Proteins are functional. Medical search. Frequent questions

Among the bacterial systems available, the Gram-positive lactic bacterium, Lactococcus lactis , traditionally used in food fermentations, is nowadays widely used for large-scale production and functional characterization of bacterial and eukaryotic membrane proteins. (springer.com)
The aim of this chapter is to describe the different possibilities for the functional characterization of peripheral or intrinsic membrane proteins expressed in Lactococcus lactis . (springer.com)
First, I focused on functional characterization of the NLS1 and NLS2 domains as potential nuclear localization signals in TWIST. (uni-marburg.de)
Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein. (tropmedres.ac)
Bioinformatic and functional characterization of cyclic-di-GMP metabolic proteins in Vibrio alginolyticus unveils key diguanylate cyclases controlling multiple biofilm-associated phenotypes. (bvsalud.org)

Large macromolecules, including proteins and their complexes, very often adopt multiple conformations. (biorxiv.org)
Large macromolecules, including proteins and their complexes, are intrinsically flexible, and this flexibility is often linked with their function. (biorxiv.org)
The study of protein complexes and protein functional modules has become an important method to further understand the mechanism and organization of life activities. (biomedcentral.com)
More and more clustering algorithms are proposed to identify protein complexes with the constantly development of proteomics. (biomedcentral.com)
We find that topological structure and attribute information are very effective in identifying protein complexes by analyzing the existing mainstream PPI network methods for identifying protein functional modules [ 12 , 13 ], even though there are not much approaches take both information into consideration. (biomedcentral.com)
Calculating the similarity between gene expression patterns (co-expression degree) by using gene expression data has an important guiding function in understanding the relationship between the corresponding proteins of the gene, and can help to identify whether different proteins have same or similar functions and whether they can be composed as protein complexes or functional modules. (biomedcentral.com)
Proteins can also work together to achieve a particular function, and they often associate to form stable protein complexes. (wikipedia.org)
Currently available projects include computational investigations of functional materials in a broad sense, including organic molecules, transition metal complexes and polymeric systems, nanostructured inorganic materials, as well as surfaces and interfaces. (lu.se)

On the basis of available structural information and functional models design peptides based on the interaction domain between ERCC1 and XPF. (uu.nl)
In: Mus-Veteau I (ed) Membrane proteins production for structural analysis. (springer.com)
The functional properties such as solubility and gelling capacity and secondary structural elements of jackfruit seed protein isolate (JSPI) were studied. (banglajol.info)
Based on the observed structural and functional features, JSPI has prospects to be used as a supplementary ingredient in future food formulations. (banglajol.info)
Protein functional properties are determined to a large extent by a protein s physicochemical and structural properties ( Diniz and Martin, 1997 ). (scialert.net)
To evaluate the structural features of GSH required for interaction with the protein, we investigated the ability of a series of GSH analogs to enhance GSH stimulatable transport of [ 3 H]estrone 3-sulfate (E 1 SO 4 ). (aspetjournals.org)
Proteins also have structural or mechanical functions, such as actin and myosin in muscle and the proteins in the cytoskeleton, which form a system of scaffolding that maintains cell shape. (wikipedia.org)
Structural and functional studies of the glycerol channel aquaporin 7. (lu.se)

