• Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
  • The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. (wikipedia.org)
  • Children with Down syndrome: association of Bcl-I polymorphism of nuclear receptor subfamily 3 group C member 1 gene with obesity. (cdc.gov)
  • The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. (bdbiosciences.com)
  • CD45, previously called LCA (leukocyte common antigen), T200, or Ly5 in mouse, is member C of the class 1 (receptor-like) protein tyrosine phosphatase family (PTPRC) (1, 2). (rndsystems.com)
  • CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. (biolegend.com)
  • CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. (biolegend.com)
  • CD45, also known as leukocyte common antigen (LCA), protein tyrosine phosphatase, receptor type I (PTPR) is a type I transmembrane protein encoded by PTPR gene specifically expresses in hematopoietic cells. (biomabinc.com)
  • We found evidence of genetic linkage of OCD to regions on chromosomes 1, 3, 6, 7, and 15. (hopkinsmedicine.org)
  • 4, 5 Four QTLs identified as pulmonary adenoma susceptibility (Pas) loci 1-4 have been mapped, respectively, to mouse chromosomes 6, 17, 19, and 9. (bmj.com)
  • It is a variably glycosylated 180‑220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin (1‑3). (rndsystems.com)
  • The CD45 isoforms detected in rat are cell type-, maturation-, and activation state-specific. (bdbiosciences.com)
  • CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure (1‑5). (rndsystems.com)
  • These isoforms are very specific to the activation and maturation state of the cell as well as cell type. (biolegend.com)
  • Dfferentially spliced transcription of exon 4, 5 and 6 yields 6 isoforms: ABC (exon 4, 5 and 6), AB (exon 4 and 5) or BC (Exon 5 and 6), A (only exon 4), B (only exon 5) and O (no exon 4, 5, or 6). (biomabinc.com)
  • Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
  • Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
  • GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27]. (abic2004.org)
  • ABBV-CLS-484 hydrochloride is an inhibitor of phosphatase PTPN2/N1 (Protein Tyrosine Phosphatase Non-Receptor Type 2/1), and a highly effective immunotherapy agent with monotherapy efficacy across mouse tumor models. (axonmedchem.com)
  • Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. (signalchem.com)
  • By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction (2). (signalchem.com)
  • Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
  • CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds (3, 6‑8). (rndsystems.com)
  • CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders (6, 7). (rndsystems.com)
  • C57BL/6 splenocytes were stained with CD45 (clone I3/2.3) PE/Cyanine7 (filled histogram) or rat IgG2b PE/Cyanine7 isotype control (open histogram). (biolegend.com)
  • CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. (biolegend.com)
  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. (cancerindex.org)
  • DEGs in GO analysis were enriched in biological processes about inflammation and in KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signaling pathway and NF-κB signaling pathway. (researchsquare.com)
  • 2. Yamamoto, T. et al: The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. (signalchem.com)
  • It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
  • Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
  • Pathogenesis: We are investigating MAP role in Crohn's and Type I Diabetes in association with single nucleotide polymorphisms (SNPs) in disease-specific genes. (ucf.edu)
  • This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3). (ox.ac.uk)
  • Human cell 2021 8 34 (6): 1671-1681. (cdc.gov)
  • Frontiers in cell and developmental biology 2021 6 9 641152. (cdc.gov)
  • Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Protein Tyrosine Phosphatase, Non Receptor Type 11 (PTPN11) in samples from tissue homogenates or other biological fluids. (worldcarecouncil.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Different mutations of EDA gene and EDAR gene could make different influence on the protein function and lead to the occurrence of HED. (bvsalud.org)
  • Vertebrate enteropeptidase ( EC 3.4.21.9 ), a type II membrane protein of the intestinal brush border, which activates trypsinogen. (embl.de)
  • 1. Gupta, S. et al: A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. (signalchem.com)
  • In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)
  • It was identified that the insulin sensitizing effect of chemical constituents from Radix Paeoniae Rubra is modulated by the inhibition of protein-tyrosine phosphatase 1B [ 6 ]. (hindawi.com)
  • The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
  • Apical endosomal glycoprotein from rat, a protein probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. (embl.de)
