AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Protein Tyrosine PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 1Receptor-Like Protein Tyrosine Phosphatases, Class 2Protein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 2Protein Tyrosine Phosphatase, Non-Receptor Type 6TyrosineReceptor-Like Protein Tyrosine Phosphatases, Class 3Receptor-Like Protein Tyrosine Phosphatases, Class 4Protein Tyrosine Phosphatases, Non-ReceptorReceptor-Like Protein Tyrosine Phosphatases, Class 5Receptor-Like Protein Tyrosine PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 12SH2 Domain-Containing Protein Tyrosine PhosphatasesPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 13VanadatesReceptor-Like Protein Tyrosine Phosphatases, Class 7Phosphoprotein PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 22Signal TransductionReceptor-Like Protein Tyrosine Phosphatases, Class 8Protein Tyrosine Phosphatase, Non-Receptor Type 3PhosphotyrosineProtein-Tyrosine KinasesProtein Phosphatase 2Intracellular Signaling Peptides and ProteinsProtein Phosphatase 1Molecular Sequence DataAmino Acid SequenceAntigens, CD45Acid Phosphatasesrc Homology DomainsEnzyme InhibitorsEnzyme ActivationCell Linesrc-Family KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 4Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Phosphoric Monoester HydrolasesCells, CulturedProtein BindingPhosphoproteinsGenisteinSubstrate SpecificityProto-Oncogene Proteins pp60(c-src)Base SequenceKineticsRecombinant Fusion ProteinsDual-Specificity PhosphatasesTransfectionMutationProto-Oncogene Proteins c-fynProtein Structure, TertiaryRecombinant ProteinsTumor Cells, CulturedCatalytic DomainSequence Homology, Amino AcidBinding SitesProto-Oncogene ProteinsBlotting, WesternReceptors, Cell SurfaceRNA, MessengerCloning, MolecularPrecipitin TestsIsoenzymesMice, KnockoutGlucose-6-PhosphataseReceptor Protein-Tyrosine KinasesTyrosine 3-MonooxygenaseCOS CellsMembrane ProteinsMitogen-Activated Protein Kinasescdc25 PhosphatasesGene Expression Regulation, EnzymologicAdaptor Proteins, Signal Transducing3T3 CellsDown-RegulationOkadaic AcidTyrphostinsReceptor, InsulinGene ExpressionMice, Inbred C57BLReceptor, Epidermal Growth FactorCell AdhesionJurkat CellsFocal Adhesion Protein-Tyrosine KinasesJanus Kinase 2PaxillinSTAT3 Transcription FactorFocal Adhesion Kinase 1GRB2 Adaptor ProteinReceptors, Antigen, T-CellImmunoblottingPhosphopeptidesProteinsT-LymphocytesDNA, ComplementaryAntigens, CDNerve Tissue Proteins
KinasesPhosphorylationSubunitELISA KitMonths from date of receiptAntigenPTPRCInhibitionMutations20212023RegulationCD45Cytokine receptorResiduesInterleukinAntibodyCytoplasmicRegulatorLigandsExtracellularPathwaysSpleenInhibitors20162018HumansNuclearLymphomaComplexSpeciesInteractionComplexesSignaling lymphocyImmunologicalInsulin receptorResidueGenesAutoimmuneShown to interactDisordersMembraneAffinity chromatographyTherapeuticDefectsAMPK
Kinases4
  • It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. (origene.com)
  • This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (origene.com)
  • Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • OBJECTIVE: The receptor-like protein-tyrosine phosphatase (PTP) CD148 and the nontransmembrane PTP1-B have been shown to be net positive regulators of Src family kinases in platelets. (ox.ac.uk)
Phosphorylation14
  • CCDC180 is predicted to undergo a variety of post-translational modifications: Phosphorylation on serine, threonine, and tyrosine residues Tyrosine sulfation Sumoylation O-linked β-N-acetylglucosamine modification of a serine residue CCDC180 is predicted to localize to the nucleus, and it contains four nuclear localization sequences. (wikipedia.org)
  • Silencing of receptor protein tyrosine phosphatase (RPTP)α, a VacA receptor, reduced VacA-induced Src phosphorylation. (elsevierpure.com)
  • Src is responsible for tyrosine phosphorylation of CagA at its Glu-Pro-Ile-Tyr-Ala (EPIYA) variant C (EPIYA-C) motif in Helicobacter pylori-infected gastric epithelial cells, resulting in binding of CagA to SHP-2 phosphatase. (elsevierpure.com)
