• It is now well established that the members of the PTP (protein tyrosine phosphatase) superfamily play critical roles in fundamental biological processes. (biochemj.org)
  • The protein tyrosine phosphatase PTPN22( C1858T) allelic polymorphism is associated with increased susceptibility for development of systemic lupus erythematosus (SLE) and other autoimmune diseases. (rupress.org)
  • Proteomic analysis of cisplatin-induced cochlear damage: Methods and early changes in protein expression. (wikigenes.org)
  • In the presence of sodium vanadate, a phosphatase inhibitor, phosphorylated Stat1 accumulated in the nucleus as the total amount of Stat1 in the cytoplasm declined to low levels. (pnas.org)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • By analyzing the flow of Stat1 from cytoplasm to nucleus upon receptor-JAK inactivation and the effect of phosphatase inhibition on Stat1 subcellular localization, we provide evidence that a nuclear tyrosine phosphatase plays a major role in Stat1 inactivation and nuclear export. (pnas.org)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The protein tyrosine phosphatase Shp2 is a positive regulator of growth factor signaling. (pnas.org)