Proteins allow scientists. Medical search. Frequent questions

The researchers sought to develop a strategy to reduce the buildup of these proteins and increase treatment options for these patients. (scripps.edu)
Using a chemical biologic approach, the researchers showed that activation of the UPR-associated protein ATF6 increases expression of many ER proteins involved in regulating protein folding and trafficking and reduces secretion of disease-associated light chains without causing toxic consequences. (scripps.edu)
Researchers have created engineered proteins that lowered body weight, bloodstream insulin, and cholesterol levels in obese mice, rats, and primates. (latimes.com)
In mice who got a bioengineered version of the GDF15 protein, the researchers observed even more remarkable changes. (latimes.com)
The Amgen researchers accomplished this by fusing the protein with other agents that would not break down so quickly. (latimes.com)
Researchers investigate proteins to uncover new biological pathways and hunt for disease cures. (the-scientist.com)
In a second paper published in the Nov. 8 online issue of the journal Physical Review Letters, the scientists offer a detailed description of their novel device, an advanced version of the "optical trap," which uses infrared light to trap and control the forces on a functional protein, allowing researchers to monitor the molecule's every move in real time. (sciencedaily.com)
In the past, researchers found that they could split proteins using light and chemical signals, but finding the precise spot to make the split was a matter of trial and error, which would not be practical for actual medical treatments and scientific procedures. (genengnews.com)
To find the best sites for protein splits, the researchers analyzed how several proteins were split in the past and used that data to create a mathematical model of the protein's structure, or physical scoring model. (genengnews.com)
The researchers used the algorithm to identify split sites on a number of proteins, including tyrosine kinase Lyn, guanosine nucleotide dissociation inhibitor, and guanine exchange factor. (genengnews.com)
The ability to split proteins-and then make them functional again-could have far-reaching implications, note the researchers. (genengnews.com)
Researchers at KI and SLU have discovered that spider silk proteins can be fused to biologically active proteins and be converted into a gel at body temperature. (phys.org)
In the future, the researchers hope to develop an injectable protein solution that forms a gel inside the body. (phys.org)
The researchers at KI and SLU have been particularly interested in the spiders' ability to keep proteins soluble so that they do not clump together before the spinning of the spider silk. (phys.org)
University at Buffalo researchers have discovered a way to easily and effectively fasten proteins to nanoparticles - essentially an arranged marriage - by simply mixing them together. (buffalo.edu)
Next, the researchers mixed the modified proteins and nanoparticles in water. (buffalo.edu)
The researchers also tested proteins that target cancer cells. (buffalo.edu)
Using an innovative version of mass spectrometry method and advanced algorithms, the researchers discovered and analyzed all the mistakes that occur in protein production in a single amino acid cell - in yeast and bacterial cells. (weizmann-usa.org)
The mice with enhanced immunity produced high levels of a hitherto unknown protein, which the researchers named lymphocyte expansion molecule, or LEM. (innovationtoronto.com)
Researchers at the University of Washington are using AI to design new kinds of proteins. (wxxinews.org)
By including gold atoms in the fabrication process, researchers in Japan and Poland have created nano-sized protein cages with 'impossible' geometries. (asianscientist.com)
AsianScientist (May 29, 2019) - An international team of researchers has succeeded in creating a 'protein cage'-a nanoscale structure for targeted drug delivery in the body-that is durable and can be readily assembled or disassembled. (asianscientist.com)
The researchers noted that with their approach, proteins that were previously ignored because they had the 'wrong' shape can now be considered for drug delivery. (asianscientist.com)
This protein helps regulate breathing in adult mice and gets breathing going in newborn mice, researchers report online December 21 in Nature . (sciencenews.org)
Dalhousie University, Canada researchers have developed a new web-based tool called Multiple Protein Profiler (MPP) that can efficiently calculate 12 key physicochemical properties of. (cbirt.net)
An international team of researchers led by scientists at the University of Cambridge and MSD has created the first detailed genetic map of human proteins, the key building blocks of biology. (familywnews.com)
Previously, there was only a small fraction of this knowledge, mainly because researchers could measure only a few blood proteins simultaneously in a robust manner. (familywnews.com)
The researchers used a new technology ("SOMAscan") developed by a company, SomaLogic, to measure 3,600 proteins in the blood of 3,300 people. (familywnews.com)
In some cases, the researchers identified multiple genetic variants influencing levels of a protein. (familywnews.com)

