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  • synthesis
  • The team demonstrated an unbalanced ribosomal RNA and ribosomal protein synthesis during oncogene-induced senescence, a response that prevents cancer formation. (phys.org)
  • In the lab, senescent cells shut down ribosomal RNA synthesis but kept producing ribosomal proteins. (phys.org)
  • neuronal
  • Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. (genecards.org)
  • subunits
  • In the G1 phase of the cell cycle, RB is phosphorylated at low levels and associates with E2F transcription factors, which are dimeric proteins containing E2F and differentiation-related polypeptide (DP) subunits. (nih.gov)
  • human
  • A research team at the University of Basel's Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. (phys.org)
  • Dupilumab is a human monoclonal antibody that specifically inhibits overactive signaling of two key proteins, interleukin (IL)-4 and IL-13, which are believed to be major drivers of the persistent underlying inflammation in AD. (ptcommunity.com)
  • Recombinant Human Cyclin-Dependent Kinase Inhibitor 2A produced in E.coli is a single non-glycosylated polypeptide chain containing 156 amino acids and having a molecular mass of approximately 16.5 kDa. (creativebiomart.net)
  • peptide
  • It has been reported that the p16 antitumor peptide dramatically inhibits the growth of highly aggressive leukemia/lymphoma through the restoration of p16 function ( 5 ). (spandidos-publications.com)
  • binds
  • To transmit the apoptotic signal ( Schlottmann and Coggeshall, 1996 ), CD95 associates via its death domain with the Fas-associating protein with death domain (FADD/MORT1), which binds FADD-like ICE (interleukin 1-converting enzyme) (FLICE/caspase 8/MACH-1). (aspetjournals.org)
  • autosomal
  • In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. (genecards.org)
  • cancer
  • In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death. (news-medical.net)
  • Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer. (abcam.com)
  • MicroRNAs, small RNAs that inhibit the translation of their target mRNAs ( 8 ), play important roles in cancer development. (aaccjnls.org)
  • Eugenol inhibited also several other breast cancer related oncogenes, such as NF-κB and cyclin D1. (biomedcentral.com)