  • Challenging AZ-521 cells with wild-type H. pylori induced phosphorylation of CagA, but this did not occur when challenged with a vacA gene-disrupted mutant strain. (elsevierpure.com)
  • Following siRNA-mediated RPTPα knockdown in AZ-521 cells, infection with wild-type H. pylori and treatment with VacA did not induce CagA phosphorylation. (elsevierpure.com)
  • Furthermore, employing flow cytometry, Western blotting and adhesion assays for PBMCs and Jurkat-T cells, we elucidate that insulin enhances fibronectin adherence of quiescent lymphocytes through non-canonical signalling involving insulin-like growth factor-1 receptor (IGF-1R) autophosphorylation, phospholipase C gamma-1 (PLCγ-1) Tyr783 phosphorylation and inside-out activation of ß-integrins respectively. (bvsalud.org)
  • ed protein tyrosine phosphatase non-receptor type 12 (PTPN12) at Ser434 and inhibited PTPN12 activity, thus enhancing phosphorylation of Janus kinase 2 (JAK2), which phosphorylated growth factor receptor bound protein 2 (GRB2) at Tyr160 to promote GRB2 dimers dissociation and recruitment of GRB2 to SVCT2, leading to further ERK activation. (archive.org)
  • Phosphorylation of YAP at S381 by Lats1/2 primes the proteins for following phosphorylation at multiple sites, which in turn prospects to polyubiquitination and degradation 27. (colinsbraincancer.com)
  • Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
  • We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
  • The expression of a mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity. (nature.com)
  • Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)
  • 7 The JAKs also trigger the activation and tyrosine phosphorylation of STAT5, causing parallel dimerization, nuclear translocation and tetramerization of STAT5. (nature.com)
  • However, they exhibited a marginal reduction in α(IIb)β(3)-mediated Src family kinase activation and tyrosine phosphorylation. (ox.ac.uk)
Subunit3
  • This activation is mediated by tyrosine dephosphorylation of the AMPKα subunit. (bvsalud.org)
  • The CaMKIIα-tTA transgene inserted on chromosome 12, resulting in a 508 kb deletion that affects five mouse genes: Vipr2 (vasoactive intestinal peptide receptor 2), Wdr60 (WD repeat-containing protein 60), Esyt2 (extended synaptotagmin-like protein 2), Ncapg2 (non-SMC condensin II complex, subunit G2), and Ptprn2 (protein tyrosine phosphatase, receptor type, N polypeptide 2). (alzforum.org)
  • S3I-201 Insulin, GAD (GAD, 65-kDa isoform), the tyrosine-like phosphatase proteins IA-2, the islet-specific blood sugar-6-phosphatase catalytic subunit-related proteins (IGRP), and the lately recognized cation efflux transporter ZnT8 are well characterized and generally targeted autoantigens (2C8). (insulin-receptor.info)
ELISA Kit2
  • Description: A sandwich ELISA kit for detection of Protein Tyrosine Phosphatase, Non Receptor Type 11 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (worldcarecouncil.org)
  • Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
Months from date of receipt1
  • 12 months from date of receipt, -20 to -70 °C as supplied. (novusbio.com)
Antigen3
  • Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. (antibodiesinc.com)
  • The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. (bdbiosciences.com)
  • This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. (origene.com)
PTPRC1
  • Full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell. (origene.com)
Inhibition4
  • The deletion mutant maintains the catalytic activity but is unable to carry out inhibition of proliferation on HeLa cells, achieved by the wild type form, since it does not reach the plasma membrane. (unina.it)
  • It was identified that the insulin sensitizing effect of chemical constituents from Radix Paeoniae Rubra is modulated by the inhibition of protein-tyrosine phosphatase 1B [ 6 ]. (hindawi.com)
  • In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. (cancerindex.org)
  • The inhibitory effect of cAMP could not be reversed by inhibition of cAMP-dependent protein kinase (PKA) but was blocked by depletion of the alternative intracellular cAMP sensor exchange protein activated by cAMP 1 (Epac1), which is also required to observe SOCS-3 accumulation in response to cAMP. (gla.ac.uk)