Using a combination of computational and experimental techniques, a research team at the University of Massachusetts Amherst led by molecular biologist Lila Gierasch has demystified the pathway of interdomain communication in a family of proteins known as Hsp70s - a top target of dozens of research laboratories trying to develop new anti- cancer drugs , antibiotics and treatments for Alzheimer's and Parkinson's diseases . (bionity.com)
As she explains, heat shock proteins in the Hsp70 family - molecular weight 70 - are "a really important class of molecular chaperones that have many important jobs in the cell, including binding to client proteins to assist their folding, or to keep them from pathologically aggregating, or to keep them unfolded so they can pass threadlike through a membrane. (bionity.com)
Identifying the molecular states relevant to protein functioning is necessary for our understanding of biological processes. (biorxiv.org)
Key molecular determinants of this process are G protein-coupled receptor kinases (GRKs) and arrestins (Chuang, 1996a). (open.ac.uk)
To gain insight into the value of the provided data, we used our new similarity measure based on the Gene Ontology to evaluate the molecular functions and biological processes of interacting proteins or domains. (mpg.de)
Despite recent findings regarding the functional implications of TRPM4 in cardiac diseases, the molecular and cellular mechanisms leading to altered conduction are poorly understood. (frontiersin.org)
Mulder went on to identify the products of protein degradation such as the amino acid leucine for which he found a (nearly correct) molecular weight of 131 Da. (wikipedia.org)
Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. (lu.se)
This program explores the molecular structures and functional mechanisms of proteins. (lu.se)

These are locations where proteins are particularly sensitive to relay certain changes in their structure and function as a result of external stimuli including other proteins, small molecules, water or ions. (sciencedaily.com)
While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. (nature.com)
These specific aspects are reviewed in this article, with separate attention being paid to small organic molecules and protein therapeutics. (snmjournals.org)
Although microdosing has been associated predominantly with small organic molecules and site-specific labeling, there is growing interest in applying the concept to protein therapeutics and in using some of the exclusive properties of proteins for nuclear imaging purposes. (snmjournals.org)
This article discusses the consequences of the facilitated regulations, the impact of performing studies at very low pharmacologic concentrations, and the differences in regulation and pharmacology between smaller (organic) molecules and larger (protein biologic) molecules. (snmjournals.org)
Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. (wikipedia.org)
Proteins were recognized as a distinct class of biological molecules in the eighteenth century by Antoine Fourcroy and others, distinguished by the molecules' ability to coagulate or flocculate under treatments with heat or acid. (wikipedia.org)
Some genes act as instructions to make molecules called proteins. (medlineplus.gov)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
Computational modelling of functional molecules and materials. (lu.se)

In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)
An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)

Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal consortium. (nature.com)
Our analysis of this data reveals an absolute protein-to-RNA ratio of 10 2 -10 4 for bacterial populations and 10 3 -10 5 for an archaeon, which is more comparable to Eukaryotic representatives' humans and yeast. (nature.com)
Indeed, the protein-to-RNA ratio per sample of the bacterial populations matched previous calculations for the existing example from axenically cultured E. coli 2 . (nature.com)
This protein domain, often found in bacterial species, is actually of viral origin. (wikipedia.org)

Each protein is built using sequences of 20 different amino acids. (sciencedaily.com)
In search for global principles that may explain the organization of the space of all possible proteins, we study all known protein sequences and structures. (aaai.org)
Our protein space contains all protein sequences in a non-redundant (NR) database, which includes all major sequence databases. (aaai.org)
Our analysis has been the amino acid sequences in proteins differ from what is carried out using two different methods, which differ substantially expected from random sequences in a statistically significant from what is used in ref. 3, although the starting point is similar. (lu.se)
For sequences with a typical fraction of hydrophobic residues, we impact on how permissive with respect to sequence specificity find that the nonrandomness can be interpreted as anticorrela- the protein folding process is-- only sequences with nonran- tions. (lu.se)
permissive with respect to sequence specificity the protein folding process is, we have carried out the same analysis for a Section 1: Introduction toy model (7, 8), for which unbiased samples of folding and Hydrophobicity is widely believed to play a central role in the nonfolding sequences can be obtained. (lu.se)

Like other biological macromolecules such as polysaccharides and nucleic acids, proteins are essential parts of organisms and participate in virtually every process within cells. (wikipedia.org)

Short polypeptides, containing less than 20-30 residues, are rarely considered to be proteins and are commonly called peptides. (wikipedia.org)

Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. (wikipedia.org)
However, many genes do not code for proteins . (medlineplus.gov)

Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. (scienceopen.com)
In this context, the exploration of temporal interplay between populations with different lifestyles (comprising metabolism, motility, sporulation, etc.) becomes of primary importance to interpret the changes in fundamental quantities in a microbial community, such as the protein-to-RNA ratio that ultimately impacts the overarching community phenotype(s). (nature.com)
Many proteins are enzymes that catalyse biochemical reactions and are vital to metabolism. (wikipedia.org)
Here, a large set of 63 proteins were predicted to participate in c-di-GMP metabolism ( biosynthesis or degradation) in a pathogenic V. alginolyticus strain HN08155. (bvsalud.org)
The serum protein level reflects the balance between protein synthesis, metabolism, and protein loss. (medscape.com)

Proteins' structures are heterogeneous, so energy will flow through them in regions where the atoms are more densely packed together. (sciencedaily.com)
Here, we report the crystal structures of the effector domains from two oomycete RXLR proteins, Phytophthora capsici AVR3a11 and Phytophthora infestans PexRD2. (jic.ac.uk)
This model, hereafter formation of three-dimensional protein structures. (lu.se)
The quest for tastier, more sustainable vegan cheese has led Swedish food company Cassius AB to take a closer look at cheese protein structures. (lu.se)

Recently we have implemented an in vitro assay that functionally resembles the DNA repair reaction and assays to study protein-protein and protein-DNA interactions. (uu.nl)
Protein S assays can be either functional or immunological. (medscape.com)
Techniques for measuring protein S antigen include enzyme-linked immunosorbent assays (ELISAs) and radioimmunoassays. (medscape.com)
Functional assays measure only free (physiologically active) protein S. Functional assays are usually based on either the prothrombin time (PT) or the activated partial thromboplastin time (aPTT). (medscape.com)
With aPTT-based functional protein S assays, platelet-poor plasma is incubated at 37°C with the following: protein S-deficient plasma, phospholipid, a contact activator (eg, Kaolin), and either an excess of activated protein C or an activator of protein C .Typically, the incubation period is 1-4 minutes, after which calcium is added to initiate clotting. (medscape.com)
For PT-based functional protein S assays, the activated protein C cofactor activity of protein S is measured based on the degree of prolongation of a PT-based clotting time. (medscape.com)
Immunological assays measure total protein S, both free protein S and bound protein S. In rare circumstances, the level of immunological protein S is normal but some functional abnormality exists (ie, a true type 2 deficiency). (medscape.com)

Wang and Dokholyan hypothesized that the physical forces from interactions between the atoms that make up the amino acids would allow them to predict allosteric pathways and sites in proteins. (sciencedaily.com)
Ohm was designed to account for the interactions between atoms and identifies areas of density in proteins to predict allosteric pathways and sites in proteins. (sciencedaily.com)
Moreover, targeting protein functional motions bears a great potential to control and modulate proteins' activities and interactions in physio-pathological contexts. (biorxiv.org)
These techniques provide valuable insights on proteins' functioning and interactions with their environment. (biorxiv.org)
Using our similarity measure, we compare predicted domain-domain and human protein-protein interactions with experimentally derived interactions. (mpg.de)
Deciphering protein–protein interactions. (crossref.org)

In this study, the sp2 gene was cloned and expressed in Escherichia coli to produce a 6xHis-tagged fusion protein, which was then used to generate a polyclonal antibody. (hindawi.com)
The present study was thus undertaken to determine how TWIST1 gene mutations affect protein function. (uni-marburg.de)
TWIST belongs to class B bHLH proteins which are known to form stable heterodimers with members of class A bHLH transcription factors including gene products of E12 and E47, respectively. (uni-marburg.de)
Developing a protein function module recognition method ECTG based on Topological Features and Gene expression data for Protein Complex Identification. (biomedcentral.com)
ECTG(Evolutionary Clustering Algorithm Based on Topological Features and Gene expression data for Protein Complex Identification). (biomedcentral.com)
This method is based on evolutionary algorithm (EA), which effectively fuses protein topology and gene expression data. (biomedcentral.com)
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. (nih.gov)
Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation. (nih.gov)
Derived by automated computational analysis using gene prediction method: Protein Homology. (string-db.org)
The sequence of amino acid residues in a protein is defined by the sequence of a gene, which is encoded in the genetic code. (wikipedia.org)
Guided by protein homology, conserved domains and gene context information, a representative subset of 22 c-di-GMP metabolic proteins were selected to determine which ones affect biofilm -associated phenotypes . (bvsalud.org)
A gene is the basic physical and functional unit of heredity. (medlineplus.gov)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

