• The H240R protein (pH240R), encoded by the H240R gene of African swine fever virus (ASFV), is a 241-amino- acid capsid protein . (bvsalud.org)
  • We previously showed that the deletion of H240R from the ASFV genome , creating ASFV-ΔH240R, resulted in an approximately 2-log decrease in infectious virus production compared with the wild-type ASFV strain (ASFV-WT), and ASFV-ΔH240R induced higher interleukin 1 ß ( IL-1 ß) production in porcine alveolar macrophages (PAMs) than did ASFV-WT, but the underlying mechanism remains to be elucidated. (bvsalud.org)
  • IMPORTANCE African swine fever (ASF), a lethal hemorrhagic disease , is caused by African swine fever virus (ASFV). (bvsalud.org)
  • Here, we showed that ASFV with a deletion of the H240R gene exhibits high-level expression of interleukin 1 ß ( IL-1 ß), a proinflammatory cytokine , in porcine alveolar macrophages and that the H240R protein (pH240R) exhibits robust inhibitory effects on IL-1 ß transcription and production . (bvsalud.org)
  • Here we describe an African swine fever virus (ASFV) protein encoded by the open reading frame 5-AR that shares structural and functional similarities with the family of bacterial histone-like proteins which include histone-like DNA binding proteins, integration host factor, and Bacillus phage SPO1 transcription factor, TF1. (illinois.edu)
  • Monospecific antiserum prepared to the 5-AR bacterial expression product specifically immunoprecipitated a protein of approximately 11.6kDa from ASFV infected swine macrophages at late times post-infection. (illinois.edu)
  • The African swine fever virus (ASFV) j4R protein is expressed late during the virus replication cycle and is present in both the nucleus and the cytoplasm of infected cells. (ox.ac.uk)
  • In order to develop ASF serodiagnostic reagents with high specificity and sensitivity, in the present study, the antigenic epitopes of P72 protein of African swine fever virus (ASFV) were analyzed, and the ASFV multi-epitope fusion gene MeP72 in tandem with the dominant linear epitopes was constructed. (elis.sk)
  • Compared with commercial ASFV kits, the sensitivity and specificity of ASFV CGIA based on reMeP72 protein were 85.7% and 97.6%, respectively. (elis.sk)
  • CD2 displays structural and functional similarities with African swine fever virus (ASFV) LMW8-DR, a protein that is involved in cell-cell adhesion and immune response modulation, suggesting a possible role in the pathogenesis of ASFV infection. (wikipedia.org)
  • This project research project seeks to develop an African swine fever virus (ASFV) sub unit vaccine, using raccoon pox virus as vector, which can protect against the epidemiologically relevant strain Georgia 2007. (usda.gov)
  • Develop an ASFV subunit vaccine candidate using racoon pox as a vector with the co-expression of several (6-18) immunogenetic viral proteins. (usda.gov)
  • The 5-10 most immunogenic African swine fever virus (ASFV) proteins will be selected based in results previously obtained by ARS, PIADC, where these proteins were identified by peptide scanning immune microarray. (usda.gov)
  • Based on this information, the corresponding recombinant plasmids will be commercially synthesized placing the selected ASFV proteins under the regulation of specific different promoters already tested in their efficacy in our laboratory. (usda.gov)
  • Once purified by successive purification steps, expression of ASFV recombinant proteins will be tested in vitro using monoclonal and monospecific polyclonal antibodies. (usda.gov)
  • Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can trigger an immune response in pigs. (pirbright.ac.uk)
  • To develop strategies to control African Swine Fever Virus (ASFV) studies will be conducted to provide information about the mechanisms of viral replication, virus host interaction and virulence in the natural host. (usda.gov)
  • Rabbits were immunized with recombinant, IMAC-purified, ASFV p72 protein. (european-virus-archive.com)
  • In relation to African Swine Fever Virus (ASFV), spray dried plasma is exclusively made up from blood of healthy animals after veterinary approval from farms free of ASFV under supervision and control of competent authorities. (eapa.biz)
  • The manufacturing process of EAPA members contains several independent safety steps that contribute to the safety of blood products in front of different pathogens that affect the swine industry, including ASFV. (eapa.biz)