Mutations4
  • XLP type 2 (XLP2) is caused by mutations in the XIAP gene. (medscape.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Both are linked to transformation due to deregulated kinase/phosphatase signaling or STAT5 gain-of-function (GOF) mutations. (nature.com)
  • Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. (cdc.gov)
20211
  • Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
20232
Regulation4
  • This protein is known to localize to the nucleus and is thought to be involved in regulation of transcription as are many proteins containing coiled-coil domains. (wikipedia.org)
  • PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. (antibodiesinc.com)
  • Regulation of receptor-type phosphatases can involve the formation of higher-order structures, but the exact role played in this process by protein domains is not well understood. (unina.it)
  • Given the stringent, cell type-specific regulation of this pathway, these data raise the possibility that vulnerability to SE-induced cell death may, in part, depend on the capacity of a cell to elicit a MAPK pathway-dependent neuroprotective response. (jneurosci.org)
CD452
  • CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. (bdbiosciences.com)
  • The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. (bdbiosciences.com)
Cytokine receptor1
  • In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation. (gla.ac.uk)
Residues1
  • OGT transfers O-GlcNAc moieties from UDP-GlcNAc to serine and threonine residues of proteins and O-GlcNAcase (OGA) catalyzes the opposite reaction to remove O-GlcNAc. (nature.com)
Interleukin2
  • Here we demonstrate that elevation of cyclic AMP (cAMP) levels in human umbilical vein endothelial cells (HUVECs) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-α/IL-6 (sIL-6R-α/IL-6) trans-signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate. (gla.ac.uk)
  • A novel pathogenic mutation on the interleukin-7 receptor has been described in a newborn. (medscape.com)
Antibody1
  • Bulk Order Inquiry for Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody FL550 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
Cytoplasmic1
  • 15 The dynamic addition and removal of O-GlcNAc has been described for multiple cytoplasmic and nuclear proteins and it affects the function of various signaling molecules and transcription factors. (nature.com)
Regulator3
  • PTPN23 is a regulator of endosomal trafficking functioning to move activated membrane receptors, such as EGFR, from the endosomal sorting complex towards the ESCRT-III complex for multivesicular body biogenesis, lysosomal degradation, and subsequent downregulation of receptor signaling. (edu.sa)
  • Here, we report that high levels of the striatal-enriched protein tyrosine phosphatase (STEP), a key regulator of ERK/MAPK signaling, are found in vulnerable somatostatin-immunoreactive hilar interneurons. (jneurosci.org)
  • Our data reveal that the vulnerable cells express high levels of striatal-enriched protein tyrosine phosphatase (STEP), which is a key regulator of the extracellular signal-regulated kinase (ERK) pathway. (jneurosci.org)
Ligands2
  • The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. (cancerindex.org)
  • New modeling approaches reveal 'hidden' low-occupancy conformational states for protein and ligands. (rcsb.org)
Extracellular4
  • Although the molecular mechanisms responsible for the selective vulnerability of these cells are not well understood, activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway has been implicated in neuroprotective responses to excitotoxicity in other neuronal populations. (jneurosci.org)
  • This is followed by their culture on extracellular matrix (ECM) protein coated tissue culture flasks in presence of endothelial cell growth medium. (bvsalud.org)
  • This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. (origene.com)
  • 3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)
Pathways2
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Although PTPN14 continues to be implicated like a downstream effector of Akt 40, the signaling pathways controlled by this tyrosine phosphatase never have been well characterized. (colinsbraincancer.com)