The protein fluoresces green when exposed to blue light, and the gene that makes it has been added to organisms as diverse as bacteria, yeast, insects and even humans , to prove that "alien" genes can be inserted, expressed and passed on. (newscientist.com)
To overcome this difficulty, the team adapted a method that some of the members had already been working on - one that searches the "translatome" as opposed to the genome - to find the proteins involved in communicating changes arising from master regulator genes. (medicalnewstoday.com)
DNA is often compared to a twisted ladder consisting of two strands connected by molecular rungs called "bases," which are known by the abbreviations A, T, G and C. Lengthier DNA sequences code for genes, which contain explicit instructions for building a specific protein. (sciencedaily.com)
A typical DNA ladder carries thousands of genes that encode thousands of proteins, which keep the organism alive and functioning. (sciencedaily.com)
UPTON, NY-Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells. (bnl.gov)
Ribosomes are factories inside cells where messages coming from genes are decoded and new proteins pieced together on an assembly line. (analytica-world.com)
Proteins play key role in genes that help auditory hair cells grow. (apexaudiology.com)
Compared to genes, proteins have been relatively understudied in human blood, even though they are the 'effectors' of human biology, are disrupted in many diseases, and are the targets of most medicines," says Dr. Adam Butterworth from the Department of Public Health and Primary Care at the University of Cambridge, a senior author of the study. (familywnews.com)

Develop and implement methods for expression, purification and biochemical and biophysical characterization of recombinant proteins. (zymoresearch.com)
Candidate should be well versed in recombinant protein expression, purification and characterization. (zymoresearch.com)
Experience of working with antibodies and recombinant proteins. (fusionantibodies.com)

The Center for Molecular Protein Science (CMPS) brings together scientists active within the fields of biochemistry, molecular biophysics, structural biology, and physical and theoretical chemistry. (lu.se)

A Stanford University research team has designed the first microscope sensitive enough to track the real-time motion of a single protein down to the level of its individual atoms. (sciencedaily.com)
But eventually, using intensely bright beams of x-rays at the National Synchrotron Light Source (NSLS) at Brookhaven and the Advanced Photon Source (APS) at Argonne National Laboratory-both DOE Office of Science User Facilities-they gathered sufficient data on the arrangement of the proteins' atoms. (bnl.gov)
We were able to replace the complex interactions between proteins with simple 'staples' based on the coordination of single gold atoms," Heddle explained. (asianscientist.com)
With the gold atoms, however, the proteins could assemble into large hollow complexes, ideal for encapsulating drugs. (asianscientist.com)
Scientists at Atomic Physics are pursuing research on the properties of atoms and molecules, mainly using advanced laser techniques. (lu.se)

For the first time, UNC School of Medicine scientists have discovered that these viruses use a human protein called barrier-to-autointegration factor 1, or BAF, to evade our innate immune response, allowing the viruses to spread and cause disease. (scienceblog.com)
These findings, published in Nature Communications , suggest that BAF and related proteins could be therapeutic targets to prevent these viruses from spreading and leading to cancers, such as Kaposi sarcoma, non-Hodgkin lymphoma, Hodgkin lymphoma, multicentric Castleman disease, nasopharyngeal carcinoma, and gastric cancer. (scienceblog.com)
Viruses are in a constant battle with the cellular immune system, which includes the protein cyclic GMP-AMP synthase, or cGAS, which binds to viral DNA and sounds the alarm to trigger immune responses and fight the viral invaders," said senior author Blossom Damania, PhD, the Boshamer Distinguished Professor of Microbiology and Immunology and member of the Lineberger Comprehensive Cancer Center. (scienceblog.com)
In the case of KSHV and EBV, the expression of BAF is increased upon infection, suggesting that these viruses take advantage of this host protein to blunt the immune response to infection. (scienceblog.com)
With less cGAS protein available in the infected cell to detect DNA, the cells mount weaker immune responses, which allows these two viruses to replicate and spread more efficiently. (scienceblog.com)
In her own research, Dunham is examining how viruses such as HIV, upon hijacking ribosomes, use special tricks that cause the assembly line to slip, as well as how other antibiotics and toxin proteins interact with parts of the ribosome. (analytica-world.com)
Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies. (innovationtoronto.com)
Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. (innovationtoronto.com)
Proteins are molecules that do much of the day-to-day work in biology: They build muscles and organs, they digest food, they fight off viruses. (wxxinews.org)
The most famous examples are viruses where the protein cage acts as a carrier of viral genetic material into host cells. (asianscientist.com)
Specifically, it works by blocking proteins called "neuraminidase," which are located on the surface of flu viruses and play an important role in how these viruses cause infection. (cdc.gov)
Neuraminidase are the proteins that allow flu viruses to escape infected cells, and for that reason, antiviral drugs that block neuraminidase proteins, like oseltamivir, help to limit further infection. (cdc.gov)