Immunoprecipitation of recombinant LC in FCV infected cells identified the cellular protein annexin A2 as a binding partner, providing a potential mechanism for the cell-rounding phenotype observed in transient expression experiments. (umd.edu)
We showed that in a heterologous expression system recombinant hPAFR stimulated inositol phosphates production and intracellular cAMP accumulation, through the coupling with Gq/ 11 and Gs proteins, respectively. (open.ac.uk)
A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)

Soy protein isolate was used to prepare the hydrogel using a cold-gelation process to encapsulate a bioactive ingredient. (nutraingredients.com)
This study was undertaken to isolate the protein from jackfruit seeds and characterizing the physicochemical and functional properties of the isolated protein. (banglajol.info)
Total protein content in the isolate was determined by the Kjeldahl method. (banglajol.info)
Emulsions prepared with ultrasound treated milk protein isolate, pea protein isolate and bovine gelatin yielded smaller, stable emulsion droplets in comparison to their untreated counterparts. (bham.ac.uk)
Almond protein isolate (API) solutions were less viscous than those of soy protein isolate (SPI). (nuthealth.org)

We conclude that the core α-helical fold enables functional adaptation of these fast evolving effectors through (i) insertion/deletions in loop regions between α-helices, (ii) extensions to the N and C termini, (iii) amino acid replacements in surface residues, (iv) tandem domain duplications, and (v) oligomerization. (jic.ac.uk)
In particular, TWIST NLS1 altered at amino acid position K38R was found to be retained in the cytoplasm of transiently transfected U2-OS cells, suggesting that NLS1 is functional and essential for the nuclear transport of TWIST. (uni-marburg.de)
The company (which has partnered with PURIS to develop additional production capacity for pea protein ), has been researching corn protein for a while, in part because it has an appealing amino acid profile and is not a major allergen, said Matthew Jacobs, global product line director for plant proteins at Cargill. (foodnavigator-usa.com)
"We've developed corn protein that can deliver 70-90% protein with a high branch chain amino acid content, particularly leucine, does not require allergen labeling, and is sourced from a sustainable, consistent supply ," he told FoodNavigator-USA at the Natural Products Expo West show last week. (foodnavigator-usa.com)
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. (wikipedia.org)
PROT data base (6) of functional proteins, this method yields model containing only two amino acid types, hydrophobic and clear evidence for nonrandomness. (lu.se)

He said that many drugs on the market, such as G Protein-Coupled Receptor (GPCR) drugs, may cause unintended side effects because they target proteins that are similar in structure to their intended target. (sciencedaily.com)
Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)

Due to their unique properties, expression and study of membrane proteins in heterologous systems remains difficult. (springer.com)
Kunji ERS, Slotboom DJ, Poolman B (2003) Lactococcus lactis as host for overproduction of functional membrane proteins. (springer.com)
Monné M, Chan KW, Slotboom DJ, Kunji ERS (2005) Functional expression of eukaryotic membrane proteins in Lactococcus lactis. (springer.com)
Protein crowding induces membrane curvatures through an entropic mechanism. (portlandpress.com)
Crowding of asymmetric proteins results in an asymmetric lateral pressure across the membrane which can be used by cells in a number of biological processes involving membrane remodeling. (portlandpress.com)
Our unique membrane filtration process makes this premium option possible, meaning that now, organic protein tastes and functions better than ever before. (newsfilecorp.com)

