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  • homolog
  • N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. (nih.gov)
  • SHP1
  • Recombinant protein encompassing a sequence within the center region of human SHP1. (genetex.com)
  • SHP1 antibody detects SHP1 protein by western blot analysis. (genetex.com)
  • SHP1 antibody immunoprecipitates SHP1 protein in IP experiments. (genetex.com)
  • IP Sample: HeLa whole cell lysate/extract A : 30 μg whole cell lysate/extract of SHP1 protein expressing HeLa cells B : Control with 3 μg of pre-immune rabbit IgG C : Immunoprecipitation of SHP1 by 3 μg of SHP1 antibody (GTX102864) 7.5% SDS-PAGE The immunoprecipitated SHP1 protein was detected by SHP1 antibody (GTX102864) diluted at 1 : 1000. (genetex.com)
  • Biologically, darinaparsin caused phosphorylation of ERK (and relevant downstream substrates) primarily by decreasing the inhibitory SHP1 phosphatase and coimmunoprecipitation showed significant ERK/SHP1 interaction. (umassmed.edu)
  • Organism
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • section shows the unique identifier assigned by the NCBI to the source organism of the protein. (uniprot.org)
  • The network for 'peptidyl tyrosine modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. (princeton.edu)