Loading...
  • encode
  • Further, numerous studies from several different herpesvirus systems have provided unifying evidence that these viruses encode factors that elicit a cell cycle block, thereby actively preventing entry into S phase. (asm.org)
  • A biological and biochemical analysis, carried out on a series of in-frame insertion and deletion mutations within the gag-myc gene of MC29, revealed several mutations within the 5' portion of the v-myc gene that encode proteins either completely defective for transformation or compromised in their ability to transform chicken embryo fibroblasts but not macrophages. (asm.org)
  • hypothesis
  • Dr. Pankaj Serh's laboratory at National Brain Research Centre, New Delhi, India took cue from the hypothesis and investigated into the cytotoxic properties of Tat proteins of viral clades on primary human neurons. (yu.edu)
  • The results reported herein support the hypothesis that Myc proteins function as regulators of transcription in a variety of cell types and clearly point out the necessity of putative regulatory domains within the amino-terminal half of the Myc protein. (asm.org)
  • The defective ribosomal product (DRiP) hypothesis of endogenous Ag processing posits that rapidly degraded forms of nascent proteins are a major source of peptide ligands for MHC class I molecules. (jimmunol.org)
  • These observations extend the relevance of the DRiP hypothesis to viral proteins generated in their natural context. (jimmunol.org)
  • This rapidity of presentation, coupled with the relatively long half-life ( t 1/2 ) of most viral proteins, engendered the defective ribosomal product (DRiP) hypothesis of Ag presentation: a subset of newly synthesized proteins are defective in some manner and rapidly degraded intracellularly, yielding peptides for MHC class I Ag presentation to enable rapid immunosurveillance of viral and cellular translation products ( 2 ). (jimmunol.org)
  • The DRiP hypothesis is strongly supported, however, by functional studies that temporally link protein synthesis with peptide generation. (jimmunol.org)
  • Expression
  • The presence of virus was compared with inflammatory markers such as infiltrating T cells, HLA-DR expression, and transglutaminase 2-targeted IgA deposits. (diabetesjournals.org)
  • More specifically, the study demonstrated an accumulation of E2F factors complexed with the retinoblastoma tumor suppressor protein, pRb, which inhibits E2F-mediated activation of S-phase-specific gene expression. (asm.org)
  • Dr. Sunit Singh at Centre for Cellular and Molecular Biology, Hyderabad, India is investigating on how Tat proteins derived from different viral clades could influence miRNA expression pattern of Brain microvascular endothelial cells. (yu.edu)
  • Further, expression of the transformation defective variant dl91-137 in chicken fibroblasts inhibited subsequent transformation by wild-type MC29. (asm.org)
  • KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca 2+ ] i and attenuating the expression of phosphorylated cAMP-response element-binding protein (CREB), c-Fos, and neuron-derived orphan receptor-1 (NOR-1). (pubmedcentralcanada.ca)
  • Mutant
  • Cells infected by this mutant accumulated higher levels of viral covalently closed, circular DNA (cccDNA) than those infected by wild-type virus. (asm.org)
  • Infectious
  • First, we briefly review the current evidence for the immunological approach to the prevention of infectious complications associated with defective antibody responses in CLL and MM. We then survey the current challenges derived from the improvements in diagnosis and therapy of hematological malignancies and discuss some practical issues. (frontiersin.org)
  • pathogenic
  • In this particular case, the KAN-1-induced defective RNA-encoded protein PB2∆ enhances the overwhelming immune response characteristic for highly pathogenic H5N1 viruses, leading to a more severe phenotype in vivo. (sigmaaldrich.com)
  • mRNA
  • The full-length cDNA corresponding to the mRNA of the fusion (F) protein of the Yamagata-1 strain of subacute sclerosing panencephalitis (SSPE) virus was cloned, and its complete nucleotide sequence was determined. (semanticscholar.org)
  • This plant defense system results in degradation of mRNA produced both by the transgene and the virus. (apsnet.org)
  • tissue culture
  • Virus-free stocks are obtained by virus elimination through heat therapy and/or meristem tissue culture, but this approach is ineffective for viral diseases transmitted by vectors. (apsnet.org)
  • induces
  • Avian myelocytomatosis virus MC29 induces a wide variety of neoplastic diseases in infected birds and transforms cells of the macrophage lineage as well as fibroblasts and epithelial cells. (asm.org)
  • Genetic
  • Genetic engineering brings new hope for the effective control of plant virus diseases. (apsnet.org)
  • The concept of pathogen derived resistance (Sanford and Johnston, 1985) has stimulated research on obtaining virus resistance through genetic engineering. (apsnet.org)
  • Compared to conventional breeding for virus resistance, genetic engineering provides a quicker and more precise technology to obtain plants that are resistant to viruses, although most transgenic virus-resistant plants are still under laboratory development. (apsnet.org)
  • In contrast to these viruses, herpesviruses contain a much greater genetic complexity that encodes a viral DNA polymerase, as well as accessory factors involved in generating nucleotide pools, etc. (asm.org)
  • A virus consists of genetic material, which may be either DNA or RNA, and is surrounded by a protein coat and, in some viruses, by a membranous envelope. (thefreedictionary.com)
  • Because host cells do not have the ability to replicate "viral RNA" but are able to transcribe messenger RNA, RNA viruses must contain enzymes to produce genetic material for new virions. (thefreedictionary.com)
  • Baumert TF, Barth H, Blum HE (2005) Genetic variants of hepatitis B virus and their clinical relevance. (springer.com)
  • latent
  • Some viruses do not produce rapid lysis of host cells, but rather remain latent for long periods in the host before the appearance of clinical symptoms. (thefreedictionary.com)
  • sequences
  • Mutations within the 3' end of the v-myc gene which disrupt sequences encoding the basic/helix-loop-helix region were defective for transformation of both fibroblasts and macrophages. (asm.org)
  • interactions
  • As discussed here, regulation of the cell cycle during herpesvirus DNA replication has evolved as a complex series of interactions involving multiple viral factors, further implying an important role for this function in the life cycle of the virus. (asm.org)
  • The purpose of this review is to bridge the current understanding of virus-cell cycle interactions for these three herpesvirus lytic replication systems. (asm.org)
  • We focus on the NS1-RNA and NS1-protein interactions that are fundamental to these processes, and highlight apparent strain-specific ways in which different NS1 proteins may act. (microbiologyresearch.org)
  • novel
  • Novel Gammaherpesvirus Functions Encoded by Bovine herpesvirus 6 (Bovine Lymphotropic virus). (unl.edu)
  • A novel inhibitor of the NF-κB signaling pathway encoded by the parapoxvirus orf virus. (unl.edu)
  • Finally, we outline practical applications that future studies on NS1 may lead to, including the rational design and manufacture of influenza vaccines, the development of novel antiviral drugs, and the use of oncolytic influenza A viruses as potential anti-cancer agents. (microbiologyresearch.org)
  • BZLF1
  • We now use deletional, site-directed, and chimeric mutagenesis, together with gene transfer, to show that a 43-kilodalton protein, encoded in the BZLF1 open reading frame of het DNA, is responsible for this process. (uni-regensburg.de)