Scientists at The Scripps Research Institute (TSRI) have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases. (scripps.edu)
NEI-funded scientists from The Scripps Research Institute have discovered how a protein called α2δ4 establishes proper vision. (nih.gov)

ECSA Scientific Day 2023 (23 November 2023): Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a black South African population, according to HIV status. (who.int)
Antibodies against E6, E7 and L1 proteins of HPV16 and HPV18 were measured in sera of 535 cases of noncervical HPV-related cancers (anal (n=104), vulval (n=211), vaginal (n=49), penile (n=37) and oropharyngeal (n=134)) and 6,651 non-infection-related cancer controls, from the Johannesburg Cancer Study that recruited Black South African with newly diagnosed cancer between 1995 and 2016. (who.int)
urinary proteins and specific IgE antibodies (3). (cdc.gov)

Experience with Mass Spectrometry of proteins and peptides. (hydrogengroup.com)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)

The protein trend is already here but we should make plant proteins more functional and we need to start using protein-packed grains as well. (nutraingredients.com)
We have developed a completely new method for creating a three-dimensional gel from spider silk that can be designed to deliver different functional proteins," says Anna Rising, research group leader at the Department of Biosciences and Nutrition, Karolinska Institutet (KI) and professor at the Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences (SLU). (phys.org)
We have let bacteria produce this part of the protein linked to functional proteins, including various drugs and enzymes. (phys.org)
In addition, it can be fused to functional proteins that preserve their function in the gel. (phys.org)

You'd end up "just trying them out one at a time, to see what fits the best," says David Baker, the senior scientist who runs the lab. (wxxinews.org)
Enlaza is seeking a Computational Scientist/ Senior Scientist / Principal Scientist to help design and develop first-in-class covalent protein therapeutics. (enlazatx.com)

Scientists have discovered a "Big Bang" of Alzheimer's disease - the precise point at which a healthy protein becomes toxic but has not yet formed deadly tangles in the brain. (technologynetworks.com)
This changes much of how we think about the problem," said Dr. Marc Diamond, Director for UT Southwestern's Center for Alzheimer's and Neurodegenerative Diseases and a leading dementia expert credited with determining that tau acts like a prion - an infectious protein that can self-replicate. (technologynetworks.com)
The study published in eLife contradicts the previous belief that an isolated tau protein has no distinct shape and is only harmful after it begins to assemble with other tau proteins to form the distinct tangles seen in the brains of Alzheimer's patients. (technologynetworks.com)
JERUSALEM, Aug. 1 (Xinhua) - Israeli scientists have discovered when and where mistakes occur in the cellular manufacture of proteins, which may help with Alzheimer's and cancer researches, the Weizmann Institute of Science (WIS) reported Thursday. (weizmann-usa.org)
Some mistakes, for example, might cause misfolded proteins to aggregate in a cell, as happens in Alzheimer's disease, whereas others may give a cell an evolutionary advantage. (weizmann-usa.org)
Scientists studying Alzheimer's disease (AD) have identified thousands of genetic variants in the genome in the development of this progressive neurodegenerative disease. (news-medical.net)

Such errors can originate from spelling mistakes in the DNA, but much more common are mistakes occurring later, when the genetic message is copied and sent to the ribosome, the cell's protein "factory. (weizmann-usa.org)