  • Genotyping of ASFV isolates by partial sequencing of the B646L gene that encodes the major capsid protein p72 has identified 22 genotypes ( 6 ). (cdc.gov)
  • African swine fever virus (ASFV) is the only member of the Asfarviridae family and is a large, double-stranded DNA virus, which replicates in the cytoplasm of infected cells. (biopremier.com)
  • Its inapparently infected natural hosts (warthogs, bushpigs) act as reservoir hosts for ASFV in Africa. (biopremier.com)
  • ASFV is endemic to sub-Saharan Africa. (biopremier.com)
  • ViroReal® Kit ASF Virus uses real-time PCR for the detection of the major capsid protein gene p72 of ASFV. (biopremier.com)
  • Despite efforts made over past decades, there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an urgent need to develop novel strategies. (mdpi.com)
  • African swine fever virus (ASFV) is an acute and persistent swine virus with a high economic burden that encodes multiple genes to evade host immune response. (mdpi.com)
  • African swine fever (ASF) is a haemorrhagic devastating pig disease with mortality rates up to 100% caused by African swine fever virus (ASFV). (intvetvaccnet.co.uk)
  • The generation of recombinant attenuated ASFV isolates is a very promising approach, but a subunit vaccine would be a much safer and cheaper approach to vaccination and would pose less constraints for licensing in both scenarios, the European and the African. (intvetvaccnet.co.uk)
  • African swine fever virus (ASFV) is the causative agent of African swine fever (ASF). (intvetvaccnet.co.uk)
  • From the 178 plasmids sent, 167 were able to grow in bacterial culture and 92 of the ASFV proteins were expressed individually in mammalian cells. (intvetvaccnet.co.uk)
  • An ASFV virus neutralization assay (VNA) was set-up to evaluate the capacity of the anti-sera to inhibit the viral infection in the wild boar cell line WSL. (intvetvaccnet.co.uk)
  • The in vivo immunogenicity of the antigens will be tested in the near future thanks to a recently funded follow-up project, Thus, the polyclonal sera obtained after immunization will allow confirming the VNA of the individual proteins and select the best antigen cocktail to rationally designed a future antibody based ASFV subunit vaccine. (intvetvaccnet.co.uk)
  • Bastos ADS , Penrith ML , Cruciere C , Edrich JL , Hutchings G , Roger F , Genotyping field strains of African swine fever virus by partial p72 gene characterisation. (cdc.gov)
  • An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. (embl.de)
  • Virulence and transmission characteristics of clade 2.3.4.4b H5N6 subtype avian influenza viruses possessing different internal gene constellations. (qxmd.com)
  • CUSABIO is a leading biotechnology company specialized in production of high quality products for gene, protein, antibody, ELISA kit. (cusabio.com)
  • Signals that induce NF-κB activity cause the phosphorylation of IκBs their dissociation and subsequent degradation allowing NF-κB proteins to Brassinolide supplier enter the nucleus and induce gene expression. (biosemiotics2013.org)
  • All human infections caused by a new influenza subtype are required to be reported under the International Health Regulations (IHR, 2005).4 This includes any influenza A virus that has demonstrated the capacity to infect a human and its haemagglutinin gene (or protein) is not a mutated form of those, i.e. (who.int)
  • The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed. (who.int)
  • Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
  • For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)
  • Recombinant viral proteins are used in specific for the research and development of antibodies, vaccines and drugs. (trenzyme.shop)
  • Therefore, we provide you a continously growing catalog of off-the-shelf recombinant viral proteins. (trenzyme.shop)
  • Rojo G , Garcia-Beato R , Vinuela E , Salas ML , Salas J . Replication of African swine fever virus DNA in infected cells. (cdc.gov)
  • Viruses have optimized their evading tactics for superior replication and spreading to counteract host immunity. (frontiersin.org)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • Many of these virus proteins inhibit the host s immune system thus facilitating virus replication and persistence. (visavet.es)
