SynthaseReductaseEnoylBacillusCompoundsEnzymesMalonylHoloMitochondrialDehydrogenasePolyketide synthasesEscherichiaMacromoleculesACPsGenesSpeciesMutationBiosynthesisSynthesisChemicalsColiAmino acidPreferenceChainsCatalyzesSequenceScopeCrystallographyFamilyTargetsFrequentDomainsEnzymaticReviewVariantsStructureUnique
Synthase3
- This coupling is mediated by acyl carrier protein synthase (ACPS), a 4'-phosphopantetheinyl transferase. (wikipedia.org)
- Therefore, molecular docking was also used in the present study to simulate the binding of cordycepin with different antibacterial targets, such as β-ketoacyl-(acyl-carrier-protein) synthase III (FabH), DNA gyrase B and thymidylate kinase, in order to identify the most likely antimicrobial mechanism of cordycepin. (spandidos-publications.com)
- We found that sphingomyelin is enriched in migrasomes and identified sphingomyelin synthase 2 (SMS2) as an essential protein for migrasome biogenesis. (bvsalud.org)
Reductase3
- Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
- β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
- Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolution. (ox.ac.uk)
Enoyl1
- The other 2 activities of the protein are 2-enoyl coenzyme A (CoA) hydratase (LCEH) and long-chain 3-ketoacyl CoA thiolase (LCKT). (medscape.com)
Bacillus2
- L-cystine-binding protein TcyAGene Names: tcyAResearch Areas: OthersOrganism: Bacillus subtilis (strain 168)AA. (joplink.net)
- acyl-carrier-protein S-malonyltransferase [Bacillus anthracis str. (yeastrc.org)
Compounds2
- This enzyme complex metabolizes long-chain fatty acids, and the long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity is specific for compounds of C12-C16 chain length. (medscape.com)
- This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)
Enzymes1
- These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
Malonyl11
- malonyl CoA-acyl carrier protein transacylase, putative [Geobacter sulf. (yeastrc.org)
- AF237571_1 malonyl CoA-acyl carrier protein transacylase precursor [Plasmo. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Anaplasma phagocytophilu. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Campylobacter jejuni RM1. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Carboxydothermus hydroge. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Colwellia psychrerythrae. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Dehalococcoides ethenoge. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Ehrlichia chaffeensis st. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Geobacter sulfurreducens. (yeastrc.org)
- malonyl CoA-acyl carrier protein transacylase [Neorickettsia sennetsu s. (yeastrc.org)
- PREDICTED: similar to Malonyl CoA-acyl carrier protein transacylase, mi. (yeastrc.org)
Holo1
- Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
Mitochondrial7
- In the majority of cases, Rf genes produce proteins that act directly on the CMS conferring mitochondrial transcripts by binding them specifically and promoting processing events. (frontiersin.org)
- These unusual ORFs are maternally inherited, and effectively translated into novel mitochondrial proteins, with the resulting failure to produce functional pollen as the sole observed phenotype ( Chen and Liu, 2014 ). (frontiersin.org)
- In the majority of cases, Rf genes produce proteins that bind specifically to the CMS conferring transcripts in the mitochondria and promote processing events leading to a strong reduction in the production of mitochondrial CMS-inducing proteins (reviewed in Chen and Liu, 2014 ). (frontiersin.org)
- How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)
- Long-chain 3-hydroxy acyl-coenzyme A dehydrogenase (LCHAD) is 1 of 3 enzymatic activities that make up the trifunctional protein of the inner mitochondrial membrane. (medscape.com)
- The molecular defect occurs in the mitochondrial trifunctional protein (MTP). (medscape.com)
- Schematic demonstrating mitochondrial fatty acid beta-oxidation and effects of long-chain acyl CoA dehydrogenase deficiency (LCHAD) deficiency. (medscape.com)
Dehydrogenase7
- The protein is an octamer composed of 4 alpha subunits that contain the LCEH and long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activities, and 4 beta subunits that contain the LCKT activity. (medscape.com)
- Affected infants with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency, which is inherited as an autosomal recessive trait, present in infancy with acute hypoketotic hypoglycemia. (medscape.com)
- Some patients who are deficient in all 3 enzymatic activities of the protein have been described, although most have an isolated long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency, which results in the inability to metabolize long-chain fatty acids. (medscape.com)
- Patients with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase deficiency may develop a profound CNS deficiency of docosahexanoic acid ethyl ester (DHA), 22:6n-3. (medscape.com)
- Occurrence frequency of either isolated long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity deficiency or trifunctional protein deficiency is unknown in the United States. (medscape.com)
- Patients with long-chain 3-hydroxy acyl-coenzyme A dehydrogenase activity deficiency usually present with hypoketotic hypoglycemia, cardiomyopathy, hypotonia, and hepatomegaly at a median age of 6 months. (medscape.com)
- Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review. (cdc.gov)
Polyketide synthases1
- 4'-Phosphopantetheine is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). (wikipedia.org)
Escherichia1
- Modulations in lipid A and phospholipid biosynthesis pathways influence outer membrane protein assembly in Escherichia coli K-12. (wikigenes.org)
Macromolecules1
- To cause sensitization, a chemical must bind to macromolecules (proteins) in the skin. (cdc.gov)
ACPs4
- The ACPs are small negatively charged α-helical bundle proteins with a high degree of structural and amino acid similarity. (wikipedia.org)
- The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. (wikipedia.org)
- This study determines the substrate tolerance of the AH PedC for a range of acyl-ACPs. (worktribe.com)
- Clear preference towards short, linear acyl-ACPs is shown, with acetyl-ACP the best substrate. (worktribe.com)
Genes1
- Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
Species1
- The most common of these are E-3M2H and (RS)-3-hydroxy-3-methlyhexanoic acid (HMHA), which are released through the action of a specific zinc-dependent N -alpha-acyl-glutamine aminoacylase (N-AGA) from Corynebacterium species. (medscape.com)
Mutation4
- The gene for the protein has been cloned and a common mutation, G1528C , has been identified in 87% of mutant alleles. (medscape.com)
- Analysis of the frequency of the most common mutation ( G1528C ) revealed a carrier frequency of 1:240 in Finland. (medscape.com)
- Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients. (cdc.gov)
- Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. (cdc.gov)
Biosynthesis3
- The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. (wikipedia.org)
- Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
- Carrier of the growing fatty acid chain in fatty acid biosynthesis. (cusabio.com)
Synthesis2
- This product represents a full-length Acyl carrier protein (ACP), a vital component involved in the initiation and elongation steps of fatty acid synthesis in Staphylococcus aureus, an organism known for its robust resistance mechanisms and implications in human health. (cusabio.com)
- The contributors describe the mechanisms by which the agents disrupt cell wall assembly and maintenance, membrane synthesis and integrity, DNA and RNA metabolism, protein synthesis, and the folate cycle. (cshlpress.com)
Chemicals1
- Expert systems containing information about the relationship between the chemical structure and the ability of chemicals to haptenate proteins are available. (cdc.gov)
Coli2
- It is one of the most abundant proteins in cells of E. coli. (wikipedia.org)
- Originated from the Staphylococcus aureus strain Mu50 / ATCC 700699, this recombinant acpP protein is expressed in an E.coli system and includes the complete sequence of 1-77 amino acids. (cusabio.com)
Amino acid1
- PPR proteins have in common a canonical P-type 35 amino acid domain repeated in tandem up to 30 times. (frontiersin.org)
Preference1
- It has a preference for acyl groups with a carbon chain length between 4 to 16. (bvsalud.org)
Chains1
- They have been hypothesised to perform a proofreading function by removing acyl chains from stalled sites. (worktribe.com)
Catalyzes1
- An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein]. (bvsalud.org)
Sequence2
- Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)
- The PPR protein family is consequently divided in subfamilies depending on the number and type of repeats present in their sequence as well as optional C-terminal domains. (frontiersin.org)
Scope1
- SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Crystallography1
- The structures of a number of acyl carrier proteins have been solved using various NMR and crystallography techniques. (wikipedia.org)
Family2
- This protein family is largely expanded in land plant genomes. (frontiersin.org)
- ASOB2 has been identified as apolipoprotein D (apoD), a known member of the lipocalin family of carrier proteins. (medscape.com)
Targets1
- 4'-Phosphopantetheinyl transferases (PPTases) play an essential role in activating the carrier protein domains of mega-synthases involved in primary and secondary metabolism and have been validated as promising drug targets in multiple pathogens. (bvsalud.org)
Frequent1
- PPR proteins represent the most frequent protein class among identified Rfs and they exhibit ideal characteristics to evolve into restorer of fertility when the mechanism of restoration implies a post-transcriptional action. (frontiersin.org)
Domains1
- Acyl hydrolase (AH) domains are a common feature of trans-AT PKSs. (worktribe.com)
Enzymatic1
Review1
- Here, we review the literature that highlights those characteristics and help explain why PPR proteins are ideal for the roles they play as restorers of fertility. (frontiersin.org)
Variants1
- Whole-body MRI within a surveillance program for carriers with clinically actionable germline TP53 variants - the Swedish constitutional TP53 study SWEP53. (cdc.gov)
Structure1
- Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. (expasy.org)
Unique1
- The etiology of the severe peripheral neuropathy of trifunctional protein deficiency may result from the unique metabolite, 3-keto-acyl-CoA, after conversion to a methylketone via spontaneous decarboxylation. (medscape.com)