If we can develop a strategy to reduce the load that's coming from these proteins, then we can open up treatment options that could be broadly applied to treat multiple systemic amyloid diseases," said Luke Wiseman, assistant professor at TSRI and a senior author of the new research. (scripps.edu)
From sample preparation to real-time analyses, scientists embarking on protein research journeys need to equip themselves with technical knowledge. (the-scientist.com)
For relevant, reliable, and reproducible protein research, scientists need to understand the principles behind different methods and tools. (the-scientist.com)
The research, led by scientists at the University of Cambridge Metabolic Research Laboratories at the Institute of Metabolic Science, discovered that the protein BMP8B acts on a specific metabolic system (which operates in the brain and the tissues) to regulate brown fat, making it a potential therapeutic target. (cam.ac.uk)
The process to split a protein is a little like splitting an apple, but when people split apples they usually don't have any intention of reassembling the pieces back into a healthy apple, according to Onur Dagliyan, Ph.D., research fellow in neurobiology, Harvard Medical School. (genengnews.com)
Silk fibroin can be used in transistors, which are used in e-paper, and increase their efficiency, according to a research paper presented by the scientists from National Tsing Hua University in the northern city of Hsinchu, on Sunday. (phys.org)
Uncommon in medicine, polyhistidine-tags are used extensively in protein research. (buffalo.edu)
Even as research on the ribosome, one of the cell's most basic machines, is recognized with a Nobel Prize, scientists continue to achieve new insights on the way ribosomes work. (analytica-world.com)
A scientist is someone who conducts scientific research to advance knowledge in an area of interest. (salary.com)
The team of scientists published research in the Journal of Investigative Dermatology 1 showing how the protein arginase1 speeds up the rate of chemical reactions in skin cells. (ddw-online.com)
Scientists say its radically sped up their research. (wxxinews.org)
The research team identified 19 plasma hub proteins (indicated as yellow dots in the figure) in AD patients, which are irregular compared to healthy people. (eurekalert.org)
Scientists from the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim (UMM) successfully tested a new form of cellular immunotherapy against brain tumors in mice for the first time. (news-medical.net)
This phase 1 clinical trial is the culmination of years of research and development made possible by the unique collaborative setting that the VRC offers by bringing together top scientists, manufacturing expertise, and an outstanding clinical team," VRC Director John Mascola, MD, said in the news release. (medscape.com)

Usually, when scientists want to look for molecular changes that affect disease, they use genetic sequencing to create a profile of the variations in gene expression. (medicalnewstoday.com)
The translatome is the complete collection of messenger molecules that are involved with translating genetic information from DNA and carrying it to sites where proteins are made inside cells. (medicalnewstoday.com)
With genetically engineered mice, the team captured the genetic messages being translated into proteins in dopaminergic neurons in the mice's midbrain region. (medicalnewstoday.com)
In the Nature study, Block and his colleagues tackled a fundamental principal of biology known as the central dogma, which states that in living organisms, genetic information flows from DNA to RNA to proteins. (sciencedaily.com)
The study, published today in the journal Nature , characterised the genetic underpinnings of the human plasma 'proteome', identifying nearly 2,000 genetic associations with almost 1,500 proteins. (familywnews.com)
MSD scientists were instrumental in highlighting how the proteomic genetic data could be used for drug discovery. (familywnews.com)
By linking drugs, proteins, genetic variation and diseases, the team has suggested existing drugs that could potentially also be used to treat a different disease, and increased confidence that certain drugs currently in development might be successful in clinical trials. (familywnews.com)

Prior to the current study, the scientists already knew that Rumi modifies Notch by adding glucose molecules to the protein. (bnl.gov)
Scientists made the discovery after extracting tau proteins from human brains and isolating them as single molecules. (technologynetworks.com)

Controlling protein activity with chemogenetics and optogenetics has proven to be powerful for testing hypotheses regarding protein function in rapid biological processes. (genengnews.com)

They have previously developed a method for the production of valuable proteins which mimics the process the spider uses to produce and store its silk proteins. (phys.org)

Scientists from the biotechnology company Amgen Inc. report they have identified and improved upon a naturally occurring protein that brought about significant changes in obese mice and monkeys, including weight loss and rapid improvements on measures of metabolic and heart health. (latimes.com)
After 35 days, obese mice treated with the bioengineered GDF15 proteins lost roughly 20% of their body weight, while mice getting a placebo gained about 6% over their starting weight, according to the study. (latimes.com)
When mice were offered the rich condensed milk, triglyceride levels remained at baseline or rose by about 20% in those who got the engineered proteins, while levels more than doubled in the untreated mice. (latimes.com)
The experiments showed that when mice lacked the protein BMP8B they found it more difficult to maintain their normal body temperature. (cam.ac.uk)
When mice lack these proteins in particular clusters of nerves, the mice either die within 24 hours of birth (blue, purple) or have breathing problems as adults (red). (sciencenews.org)
Experiments in mice have identified a protein that senses when the lungs are full of air . (sciencenews.org)
Hertzano and her colleagues used mice whose auditory hair cells glow with a green fluorescent protein, allowing the cells to be identified from other kinds of cells. (apexaudiology.com)
The scientists then moved on to study mice which had been genetically altered so that their hair cells lacked two of the RFX transcription factors. (apexaudiology.com)

