• 100 µg, ABP-PAB- (100 µg) Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). (allelebiotech.com)
  • This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. (genecards.org)
  • The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. (wikipedia.org)
  • PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain - post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). (wikipedia.org)
  • This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein. (wikipedia.org)
  • The C-terminal carboxylate group is bound by a nest (protein structural motif) in the PDZ domain. (wikipedia.org)
  • PDZ is an acronym derived from the names of the first proteins in which the domain was observed. (wikipedia.org)
  • Earlier that year, another set of scientists had claimed to discover a new protein domain which they called a DHR domain. (wikipedia.org)
  • PDZ domain structure is partially conserved across the various proteins that contain them. (wikipedia.org)
  • Contains 1 tyrosine-protein phosphatase domain. (abcam.com)
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain. (abcam.com)
  • Taxonomic distribution of proteins containing PDZ domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with PDZ domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing PDZ domain in the selected taxonomic class. (embl.de)
  • Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-termini of substrate proteins, separate from its catalytic site. (embl.de)
  • In this work, we show that substrate recognition of Tsp is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. (embl.de)
  • The isolated PDZ domain (amino acids 206-334) is capable of folding into a well-behaved structure and binds to a nonpolar peptide with a dissociation constant (K(D)) of 1.9 microM, similar to that of the intact Tsp protein. (embl.de)
  • The use of a separate substrate recognition domain such as a PDZ domain may be a general mechanism for achieving selective protein degradation. (embl.de)
  • High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas. (nih.gov)
  • Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades proteins bearing a nonpolar C-terminus. (embl.de)
  • This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. (nih.gov)
  • Approximately 90% bound to human serum protein (mainly albumin) at plasma concentrations between 1 and 10 mg/L. (drugbank.ca)
  • Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. (princeton.edu)
  • this interaction increases the PTPN11 phosphatase activity. (rcsb.org)
  • However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. (embl.de)
  • Researchers demonstrated how temozolomide-perillyl alcohol conjugate also exhibited its cytotoxicity against non-small cell lung cancer, the most common type of lung cancer, as evidence from cell/tumor proliferation inhibition, G2/M arrest, DNA damage and mitochondrial apoptosis. (pulmonarycellnews.com)
  • The observed type of heredity associated with MS is characteristic of polygenic diseases, which arises from a joint contribution of a number of independently acting or interacting polymorphic genes. (deepdyve.com)
  • For cells to function properly it is important for components-proteins and other molecules- to be in the right place at the right time. (wikipedia.org)
  • Blue cells = expressed in wild-type. (jax.org)
  • Several studies involving humans and animal models have provided evidence for genetic influences on susceptibility to diabetic nephropathy or ESRD and their related phenotypes ( 3 , 4 ). (diabetesjournals.org)
  • Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. (nih.gov)
  • Photoaffinity labeling with a fluorescent nonpolar peptide caused the covalent attachment of the peptide to a single site on the Tsp protein. (embl.de)