  • However certain virus infection such as African swine fever virus inhibits NF-κB activation which results in enhancement of virus replication and thereby contributing to virus-induced pathogenesis [14]. (biosemiotics2013.org)
  • It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family such as calcium/calmodulin-dependent kinase II, which plays a crucial role in replication and pathogenesis of the virus. (ac.ir)
  • Rubella Virus Replication and Links to TeratogenicityJIA-YEE LEE* ANDD. (vdocuments.net)
  • 577Role of Cellular Proteins in RV Replication. (vdocuments.net)
  • 1,10,12,13 It has been hypothesized that ongoing, undetected RESTV infections and replication in pigs and other animals could result in the emergence of more pathogenic viruses in humans and/or livestock. (who.int)
  • Rowlands RJ , Michaud V , Heath L , Hutchings G , Oura C , Vosloo W , African swine fever virus isolate, Georgia, 2007. (cdc.gov)
  • The detection of IgY in yolk samples by ELISA using streptavidin-biotin binding as part of the assay methodology requires some technology to neutralize high concentration of biotin on sample or more steps beyond delipidation to isolate the target protein. (preprints.org)
  • Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Zinc finger protein B385R (Ken-092), recombinant protein from E. coli. (nexeonmedsystems.com)
  • The development of intervention strategies to control Classical Swine Fever will based on research of live attenuated vaccines (LAV). (usda.gov)
  • This virus is the causative agent of African swine fever, a haemorrhagic fever with high mortality rates in domestic pigs, European wild boar and American wild pigs. (biopremier.com)
  • It discusses the causative agent for ASF, its origins in Africa and its subsequent spread into other regions of the world. (bdspublishing.com)
  • Rubella virus (RV) is the causative agent of the diseasecommonly known as German measles. (vdocuments.net)
  • Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is an acute and highly contagious enteric disease of pigs, which leads to high morbidity and mortality in the suckling piglets, thereby bringing huge economic losses to the global pig industry. (cabi.org)
  • The recent incursions of African swine fever (ASF), a severe, highly contagious, transboundary viral disease that affects members of the Suidae family, in Europe and China have had a catastrophic impact on trade and pig production, with serious implications for global food security. (mdpi.com)
  • African swine fever is a highly contagious disease that kills up to two-thirds of infected animals. (royalsociety.org.nz)
  • Influenza viruses are highly contagious and can cause seasonal epidemics, manifesting as an acute febrile illness with variable degrees of severity, ranging from mild fatigue to respiratory failure and death. (medscape.com)
  • Since Cas9 has no DNA recognition specificity except for the PAM sequence, simple multiplication of gRNAs along with a common Cas9 protein results in multiplex genome engineering. (nature.com)
  • Comparison of the genome sequences of nonpathogenic and pathogenic African swine fever virus isolates. (cdc.gov)
  • Genome condensation and packaging are essential processes in the life cycle of viruses. (mdpi.com)
  • Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. (visavet.es)
  • A Custom Hepatitis A Virus Assay for Whole-Genome Sequencing. (cdc.gov)
  • African swine fever (ASF) is an acute and severe infectious disease that seriously endangers the global porcine industry. (elis.sk)
  • 90,000 animals died or were destroyed (www.oie.int). Experimental infections of pigs confirmed that isolates obtained after introduction of ASF into Armenia and the Russian Federation cause acute disease and result in high mortality rates (www.efsa.europa.eu/en/scdocs/scdoc/1556.htm). (cdc.gov)
  • There is little information on their evolution in Jordan so this study investigated the genetic and antigenic variability of A(H1N1)pdm09 and H3N2 viruses in Jordan by performing phylogenetic and genetic analyses of the HA and NA genes of A(H1N1)pdm09 and H3N2 viruses between 2011 and 2013. (who.int)
  • Jordanian H1N1 viruses had mutations that are characteristic of antigenic group 6 while H3N2 virus mutations belonged to group 3. (who.int)
  • Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. (cdc.gov)