In the Nature experiment, we carried out the highest-resolution measurement ever made of an individual protein," says Steven Block, professor of applied physics and of biological sciences. (sciencedaily.com)
About half of these proteins have known functions, while the other half are not yet associated with any biological process. (isaaa.org)
Advanced degree (PhD preferred) in protein chemistry/molecular biology/chemical engineering or a relevant biological science and 6+ years of industry experience. (hydrogengroup.com)
His team's next steps are to develop a simple clinical test that examines a patient's blood or spinal fluid to detect the first biological signs of the abnormal tau protein. (technologynetworks.com)
The scientist will rationally design novel protein-based therapeutics integrating structural, chemical and biological data, and using cutting-edge computational methodologies, artificial intelligence and machine learning techniques. (enlazatx.com)
We want to understand the molecular mechanisms of biological processes by exploring the structure, dynamics, interactions and function of proteins. (lu.se)

With the availability of genome sequences of organisms, scientists are now able to study the details of the sequence to advance developments in plants and other organisms. (isaaa.org)
How could sequences from different strains of a virus help scientists trace the path of an infection? (cdc.gov)

Scientists believe the causes of Parkinson's disease center around what are called dopaminergic neurons. (medicalnewstoday.com)
The team found that the two proteins SATB1 and ZDHHC2 are more abundant in the dopaminergic neurons in the SNpc than in the VTA. (medicalnewstoday.com)
Abnormal accumulations of a protein called tau can collect inside neurons, forming tangled threads and eventually harming the synaptic connection between neurons. (technologynetworks.com)
This exposed portion causes it to stick to other tau proteins, enabling the formation of tangles that kill neurons. (technologynetworks.com)

It was very hard to get sufficient samples," said Hongjun Yu, a postdoctoral scientist working with Li and the first author of the paper, noting that the proteins make very small crystals with a hard to solve structure. (bnl.gov)
I'm Fazlur Rahman Talukdar, a postdoctoral scientist in the Epigenomics and Mechanisms Branch. (who.int)

The scientists obtained crystals by growing heat-tolerant bacteria found at thermal vents at the bottom of the ocean. (analytica-world.com)

In addition, it paves the way for studying interactions between the ribosome and other proteins similar to EF-G that fit into the same spot. (analytica-world.com)
Another problem is complexity-most protein-protein interactions are mediated via complex networks of weak chemical bonds that are very difficult to engineer from scratch. (asianscientist.com)

The accumulation of these proteins damages organs such as the heart, kidney and gut, leading to organ malfunction and, eventually, death. (scripps.edu)
Other proteins made by the body can enhance heat production in brown fat, such as thyroid hormone but often these proteins have important effects in other organs too. (cam.ac.uk)

The proteins, meanwhile, are modified with a chain of amino acids called a polyhistidine-tag. (buffalo.edu)
Wrong amino acids are inserted into a protein at this stage at the average rate of one in about 1,000 amino acids (almost one mistake per protein). (weizmann-usa.org)
Proteins themselves are built of simpler compounds known as amino acids. (wxxinews.org)
The problem is that these amino acids can be combined in a nearly infinite number of ways to make a nearly infinite number of proteins. (wxxinews.org)

Human papillomavirus (HPV) proteins may elicit antibody responses in the process towards HPV-related malignancy. (who.int)

Protein highlights 'ideal mechanism' for development of new therapies to fight obesity. (cam.ac.uk)
At the University of Washington, Vazquez-Torres is one of about 200 scientists working in a laboratory to design new therapies using proteins . (wxxinews.org)

Interestingly, the team reported that ATF6 activation increases the ability of the cell to "read" the stability of proteins. (scripps.edu)
Characterize protein and enzyme stability and activity. (zymoresearch.com)
Moreover, within each protein, translation errors are much more common at positions that are less critical to the protein's function and stability. (weizmann-usa.org)
The scientists found the material showed stability in water, visible transparency, and oil resistance. (foodmatterslive.com)

In light chain amyloidosis, mutations in immunoglobulin light chains make the proteins unstable, allowing them to unfold in the blood and form toxic clusters (aggregates) that damage the heart. (scripps.edu)
We want to make these proteins respond with certain activities based on the light-optogenetic-or chemical-chemogenetic-signals that we provide. (genengnews.com)
Taiwanese scientists say they have discovered that a protein created by silkworms in the production of silk can be used to manufacture a component that will make e-books more efficient. (phys.org)
One of the goals is to develop an injectable protein solution that forms a gel inside the body, which could be used in tissue engineering and for drug release, but also make gels that can streamline chemical processes where enzymes are used. (phys.org)
How much does a Protein Scientist make in the United States? (salary.com)
According to the scientists, the findings will make it possible to examine the impact of mistakes on neurodegenerative diseases, cancer, aging and evolution of the species. (weizmann-usa.org)
Make a donation and help Weizmann scientists pursue a better tomorrow. (weizmann-usa.org)
AI similar to the kind used to make images is now being used to design synthetic proteins. (wxxinews.org)
AI scientists can really be more systematic, more comprehensive and not make errors," says Yolanda Gil, director of AI and data science initiatives at the Information Sciences Institute at the University of Southern California, who is attending the event. (wxxinews.org)