  • its intracellular (COOH-terminal) region contains two PTP catalytic domains while the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), and differing levels of glycosylation. (bdbiosciences.com)
  • CD45R0 is the shortest form, lacking exons 4, 5 and 6 which encode aa 30‑169. (rndsystems.com)
  • It consists at least of a catalytic light chain and a multidomain heavy chain which has 2 LDL receptor class A domains, a MAM domain, a SRCR domain and a CUB domain. (embl.de)
  • The mouse CD45RABC cDNA encodes 1291 amino acids (aa), including a 23 aa signal sequence, a 541 aa extracellular domain containing the splicing region, a cysteine-rich region and two fibronectin type III domains, a 22 aa transmembrane sequence, and a 705 aa cytoplasmic domain that contains two phosphatase domains, D1 and D2. (rndsystems.com)
  • 6 Inbred mouse strains vary in their susceptibility to cancer and two extreme strains are A/J (susceptible) and C57BL/6J (B6, resistant). (bmj.com)
  • Mouse pulmoary adenoma susceptibility loci (Pas) as mapped in crosses of strains A/J and C57BL/6. (bmj.com)
  • The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
  • Xenopus laevis thyroid hormone induced protein B. This protein contains 4 MAM domains. (embl.de)
  • The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. (cancerindex.org)
  • Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. (molcells.org)
  • Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)
  • Both chlordecone and E2 activated splenic B cells and enhanced GC reactions, as shown by upregulated protein expression of GL7, CXCR5, and CXCR4. (nih.gov)
  • Both treatments increased B-cell bcl-2 and shp-1 gene expression and enhanced ICAM-1 and VCAM-1 protein levels in GC B cells. (nih.gov)
  • It is expressed on memory cells, while intermediate sizes are expressed on other T cells (3, 4, 6). (rndsystems.com)
  • It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. (biolegend.com)
  • Programmed cell death protein 1 (PD-1) receptors in activated T cells and their ligand programming death force 1 (PD-L1) are the main checkpoint signals that control T cell activity. (bvsalud.org)
  • A common heterophilic ligand for these RTK family members is definitely Gas6 a vitamin K-dependent protein that is widely secreted by most cells including the lungs intestine Serping1 and vascular endothelium (43). (exposed-skin-care.net)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
  • [ 6 ] In addition, a case of PAS III complicated with autoimmune hepatitis was reported from Japan. (medscape.com)
  • 2020. Sci Adv. 6:eaax7515. (biolegend.com)
  • 2020, 6(38): eabc0330. (titech.ac.jp)
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
  • The domain has been shown to play a role in homodimerization of protein-tyrosine phosphatase mu [ ( PUBMED:7782276 ) ] and appears to help determine the specificity of these interactions. (embl.de)
  • Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
  • However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. (techscience.com)
  • Previous findings indicate an association between hypothyroidism and higher macrophage inflammatory response with release of pro-inflammatory cytokines (interleukin-1 (IL-1), IL-6 and tumour necrosis factor-α). (bmj.com)
  • Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
  • Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment. (westminster.ac.uk)
  • [ 8 ] This patient had DQA1 0102, 0103 and DQB1 0602, 0601 that were considered as type 1 diabetes-protective HLA alleles. (medscape.com)
  • In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family (1). (signalchem.com)
  • This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. (wikipedia.org)
  • Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • paratuberculosis (MAP) in the etiology of Crohn's disease and Type I Diabetes. (ucf.edu)
  • These PTPases have an extracellular region which consists of a MAM domain followed by an Ig-like domain and four fibronectin-type III domains. (embl.de)
  • Our most significant finding was for a genetic marker on chromosome 9, near the protein tyrosine phosphatase receptor type D gene (PTPRD). (hopkinsmedicine.org)
  • Unlike other SGAs, such as clozapine and olanzapine, risperidone is a derivative of benzisoxazole with multiple receptor antagonist properties, making it more effective against negative symptoms and more beneficial on both affective symptoms and cognitive impairments ( 11 ). (frontiersin.org)
  • BACKGROUND: As an important component of the Hippo pathway, WW domain-containing transcription regulator 1 (TAZ), is a transcriptional coactivator that is responsible for the progression of various types of cancers. (bvsalud.org)
  • However, the detailed mechanism of Fra-1 in GC is unclear, such as the identification of Fra-1-interacting proteins and their role in GC pathogenesis. (techscience.com)
  • Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. (wikipedia.org)