the perinuclear region, the minus end of microtubules, it seemed likely that dynein are involved in the autophagosome movement. (soken.ac.jp)
As microtubules start to organize, their minus ends begin to come together and move outward away from the chromosomes, forming multiple spindle poles at the periphery of the array in what is called the multipolar stage. (jhunewsletter.com)
An observation that surprised Wignall was that when chromosomes detached from microtubules, these microtubules would reorganize around the chromosomes and later segregate them, even in the absence of both KLP-18 and dynein. (jhunewsletter.com)

Dyneins can be divided into two groups: cytoplasmic dyneins and axonemal dyneins, which are also called ciliary or flagellar dyneins. (wikipedia.org)
cytoplasmic dyneins and axonemal dyneins , which are also called ciliary or flagellar dyneins. (wikipedia.org)
The movement of cytoplasmic dyneins is usually directed towards the center of the cell. (neurodegenerationresearch.eu)

The other projection, the extended tail, binds to the light intermediate, intermediate and light chain subunits which attach dynein to its cargo. (wikipedia.org)
The protein attaches (binds) to a group of proteins called the dynein complex, turning it on (activating it) and helping it bind to other cellular materials for transport. (medlineplus.gov)
A new study shows that when the gene Foxp2 is knocked out in mouse striatal neurons (top right panel), the protein dynactin (stained red) and the chain that binds dynactin and dynein (stained green) show abnormal spacing compared to wildtype neurons (top left panel). (medicalxpress.com)
found that the Kar3-Cik1 motor binds to and transports a protein complex that is crucial for separating chromosomes during cell division. (elifesciences.org)

Many viruses use the microtubule transport system to transport nucleic acid/protein cores to intracellular replication sites after invasion host the cell membrane. (wikipedia.org)
What started as an informal meeting among a handful of labs involved in intracellular trafficking has grown to include tens of labs, both young and established, all interested in understanding the cytoskeleton and motor proteins in the context of intracellular trafficking. (silverchair.com)
Dyneins are large microtubule motor proteins required for mitosis intracellular transport and ciliary and flagellar motility1 2 They generate force through a powerstroke mechanism which is an ATP-consuming cycle of pre- and post-powerstroke conformational changes that cause relative motion between different dynein domains3-5. (researchensemble.com)
Dyneins can be either axonemal, facilitating the movement of cilia and flagella, or cytoplasmic, transporting several intracellular cargos along microtubule tracks. (neurodegenerationresearch.eu)
Intracellular degradation of proteins and organelles by the autophagy-lysosome system is essential for cellular quality control and energy homeostasis. (bvsalud.org)

Using an advanced imaging technique and complex computational algorithms, researchers have created the first detailed, 3D imaging of a group of proteins called dyneins that may lead to a better understanding of the underlying causes of spinal muscular atrophy (SMA) and other neurodegenerative diseases. (smanewstoday.com)

Shulin (magnified on left) locks the triple-headed ciliary outer dynein arm motor into a closed inhibited state. (cam.ac.uk)
This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. (utsouthwestern.edu)

of native dyneins in three conformational says were also analysed to compare the post-powerstroke axonemal dyneins and conservation of structural features among evolutionarily distant species (Supplementary Fig. 2). (researchensemble.com)
Physique 2 structures of sea urchin axonemal dyneins in the post-powerstroke state as revealed by cryo-ET. (researchensemble.com)

Dynein carries organelles, vesicles and possibly microtubule fragments along the axons of neurons toward the cell body in a process called retrograde axonal transport. (wikipedia.org)
In nerve cells (neurons), the BICD2 protein helps the dynein complex transport sac-like structures called synaptic vesicles. (medlineplus.gov)
Overactivity of the BICD2 protein changes its ability to bind with the dynein complex, leading to reduced movement of proteins, synaptic vesicles, and other materials within cells. (medlineplus.gov)
For my thesis, under the direction of Dr. Dupuis Luc, I focused on a molecular motor called Dynein, which allows the transport of cellular elements (mitochondria, vesicles, proteins…) from the extremity of neurons to the center of the cell. (thefemalescientist.com)
u003cbr /\u003e Cytoplasmic dynein and kinesin are microtubule-dependent motor proteins responsible for transport of a variety of organelles and vesicles. (soken.ac.jp)