We are seeking a Principal Scientist to work with the Cell Therapy teams at Regeneron Pharmaceuticals as we work towards deploying CAR-T cells to. (biospace.com)
The Sr. Principal Scientist will be accountable for all process development related activities for the drug product, with focus on late-stage devel. (biospace.com)

Synthetic biologists are interested in making artificial protein cages, but they often run into geometry problems-some candidate proteins are automatically ruled out because they have the wrong shape and cannot assemble into cages. (asianscientist.com)

The clusters] can be made using protein extrudates, different proteins, different levels and we can combine those with some other grains like puffed rice, nuts, or dried fruits with the help of binders like honey, glucose or sugar. (nutraingredients.com)

The two proteins - SATB1 and ZDHHC2 - appear to protect the brain cells most affected by Parkinson's disease. (medicalnewstoday.com)
Current treatments for light chain amyloidosis involve chemotherapy to kill the dysfunctional cells that secrete the disease-associated proteins, but about 30 percent of patients have significant buildup of light chain in the heart, making them too weak for this treatment. (scripps.edu)
We demonstrate SPELL by applying it to proteins of various shapes and sizes in living cells. (genengnews.com)
You want to turn them off and turn them on, and people in the field are trying to find ways to control those proteins, just to be able control those cells. (genengnews.com)
One of these target proteins … plays an important role in how cells sense their neighbors … and how much they should grow-like a master controller. (bnl.gov)
Further assessment of these proteins is expected to bring more discoveries about their functions in photosynthetic cells, and how the photosynthetic cells might be adapted to survive various environmental conditions. (isaaa.org)
Whilst scientists already know that arginase1 is expressed by cells in the skin including immune cells and keratinocytes, the function of arginase1 in keratinocytes was not well understood. (ddw-online.com)
Cytotoxic T cells with the protein LEM stained. (innovationtoronto.com)
SCIENTISTS have discovered a way to blow the "doors" off cancer cells for the first time, a study shows. (innovationtoronto.com)
The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. (wikipedia.org)
A new study led by scientists at the University of Maryland School of Medicine (UM SOM) has found a key clue to how these hair cells develop. (apexaudiology.com)
The current study identified a new role for a particular group of proteins, known as RFX transcription factors, in the development and survival of the hair cells. (apexaudiology.com)
Ferritin is a natural protein that can be found in cells from all living species. (medscape.com)

In related studies published recently in the journals Proceedings of the National Academy of Sciences ( PNAS ) and Chemistry & Biology , Wiseman and his colleagues described a process that can catch unstable proteins before they are released from the cell and form deposits. (scripps.edu)
Being a Soil Scientist may require a bachelor's degree in agricultural sciences or a related field with at least 5 years of work experience. (salary.com)
We are seeking a highly motivated individual to join the BST automation team in Regenerons Protein Expression Sciences department. (biospace.com)
The DLS Snapshot is a quick glimpse into the background of scientists in the Division of Laboratory Sciences-CDC's Environmental Laboratory. (cdc.gov)

Our work describes the structure and function of an important enzyme called Rumi, which adds a glucose molecule to several signaling proteins to modify their activities," said the study's lead author, Huilin Li, a biologist at the U.S. Department of Energy's Brookhaven National Laboratory and Stony Brook University. (bnl.gov)
Picking up on recent discoveries that the Notch-modifying enzyme known as Rumi is necessary for animal development and that various mutants of Rumi are linked with a form of skin hyperpigmentation known as Dowling-Degos disease (made by scientists at the Baylor College of Medicine and the University of Bonn, Germany), Li's group became focused on this particular enzyme. (bnl.gov)
There are other examples of proteins modified by other simple sugars, but Rumi is the first enzyme known to specifically add glucose. (bnl.gov)

This is because more abundant proteins would clutter up the cell much sooner if they contained errors, so that the cell would not have survived evolution. (weizmann-usa.org)