Signaling at and between allosteric sites in proteins regulate many biological processes. (sciencedaily.com)
I wanted to determine if the TWIST protein or its conserved motifs interact with other regulatory proteins to help to regulate the TWIST transcriptional activity. (uni-marburg.de)
By comparing phenotypic differences between the wild-type and mutants or overexpression strains , we found that 22 c-di-GMP metabolic proteins can separately regulate different phenotypic outputs in V. alginolyticus. (bvsalud.org)

The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
VCP primarily identifies ubiquitylated proteins in these pathways and mediates their unfolding and degradation by the 26S proteasome. (portlandpress.com)
VCP interacts with adaptor proteins to identify ubiquitylated substrates for degradation by the proteasome. (portlandpress.com)
Recent evidence indicates that altered degradation rate of mutant proteins represents a pathogenic mechanism underlying genetic diseases. (frontiersin.org)
Albumin loss through the gastrointestinal tract normally accounts for 2-15% of the total body degradation of albumin, but, in patients with severe protein-losing gastrointestinal disorders, the enteric protein loss may reach up to 60% of the total albumin pool. (medscape.com)

FoXO1 activity is regulated in response to different physiological or pathogenic conditions by changes in protein expression and post-translational modifications. (scienceopen.com)

To better understand the functional characteristics and fine specificity of protective human Abs to DBPII, we sorted single DBPII-specific IgG+ memory B cells from three individuals with high blocking activity to DBPII. (tropmedres.ac)

Methods commonly used to study protein structure and function include immunohistochemistry, site-directed mutagenesis, X-ray crystallography, nuclear magnetic resonance and mass spectrometry. (wikipedia.org)

Fewer calories and ease of digestion are seen as the top benefits of plant protein. (foodnavigator-usa.com)
Digestion breaks the proteins down for metabolic use. (wikipedia.org)

The results indicated that overexpression of four c-di-GMP metabolic proteins , including VA0356, VA1591 (CdgM), VA4033 (DgcB) and VA0088, strongly enhanced rugose colony morphotypes and strengthened Congo Red (CR) binding capacity, both of which are indicators of biofilm matrix overproduction. (bvsalud.org)
Overall, the high abundance of c-di-GMP metabolic proteins in V. alginolyticus suggests that c-di-GMP signaling and regulatory system could play a key role in its response and adaptation to the ever-changing marine environment . (bvsalud.org)

Many cellular proteins are reversibly modified by O-linked N-acetylglucosamine (O-GlcNAc) moieties on Ser and Thr residues. (scienceopen.com)
For example, when Escherichia coli is grown axenically in steady state, we can expect that each RNA molecule corresponds to 10 2 -10 4 of the matching protein (absolute protein-to-RNA ratio, hereafter referred protein-to-RNA ratio) and the variation in the level of cellular RNA explains ~29% of the variation in the amount of detectable protein 2 . (nature.com)

She describes the three parts of a folded Hsp70 protein as a nucleotide-binding domain and substrate-binding domain linked by a "mysterious" interdomain linker, which becomes part of the structure when a small molecule, adenosine triphosphate (ATP), binds to the Hsp70. (bionity.com)
In the interaction with proteins, lead binds with virtually every available functional group, including sulfhydryl, amine, phosphate, and carboxyl groups, with sulfhydryl having the highest affinity. (cdc.gov)

Ohm may be useful for biomedical researchers seeking to identify allosteric sites in proteins that play key roles in biological processes of certain diseases. (sciencedaily.com)

By restraining mammalian forkhead proteins, SIRT1 also reduces forkhead-dependent apoptosis. (scienceopen.com)

In an emerging field like alternative proteins, research funding has an outsized catalytic effect, serving to generate preliminary data that stimulates follow-on investment from conventional funding mechanisms. (gfi.org)
Mechanisms for gastrointestinal protein loss include lymphatic obstruction, mucosal disease with erosions, ulcerations, or increased mucosal permeability to proteins as a result of cell damage or death. (medscape.com)
These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)