Dynein transports various cellular cargos, provides forces and displacements important in mitosis, and drives the beat of eukaryotic cilia and flagella. (wikipedia.org)
Cilia with a mutant form of the Kurly protein are wild and disorganized. (princeton.edu)
A new study of a protein found in cilia - the hair-like projections on the cell surface - may help explain how genetic defects in cilia play a role in developmental abnormalities, kidney disease and a number of other disorders. (princeton.edu)
The researchers at Princeton University and Northwestern University found that the protein, which goes by the name C21orf59 or "Kurly," is needed for cilia to undulate to keep fluid moving over the surface of cells. (princeton.edu)
They also found that the protein is needed during development to properly orient the cilia so that they are facing the right direction to move the fluid. (princeton.edu)
It's extremely exciting that we've found a single protein that is responsible for these two functions - orientation and motility - in cilia," said Rebecca Burdine , an associate professor of molecular biology at Princeton University. (princeton.edu)
Despite their importance in human disease, very little is known about how cilia motility and orientation are coordinated, so this protein will provide an important gateway into looking at this process. (princeton.edu)
Caption: Staining of cilia (hair-like projections in green and nuclei in blue) in zebrafish kidney tubules show cilia are disorganized and oriented incorrectly in fish with mutated Kurly protein (bottom panel) versus normal Kurly (top panel). (princeton.edu)
In the zebrafish kidney, the researchers found that the Kurly protein enabled cilia to orient themselves in a uniform direction, and most importantly, in the proper direction to facilitate the flow of fluid along the narrow channels in the kidney. (princeton.edu)
Researchers in Burdine's laboratory found that Kurly's role in cilia movement stems from its ability to ensure proteins called dynein arms are correctly located in the cilia. (princeton.edu)
The researchers also found that the mutation they discovered rendered the Kurly protein sensitive to temperature, and used this trait to find that the Kurly protein may be involved in initiating movement rather than keeping the cilia moving once they've started. (princeton.edu)
The airways in our lungs are kept clear of mucus by the rhythmic beating motion of slender cellular extensions called cilia. (cam.ac.uk)
This motion is known to be driven by dynein molecular motors, but it hasn't been clear how the dyneins are delivered into the cilia after assembly in the cell cytoplasm. (cam.ac.uk)
Shulin locks the three arms of ODAs together to allow unimpeded delivery of dyneins to the cilia. (cam.ac.uk)
One of these factors was found to inactivate the ODA motor and lock its three arms together, so allowing unimpeded delivery of dyneins to the cilia. (cam.ac.uk)
The identification of Shulin as a key protein that allows unimpeded delivery of dynein motors to the cilia is a step towards this. (cam.ac.uk)
Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. (utsouthwestern.edu)
Short, hair-like structures called cilia (plural: cilium) are used to transport materials or complete cells, like paramecia, along the surface of cells (such as the cilia of cells lining the Fallopian tubes, which transport the ovum into the uterus, or the cilia of cells lining the respiratory system, which capture particulate matter and transport it toward the nose). (risingacademy.org)
An ATPase called dynein transfers the energy generated during ATP hydrolysis into the mechanical labour required to beat cilia and flagella. (risingacademy.org)
Eukaryotic flagella have far more proteins than motile cilia and share some of their motion and control mechanisms. (risingacademy.org)
Selected proteins can operate normally thanks to cilia. (risingacademy.org)
A potential mechanism underlying hypothalamic neuron cilia-related obesity is impaired ciliary localization of G protein-coupled receptors involved in the regulation of appetite and energy metabolism. (inforang.com)
The list of obesity-linked ciliary proteins is expending and this supports a tight association between cilia and obesity. (inforang.com)
For cilia growth, ciliary membranes and axonemal proteins are synthesized in the cytoplasmic endoplasmic reticulum-Golgi and transported to the basal body area and then to the ciliary tip. (inforang.com)

Martinez-Carrera LA, Wirth B. Dominant spinal muscular atrophy is caused by mutations in BICD2, an important golgin protein. (medlineplus.gov)

A thesis is proposed here, based on rational argument that depletion of the cytoskeletal organizer protein shank3 may result in defective nNOS membrane localization, resulting in defective nitric oxide synthesis. (frontiersin.org)
The 2019 edition of the meeting, held from 18-20 October at the National Brain Research Centre (NBRC), Manesar, India and organised by Mahak Sharma (Indian Institute of Science Education and Research, Mohali) and Anindya Ghosh Roy (NBRC), was witness to stimulating research on a range of topics related to the cytoskeleton, including cytoskeletal organization, motor protein function and regulation, mechanical forces and vesicular transport, and trafficking in health and disease. (silverchair.com)
00:00:26.26 And these proteins are able 00:00:29.00 to walk along a cytoskeletal track 00:00:31.23 and transport a variety of different types of cargos 00:00:34.25 inside of cells. (ibiology.org)