For isolating and developing the green fluorescent protein (GFP) from a jellyfish, the 2008 Nobel prize for chemistry has been awarded jointly to three scientists. (newscientist.com)
several scientists who went on to win a Nobel Prize. (lu.se)

He cites a compelling reason for cautious optimism: Tafamidis, a recently approved drug, stabilizes a different shape-shifting protein called transthyretin that causes deadly protein accumulation in the heart, similar to how tau overwhelms the brain. (technologynetworks.com)

In a second study, published October 23 online ahead of print by the journal Chemistry and Biology , Wiseman and his team asked if ATF6 activation could be similarly used to reduce secretion and aggregation of transthyretin-a protein that aggregates in association with other systemic amyloid diseases referred to as the transthyretin amyloidoses. (scripps.edu)
With arduous chemistry, scientists can do it. (buffalo.edu)

Scientists have found that aptly named extremely long-lived proteins (ELLPs) in the brains of rats can persist for more than one year-a result that suggests the proteins, also found in human brains, last an entire lifetime. (the-scientist.com)
Scientists at The University of Manchester have found a protein in the skin which could help untreatable wounds heal faster. (ddw-online.com)
I've spent about an hour searching online and haven't found anything but ambiguity (which scientists, which protein/mutation, etc). (stackexchange.com)
Scientists have found a hidden weakness of the superbug MRSA. (thenakedscientists.com)
The scientists found they could counter this problem by including certain soy proteins in the material structure of bacterial cellulose. (foodmatterslive.com)

This approach identified an ER mechanism called the Unfolded Protein Response, or UPR, as a pathway whose activation preferentially reduces secretion of disease-associated light chains. (scripps.edu)

Structural data for over 180,000 proteins. (apple.com)

Asian Scientist Magazine is an award-winning science and technology magazine that highlights R&D news stories from Asia to a global audience. (asianscientist.com)

With Special K Protein in the US, for example, Kellogg delivered 10 g protein per 22 g serving - a challenge made possible by using a lot of wheat gluten, Asif explained. (nutraingredients.com)
Soy protein isolates made up the protein content in the cereal and the amino acid lysine was added to compensate losses during production. (nutraingredients.com)
Usually made from many protein subunits and having a hollow interior, these protein cages carry out many important tasks. (asianscientist.com)
It displays part of hemagglutinin (HA), an influenza protein, on the surface of a microscopic nanoparticle made of nonhuman ferritin. (medscape.com)

Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Soil Scientist studies, investigates, and conducts experiments on different soil/plant types to determine use capabilities of soils, and effects of alternative practices on soil productivity. (salary.com)

The study is also significant for another reason - the molecular searching method that the team used to find the two proteins. (medicalnewstoday.com)
In the recent PNAS study, the Wiseman lab, in collaboration with Jeffery Kelly's lab at TSRI, focused on a systemic amyloid disease called light chain amyloidosis, where the unstable proteins are called light chain immunoglobulins. (scripps.edu)
The team published its study (" Computational design of chemogenetic and optogenetic split proteins ") in Nature Communications . (genengnews.com)
The new study shows that the N-terminal domain also has the ability to change shape and transition to small fibrils that cause the protein solution to be converted into a gel if incubated at 37 degrees Celsius. (phys.org)
The AI also requires examples to learn from, and luckily, scientists have spent decades and billions of dollars developing a massive database full of proteins that it can study. (wxxinews.org)
Earth Scientist and glaciologist, Shakil Ahmad Romshoo, who has co-authored the study 'Anthropogenic climate change drives melting of glaciers in the Himalaya', said that there is a direct link between black carbon and the melting of glaciers. (dailypioneer.com)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)
6. Molecular evidence from DNA, RNA, or proteins is used to study outbreaks. (cdc.gov)

In particular, I serve in the Protein Biomarker Laboratory. (cdc.gov)

From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist , where he started in 2007 as a Staff Writer. (the-scientist.com)
Tina Arndt et al, Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform, Nature Communications (2022). (phys.org)

Thus, a team of scientists at the Carnegie Institution for Science led by Arthur Grossman identified the specific proteins in plants and algae that are absent in the genomes of non-photosynthetic organisms. (isaaa.org)
It was not until the 19th century that the term scientist came into regular use after it was coined by the theologian, philosopher, and historian of science William Whewell in 1833, to describe the noted polymath Mary Somerville. (salary.com)
In modern times, many scientists have advanced degrees in an area of science and pursue careers in various sectors of the economy such as academia, industry, government, and nonprofit environments. (salary.com)
Being an Animal Scientist I requires a degree in animal science. (salary.com)