  • African swine fever (ASF) is a hemorrhagic fever in domestic pigs that causes serious economic losses and high mortality rates. (cdc.gov)
  • Pig recovered from infection are immune to infection with virulent strains and wild African pigs are resistant to the disease. (intvetvaccnet.co.uk)
  • and also with anti-sera from wild African pigs (warthogs), naturally resistant to the disease. (intvetvaccnet.co.uk)
  • The University of Missouri has also bred the first pigs resistant to Porcine Reproductive and Respiratory Syndrome by suppressing the production of a protein within the pigs that the virus uses to help it spread. (royalsociety.org.nz)
  • Earlier this month, Bloomberg News reported that, " African swine fever is re-emerging in Asia , threatening to upend efforts to replenish national herds after the virus killed tens of millions of pigs in the region and created a huge shortage of meat protein. (illinois.edu)
  • A new outbreak of African swine fever in the world's leading hog-producing nation is killing increasing numbers of Chinese pigs, with the sow herd falling 3% to 5% each month since December , according to a report Tuesday from Rabobank. (illinois.edu)
  • African swine fever, a disease harmless to humans but nearly always fatal to pigs, has taken a huge bite out of China's hog supplies in recent years. (illinois.edu)
  • In Asia, Bhutan, Mongolia and Myanmar have recorded new cases of African swine fever in domestic pigs, and the disease has also returned to one region of Russia's Far Eastern district. (feedstrategy.com)
  • African swine fever outbreaks are hitting more domestic pigs in southeastern and eastern Europe, with non-commercial herds bearing the brunt of the virus onslaught. (feedstrategy.com)
  • The presence of RESTV in pigs poses a possibility of genetic evolution of the virus. (who.int)
  • The overall public health risk from currently known influenza viruses at the human-animal interface has not changed, and the likelihood of sustained human-to-human transmission of these viruses remains low. (who.int)
  • Influenza viruses are considered one of and NA genes of A(H1N1)pdm09 erated with SeqMan DNA Lasergene the most common causes of respira- and H3N2 viruses in Jordan between 7 software (DNASTAR, Madison, tory infection among humans and they March 2010 and March 2013. (who.int)
  • ABSTRACT Understanding the genetic evolution of A(H1N1)pdm09 and H3N2 viruses can help better select strains to be included in the annual influenza vaccine. (who.int)
  • Iyer LM , Balaji S , Koonin EV , Aravind L . Evolutionary genomics of nucleo-cytoplasmic large DNA viruses. (cdc.gov)
  • it is the only member of the family Asfaviridae , although it shares similarities with other virus families in the superfamily of nucleo-cytoplasmic large DNA viruses ( 2 - 4 ). (cdc.gov)
  • With purified recombinant protein production and peptide synthesis to display limited/selected epitopes, intrinsic factors that can affect the functioning of resulting antibodies can be more easily selected for. (preprints.org)
  • In the last years outbreaks sporadically occurred also outside Africa. (biopremier.com)
  • Among the recent outbreaks of African swine fever to be confirmed in Europe are two affecting commercial farms in northwestern Italy and in the North Caucasian district of Russia. (feedstrategy.com)
  • Further cases of African swine fever have been confirmed across several South African provinces, with a possible emergence of a spike in outbreaks in Eastern Cape. (feedstrategy.com)
  • Risk for intrauterine infection appears to differ between virus clades, but clinicians should be aware of potential for intrauterine monkeypox virus transmission among pregnant persons during ongoing and future mpox outbreaks. (cdc.gov)
  • There have been five documented outbreaks of Ebola Reston virus (RESTV) in animals epidemiologically linked to the Philippines. (who.int)
  • The results showed that CGIA did not cross-react with positive sera of viruses, such as classical swine fever virus (CSFV), porcine circovirus type 2 (PCV2), pseudorabies virus (PRV), porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SIV), showing high specificity. (elis.sk)
  • 20ºC) during minimum 14 days has been demonstrated to be effective in inactivating enveloped viruses similar to ASF like porcine epidemic diarrhoea virus (PEDV) or porcine reproductive and respiratory syndrome virus (PRRSV). (eapa.biz)