The force-generating ATPase activity of each dynein heavy chain is located in its large doughnut-shaped "head", which is related to other AAA proteins, while two projections from the head connect it to other cytoplasmic structures. (wikipedia.org)
The dynein arms have ATPase activity. (cytochemistry.net)

Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)
While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
For example, chromosomes are bound to molecular motors (kinesin and dynein) and under their power, are moved into the two halves of a cell during cell division. (illinois.edu)
00:04:12.03 with a red fluorescent protein, 00:04:14.00 and the chromosomes 00:04:15.17 with a green fluorescent protein, 00:04:17.14 and if you look at this 00:04:19.12 in a Drosophila embryo, 00:04:21.01 you can see the chromosomes, 00:04:23.04 the formation of the mitotic spindle, 00:04:25.28 and the physical motion 00:04:27.25 of these chromosomes here. (ibiology.org)
In spermatocytes, chromosomes have kinetochore proteins that make end-on attachments to the spindle. (jhunewsletter.com)

Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. (wikipedia.org)
Each subunit has a region called a motor domain (also known as its 'head') that can bind to the microtubule and to a molecule called ATP, which provides the energy required for the motor to step forward. (elifesciences.org)
Collectively, these results led to the discovery of the first small molecule inhibitor of the mitotic kinesin Kif18A, which could be employed as a powerful tool to functionally dissect and characterize the different properties of this motor protein. (uni-konstanz.de)
A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)

Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. (wikipedia.org)
Furthermore, there are important microtubule associated proteins (MAPs) projecting from one of the microtubule subunits. (cytochemistry.net)
unlike most of the motors in this group (which work together in pairs), Kar3 motor protein subunits each bind to and work with non-motor protein subunits, including one called Cik1. (elifesciences.org)
For example, two blades of Rsa4's C-terminal propeller attach to a structural feature called the central protuberance, which helps hold the two ribosomal subunits together. (rupress.org)

It has been recently reported that motor proteins like myosin Va play important role in transcytosis of nNOS. (frontiersin.org)
Dynein light chain LC8-nNOS from acto-myosin Va is possibly exchanged with shank, which thereafter facilitates transposition of nNOS for binding with palmitoyl-PSD95 at the nerve terminal membrane. (frontiersin.org)
Evidence has suggested the role of motor proteins like myosin Va in transposition of nNOS within the nerve terminals to the membranes to facilitate nitrergic neurotransmission ( 11 , 12 ). (frontiersin.org)
pattern-dependent era of myosin moves, in collaboration with known microtubule/dynein pathways, may expand division axis diversity during advancement greatly. (researchassistantresume.com)
Kinesin also transports myosin, an actin motor protein, that helps generate force and movement, and dyneins, motor proteins that go to the negative end of the microtubule. (satnavmag.com)
It transports the huge sack of protein attached to its tail and other myosin and dyneins attached to it along the microtubule. (satnavmag.com)

It contains minute crystalline particles (otoliths) of CALCIUM CARBONATE and protein on its outer surface. (lookformedical.com)
There are many different proteins involved in the complex inner and outer membrane structures. (jonlieffmd.com)
Radial spokes connect the outer microtubular doublets with a central sheath of protein around the central tubules. (medscape.com)
The dynein arms press on the neighbouring outer doublets, causing a sliding movement to happen between adjacent outer doublets, using ATP generated by mitochondria near the base of the cilium or flagellum as fuel. (risingacademy.org)

One of these molecular motors is the dynein protein complex, a large cluster of proteins that is responsible for shuttling molecules along microtubule scaffolds within cells. (medicalxpress.com)
Using a unicellular ciliate model organism, Tetrahymena , Andrew Carter's group , in the LMB's Structural Studies Division, has discovered a novel protein, which they named Shulin, that packages these molecular motors for delivery. (cam.ac.uk)
After joining the Department of Physics at the University of Illinois in 1997, his interest has turned to molecular motors-proteins whose job is moving cargoes around the cell. (illinois.edu)

They begin from centers which contain proteins needed for their formation (tubulin, etc. (cytochemistry.net)
The main structural protein of these doublets is tubulin. (medscape.com)
One protein (flagellin), which bears no resemblance to tubulin or dynein, makes up the bacterial flagellum, a specialised component of the extracellular cell wall. (risingacademy.org)