Storage protein 2 (SP2) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis. (hindawi.com)
A recent study showed that another protein in silkworm hemolymph, storage protein 2 (SP2), can also inhibit staurosporine-induced HeLa cell apoptosis and ROS generation [ 8 ]. (hindawi.com)

All the estimated nutritional parameters based on amino acids composition suggested that Nile tilapia protein hydrolysates and concentrates have good nutritional quality and could be used as protein ingredient in food industries. (scialert.net)

Identification and functional. (uni-marburg.de)
Karl Heinrich Ritthausen extended known protein forms with the identification of glutamic acid. (wikipedia.org)

According to Dokholyan, Ohm's ability to predict allosteric sites in proteins may be useful for developing targeted therapeutics for certain disease states. (sciencedaily.com)

Large amounts of protein and domain interaction data are being produced by experimental high-throughput techniques and computational approaches. (mpg.de)

Evolutionary alignment of Twist proteins from different species, indicate TWIST contain 4 additional conserved regions such as NSEEE, NLS1, NLS2, and WR-domain besides the bHLH motif. (uni-marburg.de)

Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target? (scienceopen.com)

Protein S, a vitamin K-dependent plasma glycoprotein, is synthesized in the endothelium. (medscape.com)

Dokholyan, a member of the Penn State Cancer Institute, said that Ohm can analyze allosteric paths in any protein and that researchers can access the tool through a server on his lab's website. (sciencedaily.com)
The clustering algorithms used to analyze the information contained in protein-protein interaction network are effective ways to explore the characteristics of protein functional modules. (biomedcentral.com)

Shortly after or even during synthesis, the residues in a protein are often chemically modified by post-translational modification, which alters the physical and chemical properties, folding, stability, activity, and ultimately, the function of the proteins. (wikipedia.org)

Ohm identifies regions and pathways of atomic density that allow it to predict allosteric sites in proteins. (sciencedaily.com)
Researchers around the world can use Ohm to predict allosteric sites and pathways in their protein of interest," Wang said. (sciencedaily.com)
Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. (portlandpress.com)

Research suggests that ageing may reduce the body's ability to absorb or process proteins, which could mean that protein requirements increase with age. (ausfoodnews.com.au)
When the rate of gastrointestinal protein loss exceeds the body's capacity to synthesize new proteins, hypoproteinemia develops. (medscape.com)

A feature unique to vesiviruses is the presence of a ~14-18 kDa protein of unknown function designated as leader of the capsid (LC) that is expressed as part of a capsid precursor encoded in open reading frame 2 (ORF2). (umd.edu)
The ORF2 precursor contains the LC fused to the major capsid protein, VP1, which is proteolytically cleaved by the viral protease to release the LC and the mature VP1. (umd.edu)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

Nevertheless, experimental protein structure determination remains a time consuming and costly process. (biorxiv.org)
The experimental results show that the ECTG algorithm can detect protein functional modules better. (biomedcentral.com)

Cargill will have commercial quantities of Non GMO corn protein available by 2022 as it seeks to capitalize on growing demand for plant-based proteins. (foodnavigator-usa.com)
Vancouver, British Columbia--(Newsfile Corp. - December 8, 2022) - Burcon NutraScience Corporation (TSX: BU) ("Burcon" or the "Company"), a global technology leader in the development of plant-based proteins for foods and beverages, is pleased to announce that its joint venture company, Merit Functional Foods Corporation ("Merit") has launched its first USDA Certified Organic protein ingredient, Organic Peazazz C™ 850. (newsfilecorp.com)

Participants were divided into quartiles according to intake levels of total, animal and plant protein. (ausfoodnews.com.au)
No consistent association was observed between plant protein intake and future higher-level functional decline in in either sex. (ausfoodnews.com.au)
While some new sources of plant protein present challenges in that firms need to find viable markets for the other parts of the seed or grain, there is already a massive infrastructure in place to process corn oil, starches and sweeteners, so that is not an issue for corn protein, he said. (foodnavigator-usa.com)
The key players like Nestle, Merit, and Burcon have entered into a joint development agreement for the development of plant protein ingredients and their application in the plant-based food &beverages. (alliedmarketresearch.com)