  • In summary, the EAPA members manufacturing process for spray-dried plasma has multiple safeguards to assure that our products are safe against all known porcine viruses and effective for use in animal nutrition worldwide. (eapa.biz)
  • 3: Determine the mechanisms that drive ASF viral evolution, including determine the molecular determinants that drive virus evolution in ASF-historical endemic settings and determine the molecular determinants that are affecting virus evolution in new ASF-endemic settings. (usda.gov)
  • Saharan Africa and the island of Sardinia in Europe and was endemic to Spain and Portugal from 1960 until the mid 1990s. (cdc.gov)
  • The disease is endemic in Africa but now it is also present in the Russian Federation and other Eastern European countries, becoming a global threat. (intvetvaccnet.co.uk)
  • Subtyping of the virus was not performed, but the mother and fetus were almost certainly infected with the clade I variant that was endemic in the Democratic Republic of the Congo at the time. (cdc.gov)
  • Ebola virus is one of at least 30 known viruses capable of causing viral hemorrhagic fever syndrome. (medscape.com)
  • No specific therapy is available that has demonstrated efficacy in the treatment of Ebola hemorrhagic fever. (medscape.com)
  • In 2022, we received 51 eligible applications from citizens of 13 African countries enrolled in 30 institutions spanning 17 countries and 4 continents. (mammalogy.org)
  • ORF-Interrupting Mutations in Monkeypox Virus Genomes from Washington and Ohio, 2022. (cdc.gov)
  • The natural Cas9 protein possesses a nuclease activity and can induce a DNA double-strand break (DSB) in any genomic sequence guided by a gRNA, provided that a protospacer adjacent motif (PAM) sequence exists in the target locus 3 , 4 , 5 . (nature.com)
  • The team hopes to develop a vaccine using these proteins that is capable of protecting against the deadly disease. (pirbright.ac.uk)
  • 1. Develop intervention strategies to control and eradicate Classical Swine Fever (CSF), including determining immune mechanisms mediating early protection and its application in blocking infection and preventing transmission, and discovering effective CSF vaccine platforms specifically designed for disease control and eradication. (usda.gov)
  • 2. Develop intervention strategies to control African Swine Fever (ASF) including identify functional genomics of virus-host determinants of virulence and transmission, determining host mechanisms of ASF immune protection, determining host mechanisms of ASF disease tolerance in wild suids. (usda.gov)
  • The second step is the spray-drying process at high temperatures (80ºC throughout its substances) that inactivates high heat resistant viral microorganisms (using different model viruses), including non-enveloped viruses like swine vesicular disease virus. (eapa.biz)
  • African swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. (visavet.es)
  • The disease has been a variable impacting both pork trade and prices , as well as protein feed demand and soybean exports . (illinois.edu)
  • As the first ever cases of African swine fever are identified in Sweden, veterinary experts from the Balkan states have met to discuss ways of controlling the disease. (feedstrategy.com)
  • [ 1 ] The outbreak of Ebola virus disease in West Africa from 2014 to 2016, involving Zaire ebolavirus , was the largest outbreak of Ebola virus disease in history. (medscape.com)
  • As of September 17, 2019, an active outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC) had resulted in 3,034 confirmed and 111 probable cases of Ebola virus disease, including 2,103 attributable deaths. (medscape.com)
  • Human infections with viruses of animal origin are expected at the human-animal interface wherever these viruses circulate in animals. (who.int)
  • Even though small clusters of A(H5) virus infections have been reported previously including those involving healthcare workers, current epidemiological and virological evidence suggests that influenza A(H5) viruses have not acquired the ability of sustained transmission among humans, thus the likelihood is low. (who.int)
  • Observations of infections with and illness due to parainfluenza, mumps and respiratory syncytial viruses and Mycoplasma pneumoniae. (cdc.gov)
