Signal TransductionCells, CulturedMyeloid Differentiation Factor 88Cell LineMice, KnockoutApoptosisPhosphorylationMice, Inbred C57BLTumor Suppressor Protein p53Enzyme ActivationCalciumDNA-Binding ProteinsEnzyme InhibitorsMolecular Sequence DataRNA, MessengerGene Expression RegulationTransfectionBlotting, WesternToll-Like Receptor 4Cell Line, TumorMutationMitogen-Activated Protein KinasesNF-kappa BProtein-Serine-Threonine KinasesProtein BindingTranscription FactorsTime FactorsUp-RegulationCarrier ProteinsRNA, Small InterferingToll-Like Receptor 2Dose-Response Relationship, DrugMitogen-Activated Protein Kinase 3Models, BiologicalMAP Kinase Signaling SystemReverse Transcriptase Polymerase Chain ReactionAmino Acid SequenceBase SequenceKineticsCell SurvivalMacrophagesTranscription, GeneticMitogen-Activated Protein Kinase 1CaspasesNuclear ProteinsPromoter Regions, GeneticCaspase 3Fibroblastsp38 Mitogen-Activated Protein KinasesAdaptor Proteins, Signal TransducingLipopolysaccharidesRecombinant ProteinsCell Cycle ProteinsTumor Necrosis Factor-alphaMembrane ProteinsTumor Cells, CulturedProtein Kinase CToll-Like ReceptorsProtein TransportCell ProliferationMembrane GlycoproteinsCell NucleusTrans-ActivatorsHeLa CellsPhosphatidylinositol 3-KinasesRNA InterferenceRats, Sprague-DawleyProto-Oncogene ProteinsDown-RegulationCell CycleCell DivisionMice, Inbred BALB CTranscriptional ActivationIntracellular Signaling Peptides and ProteinsCyclin-Dependent Kinase Inhibitor p21Caspase 8Gene ExpressionCell DifferentiationInterleukin-6Recombinant Fusion ProteinsProtein-Tyrosine KinasesCaspase 9Immunity, InnateProto-Oncogene Proteins c-aktFlow CytometryExtracellular Signal-Regulated MAP KinasesCell MovementDNA DamageCytokinesBiological TransportMice, TransgenicAdaptor Proteins, Vesicular TransportBinding SitesActive Transport, Cell Nucleusbcl-2-Associated X ProteinIsoenzymesGenes, ReporterTranscription Factor AP-1Saccharomyces cerevisiae ProteinsProteins