They tested the functionality of the program by inputting the genetic data from 20 proteins with known allosteric sites to see if the program would accurately predict the same spots. (sciencedaily.com)
The second aim of my work was to identify the interacting proteins that could influence the functionality of TWIST using yeast-two-hybrid assay. (uni-marburg.de)
With over two decades of experience formulating high-purity proteins that have superior functionality, taste and nutrition, Burcon has amassed an extensive patent portfolio covering its novel plant-based proteins derived from pea, canola, soy, hemp and sunflower seeds, among other plant sources. (newsfilecorp.com)

A diet high in protein, particularly animal protein, may help elderly male individuals function at higher levels physically, psychologically and socially, according to a study published on 12 March 2014 in the Journal of the American Geriatrics Society. (ausfoodnews.com.au)
Men in the highest quartile of animal protein intake had a 39 per cent decreased odds of experiencing higher-level functional decline than those in the lowest quartile. (ausfoodnews.com.au)
More than half of world s population depends on fish as a principal source of animal protein ( Jhingram, 1987 ). (scialert.net)
Many species of tilapia have been cultured in developing countries, where animal protein is lacking. (scialert.net)
These key drivers have shifted the consumer purchasing habit from animal protein to alternative sources of protein. (alliedmarketresearch.com)

To under- denoted the AB model, consists of chains of two kinds of stand the statistical distribution of hydrophobicity along proteins ``amino acids'' interacting with Lennard-Jones potentials. (lu.se)
Evaluation of different methods to calculated reduction potentials for heme proteins. (lu.se)

Abnormal or misfolded proteins are degraded more rapidly either due to being targeted for destruction or due to being unstable. (wikipedia.org)

These studies elucidate the structure-function relationship of these DNA repair proteins. (uu.nl)
Understanding the function of the \(\char{cmti10}{0x57}\)\(\char{cmti10}{0x46}\)\(\char{cmti10}{0x53}\)\(\char{cmti10}{0x31}\) protein-product wolframin, would enable developments in targeted therapy for WS patients and important insights to its possible contribution to type-2 diabetes pathogenesis. (bham.ac.uk)
Our data suggests that some \(\char{cmti10}{0x57}\)\(\char{cmti10}{0x46}\)\(\char{cmti10}{0x53}\)\(\char{cmti10}{0x31}\)-mutations may allow residual protein function and these findings lay the groundwork for future functional investigation of mutated wolframin to explore this hypothesis further. (bham.ac.uk)
This organization extends our ability to predict the structure and function of many proteins beyond what is possible with existing tools for sequence analysis. (aaai.org)
The function of this protein domain is to digest DNA. (wikipedia.org)
The protein C and free protein S functional and activity tests measure the amount of each protein and evaluate whether they are performing their proper function in the body. (medscape.com)

Moreover, this study also substantiates that abdominal massage can mitigate functional diarrhea by altering the intestinal microbiota structure and decreasing the number of bacteria that damage intestinal mucosal barriers. (figshare.com)
Furthermore, massaging from two different directions, clockwise (CW) and counter-clockwise (CCW) massage, would not significantly influence the effect of the massage on intestinal microbiota or tight junction proteins. (figshare.com)
Proteins entering the gastrointestinal tract are metabolized into constituent amino acids by gastric, pancreatic, and small intestinal enzymes and are reabsorbed. (medscape.com)

VCP identifies ubiquitylated substrates through numerous dedicated adaptor proteins and unfolds substrates by threading them through a central pore in the hexamer ( Figure 1 ). (portlandpress.com)
GFI identifies the most pressing technological bottlenecks and prioritizes the most promising solutions to accelerating alternative proteins. (gfi.org)