Overexpression of dynamitin,which is known to disrupt dynein-and dynactin-dependent organelle movement, inhibited autophagosome movements. (soken.ac.jp)
In addition, endogenous LC3 colocalized with dynein-dynactin complex. (soken.ac.jp)
These results indicate that autophagosomes are linked with the dynein-dynactin comples through the interaction between LC3 and dynein intermediate chain. (soken.ac.jp)
u003cbr /\u003e From these results, I concluded that 1) autophagosome movement is dependent on icrotubule and dynein/dynactin motor complex, 2) this movement is necessary for targeting of autophagosomes to lysosomes in mammalian cells,and 3) LC3 plays an important role in assembly of the transport machinery. (soken.ac.jp)

For example, shank proteins are located further away from the membrane in the cytosolic faces of the PSDs, facing the actin cytoskeleton. (frontiersin.org)
In this review, the hypothesis is forwarded that nNOS delivered to subcortical cytoskeleton requires interactions with scaffolding proteins prior to docking at the membrane. (frontiersin.org)

Wignall found that dynein was crucial in exerting this counterbalancing inward force and limiting spindle sizes, a finding that was consistent with that in mitosis. (jhunewsletter.com)

The process of the chemical exchanges involved in creating 'happiness' is facilitated by a kinesin motor protein. (satnavmag.com)

Several studies show evidence that genetic mutations in dyneins underlie some neurodegenerative disorders such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and motor neuron diseases. (neurodegenerationresearch.eu)

Our study provides new insights into the molecular mechanisms of the endocytic pathway and the function of the vacuolar protein sorting-associated (VPS) protein family. (bvsalud.org)
VPS13 , vacuolar protein sorting-associated protein. (cdc.gov)

The motion of individual kinesins, and individual dyneins, could be measured, and surprisingly, they could move cargo around more than 10 times faster than what had been measured in vitro! (illinois.edu)
i.e. the pre-I dyneins were held in place (instead of diffusing in space) by their tails anchoring to the cargo-microtubule and other domains contacting neighbouring axonemal structures. (researchensemble.com)
It can be argued, therefore, that kinesin proteins are responsible for the fulfilment of our happiness, through delivering their serotonin cargo to nerve synapses. (satnavmag.com)
Both the kinesin protein and Sisyphus's entire existence are characterised by the repetition of the same endless task of transporting a piece of cargo - over and over again. (satnavmag.com)

Dynein functions at two different mobile places: the cell cortex as well as the cytoplasm. (researchassistantresume.com)

In the autophagic process, part of the cytosol or organelles is first enclosed by double-or multiple-membrane structures called \u0027autophagosome\u0027.Eventually, the autophagosomes fuse with lysosomes and the sequestered contents and the inner membranes are degraded by lysosomal hydrolases. (soken.ac.jp)
Therefore, researchers called lysosomes the "garbage disposals" of cells [ 1 ]. (biomedcentral.com)

The BICD2 gene provides instructions for making one of a family of proteins called golgins. (medlineplus.gov)
The BICD2 gene mutations that cause SMA-LED replace single protein building blocks (amino acids). (medlineplus.gov)
This change and the other BICD2 gene mutations increase the activity of the BICD2 protein. (medlineplus.gov)
Mutations of a gene called Foxp2 have been linked to a type of speech disorder called apraxia that makes it difficult to produce sequences of sound. (medicalxpress.com)
During a search for genes involved in this left-right patterning, the Burdine team discovered that mutations in a gene they called kur , which codes for the Kurly protein, were linked to errors in left-right orientation in zebrafish heart. (princeton.edu)
When the researchers knocked out the kur gene, the dynein proteins failed to form in the proper location. (princeton.edu)
The Northwestern team showed that when the kur gene was inactivated using a gene-editing technique called CRISPR-Cas9, the lack of a functioning Kurly protein led to the mis-positioning of a second protein on the cell surface called Prickle2, which helps cells know which direction they face. (princeton.edu)
A study published in the journal Human Mutation revealed new genetic mutations in a domain of a dynein gene. (neurodegenerationresearch.eu)

Much has been learned regarding nuclear entry, but the cellular proteins involved are still unknown and the exact role of each viral component remains controversial [ 7 ]. (biomedcentral.com)

It is known that homotypic fusion and vacuole protein sorting (HOPS) and class C core endosomal vacuole tethering (CORVET) interact with Rab-GTPases and SNARE proteins to regulate vesicle transport, fusion, and maturation in autophagy and endocytosis pathways. (bvsalud.org)

