• Downstream of epidermal growth factor receptor (EGFR) and other receptors, SHP2 is activated by binding to phosphotyrosine-containing receptors and adapter proteins, is required for complete extracellular regulated kinase 1/2 (ERK) pathway activity, which promotes cellular proliferation and survival, and regulates other signaling processes. (upenn.edu)
  • We next developed computational models and associated quantitative experimental data sets to gain quantitative understanding of the regulation of protein complexes containing SHP2 and GRB2-associated binder 1 (GAB1), the primary phosphorylated adapter with which SHP2 associates following EGFR activation. (upenn.edu)
  • Furthermore, the determination of bacterial tyrosine phosphoproteomes will likely help to uncover the fundamental roles, mechanism and critical importance of these phosphatases in a wide range of bacteria. (edu.au)
  • In particular, these phosphatases have been associated with the control of the biosynthesis of capsular polysaccharides and extracellular polysaccharides, critically important virulence factors for bacteria.RECENT ADVANCES: Deletion and over-expression of the phosphatases result in altered polysaccharide biosynthesis in a range of bacteria. (edu.au)
  • We have examined here the interaction of the LMW-PTP isoforms with caveolin-1 and its molecular mechanism, together with the consequences for their tyrosine phosphatase activities. (unifi.it)
  • This is particularly the case for the polymerase and histidinol phosphatase family, which are predominantly found in bacteria. (edu.au)
  • Caveolin-1 contains a scaffolding region that contributes to the binding of the protein to the plasma membrane and mediates protein omo- and etero-oligomerization. (unifi.it)