G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)

Rigorous industry analyses such as life cycle assessments and technoeconomic analyses also provide critical insights for identifying the most impactful levers for improving the taste, texture, price, and sustainability of alternative protein products. (gfi.org)

This protein kinase is calcium-independent and phospholipid-dependent. (nih.gov)

Proteins carry out essential functions in the body and are built using genetic code inscribed in a person's DNA. (sciencedaily.com)
Significance Statement Proteins perform their biological functions by changing their shapes and interacting with each other. (biorxiv.org)
The protein forms an oligomer and functions as an alkaline exonuclease, or in simpler terms, an enzyme that digests double-stranded DNA. (wikipedia.org)

The results show that our similarity measure is of significant benefit in quality assessment and confidence ranking of domain and protein networks. (mpg.de)

With increasing health awareness, the demand for concentrated proteins from plant sources has been rising for direct consumption or to use as an ingredient in food formulation. (banglajol.info)
Impossible Foods - which initially used wheat protein as its core ingredient - has recently reformulated its plant-based Impossible Burger to use soy protein instead. (foodnavigator-usa.com)

The aim of my work is to characterize functional domains in TWIST protein, and to determine the interacting partner for TWIST and its motifs particularly NSEEE and WR. (uni-marburg.de)
Furthermore, two more highly conserved TWIST motifs NSEEE and WR were analyzed individually to find out their interacting proteins and their role in regulating the TWIST1 transcriptional activity. (uni-marburg.de)
Conserved P(T/S)AP and PPPY motifs in the Z protein are in boldface . (cdc.gov)

The transient receptor potential melastatin 4 (TRPM4) protein is an intracellular Ca 2+ -activated non-selective cation channel, which is impermeable to Ca 2+ . (frontiersin.org)
Engagement of the highly polymorphic domain II of the P. vivax Duffy-binding protein (DBPII) with the erythrocyte's Duffy Ag receptor for chemokines (DARC) is essential. (tropmedres.ac)

Hydrogels made from soy protein could protect functional food ingredients through the gut, tapping the ever-growing health and wellness segment. (nutraingredients.com)
Lead researcher Muriel Subirade, PhD, holder of Canadian research chair in proteins, biosystems and functional foods at Laval University, told FoodNavigator that they are in discussions with industrial partners to develop soy protein hydrogels. (nutraingredients.com)
Utilizing protein fragment reconstitution, we demonstrate the reversible and repeatable functionalization of protein hydrogels. (ubc.ca)

The crude JSPI contained 76.89% protein with 58.44% solubility in aquatic solvent. (banglajol.info)
Researchers have reported that protein solubility has a close relationship with emulsifying properties ( Quaglia and Orban, 1990 ) and foaming properties ( Quaglia and Orban, 1987 , 1990 ). (scialert.net)

Anatomy26

Organisms18

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes89

Disciplines and Occupations4

Information Science5

Health Care1

Characterization5

Complexes8

Structural8

Molecular9

Molecules10

Putative3

Bacterial4

Sequences6

Nucleic acids1

Peptides1

Genes2

Metabolism5

Structures4

Assays7

Interactions6

Gene13

Recombinant3

Isolate5

Amino Acid6

Target proteins2

Membrane6

Regulate3

Degradation5

Pathogenic1

Specificity1

Crystallography1

Digestion2

Metabolic2

Cellular2

Binds2

Biological processes1

Mammalian1

Mechanisms3

Apoptosis2

Concentrates1

Identification2

Therapeutics1

Computational1

Evolutionary1

Diversity1

Glycoprotein1

Analyze2

Residues1

Pathways3

Body's2

Precursor3

Experimental2

20222

Plant protein4

Functionality3

Animal protein5

Potentials2

Abnormal1

Function6

Intestinal3

Identifies2

Receptors1

Analyses1

Kinase1

Functions3

Similarity1

Ingredient2

Motifs3

Receptor2

Hydrogels3

Solubility2