  • Sub-Objective 2.i: Identify novel virus-host genetic determinants of virulence by systematic screening of almost all previously uncharacterized virus genes. (usda.gov)
  • Sub-Objective 2.iii: identifying the immune mechanism mediating effective homologous and heterologous protection against virus infection. (usda.gov)
  • Virus infection has been consistently threatening public health. (frontiersin.org)
  • The virus neutralization assay (VNA) has allowed us not only to identify sera with neutralizing activity but also to identify sera with capacity to in vitro enhance the infection. (intvetvaccnet.co.uk)
  • Activation of NF-κB is generally a rapid response to an inducer including virus infection [15]. (biosemiotics2013.org)
  • We confirmed monkeypox virus infection in the mother, fetus, and placenta by using a monkeypox virus-specific quantitative PCR. (cdc.gov)
  • With African-derived Ebolavirus infection, there is an incubation period (typically 3-8 days in primary cases and slightly longer in secondary cases). (medscape.com)
  • The live recombinant vaccine has shown effectiveness of 97.5% in preventing infection among 90,000 individuals in an active Ebola virus outbreak in the Democratic Republic of Congo. (medscape.com)
  • A(H1N2) variant viruses and one human case of infection with an influenza A(H3N2) variant virus were reported officially.3 One additional human case of infection with an influenza A(H1N1)v virus was detected. (who.int)
  • Since the last risk assessment on 21 May 2021, one new laboratory-confirmed human case of influenza A(H5N6) virus infection was reported from China to WHO on 30 May 2021. (who.int)
  • 1. What is the likelihood that additional human cases of infection with avian influenza A(H5) viruses will occur? (who.int)
  • Additionally, bacteriophage components (endolysins and coat proteins) have a lot of applications in. (cabi.org)
  • Poxviruses E10R protein, that promotes disulfide-bond formation in coat proteins assembling in the reducing environment of the cell cytosol. (expasy.org)
  • We study the mechanism and regulation of protein synthesis, focusing on GTPases and protein kinases that control this fundamental cellular process. (nih.gov)
  • We also investigate stress-responsive protein kinases that phosphorylate eIF2alpha, viral regulators of these kinases, and how cellular phosphatases are targeted to dephosphorylate eIF2alpha. (nih.gov)
  • Dengue virus Envelope protein antibody detects Dengue virus Envelope protein protein at cytoplasm by immunohistochemical analysis. (genetex.com)
  • For several reasons there is a growing interest in the scientific community in immunoglobulin Y as antibiotic alternative and their oral administration in the polyclonal antibody (pAb) format, to maintain animal health and performance, do not require IgY purification for large-scale production, resulting in protein impurities and high concentration of biotin in the samples. (preprints.org)
  • This antibody was raised against Dengue virus 2 Envelope protein, which may cross react with Envelope protein of Dengue virus 3 but does not recignize with Envelope protein of JEV. (genetex.com)
  • Green: Dengue virus Envelope protein stained by Dengue virus Envelope protein antibody (GTX127277) diluted at 1:1000. (genetex.com)
  • Non-infected (-) and infected (+) BHK-21 whole cell extracts (5 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Dengue virus Envelope protein antibody (GTX127277) diluted at 1:25000. (genetex.com)
  • Expression of African swine fever virus envelope protein j13L inhibits vaccinia virus morphogenesis. (ox.ac.uk)
  • The H240R Protein of African Swine Fever Virus Inhibits Interleukin 1ß Production by Inhibiting NEMO Expression and NLRP3 Oligomerization. (bvsalud.org)
  • Western blot analysis was performed as a confirmation test for both expression of NSP4 protein and activation of calcium/calmodulin-dependent kinase II. (ac.ir)
  • 李暐东 , 梁布锋 , 祁自柏 , 2000: Fusion Expression of Hepatitis C Virus Core Region and NS3 Region in E .coli, Virologica Sinica, 15, 204-207. (virosin.org)
  • A) C-type lectin EP153R, B) A238L, C) CD2-like protein EP402R, D) structural protein K177R (P22). (cdc.gov)
  • Genetic Study of SARS-CoV-2 Non Structural Protein 12 in COVID-19 Patients Non Responders to Remdesivir. (cdc.gov)
  • RÉSUMÉ La compréhension de l'évolution génétique des virus A(H1N1)pdm09 et H3N2 permet de mieux sélectionner les souches devant être ajoutées au vaccin antigrippal annuel. (who.int)