These are more able to produce reactive oxygen and stimulate the process of mitochondria suicide, called mitophagy . (jonlieffmd.com)

Those malfunctions arise because Foxp2 mutations prevent the proper assembly of motor proteins, which move molecules within cells, the researchers found. (medicalxpress.com)
But back to what I do today: As I joined a bioanalytical Contract Research Organization, I am currently working on our collaborators' research projects, where we try to help them with the development of new molecules by using a particular technique called NPOT. (thefemalescientist.com)
The basic format of the yeast-two hybrid system involves the creation of two hybrid molecules, one in which the " bait ' protein is fused with a transcription factor, and one in which the " prey " protein is fused with a related transcription factor . (genomicglossaries.com)
Dynein is a microtubule motor protein that uses the energy contained in ATP (adenosine triphosphate) molecules to move. (neurodegenerationresearch.eu)

Roughly two hundred different proteins collaborate to orchestrate ribosome assembly and maturation ( 2 ). (rupress.org)

Prokaryote flagella are composed of a protein called FLAGELLIN. (lookformedical.com)
In sea urchin flagella two dynein heavy chains α- and β-dynein form a dimeric ODA complex. (researchensemble.com)
Our classification of dyneins from active flagella revealed that this α-ODA was in the pre-I and the β-ODA in the pre-II state in more than 90% of the classified ODA dimers. (researchensemble.com)
These proteins include dynein, a molecular motor that can cause flagella to bend, and propel the cell relative to its environment or propel water or mucus relative to the cell. (newworldencyclopedia.org)
Long, hair-like projections called flagella (plural: flagellum) protrude from the plasma membrane and are used to transport whole cells. (risingacademy.org)

Note that you can see the dynein arms and the nexin links. (cytochemistry.net)

A motor protein called Kar3 belongs to a group of non-processive kinesins. (elifesciences.org)
The U.S. National Science Foundation-supported discovery, showing that a motor protein called dynein powers the movement of cancer cells in soft tissue models, offers new clinical targets against metastasis and has the potential to fundamentally change how cancer is treated. (targetednews.com)

The finding that a single protein is involved in both movement and orientation is surprising, said co-first author Daniel Grimes, a postdoctoral research associate in the Burdine lab. (princeton.edu)
In this study, we show that the yeast kinesin-14 Kar3 generates processive movement as a heterodimer with the non-motor proteins Cik1 or Vik1. (elifesciences.org)
These cells contain stacks of structures called sarcomeres that enable the cells to contract and generate the force required for movement. (elifesciences.org)

Cytoplasmic dynein helps to position the Golgi complex and other organelles in the cell. (wikipedia.org)
The BICD2 protein helps the dynein complex with protein transport, positioning of cell compartments, mobility of structures within the cell, and many other cell processes. (medlineplus.gov)
reveal that the Arp2/3 activating protein WASH works with the exocyst complex to deliver MT1-MMP from late endosomes to the invadopodial plasma membrane. (scivee.tv)
The dynein complex is made up of several other proteins. (mit.edu)
We show the FHF complex is partially conserved in T. gondii, consisting of HOOK, an FTS homolog, and two parasite-specific proteins (TGGT1_306920 and TGGT1_316650). (bvsalud.org)

Apicomplexan parasites use Ca2+-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. (bvsalud.org)

this raises questions about how the Kar3 motor protein moves along the microtubule, and whether this affects the roles the motor performs. (elifesciences.org)

Golgins help maintain the structure of a cell component called the Golgi apparatus, in which newly produced proteins are modified so they can carry out their functions. (medlineplus.gov)
As a result, the Golgi apparatus breaks down into small fragments and the altered BICD2 protein becomes trapped within these fragments. (medlineplus.gov)

Additionally, dynein motor is also responsible for the transport of degradative endosomes retrogradely in the dendrites. (wikipedia.org)

Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation. (elifesciences.org)
To fulfill this task cells rely on a specialized microtubule-based structure called the mitotic spindle (Wittmann et al. (uni-konstanz.de)
00:03:51.11 And now we can take that same object 00:03:53.24 that you saw that Shinya Inoue described, 00:03:56.06 where he had observed 00:03:58.05 the mitotic spindle 00:03:59.27 with natural contrast 00:04:01.22 from the polarization microscope, 00:04:03.16 but now we can tag 00:04:05.11 specific proteins in the cell. (ibiology.org)
By taking advantage of the auxin-inducible degron system , which enabled the depletion of tissue-specific proteins in a shorter time frame than conventional methods, Wignall could effectively pinpoint proteins necessary for stabilizing spindle structures. (jhunewsletter.com)
One protein found to be required to maintain the stability of acentrosomal spindle poles was ZYG-9. (jhunewsletter.com)