Spleen1
  • These defects were associated with reduced activation of Src family kinase and spleen tyrosine kinase, suggesting a causal relationship. (ox.ac.uk)
Inhibitors1
  • In silico analysis, therefore, was performed to identify small drug-like molecules as potential inhibitors of transforming growth factor beta-2 receptor (TGFβRII). (brjnmims.org)
20161
20182
  • Indian journal of dermatology 2018 12 63 (6): 449-454. (cdc.gov)
  • Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
Humans1
  • Coiled-coil domain containing protein 180 (CCDC180) is a protein that in humans is encoded by the CCDC180 gene. (wikipedia.org)
Nuclear3
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. (cancerindex.org)
  • YAP, also called Yes-associated proteins 1, is usually an element of nuclear transcriptional complexes 9. (colinsbraincancer.com)
Lymphoma1
Complex1
  • When YAP is usually phosphorylated at S127 - an activity that is usually suffering from cell denseness C it forms a far more stable complex using the 14-3-3 protein and becomes maintained in the cytoplasm 6, 25C26. (colinsbraincancer.com)
Species1
  • The following table includes a subset of species containing protein orthologs of CCDC180. (wikipedia.org)
Interaction1
  • In the absence of SAP, interaction of CD48 on EBV-infected cells with 2B4 (a receptor belonging to the immunoglobulin superfamily that is found on natural killer [NK] cells as well as a small subset of T cells) on NK cells inhibits their ability to kill the EBV-infected cell. (medscape.com)
Complexes2
  • The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization. (unina.it)
  • However, other PTPRJ complexes, dependent on the formation of disulfide bonds, are detected by treatment with the oxidant agent H(2)O(2) or by a mutation Asp872Cys, located in the eighth fibronectin type III domain of PTPRJ. (unina.it)
Signaling lymphocy1
  • Codiscovery by other groups led to the other designations, DSHP and SAP (signaling lymphocytic activation molecule [SLAM]-associated protein). (medscape.com)
Immunological2
  • In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
  • Another feasible trigger of immunological failing is normally repeat of type 1 diabetes. (insulin-receptor.info)
Insulin receptor1
  • Pentagalloylglucose, another Radix Paeoniae Rubra constituent, acts like an insulin mimetic by binding to the insulin receptor [ 2 , 7 ]. (hindawi.com)
Residue1
  • BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
Genes1
  • This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3). (ox.ac.uk)
Autoimmune3
  • These antibodies belong to a network of natural antibodies against adrenergic, cholinergic and other G-protein coupled receptors (GPCR) which were shown to be dysregulated and dysfunctional in various autoimmune diseases ( 9 ). (frontiersin.org)
  • Type 1 diabetes (T1D) is a chronic autoimmune disease during which pancreatic β-cells are specifically damaged by an aberrant immune response. (diabetesjournals.org)
  • Type 1 diabetes is definitely an autoimmune disease characterized by the lymphocytic infiltration of the pancreatic islets (insulitis), -cell damage, and reduction of insulin release (1). (insulin-receptor.info)
Shown to interact1
  • The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. (cancerindex.org)
Disorders1
  • VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific receptors. (elsevierpure.com)
Membrane1
  • GCA (grancalcin) is usually a cytosolic protein that is translocated to the granule membrane upon neutrophil activation [26,27]. (abic2004.org)
Affinity chromatography1
  • Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. (antibodiesinc.com)
Therapeutic1
  • Current research aims to explore potential insulinotropic effects and long-term therapeutic efficacy of such herb against type 2 diabetes. (hindawi.com)
Defects2
  • Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity. (mpg.de)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
AMPK1
  • The AMP-activated protein kinase (AMPK) is known to be activated by the protein tyrosine phosphatase non-receptor type 12 (PTP-PEST) under hypoxic conditions. (bvsalud.org)