  • Peu de renseignements sont disponibles sur les mutations des virus saisonniers de la grippe A(H1N1)pdm09 et H3N2 en Jordanie. (who.int)
  • Afin de remédier à ce problème et d'étudier les variations génétiques et antigéniques des virus A(H1N1)pdm09 et H3N2, nous avons procédé à des analyses génétiques et phylogénétiques des gènes de l'hémagglutinine (HA) et de la neuraminidase (NA) de ces virus, sur la période 2011-2013 en Jordanie. (who.int)
  • L'analyse a porté sur les séquences complètes des gènes de l'HA et de la NA de 16 échantillons positifs au virus H1N1 prélevés dans le cadre de cette étude, ainsi que sur 21 séquences publiées de l'HA et 20 séquences publiées de la NA, issues de virus jordaniens disponibles sur les bases de données de gènes en ligne. (who.int)
  • Les virus H1N1 jordaniens présentaient des mutations caractéristiques du groupe antigénique 6, tandis que les virus H3N2 appartenaient au groupe 3. (who.int)
  • Emergence of a novel swine-origin influenza A (H1N1) virus in humans. (cdc.gov)
  • Otherwise, an ELISA without the use of streptavidin-biotin binding would be more advisable to avoid biotin and targets protein relationship and prevent biotin interference on results. (preprints.org)
  • At about 1.5 micrometers long, it's about the size of a small bacterium and belongs to a group known as "giant viruses," which are double-stranded DNA viruses that are (with some exceptions) visible under a light microscope. (livescience.com)
  • At the first stage of viral invasion, virus-derived double-stranded DNAs (dsDNAs) trigger the conformational change and activation of cGAS. (frontiersin.org)
  • In genetic and biochemical studies, we found that the mutation disrupts eIF2 complex integrity, impairs general translation, alters translational control of mRNAs encoding key regulatory proteins, and reduces the fidelity of translation start codon selection. (nih.gov)
  • Genetic Variability of the Monkeypox Virus Clade IIb B.1. (cdc.gov)
  • Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives. (cdc.gov)
  • For instance, because the body's molecular machinery won't recognize them, MI DNAs, MI RNAs, and MI proteins resist enzymatic degradation and can largely avoid triggering an immune response, making them attractive drug candidates. (acs.org)
  • In 2007, a new outbreak of ASF was confirmed in the Republic of Georgia, which is far from the usual geographic virus range in sub-Saharan Africa. (cdc.gov)
  • On 14 June 2019, scientists at The Pirbright Institute destroyed the final archive stocks of rinderpest virus held in the World Reference Laboratory for Rinderpest . (pirbright.ac.uk)
  • European Union Reference Laboratory for African Swine Fever. (visavet.es)
  • and to study allergenic milk protein production in cow embryos cultured in the laboratory (New Zealand). (royalsociety.org.nz)
  • While protein synthesis plays a critical role in learning and memory in model systems, human intellectual disability syndromes have not been directly associated with alterations in protein synthesis. (nih.gov)
  • Hendra virus (HeV) emerged as a zoonotic pathogen in the 1990s, causing low morbidity but high mortality in humans and horses. (cabi.org)
  • Pteropid bats are the natural reservoir of HeV and other important zoonotic viruses such as Nipah and Ebola viruses. (cabi.org)
  • Ebola virus. (medscape.com)
  • These antibodies target the glycoprotein (GP) on the Ebola virus surface, thereby blocking attachment and entry of the virus on host cell membranes. (medscape.com)
  • Peñas J, Miranda ME, de los Reyes VC, Sucaldito MN, Magpantay R. Risk assessment of Ebola Reston virus in humans in the Philippines. (who.int)
  • Ebola Reston virus (RESTV) is one of the six virus species of the Ebola virus in the family Filoviridae. (who.int)
  • The name was changed to African Research Fellowship in 2021. (mammalogy.org)
  • Here, we report an easy and efficient construction system for all-in-one CRISPR/Cas9 vectors expressing Cas9 protein and up to seven gRNAs. (nature.com)
  • Although M. sibericum poses no danger to humans and other animals, the discovery of two ancient viruses in a single sample suggests that dormant pathogens may often lurk in permafrost, researchers cautioned in a 2015 study published in the journal PNAS . (livescience.com)