PIN (protein inhibitor of neuronal nitric oxide synthase), also called DLC8, is an 8 kDa cytoplasmic protein that is a light chain of the dynein molecular motor. (novusbio.com)

Coimmunoprecipitation and GST pull-down assay showed that LC3 directly interacts with the intermediate chain of cytoplasmic dynein, which is a subunit of dynein motor comples. (soken.ac.jp)

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain the transmembrane matrix metalloproteinase MT1-MMP. (scivee.tv)

The peripheral doublets are linked to each other by proteins . (newworldencyclopedia.org)

During protein synthesis, amino acids are linked together in discrete chains hundreds of units long. (world-mysteries.com)

An antibody is used to precipitate a protein along with bound proteins. (genomicglossaries.com)

Genetic defects affecting ODA assembly or delivery can lead to a severe lung disease called Primary Ciliary Dyskinesia or to infertility, due to the role played by dyneins in the motion of sperm tails. (cam.ac.uk)

Individual dynein particles in the background image are in their open state unbound by Shulin. (cam.ac.uk)

In the new study, led by Liu, the researchers investigated one proposed mechanism, which is that Foxp2 affects motor proteins. (medicalxpress.com)
In addition, this study uncovers a novel inhibitory mechanism by which Shulin inactivates the dynein motor. (cam.ac.uk)
Our findings provide an example for a non-conventional translocation mechanism and can explain how Kar3 substitutes for key functions of Dynein in the yeast nucleus. (elifesciences.org)

Most notably, oMAP4 is required for paraxial microtubule organisation in muscle cells and prevents dynein- and kinesin-driven microtubule-microtubule sliding. (elifesciences.org)

Due to this late arrival, researchers from Australia can participate as external collaborators in proposals submitted to this call under specific conditions. (neurodegenerationresearch.eu)
The specific conditions for researchers in Australia can be found on the " Specific regulations " page of the call. (neurodegenerationresearch.eu)

Cytoplasmic dynein, found in all animal cells and possibly plant cells as well, performs functions necessary for cell survival such as organelle transport and centrosome assembly. (wikipedia.org)
Reducing equivalents produced in the Krebs cycle and in the beta-oxidation spirals are passed along a series of protein complexes embedded in the inner mitochondrial membrane (the electron transport chain). (medlink.com)

reveal how Rho GTPase and the actin-binding protein Shroom combine to regulate the localization of Rho kinase and actomyosin contractility during axis elongation. (scivee.tv)

Collectively, these are called an "axoneme", This figure shows a microtubule (top panel) in surface view and in cross section (lower left hand panel). (cytochemistry.net)
The differences observed in the post-powerstroke conformations of different dynein isoforms may be due to spatial constraints between the complexes in the axoneme or to intrinsically different functions of the dyneins. (researchensemble.com)

The release of digestive enzymes and the subsequent steps are called the acrosomal reaction and it elicits a response from the egg membranes as well. (tutordale.com)

Anatomy38

Organisms23

Diseases4

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes45

Technology, Industry, Agriculture1

Information Science5

Microtubules35

Cytoplasmic dyneins3

Binds4

Intracellular5

Group of proteins called1

Ciliary outer2

Axonemal dyneins2

Vesicles5

Cilia24

Spinal muscula1

Cytoskeletal3

ATPase2

Chromosomes5

Molecule4

Subunits4

Myosin6

Outer4

Molecular motors3

Tubulin3

Dynactin4

Cytoskeleton2

Mitosis1

Kinesin motor1

Neurodegenerative1

Vacuolar protein sorting-as2

Cargo4

Cell cortex1

Lysosomes2

Gene8

Cellular1

Pathways1

Mitochondria1

Molecules4

Different proteins1

Flagella5

Nexin1

Motor protein called2

Movement3

Complex5

Organelles1

Moves1

Golgi2

Endosomes1

Spindle5

Nitric1

Interacts1

Structures called1

Doublets1

Synthesis1

Bound1

Primary Ciliary Dy1

Particles1

Mechanism3

Driven1

Researchers2

Transport2

Regulate1

Axoneme2

Membranes1