There, a team from The Rockefeller University and Columbia University, both in New York, NY, describes finding two proteins that may play a key role in the progression of Parkinson's disease . (medicalnewstoday.com)
The team believes conventional gene expression profiling would not have been able to identify the two proteins as key protective factors. (medicalnewstoday.com)
A team of biochemists and biophysicists reports that a computer-guided algorithm may help scientists find the right place to split a protein and then reassemble it to functionality. (genengnews.com)
Li's team studied samples of a fruit-fly derived version of Rumi in complex with a Notch "surrogate"-a human protein with a Notch-like fold-that were provided by Haltiwanger. (bnl.gov)
Using advance computational tools, the team was able to identify 597 proteins unique to photosynthetic organisms and they called them GreenCut. (isaaa.org)
Maintaining and populating Protein Production Team specific databases. (fusionantibodies.com)
A team of scientists from the Chinese University of Hong Kong (CUHK) have created an edible, biodegradable, and transparent material using soy protein isolate, which they say has the potential to become a viable alternative to plastic food packaging . (foodmatterslive.com)
A spike in greenhouse gas emissions (GHGs), temperature, black carbon and other pollutants in the atmosphere is taking a toll on the glaciers in the pristine Drass region in Western Himalayas' Ladakh, a team of Indian scientists has said, warning that a 'business as usual' scenario may wipe them out forever. (dailypioneer.com)
A team of VRC scientists developed the universal influenza vaccine prototype. (medscape.com)

The work was done in collaboration with scientists at several institutions, among them Ran Elkon, PhD, an Assistant Professor and computational biologist at the Sackler School of Medicine at Tel Aviv University in Israel. (apexaudiology.com)

BUFFALO, N.Y. - Fastening protein-based medical treatments to nanoparticles isn't easy. (buffalo.edu)
The revelation offers a new strategy to detect the devastating disease before it takes hold and has spawned an effort to develop treatments that stabilize tau proteins before they shift shape. (technologynetworks.com)

One of these target proteins, called Notch, is the major receptor that controls the development of multicellular organisms. (bnl.gov)

Have scientists demonstrated an absent protein can cause chicks to be born with scales rather than feathers (as well as reptile scales to feathers)? (stackexchange.com)

She sees an aspiring scientist or engineer in Daniel, with whom she watched YouTube videos about hurricane Katrina recently. (cdc.gov)

The UPR regulates ER function through the increased expression of proteins, such as "chaperones," that directly influence the folding and secretion of destabilized proteins. (scripps.edu)
Scientists have identified a protein which regulates the activation of brown fat in both the brain and the body's tissues. (cam.ac.uk)

Neuraminidase, or NA, is another influenza surface protein. (medscape.com)
And in the lab test, if oseltamivir doesn't inhibit the function of the neuraminidase protein, we call the virus oseltamivir-resistant. (cdc.gov)

In the chemical industry , it could be fused to enzymes, a form of proteins used to speed up various chemical processes . (phys.org)
For the first time, scientists have a detailed picture of the ribosome trapped together with elongation factor G (EF-G), one of the enzymes that nudges the assembly line to move forward. (analytica-world.com)

Experience in molecular biology and protein expression from mammalian cell expression platforms and purification methods. (hydrogengroup.com)
I was fascinated with topics such as the central dogma of molecular biology and protein synthesis, which are about the mechanisms of gene expression. (who.int)

The client is looking for a Sr. Scientist to develop analytical methods for characterization of proteins for development and manufacturing activities. (hydrogengroup.com)
This position will be a SME in method development for protein characterization, responsible for leading internal and external project teams. (hydrogengroup.com)

Systemic amyloid diseases are caused by the buildup of unstable protein in extracellular environments such as the blood. (scripps.edu)
Hertzano first got interested in the genetics of hearing as an MD-PhD student at Tel Aviv University, and then pursued residency training at the UM SOM Department of Otorhinolaryngology, where she now works as a scientist and a surgeon whose practice is focused on diseases of the ear and hearing restoration. (apexaudiology.com)

My lab is interested in investigating the way cellular life works by targeting the molecular players, such as proteins and RNA, and to this extent, we have been developing tools to control those players," says Nikolay V. Dokholyan, Ph.D., G. Thomas Passananti Professor, Penn State College of Medicine. (genengnews.com)

Some scientists believe that human adult lactase polymorphism evolved in the Neolithic period, after animal milk became available for the nutrition of older children and adults. (medscape.com)

Organisms3

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Disciplines and Occupations50

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